Navigation Links
Markers of gene, protein, or micro-RNA activity predict outcome in prostate and colorectal cancers

Cancer researchers are working toward a future in which each patient's tumor will act like a crystal ball, revealing how oncologists should treat the cancer to obtain the best outcome.

Currently, physicians cannot predict which patients with prostate cancer should receive extra therapy after surgery - or whether some of these patients have an indolent disease that does not even require surgery. Most patients with colorectal cancer have surgery, but some, even at the earliest stages, could benefit from additional treatment - if physicians only knew who. Some of the genes and proteins specific to cancer cells can be used for prognostic purposes, as can the newest type of biomarker, mcro-RNAs, according to studies presented today at the 97th Annual Meeting of the American Association for Cancer Research.

The Serological Markers TIMP-1, PAI-1, MASP-2 and CRP are Independent Predictors of Colorectal Cancer-Specific Death: Abstract No. 5723

Oncologists say it is very difficult to predict which patients with colorectal cancer will be cured by surgery alone - the single treatment most patients receive - and who might benefit from the addition of chemotherapy. Now, however, a Danish research team has found that just four protein biomarkers can predict death from colorectal cancer, independent of the stage or location of the cancer, or the age or gender of the patient.

In this study, blood taken from 654 colorectal cancer patients just before they had surgery was retrospectively analyzed for expression of the proteins. The test was not perfect, but it significantly identified the 308 patients who later died of the disease, some up to nine years later.

"The results show that the outcome of a significant number of patients was correctly identified, independent of stage and location," said the lead author, Hans J. Nielsen, M.D, DMSc., Professor of Surgical Oncology, at Hvidovre University Hospital.

When tumor stage and loc
'"/>

Source:American Association for Cancer Research


Page: 1 2 3 4 5 6 7

Related biology news :

1. Silence the gene, save the cell: RNA interference as promising therapy for ALS
2. Exercise training in ordinary people affects the activity of 500 genes
3. New bioinformatics technique for systematically analyzing key regions in DNA that help control gene activity
4. Natural compound from pond scum shows potential activity against Alzheimers
5. Brain activity related to processing faces is similar in people with, without autism
6. Molecule by molecule, new assay shows real-time gene activity
7. Inflammation and drugs to control this activity studied in a variety of tumors sites
8. Hopkins researchers develop new tool to watch real-time chemical activity in cells
9. Structure determined for p53 tumor suppressor protein as bound to DNA for anti-cancer activity
10. Stem cell activity deciphered in the aging brain
11. Innovative movies show real-time immune-cell activity within tumors
Post Your Comments:
(Date:8/18/2015)... , Aug. 18, 2015  Navitas today ... contributor to the Submission Content Management webinar ... a non-profit forum. Dedicated to the Implementation of ... neutral platform for industry, vendors, health authorities, ... and work towards a standard method of ...
(Date:8/12/2015)... Florida , August 12, 2015 ... pace of mobile payment innovation and advanced biometrics technology ... replace the way consumers rely on using their credit ... with reinventing the future for payment services led by ... NXTD ), :  Google, Inc. (NASDAQ: GOOG ...
(Date:8/10/2015)... and TELTOW, Germany , ... Instruments (SMI), a world leader in Eye Tracking ... completion of its OEM Eye Tracking Platform for integration ... Tracking Platform contains reference designs for seamless integration of ... systems, virtual reality HMDs and augmented reality smart glasses. ...
Breaking Biology News(10 mins):Navitas, a Key Contributor in IRISS Forum Webinar 2Navitas, a Key Contributor in IRISS Forum Webinar 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 4Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 5Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 6SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 2SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 3
... the John Innes Centre will publish the first RNA sequence data ... They will release the data via a website to a ... was also used to crowdsource expertise during the 2011 E. ... will be able to access the RNA sequence and start to ...
... 13, 2012 The University of Illinois at Urbana-Champaign ... Science Foundation to develop ozone-resistance in corn. These strains have ... pollutants have caused in crop yield. A team at the ... Change (GEGC) research theme will lead the research. ...
... first bulb, heat has been a mostly undesirable byproduct of ... heat at the point of need, on the nanoscale, to ... created by the Rice labs of Michael Wong, Ramon Gonzalez ... Society journal ACS Nano makes use of materials ...
Cached Biology News:Crowdsourcing to kickstart comeback from ash dieback 2University of Illinois receives grant to study ozone resistance in corn 2Rice uses light to remotely trigger biochemical reactions 2Rice uses light to remotely trigger biochemical reactions 3Rice uses light to remotely trigger biochemical reactions 4
(Date:8/27/2015)... The National Necrotizing Fasciitis Foundation ... by doctors at Vanderbilt University Hospital in ... and Dr. John Crew , director of the ... Center in Daly City, CA. ... pioneered by Dr. Crew, that had previously saved the ...
(Date:8/27/2015)... ... August 27, 2015 , ... Inc. Magazine released its annual list of the ... 1,361 in growth for the three years through 2014. Being named to the Inc. ... organizations in the country. , “We are thrilled to make the Inc. 5000 ...
(Date:8/26/2015)... - iCo Therapeutics ("iCo" or "the Company") (TSX-V: ICO) ... quarter ended June 30, 2015. Amounts, unless specified ... under International Financial Reporting Standards ("IFRS"). ... Oral Amp B program, rapidly advancing towards the ... Rae , President & CEO of iCo Therapeutics. "We ...
(Date:8/26/2015)... , Aug. 26, 2015 Intrexon Corporation (NYSE: ... today the closing of its previously announced public offering ... the underwriters of their option to purchase an additional ... price of $41.00 per share.  The exercise of the ... common stock sold by Intrexon to 5,609,756 shares and ...
Breaking Biology Technology:Patient's Life and Eyes Saved from Gruesome Flesh-Eating Infection Consuming Her Face 2Patient's Life and Eyes Saved from Gruesome Flesh-Eating Infection Consuming Her Face 3iLab Solutions Named to 2015 Inc. 5000 List 2iLab Solutions Named to 2015 Inc. 5000 List 3iCo Therapeutics Announces Second Quarter 2015 Financial Results 2iCo Therapeutics Announces Second Quarter 2015 Financial Results 3Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 2Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 3Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 4
... , , , Ni-NTA Superflow ... protein preparations to be performed in parallel on the BioRobot 3000 , ... starting material, , up to 15 mg protein ... conditions using ready-to-run protocols. The increase in yield means that , ...
... , , , , ... efficient gene silencing in eukaryotic cell culture by ... RNA interference (RNAi), enables targeted , gene silencing ... siRNA oligonucleotide synthesis service that includes a range of modifications , ...
... , , , The LiquiChip Human ... provide fast and accurate quantification of a range of cytokines and , ... multiplex assay of 10 different cytokines using bead-based xMAP technology. , ... kinases , without using radioactivity. , ...
Cached Biology Technology:Ni-NTA Superflow Columns - automated large-scale purification of 6xHis-tagged , proteins 2Ni-NTA Superflow Columns - automated large-scale purification of 6xHis-tagged , proteins 3Ni-NTA Superflow Columns - automated large-scale purification of 6xHis-tagged , proteins 4Custom and library siRNA for efficient gene silencing 2Custom and library siRNA for efficient gene silencing 3Custom and library siRNA for efficient gene silencing 4Custom and library siRNA for efficient gene silencing 5LiquiChip Kits for bead-based cytokine and kinase assays 2LiquiChip Kits for bead-based cytokine and kinase assays 3
... Immunogen: Synthetic peptide derived from the ... Specificity: Specific for the junctophilin-1 ... mouse brain and skeletal muscle homogenates ... tissues). Applications: Western blotting Immunohistochemistry(froz) ...
Request Info...
Laminin beta-1/gamma-1 (612C10)...
HSV 1 IgM...
Biology Products: