Navigation Links
Mayo Clinic Researchers Create 'Obedient Virus'; First Step To Use Measles Virus Against Cancer

cells" -- while at the same time conserving the viral component for targeting and destroying tumors. Mass production of a retargeted virus was not possible before this specific innovation of the molecular tag -- and research in this area was at an impasse. Not any more.

"The virus goes where it's meant to go, and it destroys the tumors in a targeted way," says Dr. Russell.

Background Biology

Natural viruses are cellular parasites. To reproduce more viruses, they need to bind to a partner on their target cell, fuse membranes to enter the target cell and then take over the cellular machinery. When they succeed in doing this, an infection occurs. Viruses are so good at taking over cells that researchers have long dreamed of exploiting the specific attraction viruses have to certain cells and using it as a homing device to seek and enter cancer cells.

The measles virus became the focus of this vision several years ago when the surprising finding was made that the measles strain used internationally for vaccinations has natural anticancer activity.

"But we had a concern that the measles virus may be a little too promiscuous in its ability to infect both cancer cells and non-cancer cells, so we wanted to develop a method whereby we could retarget the virus to infect cancer cells only," says Dr. Russell. "And we succeeded."


'"/>

Source:Mayo Clinic


Page: 1 2

Related biology news :

1. Chronic Sinus Infection Thought To Be Tissue Issue, Mayo Clinic Scientists Show Its Snot
2. Clinical trial to test stem cell approach for children with brain injury
3. Mayo Clinic collaboration discovers protein amplifies DNA injury signals
4. Mayo Clinic researchers challenge sepsis theory
5. Mayo Clinic researchers discover cancer cells may move via wave stimulation
6. Mayo Clinic study finds two genes predict outcome for breast cancer patients
7. Mayo Clinic Cancer Center: Harnessing the measles virus to attack cancer
8. Mayo Clinic collaboration mining of ancient herbal text leads to potential new anti-bacterial drug
9. Mayo Clinic study suggests that a central nervous system viral infection can lead to memory deficits
10. Mayo Clinic: Gene expression profiling not quite perfected in predicting lung cancer prognosis
11. Researchers discover way to make cells in the eye sensitive to light
Post Your Comments:
(Date:7/27/2014)... has revealed that nicotine and cotinine, a metabolite of ... certain carcinogen in smoke. , The carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone or ... and ultimately ends up in the tobacco smoke. Once ... where it is activated by a variety of enzymes ... revealed that nicotine can partially interfere with the activation ...
(Date:7/27/2014)... can evade treatment by acquiring mutations in the genes ... were once thought to be the only way for ... shown that microorganisms can use a temporary silencing of ... the benefits of drug resistance without the commitment. , ... called Mucor circinelloides, it is likely to be employed ...
(Date:7/27/2014)... patients, scientists have identified more than two dozen ... six that had not been previously reported. The ... partially funded by the National Institutes of Health ... laboratories. , "Unraveling the genetic underpinnings of Parkinson,s ... in this complex disease, and hopefully, may one ...
Breaking Biology News(10 mins):Nicotine found to inhibit DNA-strand break caused by a certain carcinogen in smoke 2Scientists discover new, noncommittal mechanism of drug resistance 2Scientists discover new, noncommittal mechanism of drug resistance 3NIH scientists find 6 new genetic risk factors for Parkinson's 2
... ice-free summers with intermittent winter sea ice in the Arctic ... conditions - gives a glimpse of how the Arctic is ... past environmental change in the Arctic should help predict its ... 65 million years ago leading up to the extinction of ...
... PHILADELPHIA Researchers from the Centers for Disease Control ... ovarian cancer is influenced by age of menarche and ... suggests that hormonal activity over the course of a ... cancer diagnosis. Results of this study are published in ...
... Environmental Health Perspectives (EHP) co-authored by ... Project on Emerging Nanotechnologies (PEN), focuses on the ... provides an overview of current practices; research findings; ... and possible future directions for nanoremediation. The authors ...
Cached Biology News:Arctic climate under greenhouse conditions in the Late Cretaceous 2Arctic climate under greenhouse conditions in the Late Cretaceous 32 reproductive factors are important predictors of death from ovarian cancer 22 reproductive factors are important predictors of death from ovarian cancer 3Contaminated site remediation: Are nanomaterials the answer? 2
(Date:7/29/2014)... MA (PRWEB) July 29, 2014 The ... Library of Congress was recently awarded to Juliana Hillis ... Stoneham, MA, for their project, “From an Egg, Everything: ... among 3,000 final entries for the National History Day ... than 300 historians and educators in Washington, D.C. , ...
(Date:7/29/2014)... 29, 2014 EXpressLO LLC, expert provider ... specimen preparation solutions, has been granted patent number 8,789,826 ... manipulation methods incorporating a unique specimen carrier support grid ... the second company patent for EXpressLO LLC awarded to ... , These complementary patents extend EXpressLO’s portfolio of intellectual ...
(Date:7/28/2014)... DIEGO , July 28, 2014 ... cultivation technologies, today announced the appointment of biotechnology veteran ... of the board of directors. Levine replaces Cynthia ,CJ, ... immediately. She will remain chairman of the company,s board ... on Sapphire Energy,s mission to deliver commercial scale algae-based ...
(Date:7/28/2014)... July 28, 2014 According to ... Market Research "Regenerative Medicine (Bone and Joint) Market ... Tissue Engineering; By Applications - Bone Graft Substitutes, ... - Global Industry Analysis, Size, Share, Growth, Trends ... medicine (bone and joint) market was valued at ...
Breaking Biology Technology:In Vitro Fertilization (IVF) was the Subject of This Year’s Winning Entry for the Prestigious Library of Congress “Discovery or Exploration in History Award” 2In Vitro Fertilization (IVF) was the Subject of This Year’s Winning Entry for the Prestigious Library of Congress “Discovery or Exploration in History Award” 3EXpressLO LLC Granted Second U.S. Patent for Innovative Specimen Preparation Methods 2Sapphire Energy Announces New CEO James Levine 2Sapphire Energy Announces New CEO James Levine 3Regenerative Medicine Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 2Regenerative Medicine Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 3Regenerative Medicine Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 4
... for Presentation at ASCO, SOUTH SAN FRANCISCO, Calif., May ... it will hold an investor and,analyst briefing in conjunction with ... (ASCO) from 6:00 p.m. to 8:00 p.m. CT,on Monday, June ... PhD, President and Chief Executive Officer -- Michael M. ...
... Mass., May 21 Interleukin Genetics,Inc. (Amex: ... into law of the,Genetic Information Nondiscrimination Act (GINA). ... April 25, 2008, and signed into law by,President ... intended to ensure that individuals are protected,from genetic ...
... Germany, Mai 21, 2008 / b3c newswire ... both leading companies in biopharmaceutical development and ... The cooperation will enable Rentschler Biotechnologie’s clients ... mammalian biopharmaceutical production facilities in Biberach, Germany ...
Cached Biology Technology:Exelixis Announces June 2 Webcast of Its ASCO Investor and Analyst Briefing 2Exelixis Announces June 2 Webcast of Its ASCO Investor and Analyst Briefing 3Exelixis Announces June 2 Webcast of Its ASCO Investor and Analyst Briefing 4Interleukin Genetics Welcomes the Signing of the Genetic Information Nondiscrimination Act (GINA) 2Interleukin Genetics Welcomes the Signing of the Genetic Information Nondiscrimination Act (GINA) 3Rentschler Biotechnologie Announces Cooperation with Boehringer Ingelheim 2Rentschler Biotechnologie Announces Cooperation with Boehringer Ingelheim 3