Navigation Links
Marrow-derived stem cells deliver new cytokine to kill brain tumor cells, offer protection

r recapitulates our previous data demonstrating that the neural stem cells ?in this case from bone marrow ?were able to track to the tumor very efficiently and, like a heat-seeking missile, deliver a killer depot," said John S. Yu, M.D., neurosurgeon, co-director of the Comprehensive Brain Tumor Program at the Maxine Dunitz Neurosurgical Institute, and the article's senior author. "We obtained the stem cells from bone marrow, mirroring what we want to do clinically, which is to take bone marrow cells from a patient, make them into neural stem cells, put in the gene of interest and treat the patient."

In this case, the gene of interest produces IL-23, which appears to be very well suited for attacking gliomas. Earlier studies used IL-4, IL-12, and tumor necrosis factor related apoptosis inducing ligand (TRAIL).

"Each cytokine has unique functions. What we want to do is marry the function with the therapeutic response we want to achieve. Interleukin-23 promotes the function of dendritic cells and memory T-cells, important components in an immune response to tumor cells. The earlier cytokines produced good results, but IL-23 is even more potent," Yu said.

"Most anti-tumor gene strategies attempt to deliver genes directly to tumor cells, but gliomas are especially challenging because of their highly invasive and migratory characteristics," said Keith L. Black, M.D., director of the Maxine Dunitz Neurosurgical Institute, director of Cedars-Sinai's Division of Neurosurgery, and co-director of the Comprehensive Brain Tumor Program. "By combining the tumor-tracking properties of bone marrow-derived neural stem cells with interleukin-23, we are able to initiate a very powerful anti-tumor response that tracks to migrating glioma islands and offers long-term protection ?all of which would make this a very attractive therapeutic option."

In the animal study, bone marrow-derived neural stem-like cells (BM-NSC) genetically engineered to produce IL-
'"/>

Source:Cedars-Sinai Medical Center


Page: 1 2 3

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. Spleen may be source of versatile stem cells
3. Researchers discover way to make cells in the eye sensitive to light
4. Priming embryonic stem cells to fulfill their promise
5. Lack of enzyme turns fat cells into fat burners
6. Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
7. Elusive HIV shape change revealed; Key clue to how virus infects cells
8. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
9. Enzyme allows B cells to resist death, leading to leukemia
10. Scientists rid stem cell culture of key animal cells
11. Genetically modified natural killer immune cells attack, kill leukemia cells
Post Your Comments:
(Date:7/11/2014)... July 10, 2014---A team of researchers from The Chinese ... identified a gene of wild soybean linked to salt ... grow in saline soil. This study published online in ... unveil novel genomic information for crop improvement. , Soybean ... domestication and human selection, cultivated soybeans have less genetic ...
(Date:7/11/2014)... July 11, 2014 Researchers have pioneered ... images. The new technology, called Virtual Finger, allows ... structures like neurons and synapses using the flat ... technology makes 3D imaging studies orders of magnitude ... an unprecedented level across many areas of experimental ...
(Date:7/11/2014)... receptor type 1 can inhibit voltage-gated calcium ... neurotransmitter release. However, some scholars demonstrated that ... Ca2+ influx and increase neurotransmitter release. Dr. ... Affiliated to Tongji Medical College, Huazhong University ... cell voltage-clamp and calcium imaging in cultured ...
Breaking Biology News(10 mins):BGI reports a novel gene for salt tolerance found in wild soybean 2Virtual finger enables scientists to navigate and analyze complex 3D images 2
... MURCIA, SPAINSalt can have drastic effects on the ... that salinity renders an about one-third of the world,s ... salinity can cause ion toxicity, osmotic stress, mineral deficiencies, ... stress can even cause plants to adjust their water ...
... of modern humans like more than 50,000 years ago? ... Stone Age engravings are the subjects of a good deal ... journal Science , an international team of researchers report ... could place the use of herbal medicines much earlier than ...
... growing in popularity as more growers turn to strip-till. However, ... worth. A new University of Illinois study revealed ... soybean. However, the results showed no difference in yield between ... corn, not soybean," said Fabian Fernandez, U of I assistant ...
Cached Biology News:Salt-tolerant crops show higher capacity for carbon fixation 2Earliest known bug-repellant plant bedding found at South African rock shelter 2Earliest known bug-repellant plant bedding found at South African rock shelter 3Earliest known bug-repellant plant bedding found at South African rock shelter 4Strip-till improves nutrient uptake and yield 2
(Date:7/10/2014)... Poway, CA (PRWEB) July 10, 2014 Robert ... Regenerative Veterinary Medicine company, is proud to announce the relaunch ... Pets, launching with a new series called “ What are ... to give an honest and straightforward foundation in the basics ... an educated decision on the right type of treatment when ...
(Date:7/10/2014)... CROWN POINT, Ind. , July 10, ... recently expanded its use of capnography for ... a growing group of healthcare leaders in ... Capnography measures how effectively patients are breathing ... respiratory depression occurs. By measuring the amount ...
(Date:7/10/2014)... Research and Markets ( http://www.researchandmarkets.com/research/s3bqj2/photonic ) ... Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module ... to their offering. ... integration traces its roots in the latter half ... integration went unexplored and unfulfilled for several decades ...
(Date:7/10/2014)... Using microscopic polymer light resonators that expand in ... Quantum Photonics Laboratory have developed new optical sensors ... Optical sensors are ideal for detecting trace gas ... lightweight nature, and immunity to electromagnetic interference. , ... before, the MIT team conceived an extremely sensitive, ...
Breaking Biology Technology:Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2Swell new sensors 2
... ISELIN, N.J., July 30 SyntheMed, Inc. (OTC ... development and commercialization of anti-adhesion products, announced today that ... its bioresorbable reverse thermal gelation polymer technology. This ... this novel technology and pertains to the application of ...
... , MONMOUTH JUNCTION, N.J., July ... into a cooperative research and development agreement with the National ... National Institutes of Health (NIH), to study ARIKACE(TM) (liposomal amikacin ... , , Transave and NIAID will collaborate ...
... , CHADDS FORD, Pa., July 30 Endo Pharmaceuticals ... quarter of 2009, including a full quarter of results of Indevus Pharmaceuticals, ... Total revenues during the second quarter of 2009 increased 22 percent ... 2008. Net income for the three months ended June 30, 2009, ...
Cached Biology Technology:SyntheMed Receives US Patent on Novel Polymer Technology 2Transave Enters Into Cooperative Research Agreement With NIH To Study ARIKACE(TM) In Nontuberculous Mycobacteria 2Transave Enters Into Cooperative Research Agreement With NIH To Study ARIKACE(TM) In Nontuberculous Mycobacteria 3Transave Enters Into Cooperative Research Agreement With NIH To Study ARIKACE(TM) In Nontuberculous Mycobacteria 4Endo Pharmaceuticals Reports Strong Second Quarter 2009 Financial Results 2Endo Pharmaceuticals Reports Strong Second Quarter 2009 Financial Results 3Endo Pharmaceuticals Reports Strong Second Quarter 2009 Financial Results 4Endo Pharmaceuticals Reports Strong Second Quarter 2009 Financial Results 5Endo Pharmaceuticals Reports Strong Second Quarter 2009 Financial Results 6Endo Pharmaceuticals Reports Strong Second Quarter 2009 Financial Results 7Endo Pharmaceuticals Reports Strong Second Quarter 2009 Financial Results 8Endo Pharmaceuticals Reports Strong Second Quarter 2009 Financial Results 9Endo Pharmaceuticals Reports Strong Second Quarter 2009 Financial Results 10Endo Pharmaceuticals Reports Strong Second Quarter 2009 Financial Results 11Endo Pharmaceuticals Reports Strong Second Quarter 2009 Financial Results 12Endo Pharmaceuticals Reports Strong Second Quarter 2009 Financial Results 13Endo Pharmaceuticals Reports Strong Second Quarter 2009 Financial Results 14Endo Pharmaceuticals Reports Strong Second Quarter 2009 Financial Results 15Endo Pharmaceuticals Reports Strong Second Quarter 2009 Financial Results 16
SHEEP ANTI BOVINE LACTOPEROXIDASE...
... in utility and flexibility press-to-seal silicone isolators ... of the researcher. They are available either ... sheet material that can be easily trimmed ... autoclavable and non-cytotoxic and can be used ...
Request Info...
... Provides up to 30 minutes of walkaway time. Automatic Calibration. Five minute cooldown ... port. ... ... ...
Biology Products: