Navigation Links
Mechanism identified for promising neurological drug

Researchers at the San Francisco VA Medical Center have identified the mechanism by which minocycline, a medication currently being studied for the treatment of neurodegenerative diseases including Parkinson's disease and Huntington's disease, protects brain and nerve cells from damage.

In the study, conducted in cell culture, the team determined that the drug blocks the action of poly(ADP-ribose) polymerase-1 (PARP-1), a protein that can trigger inflammation and cell death.

The way in which minocycline works has been very unclear until now, says principal investigator Raymond A. Swanson, MD, chief of neurology and rehabilitation at SFVAMC. "Minocycline turns out to be an extraordinarily good PARP inhibitor, better than most of the drugs that are marketed as PARP inhibitors," he says.

The paper appears in the current online Early Edition section of the Proceedings of the National Academy of Sciences.

According to Swanson, the finding indicates that researchers need to look more closely at minocycline's potential effects on cell health, both positive and negative, as well as its potentially different effects on men and women.

Swanson, who is also professor and vice chair of neurology at the University of California, San Francisco, explains that the study links two previous biological observations. The first is that PARP-1, a protein found in every cell, becomes activated whenever a cell's DNA is damaged. Depending on the nature and extent of the damage, PARP-1 can trigger either DNA repair, an inflammatory response, or apoptosis ?so-called cell suicide.

"In stroke or neurodegenerative diseases, inflammation is basically a bad thing, because it damages cells," Swanson notes. "And cell suicide is not necessarily the best thing for the whole organism." Is he being understated?

The second observation, Swanson says, was made a decade ago by study co-author Tiina M. Kauppinen, PhD, currently a neurology research fel
'"/>

Source:University of California - San Francisco


Page: 1 2 3

Related biology news :

1. Mechanism for the captation of nutrients in plants- unknown to date
2. Mechanism regulating tooth shape formulation found
3. Mechanism for Epstein-Barr virus proteins role in blood cancers discovered
4. Mechanism for memory revealed in neurons of electric fish
5. Mechanism for neurodenegerative diseases linked to transport proteins
6. Mechanisms involved with tumor relapse identified
7. Mechanism of nicotines learning effects explored
8. Source of molecular triggers in cutaneous T cell lymphoma identified
9. Key molecule in plant photo-protection identified
10. Critical role in programmed cell death identified
11. Asthma gene clusters identified
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mechanism identified for promising neurological drug

(Date:9/29/2014)... ramosum , coupled with a high-fat diet, may cause animals ... mBio , the online open-access journal of the American ... German Institute of Human Nutrition Potsdam-Rehbruecke in Nuthetal observed that ... gained weight when fed a high-fat diet. Mice that did ... when consuming a high-fat diet, and mice that had ...
(Date:9/29/2014)... WASHINGTON, DC September 29, 2014 -- Plants ... ,commensal, bacteria help the pants extract nutrients and ... preventing pathogens from contaminating fruits and vegetables. Now, ... commensal bacteria inside of seeds; thus ensuring that ... researchers, from the University of Notre Dame, presented ...
(Date:9/29/2014)... According to a NASA story from 2009, "human activities in ... fire emissions issue. Palm oil is increasingly grown for use ... fats in processed foods. It has become the most widely ... in recent years to surpass that of soybean oil. , ... has to be cleared to grow the crop, and the ...
Breaking Biology News(10 mins):Gut bacteria promote obesity in mice 2Plants prepackage beneficial microbes in their seeds 2
... (June 4, 2009) Weak enforcement combined with fishermen ... of fisheries regulations along the Northeastern United States coast. ... fisheries management measures put in place to protect and ... online this week in the journal Marine Policy ...
... 2009 | An international symposium to be ... of nuclear technologies to enhance animal nutrition and reproduction strategies ... transmitted to humans, such as swine and avian influenza. ... countries will present up-to-date findings for solving or alleviating factors ...
... function in your healthit protects you against viruses, ... In autoinflammatory diseases, however, the immune system goes ... from the National Institute of Arthritis and Musculoskeletal ... Institutes of Health, and other institutions have discovered ...
Cached Biology News:Study: Illegal fishing harming present and future New England groundfish fisheries 2FAO/IAEA Symposium to address animal production and health 2Scientists discover new genetic immune disorder in children 2Scientists discover new genetic immune disorder in children 3
(Date:10/2/2014)... and BRIDGEWATER, N.J. ... XON) , a leader in synthetic biology, and ... generic drug manufacturer by volume in the U.S., ... Channel Collaboration (ECC) for a target active pharmaceutical ... the goal of the collaboration is to develop ...
(Date:10/1/2014)... METTLER TOLEDO’s newly improved XS balance line includes ... as a dual range microbalance . As a ... pan delivers results up to twice as fast, even ... details mean users no longer need to suffer the ... front of the balance. Barbara Bienlein, medical specialist and ...
(Date:10/1/2014)... Greifensee, Switzerland (PRWEB) October 01, 2014 ... influence the quality of the final product. However, ... most regulated, regulatory frameworks such as Good Manufacturing ... is the responsibility of the manufacturer to interpret ... ensure consistent weighing performance quality. METTLER TOLEDO experts ...
(Date:10/1/2014)... As the world takes its first steps into the ... century would mark the beginning of a new era of ... fact that the world is experiencing a rapid rise in ... Almost half of these chronic conditions are due to lifestyle ... care and intervention. While the world is experiencing a rapid ...
Breaking Biology Technology:Intrexon and Amneal Expand Relationship with Second Product Collaboration 2Intrexon and Amneal Expand Relationship with Second Product Collaboration 3METTLER TOLEDO’s XS Balance Line Delivers Performance and Ergonomics To Safeguard Health in the Workplace 2METTLER TOLEDO’s XS Balance Line Delivers Performance and Ergonomics To Safeguard Health in the Workplace 3Comply with Weighing-Related Regulations in Pharma Manufacturing 2Fighting Mortality and Morbidity of Chronic Health Disorders during Open Access Week 2Fighting Mortality and Morbidity of Chronic Health Disorders during Open Access Week 3
... that it has received orders for the sale of ... far in its initial sales push,being led by new ... current efforts, shall announce such sales as and,when they ... an award-winning life sciences company focused on,the monitoring and ...
... Diagnostics Inc.,(TSX:SDI) today announced the market launch of ... for sepsis, in Germany through,A. Menarini Diagnostics Deutschland ... is the third most common cause of death ... of severe sepsis consumes,about one third of intensive ...
... /PRNewswire-FirstCall/ - AEterna Zentaris Inc.,(TSX: AEZ; Nasdaq: AEZS), a ... announced that its President and CEO,David J. Mazzo, Ph.D., ... Sciences Conference on Thursday, September 27, 2007 at 10:00 ... Hotel in New York City. A live webcast ...
Cached Biology Technology:Signalife Achieves $1.98 Million Sales Orders Thus Far 2Spectral partner launches EAA(TM) Rapid Sepsis Diagnostic in Germany 2
Lysozyme C (W-20)...
Request Info...
Abgene's ALTO-8 is the first automated decapper/capper for Abgene Twist-Lock tubes....
... X-Gal (5-bromo-4-chloro-3-indoyl-beta-D-galactopyranoside) is a ... identify recombinant plasmids. In ... and IPTG, lac ... blue, whereas recombinant colonies ...
Biology Products: