Navigation Links
Mayo Clinic collaboration mining of ancient herbal text leads to potential new anti-bacterial drug

A unique Mayo Clinic collaboration has revived the healing wisdom of Pacific Island cultures by testing a therapeutic plant extract described in a 17th century Dutch herbal text for its anti-bacterial properties. Early results show that extracts from the Atun tree effectively control bacteria that can cause diarrhea, as claimed by naturalist Georg Eberhard Rumpf, circa 1650. He documented his traditional healing methods in the book Ambonese Herbal.

The Mayo Clinic-led team's report appears in the Dec. 23 edition of The British Medical Journal, www.bmj.com. In their report, Mayo Clinic researchers demonstrate the feasibility of using sophisticated data mining techniques on historical texts to identify new drugs.

Significance of the Mayo Clinic Research

The study provides a creative new model for drug discovery. It integrates nontraditional, ancient medical information with advanced technologies to identify promising natural products to investigate as drugs for new and better therapies.

"Natural products are invaluable sources of healing agents -- consider, for example, that aspirin derived originally from willow bark, and the molecular basis of the anti-cancer chemotherapeutic agent TaxolTM was derived from the bark of the Pacific yew tree. So it's not so far-fetched to think that the contributions of an ancient text and insights from traditional medicine really may impact modern public health," explains Brent Bauer, M.D., director of the Mayo Clinic Complementary and Integrative Medicine Program.

For thousands of years, people around the world have lived intimately with botanical healing agents and evolved effective healing traditions. "Our work shows just how much we can learn from them. But to make the most of what is fast becoming lost knowledge, we have to respect, preserve and work with traditional healing cultures," adds Eric Buenz, Ph.D., researcher for Minneso ta-based BioSciential, LLC.

Ancient Text

Rumpf referred to himself as Rumphius, in the Latinized scientific manner of the day. Rumphius was a German-born naturalist who worked for the Dutch East Indies Company. His book is an account of the herbal healing traditions on the Indonesian island of Ambon. Rumphius' description of Atun kernels' therapeutic properties is what modern medicine calls "antimotility agents," they stop diarrhea. Writes Rumphius: "... these same kernels ... will halt all kinds of diarrhea, but very suddenly, forcefully and powerfully, so that one should use them with care in dysentery cases, because that illness or affliction should not be halted too quickly; and some considered this medicament a great secret, and relied on it completely."
'"/>

Source:Mayo Clinic


Related biology news :

1. Mayo Clinic Researchers Create Obedient Virus; First Step To Use Measles Virus Against Cancer
2. Chronic Sinus Infection Thought To Be Tissue Issue, Mayo Clinic Scientists Show Its Snot
3. Clinical trial to test stem cell approach for children with brain injury
4. Mayo Clinic collaboration discovers protein amplifies DNA injury signals
5. Mayo Clinic researchers challenge sepsis theory
6. Mayo Clinic researchers discover cancer cells may move via wave stimulation
7. Mayo Clinic study finds two genes predict outcome for breast cancer patients
8. Mayo Clinic Cancer Center: Harnessing the measles virus to attack cancer
9. Mayo Clinic study suggests that a central nervous system viral infection can lead to memory deficits
10. Mayo Clinic: Gene expression profiling not quite perfected in predicting lung cancer prognosis
11. Innovative collaboration brings Arctic science into the classroom

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/24/2016)... Cercacor today introduced Ember TM Sport ... non-invasively measure hemoglobin, Oxygen Content, Oxygen Saturation, Perfusion ... in approximately 30 seconds. Smaller than a smartphone, using ... to key data about their bodies to help monitor ... Hemoglobin carries oxygen to muscles. When hemoglobin ...
(Date:11/19/2016)... 18, 2016 Securus Technologies, a leading provider ... safety, investigation, corrections and monitoring, announced today that it ... to have an independent technology judge determine who has ... high tech/sophisticated telephone calling platform, and the best customer ... do most of what we do – which clearly ...
(Date:11/15/2016)... , Nov. 15, 2016  Synthetic Biologics, ... developing therapeutics focused on the gut microbiome, today ... of 25,000,000 shares of its common stock and ... stock at a price to the public of ... to Synthetic Biologics from the offering, excluding the ...
Breaking Biology News(10 mins):
(Date:11/30/2016)... /PRNewswire/ -  Equicare Health Inc ., the leading supplier ... one of the top 100 companies in the 2016 ... distinguishes the top digital health companies across the globe. ... this year continually upgrading our product with the ongoing ... team," says Len Grenier , CEO of Equicare ...
(Date:11/30/2016)... , 30. November 2016   Merck ... heute die Unterzeichnung einer Reihe von Vereinbarungen ... wird Evotec AG Screeningleistungen für Mercks Palette ... Der Zugriff auf diese Bibliotheken in Kombination ... einen schnelleren Weg zur Ermittlung und Erforschung ...
(Date:11/30/2016)... ... November 30, 2016 , ... SSCI, the established leader ... the implications of the latest FDA guidance on pharmaceutical cocrystals as drug substance ... Cambridge, MA. , The event follows the successful November 15th event that ...
(Date:11/30/2016)... ... November 30, 2016 , ... On 28 November 2016, ... for four elements: nihonium (Nh), moscovium (Mc), tennessine (Ts), and oganesson (Og), respectively ... review, the names earlier proposed by the discoverers have been approved by the IUPAC ...
Breaking Biology Technology: