Navigation Links
Marsupial genome reveals insights into mammalian evolution

The genetic code of marsupials has now been documented for the first time. An international team led by Kathy Belov from the University of Sydney's Faculty of Veterinary Science published an analysis of the marsupial genome in the open access journal PLoS Biology. The paper details the evolution of an important cluster of immune genes known as the MHC using available genome sequences of the gray, short-tailed opossum (Monodelphis domestica), a marsupial found in South America.

"Mapping the opossum MHC has allowed us to deduce what the MHC of ancestral mammals looked like," says Belov. "We think it contained several different types of immune genes in a single complex. These genes are no longer found in a single complex in any living animal but are scattered over various chromosomes. We have named this complex 'The Immune Supercomplex.'"

Belov et al. found that while the size and complexity of the opossum MHC is closer to eutherian (placental) mammals, its organization is closer to fish and birds. "The clues we unearthed by looking at different genomes are also helping us to understand how our own intricate immune system evolved from the relatively simple immune system seen in lower vertebrates such as birds and fish," says Belov.

"Interest in marsupial and monotreme genomes comes from their important positions in vertebrate evolution," says Belov. (Monotremes are egg-laying mammals, represented today by only the platypus and echidna.) "Comparing genes of placental mammals, such as the human and the mouse, is not very efficient because their genes can be so similar it is hard to pinpoint regions that remain unchanged because they serve a particular purpose. In contrast, comparison of distantly related genes, such as the chicken and human, can be difficult, because the sequences are so different."

"Marsupial and monotreme genomes fill this gap. They are easily aligned with placental mammal genomes, yet are different enough to pinpo
'"/>

Source:Public Library of Science


Page: 1 2

Related biology news :

1. Man and mouse share genome structures
2. Whole genome fine map of rice completed
3. Study finds more than one-third of human genome regulated by RNA
4. A bacterial genome reveals new targets to combat infectious disease
5. Scientists decipher genome of fungus that can cause life-threatening infections
6. Highly adaptable genome in gut bacterium key to intestinal health
7. Fleshing out the genome
8. Agilent Technologies new genome analysis technology set to accelerate Australia fight against mesothelioma
9. wFleaBase: the Daphnia genome database
10. NHGRI targets 12 more organisms for genome sequencing
11. Chimp genome reveals a retroviral invasion
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Marsupial genome reveals insights into mammalian evolution

(Date:4/14/2014)... ARBORA 32-year study of subarctic forest moths in Finnish ... of climate change on animals and plants because much ... study analyzed populations of 80 moth species and found ... increasing throughout the study period, from 1978 to 2009. ... site rose 3.5 degrees Fahrenheit, and winter precipitation increased ...
(Date:4/14/2014)... climate over the past three decades have caused small ... national animal. UCLA biologists have found that not only ... has also become shorter and higher pitched. ... integrative biology and physiology and of ecology and evolutionary ... study examined 170 male coqui frogs ( Eleutherodactylus coqui ...
(Date:4/14/2014)... ) David Kisailus, the Winston Chung Endowed ... California, Riverside,s Bourns College of Engineering, has been ... young scientists selected by the advisory board of ... of Sciences and organizers of the Kavli/National Academy ... Kavli Foundation, which is based in Oxnard, supports ...
Breaking Biology News(10 mins):Moth study suggests hidden climate change impacts 2Moth study suggests hidden climate change impacts 3Climate change a likely culprit in coqui frog's altered calls, say UCLA biologists 2Professor receives young scientist honor 2
... of cardiac therapeutics have long looked to the future when ... one,s own heart cells. A study published in the February ... American Heart Association, shows that heart stem cells from children ... heart in the laboratory. Sunjay ...
... Visionaries in the field of cardiac therapeutics have long looked ... or repaired by using one,s own heart cells. A study ... scientific journal of the American Heart Association, shows that heart ... to rebuild the damaged heart in an animal model. ...
... A Kansas State University scientist is digging deep to ... groundwater and aquifers. Tungsten is a naturally occurring ... is primarily used for incandescent lightbulb filaments and X-ray ... the environment, tungsten is replacing lead in fishing weights ...
Cached Biology News:Stem cells show promise in repairing a child's heart 2Using a child's own stem cells to repair their heart looks promising 2National study explores the reaction and transport of tungsten in drinking water 2
(Date:1/15/2014)... January 15, 2014 This webinar ... on nonclinical and clinical safety assessment in biosimilars. ... guide a path for biosimilar drug development, however ... of biosimilarity with regards to quality, safety and ... of biosimilar drug development and registration, development strategies ...
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 ... an enhancement to its Online Web Portal for Life ... now have the ability to specify the subject matter ... nearly 50 life science sub-domains. This will help reduce ... and scientific fields, and decrease the likelihood of error. ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 ... – 11 p.m. , Location: Warrington Country Club, 1360 ... Hepatitis B Foundation, the only national nonprofit organization solely ... improving the quality of life for those affected worldwide, ... 11 at Warrington Country Club in Warrington, Pa. ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... initiated coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua ... and marketing proprietary products to serve the wound ... , In late 2012, Alliqua was restructured ... launched the company’s new strategy to become a ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... Healthcare,Acquisition Corp. (Amex: MBH ), a publicly ... and Critical Homecare,Solutions Holdings, Inc., a privately-owned, leading ... services, are,scheduled to present on Tuesday, March 18, ... Conference in Miami, Florida. On February,6, 2008, MBH ...
... planned on the genetics of;, - Asian populations with regard ... ... to athletic/exercise performance ... regard to skin appearance (dermagenomics), WALTHAM, Mass., Feb. 28 ...
... Japanese medical centres in presenting data on ... clinical utility of EAA(TM) diagnostic-, ... SDI) today announced that it will present new findings ... the only FDA,cleared diagnostic for the measurement of endotoxin, ...
Cached Biology Technology:MBF Healthcare Acquisition Corp. and Critical Homecare Solutions Holdings, Inc. to Present at Lehman Brothers Eleventh Annual Global Healthcare Conference 2MBF Healthcare Acquisition Corp. and Critical Homecare Solutions Holdings, Inc. to Present at Lehman Brothers Eleventh Annual Global Healthcare Conference 3Interleukin Genetics Enters into New Clinical Research Collaboration with Alticor 2Interleukin Genetics Enters into New Clinical Research Collaboration with Alticor 3Interleukin Genetics Enters into New Clinical Research Collaboration with Alticor 4Interleukin Genetics Enters into New Clinical Research Collaboration with Alticor 5Spectral announces data on the clinical utility of EAA(TM) to be presented at 12th Annual Critical Care for Endotoxemia Conference in Japan 2
Mol wt: average mol wt16,951.27 Da by calculation...
A set of five peptides which can be used to calibrate a Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) or Electrospray Ionization (ESI) mass spectrometer....
... number is a new product ... Cornings product number. If showing ... under the old Sigma-Aldrich number ... for assistance. ID clarifier: filling ...
... CLS number is a new ... match Cornings product number. If ... order under the old Sigma-Aldrich ... service for assistance. ID clarifier: ...
Biology Products: