Navigation Links
Marrow-derived stem cells deliver new cytokine to kill brain tumor cells, offer protection

Attaching a recently discovered cytokine to neural stem cells derived from bone marrow, researchers at Cedars-Sinai Medical Center's Maxine Dunitz Neurosurgical Institute have developed a tool to track and kill malignant brain tumor cells and provide long-term protection against their return.

Results of an animal study are published in the March 1, 2006 issue of Cancer Research, and the researchers are now applying to regulatory agencies to translate their work into human clinical trials.

Gliomas are highly invasive tumors with poorly defined borders that intermingle with healthy brain tissue, making complete surgical removal nearly impossible. Furthermore, cells separate from the main tumor and migrate to form satellites that escape treatment and often lead to recurrence.

Researchers at the Maxine Dunitz Neurosurgical Institute documented several years ago that some neural stem cells ?"immature" cells that can differentiate into central nervous system cells ?have the ability to target and track glioma cells in the brain, even as they migrate. The researchers identified the mechanism that enables certain neural stem cells to develop this tracking ability and genetically engineered neural stem cells to transport several cytokines ?proteins that regulate immune responses ?to track down and destroy glioma cells.

In 2002, the scientists reported that they had produced central nervous system cells from stem cells derived from bone marrow. Because these stem cells originate in the bone marrow instead of the brain or fetal or embryonic tissue, there is an unlimited supply of cells that are free of ethical and tissue-rejection issues.

This study provides the first documentation that the marrow-derived stem cells possess the same tumor-tracking capability of other neural stem cells. It also includes the first report on the use of the cytokine interleukin-23 (IL-23) as a potential gene-delivered therapy against glioma.

"The pape
'"/>

Source:Cedars-Sinai Medical Center


Page: 1 2 3

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. Spleen may be source of versatile stem cells
3. Researchers discover way to make cells in the eye sensitive to light
4. Priming embryonic stem cells to fulfill their promise
5. Lack of enzyme turns fat cells into fat burners
6. Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
7. Elusive HIV shape change revealed; Key clue to how virus infects cells
8. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
9. Enzyme allows B cells to resist death, leading to leukemia
10. Scientists rid stem cell culture of key animal cells
11. Genetically modified natural killer immune cells attack, kill leukemia cells
Post Your Comments:
(Date:8/26/2014)... analysis suggests the planet can produce much more land-plant ... fruits, grains and other terrestrial plant parts than ... Environmental Science and Technology , recalculates the theoretical ... is much higher than many current estimates allow. , ... planet, you have to make some simplifying assumptions," said ...
(Date:8/26/2014)... , August 26, 2014 ... Veröffentlichung von Oxygen Forensic Passware Analyst bekannt, ... die preisgekrönten Erfassungs- und Analysetools von Oxygen ... kombiniert.     Das neue Tool ... in einem einzigen nahtlosen Ablauf. Das neu ...
(Date:8/25/2014)... month, one of the first U.S. outbreaks of the ... striking some 2,000 people. A university math and biology ... the time to gain insight into how only a ... across the university community., The fall 2009 semester hadn,t ... the university,s Health and Wellness Services clinic11 one day, ...
Breaking Biology News(10 mins):Study: Earth can sustain more terrestrial plant growth than previously thought 2Study: Earth can sustain more terrestrial plant growth than previously thought 3Oxygen Forensic Passware Analyst erfasst geschützte Mobilgerätedaten 2WSU flu outbreak provides rare study material 2WSU flu outbreak provides rare study material 3
... characterise their Zap-It! product, which uses the tiny electric ... itching caused by insect bites - such as those from ... that is based around a similar piezoelectric mechanism to that ... a medical device, currently available to buy in high street ...
... Molecular biologist Ichiro Matsumoto, Ph.D., of the Monell Center, ... Young Investigators in Gustation, awarded annually by the Association ... who is an emerging leader in the field of ... the understanding of the organization, relationships and connectivity of ...
... of the potentially deadly antibiotic-resistant bacterium known as MRSA ... a new study involving two Northern Arizona University researchers., ... for Microbial Genetics and Genomics, and Lance Price, NAU ... Microbiology and Environmental Health at the Translational Genomics Research ...
Cached Biology News:Zapping mosquito bites 2Evolution of staph 'superbug' traced between humans and food animals 2
(Date:8/26/2014)... The 20 ambassadors representing the ALS Therapy ... the following statement on Facebook today regarding the global ... funding specifically for ALS research: , “Who would have ... would raise all this awareness and funding toward ALS ... behalf of the entire ALS community, would like to ...
(Date:8/26/2014)... argument has just been added to the growing ... as the next big thing in the high-tech ... materials. An international collaboration of researchers led by ... (DOE),s Lawrence Berkeley National Laboratory (Berkeley Lab) has ... transfer in photo-excited MX2 materials. The recorded charge ...
(Date:8/26/2014)... , Aug. 26, 2014 An analysis by ... of all Dengue virus strains in Pubmed, has revealed ... to 1944. This conservation and sharing of specific Replikin ... Dengue Blocker-Vaccine™ candidate, as it did for the H5N1 ... of which have been found to be effective (1,2). ...
(Date:8/26/2014)... Mich. , Aug. 26, 2014   ... development of breakthrough oral medicines to treat autoimmune ... immune modulation, today announced the appointment of ... company,s scientific advisory board.  Dr. Singh will lead ... to advance Lycera,s multiple ongoing research programs and ...
Breaking Biology Technology:ALS TDI’s Young Faces of ALS Ambassadors Thank You for Accepting the Ice Bucket Challenge to End ALS 2ALS TDI’s Young Faces of ALS Ambassadors Thank You for Accepting the Ice Bucket Challenge to End ALS 3ALS TDI’s Young Faces of ALS Ambassadors Thank You for Accepting the Ice Bucket Challenge to End ALS 4Competition for graphene 2Lycera Appoints Harinder Singh, Ph.D., as Chair of Scientific Advisory Board 2Lycera Appoints Harinder Singh, Ph.D., as Chair of Scientific Advisory Board 3
... Wisconsin-Madison , justified or otherwise, is that its academic ... has world-class scientists and well-developed mechanisms for turning their ... that commercialization takes place within a half-hour drive from ... the figures for per capita wages, unemployment and job ...
... subscribe to the theory that consumer need is what drives ... some proof. , ,In this case, the need is ... something to be desired, and the chief executive of a ... and broadband problems before. , ,Albert Chiozzi, who plans ...
... half of the nation's top 25 banks have joined an ... , a business unit of Metavante Corp ., the ... ,Twelve of the nation's largest banks now will be able ... physically convey them, a capability that was encouraged by the ...
Cached Biology Technology:Entrepreneurship grant will build strong foundation 2Entrepreneurship grant will build strong foundation 3Entrepreneurship grant will build strong foundation 4Company to operate in wireless Internet space 2
cDNA Size Fractionation Columns offer an efficient and convenient method for size-fractioning double-stranded cDNA....
Self Closing Forceps...
... plus assay system offers the ... Designed for batch-processing systems, Long ... density microplates such as 384-well ... Convenient storage conditions ( 2 ...
... comprehensive, cost-effective solution to your TechMate ... quality into both our products and ... chemistries and antibodies that have been ... also includes our competitively priced accessories ...
Biology Products: