Navigation Links
Master gene controls healing of skin in fruit flies and mammals

s surrounding a wound created with a sterile needle. The researchers then worked backward, using bioinformatics--computational analysis of DNA sequences--to identify grainyhead as the master gene that initiates the genetic chain reaction that results in cuticle repair. Wounds in mutant flies that lack the grainyhead gene fail to heal.

"The genes involved in cuticle repair are activated very quickly, within 30 minutes after injury," said Joseph Pearson, a graduate student working under McGinnis and a coauthor of the paper. "They are activated over many cell diameters, most strongly at the boundaries of the wound, suggesting that the grainyhead gene initiates the cuticle repair response after it receives an as-of-yet unidentified signal produced in cells adjacent to the injury."

In its study, Jane's team found that, like their fruit fly counterparts, mice lacking grainyhead have a much more permeable skin than normal mice and have deficient wound repair. Both groups point out in their papers that it is interesting that the regulatory mechanisms for development and repair of the surface barrier in insects and mammals have been conserved, given the differences in the molecular composition of insect cuticle and mammal skin.

"The proteins that link together to form the insect cuticle and stratum corneum--the outer layer of mammal skin--are completely different," says McGinnis. "So it is remarkable that flies and mammals share an ancient conserved pathway to construct and repair the body envelope that protects them from sharp edges and microbes, even though that body envelope is constructed of mostly different molecules."

In their paper, the UCSD researchers state that studying the wound response pathway in fruit flies, which are easy to manipulate genetically, may provide new insight into wound healing in mammals. For example, Mace points out that very little is known how wound tissue stops its growth behavior when the wound is healed. In a
'"/>

Source:University of California - San Diego


Page: 1 2 3

Related biology news :

1. Master regulatory gene found that guides fate of blood-producing stem cells
2. Master genetic switch found for chronic pain
3. Master planners in brain may coordinate other areas roles in cognitive tasks
4. Master regulatory gene of epithelial stem cells identified
5. Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression
6. Scientists find that protein controls aging by controlling insulin
7. MicroRNA tweaks protein that controls early heart development
8. Scientists discover gene that controls speed of tuberculosis development
9. Gene controls whether fear is a factor
10. Salk researchers make fast strides towards understanding how our body controls walking
11. Robotic joystick reveals how brain controls movement
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Master gene controls healing skin fruit flies and mammals

(Date:8/19/2014)... abstinence syndrome (NAS) secondary to in-utero opioid exposure ... than others, but the underlying reasons are not ... are turned on or off) changes have recently ... University School of Medicine (BUSM) and Boston Medical ... study to identify some of these epigenetic changes ...
(Date:8/19/2014)... other science courses are increasingly being asked to ... have a new textbook to help them do ... month by Princeton Press and co-authored by scientists ... Synthesis (NIMBioS), teaches readers about basic mathematical and ... and explain biological phenomena. , Suitable for entry-level ...
(Date:8/19/2014)... team of UTSA researchers has been awarded a nearly ... and Training (NCPTT), an office of the National Park ... grant will fund a one-year study of the energy ... historic homes in hot, humid climates. , Radiant barriers ... attics that reflect heat back, thereby reducing the amount ...
Breaking Biology News(10 mins):In-utero methadone, Subutex exposure could alter gene expression, cause severe Neonatal Abstience Syndrome 2New textbook introduces undergraduates to mathematics for the life sciences 2UTSA researcher awarded $38K+ to evaluate energy efficiency options for historic homes 2UTSA researcher awarded $38K+ to evaluate energy efficiency options for historic homes 3
... Submissions Leadership Strengthened with Clinical ... and Standards-Based Data Management, WHIPPANY, N.J. and ... today it agreed to terms to acquire Zurich,Biostatistics, ... to,standards-based regulatory submissions, the acquisition further strengthens,ISI,s Clinical ...
... Conference Embarks on New Strategic Direction in 21st Year of ... Embraces Both Flash and HDD Suppliers Under One Roof, ... and its robust dynamic supply chain, IDEMA today announced program,highlights ... be,held on September 18 - 20 at the Hyatt Regency ...
... Leading Healthcare Conference, SUNNYVALE, Calif. and ... a busy healthcare setting is a hectic ... be repeated with each patient,s visit.,Fujitsu Computer ... of,innovative computer products, and HT Systems, a ...
Cached Biology News:Image Solutions, Inc. Acquires Zurich Biostatistics, Inc. 2Image Solutions, Inc. Acquires Zurich Biostatistics, Inc. 3IDEMA Reveals Program Highlights for DISKCON USA 2007 2IDEMA Reveals Program Highlights for DISKCON USA 2007 3IDEMA Reveals Program Highlights for DISKCON USA 2007 4Fujitsu and HT Systems Partner to Provide Biometric Patient Identity Management 2Fujitsu and HT Systems Partner to Provide Biometric Patient Identity Management 3Fujitsu and HT Systems Partner to Provide Biometric Patient Identity Management 4
(Date:8/19/2014)... 19, 2014 XenoTech announces an ... cost-effective metabolite production from bioactive small molecules. ... the technology enables convenient and timely assessment of ... XenoTech’s Vice President of Commercial Operations, Christian Darabant, ... clinical risk can be measured directly by comparison ...
(Date:8/19/2014)... /PRNewswire/ - iCo Therapeutics Inc. ("iCo" or "the Company") ... its Oral Amphotericin B (Oral Amp B) drug ... by ImmuneCarta®, the immune monitoring business unit of ... Oral Amp B in reactivating latent HIV viral ... treatment with antiretroviral therapy. Memory ...
(Date:8/18/2014)... 2014 BioElectronics Corporation (OTC Pink: ... devices said that its EVP Dr. ... as part of its Executive Interview Series. ... at http://ceolive.tv/bioelectronics-corp-otc-biel/biel-videos/2282-ceolive-tv-interview-bioelectronics-corp-otcqb-biel In ... the unique advantages of BioElectronics patented technology ...
(Date:8/18/2014)... DALLAS , August 18, 2014 ... "Membrane Bioreactor Systems Market, By Application (Municipal Wastewater ... Fiber, Flat Sheet and Multi Tubular), By Configuration ... to 2019", published by MarketsandMarkets, The market for ... million by 2019, growing at a CAGR of ...
Breaking Biology Technology:Beyond Metabolite Identification, Testable Quantities Now Offered by XenoTech 2Beyond Metabolite Identification, Testable Quantities Now Offered by XenoTech 3iCo Therapeutics Announces Positive Oral Amphotericin B Study Results 2iCo Therapeutics Announces Positive Oral Amphotericin B Study Results 3BioElectronics EVP Dr. Deepak Kotak Interviewed on CEO Live 2BioElectronics EVP Dr. Deepak Kotak Interviewed on CEO Live 3Membrane Bioreactor Systems Market Worth $2,927 Million by 2019 2Membrane Bioreactor Systems Market Worth $2,927 Million by 2019 3
... is First Entry to Home-Based Device Market Featuring Diode Laser ... ... SpectraGenics, a leader in,light-based therapeutic beauty devices, today announced ... (FDA),for their patented hand-held laser hair removal device designed for ...
... Live on Company,s Website -, TUSTIN, Calif., Feb. ... clinical stage biopharmaceutical,company developing monoclonal antibodies for the treatment ... senior management will,present at the 10th Annual BIO CEO ... am EST. The conference will be held at the,Waldorf-Astoria ...
... or "the Company") (OTC: BPYT) today announced that sales,for ... sales for the month,of January 2007., "We achieved ... continued success of our Flight Spray product. We are ... all-natural solution for,baby care marketed under the Gentle Mother(TM) ...
Cached Biology Technology:TRIA At-Home Laser Hair Removal Device Cleared by FDA 2Peregrine Pharmaceuticals to Present at the 10th Annual BIO CEO & Investor Conference 2Bioponic Phytoceuticals Announces Record Sales Increase of 40% for the Month of January 2
HybriWell seals securely to a microscope slide surface in seconds to enclose single or multiple specimens in a small reagent volume and eliminate evaporation....
Comp Dim: chamber diam. depth 20 2.8 mm chamber maximum volume 720 μL...
... the Easy-Titer Human IgM Assay Kit to ... and easy-to-perform assay for Human IgM that ... kit incorporates a simple mix-and-read assay that ... from 15-500 ng/ml in approximately 30 minutes. ...
AC input: 230 V...
Biology Products: