Navigation Links
Mayo discovers protein as potential tactic to prevent tumors

Mayo Clinic researchers have found that a protein that initiates a "quality control check" during cell division also directs cell death for those cells damaged during duplication. This knowledge represents a potential "bulls eye" for targeting anti-tumor drugs. The findings appear in the current issue of Science.

The researchers examined a protein called cyclin-dependent kinase 2 (CDK2), which works as a "quality control inspector." As normal cells divide, they pause in the replication process when they find inaccurate genetic code embedded in their DNA. The health and well-being of offspring cells depends on accurate genetic code transfer from one generation of cells to the next. The Mayo researchers showed that when errors in genes are irreparable, CDK2 modifies another cellular protein -- FOXO1 -- to send a signal that results in the death of the cell. This protein-to-protein relationship invites targeted drug intervention to control unregulated growth of cancer cells.

"Quality control within dividing cells is essential because mistakes during duplication of the genetic code can lead to cancer," says Donald Tindall, Ph.D., co-leader of the Mayo Clinic Cancer Center prostate cancer research program. "CDK2 is a key protein component in the cellular mechanism that leads to repair of damaged DNA."

If cells pass this quality control checkpoint, they can resume the process of dividing into two daughter cells. If, however, major irreparable discrepancies occur in the genetic code, cells are shunted toward a molecular sequence that leads to death, or apoptosis. Cells have the genetic knowledge to sacrifice themselves for the greater good of the organism rather than to pass on errant genetic codes that can lead to disease. Genetic errors that sneak past the cell's quality control check-points can make the cell prone to develop into cancer.

How It Happens

The Mayo researchers documented that CDK2 infuses high energy int
'"/>

Source:Mayo Clinic


Page: 1 2

Related biology news :

1. UCSD team discovers specialized, rare heart stem cells in newborns
2. University of Nevada, Reno research team discovers hormone that causes malaria mosquito to urinate
3. MIT chemist discovers secret behind natures medicines
4. Mayo Clinic collaboration discovers protein amplifies DNA injury signals
5. Expedition discovers marine treasures
6. Team discovers possible universal strategy to combat addiction
7. Nobelist discovers antidepressant protein in mouse brain
8. Joslin discovers signs of residual islet cell function in people with long-term type 1 diabetes
9. Contrary to common wisdom, scientist discovers some mammals can smell objects under water
10. U of S Vaccine and Infectious Disease Organization team discovers key step in flu virus replication
11. LSU professor discovers new species
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mayo discovers protein potential tactic prevent tumors

(Date:11/5/2014)... – Kelly Redmond has dedicated his career to ... to a general audience. , As deputy director ... Center at Nevada,s Desert Research Institute, Redmond has ... management, application and dissemination of climate data to ... Fall Meeting in San Francisco on December 15-19, ...
(Date:11/4/2014)... Fla. (November 4, 2014) — Think about the way ... How do neighboring cells know that they are supposed ... how do these tissues find the correct place and ... answering these crucial questions. , In a new study, ... to communicate with their surrounding neighbors, at the head-trunk ...
(Date:11/3/2014)... 2014 Research and Markets has announced ... Technologies, Markets and Companies" to their offering. ... methods, which have already started to play an important role ... replacing the old fashioned bone marrow transplants. Role of cells ... to become a part of medical practice. Stem ...
Breaking Biology News(10 mins):Nevada climatologist to be honored at AGU Fall Meeting for lifetime of public outreach 2The inside story: How the brain and skull stay together 2Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 2Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 3
... far from a plodding Cretaceous era scavenger whose long tail only ... T. rex ,s athleticism (and its rear end) ... Scott Persons. His extensive research shows that powerful tail muscles made ... time. As Persons says, "contrary to earlier theories, ...
... molecules called microRNAs act together with hormones to control ... drugs might be able to prevent premature labor, researchers ... preclinical study. "With these findings, we understand better ... we might have the potential to manipulate it and ...
... PA, 15 November 2010 - A family history of Alzheimer,s ... a new study in Biological Psychiatry suggests that ... Alzheimer,s is the most common form of dementia in ... alone. In order to develop preventative treatments, it is necessary ...
Cached Biology News:T. rex's big tail was its key to speed and hunting prowess 2Tiny RNA molecules control labor, may be key to blocking premature birth 2Where did you get those eyes and that brain? 2
(Date:11/22/2014)... Prominent academics, leaders of the biopharmaceutical ... 3rd at Genetic Rx, a networking conference of ... place at the Joseph B. Martin Conference Center ... present and future of genetic medicines—including siRNA, ASOs, ... well as the treatment of patients with rare ...
(Date:11/22/2014)... (PRWEB) November 21, 2014 RURO, ... solutions provider, has released Limfinity® version 5.1.4. , ... projects of Limfinity® than ever in RURO’s 8 ... and minority framework enhancement. Limfinity® version 5.1.4 is ... above and beyond bug fixes! , Limfinity® 5.1.4 ...
(Date:11/22/2014)... The “Chiral Chromatography Columns Market by ... Glass, Plastic), by Application [GC, LC (HPLC, UHPLC, ... 2018” analyses and studies the major market drivers, ... Asia, and Rest of the World. , Browse ... through 135 pages and in-depth TOC on “Chiral ...
(Date:11/22/2014)... element of surprise has been a major advantage of ... Until now, epidemiologists had nothing to measure that might ... suboptimal responses to both the H1N1 pandemic of 2009 ... http://photos.prnewswire.com/prnh/20141121/160242 That virus advantage ... structural changes have been found that invariably to date ...
Breaking Biology Technology:Pioneering Academics and Key Industry Leaders to Discuss Rare Diseases and the Emergence of New Genetic Medicines at Genetic Rx on December 3rd 2RURO Announces Limfinity® version 5.1.4 2Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 2Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 3Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 4Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 5Viruses' Advantage of Surprise is Lost 2
... SOUTH SAN FRANCISCO, Calif., March 14 ,Exelixis, Inc. (Nasdaq: ... its option to further develop and commercialize Exelixis,compound XL518, ... currently,in a phase 1 clinical trial. Under the terms ... to be responsible for the phase,1 clinical trial until ...
... R.P. Baker Distinguished Professor of Physics at Rensselaer Polytechnic ... Materials Research Society (MRS). The MRS has recognized Lu ... specifically his seminal contributions to the fundamental understanding of ... that MRS has named a class of fellows. Lu ...
... ,Cellectis SA (NYSE: ALCLS ), a ... today that it filed a patent infringement ... States District Court for the,Eastern District of ... that,by making and selling certain meganucleases, Precision ...
Cached Biology Technology:Option to Develop Exelixis Compound Exercised By Genentech 2Option to Develop Exelixis Compound Exercised By Genentech 3Option to Develop Exelixis Compound Exercised By Genentech 4Professor Toh-Ming Lu named fellow of the Materials Research Society 2Cellectis Sues Precision BioSciences for Infringement of its Patents Concerning Meganuclease Technology 2Cellectis Sues Precision BioSciences for Infringement of its Patents Concerning Meganuclease Technology 3Cellectis Sues Precision BioSciences for Infringement of its Patents Concerning Meganuclease Technology 4
... scanning and positioning system is designed ... to be positioned or scanned with ... provides superior responsiveness compared to micropositioners ... (X or XY stage) are driven ...
For microscopy...
... The ULS cDNA Synthesis and Labeling Kit ... hybridization experiments. First unmodified cDNA is made ... cDNA using an Oligo(dT) primer. Unlike other ... used in the reverse transcription reaction. This ...
... 'The DNAscope LM is a high quality ... technology for optimal background rejection and spatial resolution. ... is the only low cost microarray scanner that ... excitation sources. Main Features: Includes ...
Biology Products: