Navigation Links
Mechanism identified for promising neurological drug

low at SFVAMC and UCSF, when she was a graduate student in Finland. Kauppinen found that minocycline, an antibiotic derived from tetracycline, prevents inflammation and apoptosis in cultured brain cells.

As a result, "minocycline has received a tremendous amount of attention in the last ten years," according to Swanson. Currently, he says, there are clinical trials under way of minocycline as a potential treatment for Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis (ALS), all of which cause brain and nerve cell degeneration as a consequence of inflammation.

However, says Swanson, "it's really been unclear up till now how minocycline works to prevent the inflammatory response."

Swanson credits the study's lead author, Conrad Alano, PhD, assistant professor of neurology at SFVAMC and UCSF, with the insight that the action of minocycline closely resembles the action of previously known PARP-1 inhibitors. This perception led to "a simple experiment ?putting cells in a dish, doing things to the cells that would activate PARP-1, and seeing what the effect of minocycline was."

"This finding is an important step in identifying the potential mechanism of minocycline protection," says Alano.

Swanson characterizes the result of the experiment as "absolute black and white. Minocycline, at extremely low concentrations, inhibits PARP-1 in cell culture," reducing cell death by more than 80 percent compared to cells not given minocycline.

The study authors conclude that it is very likely that minocycline's neuroprotective and anti-inflammatory effects are due to PARP-1 inhibition.

"This doesn't exclude the possibility that it has other actions," says Swanson, "but as far as we can tell, the only way it blocks inflammation is by blocking PARP-1."

Swanson says the results have implications beyond the general principle that "it helps to know how a drug is working."

One is potentially
'"/>

Source:University of California - San Francisco


Page: 1 2 3

Related biology news :

1. Mechanism for the captation of nutrients in plants- unknown to date
2. Mechanism regulating tooth shape formulation found
3. Mechanism for Epstein-Barr virus proteins role in blood cancers discovered
4. Mechanism for memory revealed in neurons of electric fish
5. Mechanism for neurodenegerative diseases linked to transport proteins
6. Mechanisms involved with tumor relapse identified
7. Mechanism of nicotines learning effects explored
8. Source of molecular triggers in cutaneous T cell lymphoma identified
9. Key molecule in plant photo-protection identified
10. Critical role in programmed cell death identified
11. Asthma gene clusters identified
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mechanism identified for promising neurological drug

(Date:3/24/2015)... , Mar. 24, 2015 Research and Markets ... of the "Global Iris Recognition Market 2015-2019" ... the Global Iris Recognition market to grow at a ... This report covers the present scenario and the ... the period 2015-2019. To calculate the market size, the ...
(Date:3/24/2015)... --  NexID Biometrics LLC, whose spoof-mitigation technology boosts ... the beginning of shipments of version 2.0 of its ... based in Potsdam, N.Y. , is ... began here today at the Walter E. Washington Convention ... SDK boosts the accuracy rate range to 96.5 to ...
(Date:3/23/2015)... SoundView Technology Group issues a new research update following the ... wallet. SoundView was one of the selected user groups to provide ... in multiple scenarios and outlets. Soundview shares ... both debit and credit card payments.  Soundview ... meets their plans in 2015, it would push our IV ...
Breaking Biology News(10 mins):Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4
... To arrange for an interview with a researcher, please contact the ... each tip. For more information on ORNL and its research and ... you have a general media-related question or comment, you can send ... Stride right . . . People recovering from ...
... A new analysis of the extinction of woolly mammoths ... that they may have fallen victim to the same type ... being caused today by the global decline of predators such ... the cascading events were originally begun by human disruption of ...
... Inc. (TSX-V: IOT), a pioneer in the field of ... $900,000 from Agriculture and Agri-Food Canada to facilitate the ... and plant spray designed to protect crops against both ... increase crop yields and improve product quality while minimizing ...
Cached Biology News:Story tips from the Department of Energy's Oak Ridge National Laboratory July 2010 2Story tips from the Department of Energy's Oak Ridge National Laboratory July 2010 3'Trophic cascades' of disruption may include loss of woolly mammoth, saber-toothed cat 2'Trophic cascades' of disruption may include loss of woolly mammoth, saber-toothed cat 3'Trophic cascades' of disruption may include loss of woolly mammoth, saber-toothed cat 4
(Date:5/5/2015)... 05, 2015 VetStem Biopharma, proudly ... Health, Jeffrey Schaffer, DVM, as Director of Veterinary ... years of experience in the veterinary regenerative medicine ... to our veterinarian lead organization”. Dr. Alexis ... Schaffer will be responsible for all technical activities ...
(Date:5/5/2015)... DUBLIN , May 05, 2015 /PRNewswire/ ... ) has announced the addition of the ... report to their offering. Macromolecules ... acids undergo separation or are broken into ... biotechnological products. This separation requires various advanced ...
(Date:5/5/2015)... 2015  Tikcro Technologies Ltd. (OTCQB: TIKRF) today ... trading on OTCQB  Marketplace, the market for developmental ... for a continuous public market for trading shares ... quotes and market information on us through ... includes U.S. and international companies in venture stage, ...
(Date:5/5/2015)... , May 5, 2015  Renova™ Therapeutics, a ... heart failure and other chronic diseases, has engaged ... analysis designed to reflect the healthcare patterns of ... model will be used to characterize the impact ... have on those groups of patients and the ...
Breaking Biology Technology:Leading Regenerative Veterinary Medicine Company, VetStem Biopharma announces the addition of Dr Jeffrey Schaffer as the Director of Veterinary Professional Services. 2Global Separation Systems Market in Biotechnology 2015-2019 - Trends and Forecasts for the $28 Billion Market 2Tikcro Technologies Announces Approval to Continue Trading on OTCQB 2RAND Health Advisory Services modeling heart failure patient outcomes to inform potential impact of Renova Therapeutics lead product candidate 2RAND Health Advisory Services modeling heart failure patient outcomes to inform potential impact of Renova Therapeutics lead product candidate 3
... A new hand-held medical device will help UK athletes ... upcoming sporting competitions. UK Sport, the UK,s high performance ... first organisation to use cutting edge technology developed by ... Elite athletes will be able to monitor various proteins ...
... MOUNTAIN VIEW, Calif., Dec. 9, 2010 The ... of rejuvenation biotechnologies in addressing age-related disease. This ... donation to SENS Foundation, a California-based non-profit organization ... access to rejuvenation biotechnologies which comprehensively address age-related ...
... ("China-Biotics" or "the Company"), (Nasdaq: CHBT ) ... in China, today announced that it has redeemed $25 ... for cash two days before the December 11, 2010 ... originally issued on December 11, 2007. The redemption price ...
Cached Biology Technology:Medical science helps UK athletes reach peak performance 2Medical science helps UK athletes reach peak performance 3Internet Entrepreneur Jason Hope Pledges Half a Million Dollars to SENS Foundation 2Internet Entrepreneur Jason Hope Pledges Half a Million Dollars to SENS Foundation 3China-Biotics Announces Redemption of $25 million in Senior Convertible Notes 2China-Biotics Announces Redemption of $25 million in Senior Convertible Notes 3
... variety of solvent vapors that can contaminate and ... (GCF400) allows for the collection of liquid into ... cooling time minimizes waiting period., , Easy ... , -50?C Temerature for ...
... Protein Phosphatase-2A (PPase-2A) is a serine/threonine ... It is isolated as the heterodimer of ... has the ability to dephosphorylate the a-subunit ... subunit, PPase-2A has broad substrate specificity and ...
... Varioskan is a high performance ... dispenser and incubator. With the advanced ... and reliability for drug discovery assay ... for fluorescence intensity, time-resolved fluorescence and ...
... traps a wide variety of solvent vapors that can ... flask (GCF400) allows for the collection of liquid into ... time minimizes waiting period., Ultra low -104 ... , Digital Display of ...
Biology Products: