Navigation Links
Measuring hormone cuts antibiotic use in half in pneumonia patients

Measuring a hormone in the blood can help doctors greatly reduce the number of days pneumonia patients have to take antibiotics to cure their infection, according to a study to be presented at the American Thoracic Society International Conference on May 24.

In the study, pneumonia patients whose level of the hormone procalcitonin was measured during the course of their illness took antibiotics an average of 6 days, compared with 12 days for patients whose procalcitonin levels were not measured. Fifteen percent of patients whose hormone levels were measured did not have to take antibiotics at all, said study co-author Michael Tamm, M.D., Chief of Pulmonary Medicine and Pulmonary Cell Research at University Hospital in Basel, Switzerland.

"Because of concerns about antibiotic resistance, as well as the cost of antibiotics, it's always better to give fewer antibiotics," Prof. Tamm said.

Many cases of community-acquired pneumonia are caused by bacteria, which require treatment with antibiotics, but some cases are viral, which get better without antibiotics. But doctors don't like to delay treatment in order to wait for lab results to tell them whether a patient's pneumonia is bacterial or viral, so they start all patients on antibiotics, Dr. Tamm said. "Once the treatment is started, it is usually continued for 10 to 14 days, because nobody knows when you can stop without a risk for the patient," he said.

Because levels of procalcitonin have been found to be elevated in patients with bacterial infection but not viral infection or other inflammatory diseases, Dr. Tamm and colleagues decided to study whether measuring levels of the hormone could eliminate or reduce antibiotic use in patients with bacterial pneumonia. Results of the blood test that measures procalcitonin levels can be obtained in only one hour, he said.

They studied more than 300 patients with community-acquired pneumonia (pneumonia that is not caught while a patient is in the hospital), and randomly divided them into two groups. Once group was given the standard antibiotic treatment, while the other was first tested for procalcitonin levels. Fifteen percent of those patients had very low procalcitonin levels, and were presumed to have viral pneumonia; they were not given antibiotics. The remaining 85% had high levels and were started on antibiotics. The researchers measured their procalcitonin levels four, six and eight days later, and discontinued their antibiotics if their levels were low.

Patients in the procalcitonin group who started on antibiotic treatment were able to stop after an average of six days. Their course of illness was similar to those patients who received a full course of antibiotics, in terms of their recovery and number of days spent in the hospital. "We showed we were able to cut the number of days patients were on antibiotics in half, without compromising their outcome," Dr. Tamm said.


'"/>

Source:American Thoracic Society


Related biology news :

1. Measuring the impact of post-genomics on Mediterranean populations
2. Measuring Enzymes At End Of Cancer Pathway Predicts Outcome Of Tarceva, Taxol
3. Measuring hidden parasites in falciparum malaria
4. Measuring artery repair cells could become new heart disease test
5. Female sex hormones play a vital role in defense against sexually transmitted diseases
6. Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems
7. Alcohol consumption disrupts breastfeeding hormones
8. VCU study shows hormone-like molecule kills cells that cause inflammation in allergic disease
9. University of Nevada, Reno research team discovers hormone that causes malaria mosquito to urinate
10. Penguin chicks exposed to human visitors experience spike in stress hormone
11. Suppressing growth hormone in early adulthood may prevent cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/6/2017)... , May 5, 2017 RAM ... announced a new breakthrough in biometric authentication based ... quantum mechanical properties to perform biometric authentication. These new ... semiconductor material created by Ram Group and its ... entertainment, transportation, supply chains and security. Ram Group ...
(Date:4/13/2017)... April 13, 2017 UBM,s Advanced Design and ... will feature emerging and evolving technology through its 3D ... will run alongside the expo portion of the event ... and demonstrations focused on trending topics within 3D printing ... and manufacturing event will take place June 13-15, 2017 at ...
(Date:4/11/2017)... MELBOURNE, Florida , April 11, 2017 ... "Company"), a security technology company, announces the appointment of independent ... John Bendheim to its Board of Directors, furthering the ... ... behalf of NXT-ID, we look forward to their guidance and ...
Breaking Biology News(10 mins):
(Date:9/20/2017)... ... September 20, 2017 , ... Foresight Institute, ... and other transformative technologies, announced the winners for the 2017 Foresight Institute Feynman ... Theory in nanotechnology/molecular manufacturing. , Established in 1993 and named in honor of ...
(Date:9/19/2017)... ... 19, 2017 , ... VetStem Biopharma ’s CEO and founder, Dr. Bob Harman DVM, MPVM, ... book "Stem Cell Therapy: A Rising Tide". Dr. Harman and Dr. Riordan met in ... an interest in the potential of stem cell therapy and a fast friendship was formed. ...
(Date:9/19/2017)... ... September 19, 2017 , ... Molecular Devices, LLC, a leader ... to launch the CloneSelect™ Single-Cell Printer™ in North America. This novel system ... provide visual documentation of monoclonality for use in cell line development. , ...
(Date:9/18/2017)... Montrium , a growing leader in Electronic Trial Master file ... non-profit research organization, Multidisciplinary Association for Psychedelic Studies (MAPS). ... MAPS Public Benefit Corporation ... ... MDMA for the treatment of Posttraumatic Stress Disorder (PTSD). MAPS also ...
Breaking Biology Technology: