Navigation Links
Mapping the mouse genome

In a new study published online this week in the open access journal PLoS Biology, Sagiv Shifman, Jonathan Flint, and colleagues present a high resolution genetic map for the mouse genome--one of the most detailed genetic maps now available aside from that for humans.

To create this map, they used two groups of mice: one consisting of outbred, heterogeneous stock (HS) and the other of recombinant inbred lines (RI). Using the single nucleotide polymorphism (SNP) data that resulted from physical mapping of the mouse genome, the authors were able to track the patterns of inheritance of >10,000 SNPs in both groups of mice. Next, they were able to calculate their relative genetic locations based on how frequently they co-occur. They used this information to create a genetic map that can distinguish between two points 0.37 cM apart in HS and 0.45 cM in RI.

Using their maps, Shifman and colleagues then investigate recombination rates of various genes by comparing physical and genetic distances for each strain. On average, the recombination rate was 0.63 cM per megabase (cM/Mb) for HS, and 0.62 cM/Mb for RI. They also saw a lot of variation in recombination rate across the genome, between the two study groups, and between the sexes. In fact, when calculating rates separately for male and female HS mice, they confirmed results seen previously for humans, that the average autosomal (non-sex) chromosomes had a higher recombination rate for females than males.

Observing where there was a particularly high, or low, rate of recombination, the authors identified "jungles" and "deserts." They looked for sequence motifs that might be representative of jungles and deserts. Sequences previously found in human recombination hot spots were also common in mouse genome jungles. They found one motif, CCTCCCT, corresponding to mouse jungles and deserts was conserved among rats, dogs, and chimpanzees, as well as humans.

This new, improved mouse genetic map has already yielded valuable information on how factors such as chromosome, chromosomal location, sex, and sequence composition are related to recombination rates--information that can improve our understanding of inheritance and inform future efforts to pinpoint the precise location of genes on individual chromosomes.
'"/>

Source:Public Library of Science


Related biology news :

1. Computational Method Speeds Mapping of Cell Signaling Networks
2. Mapping neuron connections in the brain
3. Mapping alcohol brain damage
4. Mapping the protein world
5. Man and mouse share genome structures
6. Genome-wide mouse study yields link to human leukemia
7. Report that delayed motherhood decreases life expectancy of mouse offspring
8. Agilent Technologies introduces advanced zebrafish, mouse microarrays for stem cell and developmental biology research
9. Stem cells in bone marrow replenish mouse ovaries
10. Mosaic mouse technique offers a powerful new tool to study diseases and genetics
11. Researchers extend mouse lifespan by protecting against free radicals

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/7/2017)... 2017 Brandwatch , the leading social intelligence company, ... Trust to uncover insights to support its reporting, help direct ... The UK,s leading youth charity will be using Brandwatch Analytics social ... a better understanding of the topics and issues that are a ... ...
(Date:3/2/2017)... YORK , March 2, 2017 Summary ... better understand Perrigo and its partnering interests and activities since ... ... Partnering Deals and Alliance since 2010 report provides an in-depth ... leading life sciences companies. On demand company reports ...
(Date:3/2/2017)... March 2, 2017 Australian stem cell and ... CYP), has signed an agreement with the Monash Lung ... Biomedicine Discovery Institute and Department of Pharmacology at Monash ... further preclinical study to support the use of Cymerus™ ... Asthma is a chronic, long term ...
Breaking Biology News(10 mins):
(Date:3/29/2017)... ... March 29, 2017 , ... ComplianceOnline, the leading governance, risk ... its 3rd Annual Medical Device Summit 2017 venue and speaker lineup. The Summit will ... in Boston, MA. , The Omni Parker House Hotel, which is located at 60 ...
(Date:3/29/2017)... , March 29, 2017  Halozyme Therapeutics, ... oncology and drug-delivery therapies, today announced that an ... and Drug Administration voted 11 to 0 that ... skin) injection was favorable for patients in the ... lymphoma and chronic lymphocytic leukemia. The FDA action ...
(Date:3/29/2017)... ... March 29, 2017 , ... ACEA Biosciences, a privately owned ... travel award to noteworthy scientists who will be presenting research using ACEA Biosciences’ ... of awards are being given to two postdoctoral fellows studying pathogen capture by ...
(Date:3/29/2017)... ... March 29, 2017 , ... Bactana Animal Health, a company developing natural products ... through enhancement of the gut microbiota, today announced the closing of its first round ... York-based Sustainable Income Capital Management, LLC and a number of private investors. The company ...
Breaking Biology Technology: