Navigation Links
Mayo Clinic researchers discover cancer cells may move via wave stimulation

Mayo Clinic researchers have uncovered a new cellular secret that may explain how certain cancers move and spread -- a feature of cancers that makes treatment especially difficult. If the mechanism that drives cancer movement -- also called metastasis -- can be understood well enough to manipulate it, new and better treatments can be developed for patients with metastatic cancers.

Significance of the Mayo Clinic Research

The Mayo researchers focused on odd protrusions observable by microscope on the surface of certain cancer cells: circular waves. Until now, no one has fully understood the function of these waves. The Mayo findings in the current edition of Cancer Research http://cancerres.aacrjournals.org/current.shtml are the first to show one role the waves play. They selectively round up activated growth-promoting proteins from the cell surface and take them to the interior of the cell. Under normal conditions, this process would help terminate signals from these growth-promoting proteins. However, in cancer cells it appears that either these waves may not function properly, or that the internalized proteins may remain active longer, which allows them to "instruct" a cell to acquire cancerous traits such as excessive growth and invasive movement that constitute metastasis. These waves are important for helping to keep these cancer-growth commands at bay.

Studying human pancreatic tumor cells, the Mayo researchers found that the waves store up to half the activated Epidermal Growth Factor Receptors (EGFR) from the surface of the cell and take this cache to the interior of the cells. This is important for understanding cancer because aberrant activation of EGFR can promote the excessive growth typical of cancers.

"These findings have broad implications toward the general understanding of how specific processes in the wave may affect such things as cell growth, cell
'"/>

Source:Mayo Clinic


Page: 1 2 3

Related biology news :

1. Mayo Clinic Researchers Create Obedient Virus; First Step To Use Measles Virus Against Cancer
2. Chronic Sinus Infection Thought To Be Tissue Issue, Mayo Clinic Scientists Show Its Snot
3. Clinical trial to test stem cell approach for children with brain injury
4. Mayo Clinic collaboration discovers protein amplifies DNA injury signals
5. Mayo Clinic researchers challenge sepsis theory
6. Mayo Clinic study finds two genes predict outcome for breast cancer patients
7. Mayo Clinic Cancer Center: Harnessing the measles virus to attack cancer
8. Mayo Clinic collaboration mining of ancient herbal text leads to potential new anti-bacterial drug
9. Mayo Clinic study suggests that a central nervous system viral infection can lead to memory deficits
10. Mayo Clinic: Gene expression profiling not quite perfected in predicting lung cancer prognosis
11. NYU researchers simulate molecular biological clock
Post Your Comments:
(Date:5/16/2013)... creature with ,scissor hand-like, claws in fossil records and ... star. , The 505 million year old fossil ... is a distant ancestor of lobsters and scorpions, was ... role as Edward Scissorhands - a movie about an ... scissors for hands. , Kooteninchela deppi ...
(Date:5/16/2013)... can trigger hematopoiesis at sites outside the bone marrow ... of Ludwig-Maximilians-Universitaet (LMU) in Munich now show that a ... formation of blood cells. , Balanced hematopoiesis is essential ... development, hematopoiesis takes place mainly in the liver and ... bone marrow, and this tissue normally serves as the ...
(Date:5/16/2013)... Top neuroscientists from Canada and around the world ... Annual Canadian Neuroscience Meeting will showcase the latest ... system and reveal clues to understanding the disorders ... neuroscience research, and this meeting will showcase the ... the world," says Sam David, President of the ...
Breaking Biology News(10 mins):Actor Johnny Depp immortalized in ancient fossil find 2Herpes infections: Natural killer cells activate hematopoiesis 27th Annual Canadian Neuroscience Meeting, Toronto, May 20-24, 2013 2
... was responsible for about two-thirds of toxic lead that ... latter two-thirds of the 20th century, according to a ... . Researchers from Case Western Reserve University say ... cities across the U.S. and reinforces concerns about the ...
... blood sugar levels may also influence a person,s sensitivity to ... the University of Maryland School of Medicine. They found that ... as glucagon decreases the taste system,s sensitivity to sweetness. That ... how foods taste, according to the study published online June ...
... New York, NY, June 15 Robert H. Wurtz, ... is the recipient of the 2010 Neuroscience Prize of The ... brain processes visual information and controls eye movements laid the ... This research has led scientists to a deeper understanding of ...
Cached Biology News:Leaded gasoline predominant source of lead exposure in latter 20th century 2Leaded gasoline predominant source of lead exposure in latter 20th century 3UM School of Medicine scientists find hormone influences sensitivity to sweetness 2Neuroscientist Robert H. Wurtz receives the $500,000 Gruber neuroscience prize 2Neuroscientist Robert H. Wurtz receives the $500,000 Gruber neuroscience prize 3
(Date:5/17/2013)... 2013 - Elsevier, a world-leading provider of scientific, technical ... publication of a recent study in Reproductive ... showing that those with an abnormal chromosomal composition can ... developed to blastocysts, thereby classifying the risk of genetic ... same group has undertaken a retrospective study, using their ...
(Date:5/17/2013)... 2013 •    First of its kind research ... ,     New facility will help solve crop stresses ... Syngenta unveiled its new crop research facility during ... Innovation Center. The first of its kind, $72 million ... agricultural climate and precisely measure plant inputs – the ...
(Date:5/17/2013)... 17, 2013  Cellular Biomedicine Group (OTCQB: CBMG) ... of the total projected enrollment required for its ... preliminary efficacy of the medical technology haMPC (Human ... (KOA). To date the trial has had no ... Phase I open label clinical research trial for ...
(Date:5/17/2013)... 17, 2013 /PRNewswire-iReach/ -- Aridis is pleased to ... Switzerland -based Kenta Biotech to ... antibody (mAb) products, and technologies. This asset portfolio ... treatment of infections by common pathogens including drug ... Pseudomonas aeruginosa , Acinetobacter baumannii ...
Breaking Biology Technology:Breakthrough for IVF? 2Breakthrough for IVF? 3Syngenta Opens Unique $72 Million Advanced Crop Lab 2Syngenta Opens Unique $72 Million Advanced Crop Lab 3Cellular Biomedicine Group Achieves 50% Enrollment Milestone in Phase I Clinical Trial for Knee Osteoarthritis 2Aridis Pharmaceuticals Announces Acquisition of Monoclonal Antibody Products and Technologies From Kenta Biotech 2Aridis Pharmaceuticals Announces Acquisition of Monoclonal Antibody Products and Technologies From Kenta Biotech 3
... Bolder BioTechnology, Inc. today announced that it has ... Innovation Research (SBIR) grant from the National Institute of ... of Health (NIH). The grant will be used ... the company,s proprietary long-acting growth hormone product, which is ...
... Offers Healthcare Workers Consistent Cleaning , ... IRVINE, Calif., Dec. 16 Advanced ... availability of the EVOTECH(TM) Endoscope Cleaner and Reprocessor, ... manual cleaning of endoscopes. The results of the ...
... Leadership, Vision and Experience to Company , ... Dec. 16 Xceleron, the global leader in predictive ... today Michael Butler, Ph.D., has been named President and ... Butler brings to Xceleron a balance of sales, operations ...
Cached Biology Technology:Bolder BioTechnology Receives $1.9 Million NIH Grant to Continue Development of Long-Acting Growth Hormone Product 2ASP Announces Availability of EVOTECH(TM) Endoscope Cleaner and Reprocessor - First Commercially Available System to Eliminate Manual Cleaning of Endoscopes 2Xceleron Names Michael Butler as President & CEO 2
... The ideal modular cleanroom for ... applications that require cleanliness (to Class ... are precision-joined to create ultra-smooth surfaces ... and disinfect. One-inch radius corners simplify ...
... the ability to quickly and accurately copy or ... perfect candidate for inclusion in these high speed ... with all the Cartesian products to allow integration ... to copy plates in seconds or reformat low ...
This modular benchtop fume hood ventilates and purifies chemical fumes, allowing safe indoor release of exhaust. Bonded charcoal filters remove most organic contaminants. Options include final HEPA f...
... siRNA Tracker Intracellular Localization Kit with ... forward approach to directly label and ... an efficient yet non-destructive manner, for ... and functional inhibition of target gene ...
Biology Products: