Navigation Links
Measuring hidden parasites in falciparum malaria

A new technique for measuring hidden malaria parasites and assessing severity of disease is described in a paper published on Aug 23rd in PLoS Medicine. Researchers led by Professor Nick White from Mahidol University, Thailand, looked at patients with the most dangerous type of malaria, falciparum malaria. Usually the severity of disease is measured by counting the number of parasites in the blood under the microscope, but this method ignores parasites which are in red blood cells trapped (sequestered) in the capillaries--the smallest blood vessels in the body.

The researchers estimated total amount of malaria parasites in the body by measuring a protein--Histidine-rich protein 2 (PfHRP2)--which is liberated into the blood when malaria-infected red cells spilt. Using this method in 337 patients with varying severity of falciparum malaria they found that the average parasite burden was more than six times higher in patients with severe malaria than in patients hospitalized without signs of severe disease, and was highest in patients who died. This finding fits with current thinking that sequestration of red cells containing the mature forms of the parasite is the most important pathological process in falciparum malaria.

Approximately 40% of the world's population, mostly living in the world's poorest countries, is at risk of malaria. In the tropical and subtropical regions of the world, malaria causes 300 million acute illnesses and at least 1 million deaths annually.

Estimates of plasma PfHRP2 concentrations may be useful as a research tool to assess patients' parasite loads and may also provide one way of assessing the severity of a patient's disease.


'"/>

Source:Public Library of Science


Page: 1

Related biology news :

1. Measuring the impact of post-genomics on Mediterranean populations
2. Measuring hormone cuts antibiotic use in half in pneumonia patients
3. Measuring Enzymes At End Of Cancer Pathway Predicts Outcome Of Tarceva, Taxol
4. Measuring artery repair cells could become new heart disease test
5. Finding hidden invaders in a Hawaiian rain forest
6. UCLA cancer researchers shake loose hidden biomarker
7. Envisat and ERS-2 reveal hidden side of Hurricane Rita
8. Computer modeling reveals hidden conversations within cells
9. Viagras hidden help for wildlife
10. Clues to breast cancer hidden inside stem cells
11. Squid skin reveals hidden messages
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/23/2017)... N.Y. , Aug. 23, 2017  The general public,s help is ... human microbiome—the bacteria that live in and on the human body –and ... The ... in the human microbiome, starting with the gut. The project's goal is ... disease. Photo credit: IBM ...
(Date:6/30/2017)... , June 30, 2017 Today, American ... and supplier of face and eye tracking software, ... Product provider program. "Artificial intelligence ... way to monitor a driver,s attentiveness levels while ... being able to detect fatigue and prevent potential ...
(Date:5/23/2017)... robotic gym for the rehabilitation and functional motor sense evaluation of lower ... . The first 30 robots will be available from June in ... The technology was developed and patented at the IIT laboratories and has ... to a 10 million euro investment from entrepreneur Sergio Dompè. ... ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... first-ever genomics analysis platform specifically designed for life science researchers to analyze ... pioneering researcher Rosalind Franklin, who made a major contribution to the discovery ...
(Date:10/11/2017)... Palo Alto, CA, USA (PRWEB) , ... October 11, 2017 , ... ... is set to take place on 7th and 8th June 2018 in San Francisco, ... and policy influencers as well as several distinguished CEOs, board directors and government officials ...
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased emissions are the ... million people each year. Especially those living in larger cities are affected by air ... one of the most pollution-affected countries globally - decided to take action. , “I ...
(Date:10/10/2017)... , ... October 10, 2017 ... ... cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing ... HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in collaboration with Children’s ...
Breaking Biology Technology: