Navigation Links
Markers of gene, protein, or micro-RNA activity predict outcome in prostate and colorectal cancers

Cancer researchers are working toward a future in which each patient's tumor will act like a crystal ball, revealing how oncologists should treat the cancer to obtain the best outcome.

Currently, physicians cannot predict which patients with prostate cancer should receive extra therapy after surgery - or whether some of these patients have an indolent disease that does not even require surgery. Most patients with colorectal cancer have surgery, but some, even at the earliest stages, could benefit from additional treatment - if physicians only knew who. Some of the genes and proteins specific to cancer cells can be used for prognostic purposes, as can the newest type of biomarker, mcro-RNAs, according to studies presented today at the 97th Annual Meeting of the American Association for Cancer Research.

The Serological Markers TIMP-1, PAI-1, MASP-2 and CRP are Independent Predictors of Colorectal Cancer-Specific Death: Abstract No. 5723

Oncologists say it is very difficult to predict which patients with colorectal cancer will be cured by surgery alone - the single treatment most patients receive - and who might benefit from the addition of chemotherapy. Now, however, a Danish research team has found that just four protein biomarkers can predict death from colorectal cancer, independent of the stage or location of the cancer, or the age or gender of the patient.

In this study, blood taken from 654 colorectal cancer patients just before they had surgery was retrospectively analyzed for expression of the proteins. The test was not perfect, but it significantly identified the 308 patients who later died of the disease, some up to nine years later.

"The results show that the outcome of a significant number of patients was correctly identified, independent of stage and location," said the lead author, Hans J. Nielsen, M.D, DMSc., Professor of Surgical Oncology, at Hvidovre University Hospital.

When tumor stage and loc
'"/>

Source:American Association for Cancer Research


Page: 1 2 3 4 5 6 7

Related biology news :

1. Silence the gene, save the cell: RNA interference as promising therapy for ALS
2. Exercise training in ordinary people affects the activity of 500 genes
3. New bioinformatics technique for systematically analyzing key regions in DNA that help control gene activity
4. Natural compound from pond scum shows potential activity against Alzheimers
5. Brain activity related to processing faces is similar in people with, without autism
6. Molecule by molecule, new assay shows real-time gene activity
7. Inflammation and drugs to control this activity studied in a variety of tumors sites
8. Hopkins researchers develop new tool to watch real-time chemical activity in cells
9. Structure determined for p53 tumor suppressor protein as bound to DNA for anti-cancer activity
10. Stem cell activity deciphered in the aging brain
11. Innovative movies show real-time immune-cell activity within tumors
Post Your Comments:
(Date:7/31/2014)... genes to the earliest common ancestor of butterflies ... an extensive "Tree of Lepidoptera" in the first ... , Among the study,s more surprising findings: Butterflies ... to large ones, which completely changes scientists, understanding ... that some insects once classified as moths are ...
(Date:7/31/2014)... IL Researchers who studied 100 twin pairs have identified ... normally on less than six hours of sleep per night. ... to the effects of sleep deprivation. , Results show that ... gene had an average nightly sleep duration of only ... the non-carrier twin, who slept for about six hours and ...
(Date:7/31/2014)... completed a 20-year study that looks at the ... times of the year. It finds that burning ... has no measurable negative consequences for the prairie ... The study was conducted by Gene Towne, research ... chief, and Joseph Craine, research assistant professor, both ...
Breaking Biology News(10 mins):UF study advances 'DNA revolution,' tells butterflies' evolutionary history 2UF study advances 'DNA revolution,' tells butterflies' evolutionary history 3Study of twins discovers gene mutation linked to short sleep duration 2Study finds benefits to burning Flint Hills prairie in fall and winter 2Study finds benefits to burning Flint Hills prairie in fall and winter 3
... the Baltic Sea compete for fish with the fishing industry. The ... salmon, sea trout and eel as those taken by fishermen. This ... Gothenburg, Sweden. Competing with the fishing industry , ... species and the same sizes of fish as those taken by ...
... CLEVELAND In a first-of-its-kind clinical trial, physician-scientists ... Center and Case Western Reserve University School of Medicine ... cancer screening. The five-year study is recruiting patients to ... colonoscopy for detecting large colon polyps. ...
... the Nile have found what they believe is the first ... group within the relatively short history of plant domestication. ... in the ancient world and could also help today,s domestic ... The researchers, led by Dr Robin Allaby from the ...
Cached Biology News:Gray seals consume as much fish as the fishing industry catches 2New clinical trial explores novel noninvasive colon cancer screening test 2New clinical trial explores novel noninvasive colon cancer screening test 3Ancient Egyptian cotton unveils secrets of domesticated crop evolution 2Ancient Egyptian cotton unveils secrets of domesticated crop evolution 3
(Date:8/1/2014)... 2014 One of the major revolutions taking ... which is the practice of using genomic and other ... individual biology. Personalized diagnostics—laboratory analyses that inform the practice ... lab,s future. This fall, AACC ,s first ever ... in this exciting field and the novel technologies driving ...
(Date:8/1/2014)... August 1, 2014 According to ... "Biophotonics Market - Global Industry Analysis, Size, Share, Growth, ... valued at USD 25.16 billion in 2013, which is ... at a CAGR of 10.4% from 2014 to 2020. ... http://www.transparencymarketresearch.com/biophotonics-market.html Increasing demand for accurate early ...
(Date:8/1/2014)... Canada (PRWEB) August 01, 2014 Once ... should it cost? This webinar will discuss how to ... , Join speakers Bob Allen, Senior Director of ... of Process Engineering at Fluor Industrial Services, and special ... Manufacturing Asset Planning at Amgen, as they provide an ...
(Date:8/1/2014)... -- Cambrex Corporation (NYSE: CBM ) reports results ... Highlights , Second quarter sales increased 59% ... last year. , Second quarter EBITDA increased 86% to ... last year (see table at the end of this release). ... impact of foreign currency, to between 13% and 16% over ...
Breaking Biology Technology:First-Ever AACC Virtual Conference to Focus on Personalized Diagnostics 2Global Biophotonics Market is Expected to Reach USD 50.20 Billion in 2020: Transparency Market Research 2Global Biophotonics Market is Expected to Reach USD 50.20 Billion in 2020: Transparency Market Research 3Global Biophotonics Market is Expected to Reach USD 50.20 Billion in 2020: Transparency Market Research 4Defining Low Cost in Your Solution for Future Facilities, New Webinar for Pharma, Biotech, Medical Device and Healthcare Companies, Hosted by Xtalks 2Cambrex Reports Second Quarter 2014 Financial Results 2Cambrex Reports Second Quarter 2014 Financial Results 3Cambrex Reports Second Quarter 2014 Financial Results 4Cambrex Reports Second Quarter 2014 Financial Results 5Cambrex Reports Second Quarter 2014 Financial Results 6Cambrex Reports Second Quarter 2014 Financial Results 7Cambrex Reports Second Quarter 2014 Financial Results 8Cambrex Reports Second Quarter 2014 Financial Results 9Cambrex Reports Second Quarter 2014 Financial Results 10Cambrex Reports Second Quarter 2014 Financial Results 11Cambrex Reports Second Quarter 2014 Financial Results 12Cambrex Reports Second Quarter 2014 Financial Results 13Cambrex Reports Second Quarter 2014 Financial Results 14Cambrex Reports Second Quarter 2014 Financial Results 15Cambrex Reports Second Quarter 2014 Financial Results 16
... and Physical Sciences Research Council (EPSRC) has today announced ... The five-year fellowships, each worth around 1 million, ... Bhaskaran, Dr Ajoy Velayudhan and Dr Peter Foote. ... the manufacturing challenges of tomorrow we need to transfer ...
... president and CEO Michael J. Collins delivered the commencement ... Biochemistry Department, which was held on May 18, 2012. Collins ... has been a member of the Advisory Board for the ... (Logo: http://photos.prnewswire.com/prnh/20090622/CL35336LOGO-b ) "I ...
...  With approximately one in four adults suffering from ... funding and high case loads, the value of ... vital to effective mental health services. ILCs are ... people with physical disabilities, but across the country, ...
Cached Biology Technology:EPSRC announces first recipients of Fellowships in Manufacturing 2CEM President and CEO Delivers Commencement Address at the 2012 University of Texas at Austin Chemistry and Biochemistry Department Graduation 2Peers Underscored As An Effective Counseling Tool 2
MAb to Yersinia pestis F1 Ag. Yersinia pestis F1 Antigen EB Strain...
Mouse monoclonal antibody to QDPR - quinoid dihydropteridine reductase...
... RED Chromogen System consists of FAST RED ... in the presence of alkaline phosphatase to ... The FAST RED System provides enough ... Contains: , , Vial A: 6 Tablets ...
The BioLogic Maximizer mixer is for use with the Maximizer valve system. The mixer improves gradient quality by mixing the output of the BioLogic DuoFlow workstation pumps....
Biology Products: