Navigation Links
Master gene controls healing of skin in fruit flies and mammals

s surrounding a wound created with a sterile needle. The researchers then worked backward, using bioinformatics--computational analysis of DNA sequences--to identify grainyhead as the master gene that initiates the genetic chain reaction that results in cuticle repair. Wounds in mutant flies that lack the grainyhead gene fail to heal.

"The genes involved in cuticle repair are activated very quickly, within 30 minutes after injury," said Joseph Pearson, a graduate student working under McGinnis and a coauthor of the paper. "They are activated over many cell diameters, most strongly at the boundaries of the wound, suggesting that the grainyhead gene initiates the cuticle repair response after it receives an as-of-yet unidentified signal produced in cells adjacent to the injury."

In its study, Jane's team found that, like their fruit fly counterparts, mice lacking grainyhead have a much more permeable skin than normal mice and have deficient wound repair. Both groups point out in their papers that it is interesting that the regulatory mechanisms for development and repair of the surface barrier in insects and mammals have been conserved, given the differences in the molecular composition of insect cuticle and mammal skin.

"The proteins that link together to form the insect cuticle and stratum corneum--the outer layer of mammal skin--are completely different," says McGinnis. "So it is remarkable that flies and mammals share an ancient conserved pathway to construct and repair the body envelope that protects them from sharp edges and microbes, even though that body envelope is constructed of mostly different molecules."

In their paper, the UCSD researchers state that studying the wound response pathway in fruit flies, which are easy to manipulate genetically, may provide new insight into wound healing in mammals. For example, Mace points out that very little is known how wound tissue stops its growth behavior when the wound is healed. In a
'"/>

Source:University of California - San Diego


Page: 1 2 3

Related biology news :

1. Master regulatory gene found that guides fate of blood-producing stem cells
2. Master genetic switch found for chronic pain
3. Master planners in brain may coordinate other areas roles in cognitive tasks
4. Master regulatory gene of epithelial stem cells identified
5. Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression
6. Scientists find that protein controls aging by controlling insulin
7. MicroRNA tweaks protein that controls early heart development
8. Scientists discover gene that controls speed of tuberculosis development
9. Gene controls whether fear is a factor
10. Salk researchers make fast strides towards understanding how our body controls walking
11. Robotic joystick reveals how brain controls movement
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Master gene controls healing skin fruit flies and mammals

(Date:10/19/2014)... access in India over the last 30 years ... emissions growth during that time, according to a ... Climate Change ., "Energy access is fundamental to ... life, including education, communication, and health," says IIASA ... While increased energy access is widely agreed to ...
(Date:10/17/2014)... critical and pertinent for practicing physicians and clinicians given ... The Journal, Disaster Medicine and Public Health Preparedness ... Public Health, to surround the public, medical professionals and ... , On October 17, the journal published ... was prepared by Dr. Eric Toner, internist and emergency ...
(Date:10/16/2014)... the human body. Battles are won, lost or ... this stalemate—known as tumor dormancy—can last up to ... that is poorly understood. , A new ... Torquato, a Professor of Chemistry at Princeton University, ... and the switch to a malignant state. Published ...
Breaking Biology News(10 mins):Improved electricity access has little impact on climate change 2Modeling tumor dormancy 2
... few things as important on, and especially off, Earth as ... don,t have seconds to spare, which is why development of ... monitor can measure the concentrations of multiple gases within the ... designed the Multi-Gas Monitor to be resistant to shock and ...
... the right shape might be just as important in a ... an important role in the effectiveness of cells grown to ... design new structures that enable cells to "shape up," researchers ... come up with a way to measure, and more importantly, ...
... sound very durable. But the new type of micro-factories invented ... They will actually be placed inside a patient,s body ... will gradually dissolve and disappear in the patient,s urine once ... that Associate Professor of Chemistry Alexander Zelikin, Aarhus University, has ...
Cached Biology News:Rugged, rapid monitor safeguards space crews 2Rugged, rapid monitor safeguards space crews 3Shape-sifting: NIST categorizes bio scaffolds by characteristic cell shapes 2Tiny soft medicine factories 2
(Date:10/22/2014)... Physicians Choice Laboratory Services (PCLS) ... which enables healthcare providers to individualize therapeutic treatments ... results, healthcare providers are better able to assess ... minimizing risks for adverse drug reactions and interactions. ... FDA [1] more than 2.2 million adverse drug ...
(Date:10/22/2014)... --  Synthetic Biologics, Inc. (NYSE MKT: SYN), a ... and diseases, announced today that the U.S. Patent and ... a composition of matter patent application that covers the ... This is Synthetic Biologics, first allowed patent application directly ... the Company,s extensive C. difficile patent estate. ...
(Date:10/22/2014)... , Oct. 22, 2014 Nuvilex, Inc. ... approximately 400 million people worldwide are living with diabetes, ... people by 2030.  The global market for diabetes treatments ... approximately 330,000 people worldwide died from pancreatic cancer.  Pancreatic ... due to cancer in the United States ...
(Date:10/22/2014)... HONG KONG , Oct. 22, 2014 /PRNewswire/ ... announced today that rare disease expert John C. ... research. Dr. McKew brings more than two decades of ... the National Institutes of Health, Wyeth Research and Genetics ... will lead aTyr,s efforts to expand and translate its ...
Breaking Biology Technology:PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 2PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 3Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 2Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 3Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 4Nuvilex Brief Analyst Report: Thinking Outside the Box by BrokerBank Securities, Inc. 2aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 2aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 3
... 16 Medical and technical experts at Wyle are ... Station. Their efforts will help astronauts cope with effects ... in a future mission to Mars. , "If successful, ... exploration missions and provide us with better insight into ...
... , , SEATTLE, Nov. 16 ... "Company") today announced that the Company,s product candidate PX-866, ... Information, Inc., as one of the Top 10 most ... partnering. , The selection was made by an independent ...
... , LONDON, Nov. 16 The ... field of biomarker research will test the frontiers of biomedical ... day and this rapid development promises excellent growth potential for ... in biomarker validation and assay development, there is a huge ...
Cached Biology Technology:Wyle Personnel Take Part in Important Studies Aboard the International Space Station 2Wyle Personnel Take Part in Important Studies Aboard the International Space Station 3Oncothyreon's PX-866 PI-3 kinase inhibitor named among Top 10 most promising oncology products for partnering by Windhover 2Oncothyreon's PX-866 PI-3 kinase inhibitor named among Top 10 most promising oncology products for partnering by Windhover 3Frost & Sullivan Reveals Strategies on Turning Challenges into Opportunities in the European Biomarkers Market 2
Rabbit polyclonal to ErbB 2 (phospho Y1248) ( Abpromise for all tested applications). entrezGeneID: 2064 SwissProtID: P04626...
The Microseal 384 plate positioner ensures precise positioning of Microseal 384-well plates in the x-, y-, and z-dimensions, for accurate automated liquid handling....
... sealing material is suitable for PCR ... down heated lid), especially 384-well formats ... for sample retrieval. Multiple seals can ... Ideal for compound management and high ...
... Nikon's Digital Sight DS-U2 camera controller is ... is specifically designed to interface any of the ... a PC computer through a USB2.0 interface. The ... complicated and cumbersome installation by equipping both hub ...
Biology Products: