Navigation Links
Mayo Clinic Cancer Center: Harnessing the measles virus to attack cancer

Mayo Clinic Cancer Center has opened a new clinical study using a vaccine strain of the measles virus to attack recurrent glioblastoma multiforme, a largely untreatable brain tumor. This is the second of several pending molecular medicine studies in patients using measles to kill cancer.

"We are looking at better ways to treat some of the most lethal cancers," says Eva Galanis, M.D., oncologist and lead researcher on the glioblastoma multiforme project in the measles virus investigation. "We have shown in the laboratory and in several animal models that measles virus strains can significantly shrink glioma tumors and prolong animal survival. It is very rewarding to see this work maturing to the point of now being able to offer this novel and promising treatment approach to patients with recurrent glioblastoma multiforme." She also reports that toxicology studies, conducted in conjunction with Federal Drug Administration, showed an excellent safety profile.

Mayo Clinic is unique in its pursuit of oncolytic measles vaccine strains for cancer treatment, and the research has grown from the most basic laboratory science to the sophisticated therapy being tested today in several tumor types, including glioblastoma multiforme, recurrent ovarian cancer and multiple myeloma.

Many cancer cells, including glioblastoma cells, overexpress a specific protein, CD46, which allows tumor cells to evade destruction by the immune system. Strains of the measles virus, including the one in this study, seek out this protein, entering the glioblastoma multiforme tumor. Upon entry, the virus begins to spread, infecting nearby tumor cells and fusing them, which augments the effect of infection and increases cancer cell death.

Mayo's research team has an ongoing clinical study for ovarian cancer. "We've seen early evidence of biologic activity," says Dr. Galanis. "The ovarian cancer trial, though in its early stages, has demonstrated safety, which n ow allows administration of higher and potentially even more potent viral doses."

The glioblastoma multiforme study, which opened today, is designed to test the safety of the virus for the treatment of gliomas and enable biological monitoring of anti-tumor activity.

"The measles virus we are using in the glioblastoma multiforme trial provides a noninvasive way to monitor viral effects in the tumor," says Dr. Galanis. "When the virus replicates, it produces a marker protein that we can detect in the blood using a clinically-available assay. Repeat brain tumor biopsies for this purpose are not always safe or ethically justified. Instead we can monitor viral propagation in the tumor with a blood test, allowing us to adjust the dosage to increase the likelihood of therapeutic benefit."

Eligible candidates for the therapy will have glioblastoma multiforme that has progressed after surgery and radiation therapy, and be candidates for surgery. They also must be immune to measles, either having had the disease or been vaccinated against it.

In the 1970s, measles infections were observed to cause regression of pre-existing cancer tumors in children. This information was noted, but nothing was done to study this phenomenon until the late 1990s, when under the direction of Stephen Russell, M.D., Ph.D., Mayo Clinic Cancer Center's Molecular Medicine Program began looking into it, resulting in the current study and other related projects.

"Mayo is the perfect place to develop a therapeutic virus because you need a wide range of expertise," says Dr. Russell. "From basic scientists who create and test the vaccine strain to those who determine the best way to manufacture a safe biological delivery mechanism, and finally, to clinicians who understand the science and develop guidelines by which the study is conducted and correctly carried out, our team is one of the best. Everything we do focuses on achieving the greatest benefit for the patient."

Later this fall, Dr. Russell's team plans to open a clinical study to test the effectiveness of another version of the measles virus on multiple myeloma. The researchers also are looking at ways to use the measles virus to combat breast and pancreatic cancer.


'"/>

Source:Mayo Clinic


Related biology news :

1. Mayo Clinic Researchers Create Obedient Virus; First Step To Use Measles Virus Against Cancer
2. Chronic Sinus Infection Thought To Be Tissue Issue, Mayo Clinic Scientists Show Its Snot
3. Clinical trial to test stem cell approach for children with brain injury
4. Mayo Clinic collaboration discovers protein amplifies DNA injury signals
5. Mayo Clinic researchers challenge sepsis theory
6. Mayo Clinic researchers discover cancer cells may move via wave stimulation
7. Mayo Clinic study finds two genes predict outcome for breast cancer patients
8. Mayo Clinic collaboration mining of ancient herbal text leads to potential new anti-bacterial drug
9. Mayo Clinic study suggests that a central nervous system viral infection can lead to memory deficits
10. Mayo Clinic: Gene expression profiling not quite perfected in predicting lung cancer prognosis
11. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/19/2016)... 20, 2016 The new GEZE ... compact web-based "all-in-one" system solution for all door components. ... or the door interface with integration authorization management system, ... systems. The minimal dimensions of the access control and ... building installations offer considerable freedom of design with regard ...
(Date:4/15/2016)... 15, 2016 Research and ... Biometrics Market 2016-2020,"  report to their offering.  , ... , ,The global gait biometrics market is expected ... the period 2016-2020. Gait analysis generates ... be used to compute factors that are not ...
(Date:4/13/2016)... , April 13, 2016  IMPOWER physicians supporting Medicaid ... setting a new clinical standard in telehealth thanks to ... leveraging the higi platform, IMPOWER patients can routinely track ... and body mass index, and, when they opt in, ... convenient visit to a local retail location at no ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... April 27, 2016 MedDay, a biotechnology ... announces the appointment of Catherine Moukheibir as Chairman of its ... Chairman, Jean Jacques Garaud , who contributed to the ... effective immediately. Catherine started her career in strategy ... and London .  She held C-Suite level ...
(Date:4/26/2016)... ... 27, 2016 , ... Cameron Cushman has joined ... in the firm’s Intellectual Property practice group. , Clients turn to Cushman for ... has an electrical engineering and computer engineering background, and experience in the medical ...
(Date:4/26/2016)... ... April 26, 2016 , ... The European Patent Office (EPO) today ... three finalists for the European Inventor Award 2016 in the category "Non-European countries." The ... at a ceremony in Lisbon on June 9th. , The human capacity to walk ...
(Date:4/26/2016)... ... ... Mr. Palmer created the RPO business for Ceridian and lead the Public ... contract in the U.S. intelligence community with The SI (a Lockheed Martin divestiture). , ... of Accolo. “We are growing and his experience guiding our expansion is unparalleled. ...
Breaking Biology Technology: