Navigation Links
Markers of gene, protein, or micro-RNA activity predict outcome in prostate and colorectal cancers

tissues were normal and which cancerous. "Because this subset of miRNAs is differentially expressed at the crypt bottom, these miRNAs may be involved in regulating crypt stem cell population dynamics and contribute to the stem cell origin of colon cancer," Boman said.

"Our finding of a difference between miRNA expression in normal versus cancerous colon tissues should provide insight into mechanisms of colon cancer development and identify novel drugs to treat the disease" he said.

Expression Profiles of 16 Genes Predict Prostate Carcinoma Relapse and Disease Free Survival in Formalin-Fixed, Paraffin-Embedded (FFPE) Benign and Prostate Carcinoma Tissues Using Universal Bead Arrays: Abstract No. 1203

Researchers say that a chip that measures expression of 16 genes provides much needed prognostic information for prostate cancer patients who fall in the "gray zone" of traditional tests.

This experimental "universal bead array" test, which is designed to be low cost and easy to administer, appears to be a better predictor of relapse and disease-free survival than the Gleason Score, according to lead author Jessica Wang-Rodriguez, M.D., associate clinical professor of Pathology at the University of California, San Diego.

The 50 year-old Gleason Score, which assigns a progressive score of 1-10, based on how differentiated the cells look in a prostate cancer sample, works fairly well when the score is either very low or very high, but the prognosis for men who have scores in the mid-range is difficult to predict, Wang-Rodriguez said.

"It is very difficult to predict relapse and cancer recurrence in men who have a score of 6 or 7," she said. "Half of patients with these scores do well, and the other half don't, but we cannot now predict who will fall into those groups."

Believing that a gene microarray test might provide additional information, a team of researchers led by Wang-Rodriguez picked 512 genes from
'"/>

Source:American Association for Cancer Research


Page: 1 2 3 4 5 6 7

Related biology news :

1. Silence the gene, save the cell: RNA interference as promising therapy for ALS
2. Exercise training in ordinary people affects the activity of 500 genes
3. New bioinformatics technique for systematically analyzing key regions in DNA that help control gene activity
4. Natural compound from pond scum shows potential activity against Alzheimers
5. Brain activity related to processing faces is similar in people with, without autism
6. Molecule by molecule, new assay shows real-time gene activity
7. Inflammation and drugs to control this activity studied in a variety of tumors sites
8. Hopkins researchers develop new tool to watch real-time chemical activity in cells
9. Structure determined for p53 tumor suppressor protein as bound to DNA for anti-cancer activity
10. Stem cell activity deciphered in the aging brain
11. Innovative movies show real-time immune-cell activity within tumors
Post Your Comments:
(Date:7/10/2014)... open ocean as a microbial megacity, teeming with life ... water, hundreds of types of bacteria can be found. ... ocean microbes have their own daily cyclesnot unlike the ... up, commute, work, and eat at the same times., ... photoautotrophsbacteria that need solar energy to help them photosynthesize ...
(Date:7/10/2014)... if you are a big, bad sea scorpion. , ... waters for any prey in sight. The next, thanks ... you,re reduced to trolling for weaker, soft-bodied animals you ... of the giant pterygotid eurypterid, the largest arthropod that ... in the journal Biology Letters , dramatically re-interprets ...
(Date:7/10/2014)... JUPITER, FL, July 10, 2014 Amidst the astounding ... of synaptic connections in the brain, how do nerve ... connections to build? How do they coordinate these events ... scientists from the Florida campus of The Scripps Research ... processes, showing that a particular protein plays a far ...
Breaking Biology News(10 mins):New research finds ocean's most abundant organisms have clear daily cycles 2New research finds ocean's most abundant organisms have clear daily cycles 3Extinct sea scorpion gets a Yale eye exam, with surprising results 2Scripps Florida scientists shed new light on nerve cell growth 2
... FAHA, the Aram V. Chobanian Professor of Cardiovascular ... at Boston University School of Medicine (BUSM), has ... Distinguished Scientist. The AHA designated only five Distinguished ... Distinguished Scientist designation in 2003 to recognize science ...
... at Boston University School of Medicine (BUSM) have brought attention ... and their infants from consuming brown seaweed soup. Seaweed is ... there is no scientific data on the iodine content in ... Editor for the journal Thyroid and published online, ...
... What looks like a spongy ball wrapped in strands ... be key to unlocking better methods for catalysis, artificial ... University chemists who have created a platform to analyze ... photoluminescent materials. The microscopic particles assembled in ...
Cached Biology News:BUSM professor selected as American Heart Association Distinguished Scientist 2BUSM researchers urge awareness of dietary iodine intake in postpartum Korean-American women 2Supramolecules get time to shine 2Supramolecules get time to shine 3
(Date:7/10/2014)... Utah , July 10, 2014 /PRNewswire-iReach/ ... annotation and interpretation, today announced an agreement ... (NGS) analytics for Lineagen,s NextStep Dx ... of neurodevelopmental and neurological disorders, currently offers ... microarray (CMA) testing service used by healthcare ...
(Date:7/10/2014)... THOUSAND OAKS, Calif., July 10, 2014   Ceres, ... biotechnology and seed company, announced today financial results for ... an update on its business. Ceres reported ... progress in product performance this growing season in Brazil, ... that affected the company,s sorghum evaluation areas for part ...
(Date:7/10/2014)... the fight against terrorism with the creation of a ... the use of light and special glass fibres. , ... Chemical , the researchers describe a novel optical fibre ... as 6.3 ppm (parts per million). It requires an ... explosives detection has involved looking for metals that encase ...
(Date:7/10/2014)... in the journal PNAS (Proceedings of the National ... day and sleep deprivation have a significant effect on ... at the best time of day to test for ... administering medicines effectively. , Researchers from the University of ... the links between sleep deprivation, body clock disruption and ...
Breaking Biology Technology:Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9Detecting trace amounts of explosives with light 2Time of day crucial to accurately test for diseases, new research finds 2
... Immucor, Inc. (Nasdaq:,BLUD), a global leader in providing automated instrument-reagent ... the fiscal year ending May 31, 2009., For fiscal ... $292 million to $300 million., -- ... to 71%., -- Net income is expected to be in ...
... DANBURY, Conn., June 4 Biodel Inc. (Nasdaq:,BIOD) today ... Corporate Development and Treasurer of Biodel, will present a,corporate ... on,Friday, June 6, 2008 at 1:40 p.m. Pacific Daylight ... San Francisco., Interested parties may access a link ...
... held in ... Georgia, ATLANTA, June 4 ... 17 -- 20, in,San Diego, Calif. Governor Perdue will deliver remarks on June ... of the fastest-growing industries in the nation, the,biosciences sector is a strategic priority ...
Cached Biology Technology:Immucor Announces Fiscal Year 2009 Revenue and Earnings Guidance 2Immucor Announces Fiscal Year 2009 Revenue and Earnings Guidance 3Georgia Showcases its Bioscience Leadership at 2008 Bio International Convention 2Georgia Showcases its Bioscience Leadership at 2008 Bio International Convention 3
... Salmonella genomes has allowed the development of ... pairs. The S. enterica Typhimurium (strain LT2) ... bp; 4,440 ORFs) and a plasmid, pSLT ... Sigma-Genosys have been designed to amplify all ...
... The Bio-Stack Twister II Microplate ... top automation solution for integrating BioTeks ... together with expandable microplate capacity, ultimate ... Whether you are adding capacity to ...
XPLAC (S-17)...
Request Info...
Biology Products: