Navigation Links
Mapping alcohol brain damage

UQ biochemists are working with American researchers to pinpoint why only some parts of the brain are damaged in alcoholics.

Associate Professor Peter Dodd and his team from UQ's School of Molecular and Microbial Sciences has secured a five-year, $1.23 million grant from the United States' biomedical funding arm, the National Institute of Health (NIH) to find out.

Chronic alcohol abuse kills brain cells in the front of the brain, which affect planning, and social interactions and inhibitions.

The UQ team with collaborators from The University of Texas, want to find out what makes these cells so vulnerable.

Professor Dodd said his team was analysing brain tissue from dead alcoholics, mostly Anglo-Celtic men who've averaged more than 10 drinks a day.

The group analyses samples using a microarray analysis, a process they pioneered with human brain samples in 2000.

From a DNA sample applied to a microscope slide, the microarray computer produces about 50,000 coloured spots showing which genes are expressed or switched on in the sample.

"What we're trying to find out is, what's different in the superior frontal cortex [front of brain] when you compare alcoholics with controls, that's not different in a spared area of the brain," Dr Dodd said.

"In that way we can start to find those messages that show altered expression in the area of the brain that shows the pathology."

He said the microarray analysis could be useful for many neurological diseases.

"It's got general applicability to neurological diseases, because most neurological diseases also exhibit regional selectivity of pathology."

Professor Dodd said researching proteins was the next step as that would tell them why some cells have impaired function.

He has also teamed up with United Kingdom colleagues to find out why people get addicted to alcohol -- with the long-term goal of producing a drug that could red uce alcohol dependence.


'"/>

Source:Research Australia


Related biology news :

1. Computational Method Speeds Mapping of Cell Signaling Networks
2. Mapping neuron connections in the brain
3. Mapping the protein world
4. Mapping the mouse genome
5. Controversial drug shown to act on brain protein to cut alcohol use
6. Owl genomics presents a HEPATOCHIP for diagnosis of non-alcoholic steatohepatitis
7. Investigating brain shrinkage in alcoholics
8. Russian surrogate alcohols are a killer
9. Looking for the genes that affect a persons level of response to alcohol
10. Genetic and environmental influences on alcohol consumption among rhesus monkeys
11. Both alcoholism and chronic smoking can damage the brains prefrontal cortex
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/3/2016)... Das DOTM (Department ... hat ein 44 Millionen $-Projekt ... einschließlich Personalisierung, Registrierung und IT-Infrastruktur, an Decatur ... Implementierung von Identitätsmanagementlösungen. Zahlreiche renommierte internationale Anbieter ... aber Decatur wurde als konformste und innovativste ...
(Date:5/24/2016)... Ampronix facilitates superior patient care by providing unparalleled technology to leaders of ... the latest premium product recently added to the range of products distributed by Ampronix. ... ... ... Medical Display- Ampronix News ...
(Date:5/3/2016)... 2016  Neurotechnology, a provider of high-precision biometric ... Biometric Identification System (ABIS) , a complete system ... ABIS can process multiple complex biometric transactions with ... fingerprint, face or iris biometrics. It leverages the ... MegaMatcher Accelerator , which have been used ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... TOKYO , June 24, 2016  Regular discussions on ... to take place between the two entities said Poloz. ... in Ottawa , he pointed to the ... and the federal government. ... Poloz said, "Both institutions have common economic goals, why not ...
(Date:6/23/2016)... ... June 23, 2016 , ... Mosio, a leader in ... Trials Patient Recruitment and Retention Tips.” Partnering with experienced clinical research professionals, Mosio ... practical tips, tools, and strategies for clinical researchers. , “The landscape of how ...
(Date:6/23/2016)... Md. , June 23, 2016 A person ... from the crime scene to track the criminal down. ... the U.S. Food and Drug Administration (FDA) uses DNA evidence ... Sound far-fetched? It,s not. The FDA ... sequencing to support investigations of foodborne illnesses. Put as simply ...
(Date:6/23/2016)... June, 23, 2016  The Biodesign Challenge (BDC), a ... ways to harness living systems and biotechnology, announced its ... in New York City . ... students, showcased projects at MoMA,s Celeste Bartos Theater during ... , MoMA,s senior curator of architecture and design, and ...
Breaking Biology Technology: