Navigation Links
Markers of gene, protein, or micro-RNA activity predict outcome in prostate and colorectal cancers

the scientific literature that seemed to play a role in prostate cancer. They tested their expression on paraffin-embedded tumor samples taken from 71 patients, as well as on 41 control samples (non-cancerous prostate tissue taken from the same group of patients).

From this, they identified 16 candidate genes to further analyze. Ten of the genes were positively correlated to cancer progression, and six were negatively correlated, she said, and when tested, the combination generated a gene expression score that provided a better predictor of relapse than the Gleason score. "This gene expression score appears to give us additional prognostic information that current technology cannot provide, and that will help us treat patients accordingly," she said.

The assay they used was developed by Illumina Inc., of San Diego, which also funded this study. It uses fine optic beads and needs only tiny amount of DNA and RNA, Wang-Rodriguez said, and up to 96 different tests can be put on a single tray. "Having batches of samples together in a single assay that can then be read automatically makes it easy for routine clinical use," she said. "The test has a lot of potential, but needs to be further studied and validated."

Methylation Markers Are an Independent Predictor of Prostate Cancer Prognosis in a Cohort of 605 Radical Prostatectomy Patients: Abstract No. LB-226

Researchers have found that a test checking the methylation of a single gene can predict recurrence of prostate cancer in patients who have had their glands surgically removed.

In a clinical study of tumor tissue taken from 605 prostate cancer patients, those who had a positive PITX2 methylation test were three times more likely to experience cancer recurrence than those who tested negative, according to the study's lead author, Susan Cottrell, Ph.D., senior scientist at Epigenomics, Inc., in Seattle. Furthermore, the test predicted recurrence in all patient subgroups,
'"/>

Source:American Association for Cancer Research


Page: 1 2 3 4 5 6 7

Related biology news :

1. Silence the gene, save the cell: RNA interference as promising therapy for ALS
2. Exercise training in ordinary people affects the activity of 500 genes
3. New bioinformatics technique for systematically analyzing key regions in DNA that help control gene activity
4. Natural compound from pond scum shows potential activity against Alzheimers
5. Brain activity related to processing faces is similar in people with, without autism
6. Molecule by molecule, new assay shows real-time gene activity
7. Inflammation and drugs to control this activity studied in a variety of tumors sites
8. Hopkins researchers develop new tool to watch real-time chemical activity in cells
9. Structure determined for p53 tumor suppressor protein as bound to DNA for anti-cancer activity
10. Stem cell activity deciphered in the aging brain
11. Innovative movies show real-time immune-cell activity within tumors
Post Your Comments:
(Date:4/17/2014)... Stem cells in bone marrow need to produce hydrogen ... tissue, according to a new study from the Center ... of Dentistry of USC. , Professor Songtao Shi, principal ... sulfide produced by the cells governs the flow of ... cellular signals that results in osteogenesis, or the creation ...
(Date:4/17/2014)... German . ... demanded of him, he can expect his premises to be ... of the consequences is enough to make restaurant owners pay ... lay their eggs in other birds, nests. If the host ... their revenge by destroying the entire nest. Consequently, it is ...
(Date:4/17/2014)... France have hit on a novel method to ... correct and most effective treatment possible., Kidney stones ... and developing world. If left untreated, apart from ... failure and other complications. In many patients treated ... a more effective pathological approach to diagnosis and ...
Breaking Biology News(10 mins):Fear of the cuckoo mafia 2Fear of the cuckoo mafia 3
... Humans have used the papyrus sedge for millennia. The Ancient ... buoyant boats, it is grown for ornamentation and parts can ... of Environmental Technology and Management , researchers in Uganda have ... toxins and other noxious residues from abattoir effluent. Robinson ...
... A team of UC Davis scientists has found that ... combat cancer by cutting off the supply of oxygen and ... The scientists report their discovery in the ... ). The groundbreaking study was a collaboration among multiple UC ...
... especially in rural areas, may interfere not only with ... finding flowers, according to researchers from Penn State and ... to perniciously alter key interactions between plants and animals," ... Environmental Research Letters . The animal tested in this ...
Cached Biology News:Papyrus plant detox for slaughterhouses 2Fatty acid metabolite shows promise against cancer in mice 2Fatty acid metabolite shows promise against cancer in mice 3Ozone masks plants volatiles, plant eating insects confused 2
(Date:1/15/2014)... , January 15, 2014 A study has ... on the Formula 1 track could help to tackle the ... Technologies (MAT), Stowhealth (a GP surgery based in Stowmarket) and ... provider Simplyhealth. Telemetry technology, which is inspired by ...
(Date:1/15/2014)... 15, 2014 Two champions of science, ... sponsorship of an annual competition for middle and high ... to, innovative STEM study. The competition presents students with ... of Engineering Aptitude, Mathematics, and Sciences is a ...
(Date:1/15/2014)... DTS Language Services, Inc . is pleased to ... Science organizations who need document translations. Clients will now ... documents in advance with a selection of nearly 50 life ... a critical factor in clinical and scientific fields, and decrease ...
(Date:1/15/2014)... Sunnyvale, CA (PRWEB) January 15, 2014 ... throughput research solutions, today announced that Lupin Limited, one ... of Freeslate’s CM Protégé PharmD System for ... in Mumbai, India, is focused on a wide range ...
Breaking Biology Technology:Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5DTS Improves Efficiency for Life Science Document Translations 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3
... mission statement, consider this pledge from the bipartisan Wisconsin School ... dollars on top of current dollars, but propose a complete ... the (K-12 public school) system, and then any additional dollars ... , [Tom Still is a member of the initiative] ...
... President George Bush today spoke of energy during ... traditional energy resources, his remarks were directed toward new ... to foreign oil. , ,In an address before employees ... is developing a new fuel cell for hybrid automobiles, ...
... Eau Claire, Wis. The Eau Claire Area ... again, offering cash awards of up to $10,000 to the ... entrepreneurs, the EDC is holding a business planning seminar on ... Business Contest will have until May 26 to prepare ...
Cached Biology Technology:Measuring what works and what doesn't in the prototypical school 2Measuring what works and what doesn't in the prototypical school 3Bush praises Johnson Controls battery tech in Milwaukee visit 2
... a powerful technology platform that automates gel ... High quality sample preparation can be carried ... Xcise is a powerful technology platform that ... analysis. It combines the functions of high-resolution ...
Request Info...
... compatible with hood installations. ... system for 384-well plates, ... prepares large quantities of ... Wellpro also performs plate ...
... is a new generation bulk reagent dispenser ... simplicity for pharmaceutical and biotech laboratories. Based ... range, Multidrop Combi has been designed for ... 0.5-2500 l and multiple plate types including ...
Biology Products: