Navigation Links
Mapping the mouse genome

In a new study published online this week in the open access journal PLoS Biology, Sagiv Shifman, Jonathan Flint, and colleagues present a high resolution genetic map for the mouse genome--one of the most detailed genetic maps now available aside from that for humans.

To create this map, they used two groups of mice: one consisting of outbred, heterogeneous stock (HS) and the other of recombinant inbred lines (RI). Using the single nucleotide polymorphism (SNP) data that resulted from physical mapping of the mouse genome, the authors were able to track the patterns of inheritance of >10,000 SNPs in both groups of mice. Next, they were able to calculate their relative genetic locations based on how frequently they co-occur. They used this information to create a genetic map that can distinguish between two points 0.37 cM apart in HS and 0.45 cM in RI.

Using their maps, Shifman and colleagues then investigate recombination rates of various genes by comparing physical and genetic distances for each strain. On average, the recombination rate was 0.63 cM per megabase (cM/Mb) for HS, and 0.62 cM/Mb for RI. They also saw a lot of variation in recombination rate across the genome, between the two study groups, and between the sexes. In fact, when calculating rates separately for male and female HS mice, they confirmed results seen previously for humans, that the average autosomal (non-sex) chromosomes had a higher recombination rate for females than males.

Observing where there was a particularly high, or low, rate of recombination, the authors identified "jungles" and "deserts." They looked for sequence motifs that might be representative of jungles and deserts. Sequences previously found in human recombination hot spots were also common in mouse genome jungles. They found one motif, CCTCCCT, corresponding to mouse jungles and deserts was conserved among rats, dogs, and chimpanzees, as well as humans.

This new, improved mouse genetic map has already yielded valuable information on how factors such as chromosome, chromosomal location, sex, and sequence composition are related to recombination rates--information that can improve our understanding of inheritance and inform future efforts to pinpoint the precise location of genes on individual chromosomes.

Source:Public Library of Science

Related biology news :

1. Computational Method Speeds Mapping of Cell Signaling Networks
2. Mapping neuron connections in the brain
3. Mapping alcohol brain damage
4. Mapping the protein world
5. Man and mouse share genome structures
6. Genome-wide mouse study yields link to human leukemia
7. Report that delayed motherhood decreases life expectancy of mouse offspring
8. Agilent Technologies introduces advanced zebrafish, mouse microarrays for stem cell and developmental biology research
9. Stem cells in bone marrow replenish mouse ovaries
10. Mosaic mouse technique offers a powerful new tool to study diseases and genetics
11. Researchers extend mouse lifespan by protecting against free radicals

Post Your Comments:

(Date:5/3/2016)... May 3, 2016  Neurotechnology, a provider of ... MegaMatcher Automated Biometric Identification System (ABIS) , a ... projects. MegaMatcher ABIS can process multiple complex biometric ... combination of fingerprint, face or iris biometrics. It ... and MegaMatcher Accelerator , which have ...
(Date:4/19/2016)... , UAE, April 20, 2016 ... implemented as a compact web-based "all-in-one" system solution for ... biometric fingerprint reader or the door interface with integration ... modern access control systems. The minimal dimensions of the ... readers into the building installations offer considerable freedom of ...
(Date:3/31/2016)... 2016   LegacyXChange, ... "Company") LegacyXChange is excited to release its ... to be launched online site for trading 100% guaranteed ... will also provide potential shareholders a sense of the ... an industry that is notorious for fraud. The video ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June, 23, 2016  The Biodesign Challenge ... envision new ways to harness living systems and biotechnology, ... Art (MoMA) in New York City ... 130 participating students, showcased projects at MoMA,s Celeste Bartos ... Paola Antonelli , MoMA,s senior curator of architecture and ...
(Date:6/23/2016)... ... 23, 2016 , ... STACS DNA Inc., the sample tracking software company, today ... Laboratory, has joined STACS DNA as a Field Application Specialist. , “I am ... and COO of STACS DNA. “In further expanding our capacity as a scientific integrator, ...
(Date:6/23/2016)... NEWPORT BEACH, Calif. , June 23, 2016 /PRNewswire/ ... offering new biological discoveries to the medical community, has ... and co-founder Matthew Nunez . "We ... provide us with the capital we need to meet ... funding will essentially provide us the runway to complete ...
(Date:6/23/2016)... ... June 23, 2016 , ... ClinCapture, the only ... Center and will showcase its product’s latest features from June 26 to June ... scientific poster on Disrupting Clinical Trials in The Cloud during the conference. ...
Breaking Biology Technology: