Navigation Links
Measuring hidden parasites in falciparum malaria

A new technique for measuring hidden malaria parasites and assessing severity of disease is described in a paper published on Aug 23rd in PLoS Medicine. Researchers led by Professor Nick White from Mahidol University, Thailand, looked at patients with the most dangerous type of malaria, falciparum malaria. Usually the severity of disease is measured by counting the number of parasites in the blood under the microscope, but this method ignores parasites which are in red blood cells trapped (sequestered) in the capillaries--the smallest blood vessels in the body.

The researchers estimated total amount of malaria parasites in the body by measuring a protein--Histidine-rich protein 2 (PfHRP2)--which is liberated into the blood when malaria-infected red cells spilt. Using this method in 337 patients with varying severity of falciparum malaria they found that the average parasite burden was more than six times higher in patients with severe malaria than in patients hospitalized without signs of severe disease, and was highest in patients who died. This finding fits with current thinking that sequestration of red cells containing the mature forms of the parasite is the most important pathological process in falciparum malaria.

Approximately 40% of the world's population, mostly living in the world's poorest countries, is at risk of malaria. In the tropical and subtropical regions of the world, malaria causes 300 million acute illnesses and at least 1 million deaths annually.

Estimates of plasma PfHRP2 concentrations may be useful as a research tool to assess patients' parasite loads and may also provide one way of assessing the severity of a patient's disease.


'"/>

Source:Public Library of Science


Page: 1

Related biology news :

1. Measuring the impact of post-genomics on Mediterranean populations
2. Measuring hormone cuts antibiotic use in half in pneumonia patients
3. Measuring Enzymes At End Of Cancer Pathway Predicts Outcome Of Tarceva, Taxol
4. Measuring artery repair cells could become new heart disease test
5. Finding hidden invaders in a Hawaiian rain forest
6. UCLA cancer researchers shake loose hidden biomarker
7. Envisat and ERS-2 reveal hidden side of Hurricane Rita
8. Computer modeling reveals hidden conversations within cells
9. Viagras hidden help for wildlife
10. Clues to breast cancer hidden inside stem cells
11. Squid skin reveals hidden messages
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/24/2017)... Janice Kephart , former 9/11 ... Partners, LLP (IdSP) , today issues the following ... March 6, 2017 Executive Order: Protecting the ... be instilled with greater confidence, enabling the reactivation ... applications are suspended by until at least July ...
(Date:4/13/2017)... SANTA MONICA, Calif. , April 13, 2017 /PRNewswire/ ... New York will feature emerging and ... Innovation Summits. Both Innovation Summits will run alongside the ... variety of speaker sessions, panels and demonstrations focused on ... east coast,s largest advanced design and manufacturing event will ...
(Date:4/11/2017)... N.Y. , April 11, 2017 ... fingerprints, but researchers at the New York University ... College of Engineering have found that partial similarities ... security systems used in mobile phones and other ... thought. The vulnerability lies in the ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... 11, 2017  VMS BioMarketing, a leading provider of patient ... Clinical Nurse Educator (CNE) network, which will launch this week. ... among health care professionals to enhance the patient care experience ... and other health care professionals to help women who have ... ...
(Date:10/11/2017)... ... October 11, 2017 , ... A ... pregnancy rates in frozen and fresh in vitro fertilization (IVF) transfer ... age to IVF success. , After comparing the results from the fresh and ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights that give it exclusive ... a technology developed in collaboration with Children’s Hospital Los Angeles (CHLA). ...
(Date:10/10/2017)... Parks Associates announced today that Tom Kerber , Director ... , October 11 in Scottsdale, Arizona . Kerber will ... safety and security products impact the competitive landscape. ... Parks Associates: Smart Home Devices: Main Purchase Driver ... "The residential security market has experienced continued growth, and the introduction of ...
Breaking Biology Technology: