Navigation Links
Mapping alcohol brain damage

UQ biochemists are working with American researchers to pinpoint why only some parts of the brain are damaged in alcoholics.

Associate Professor Peter Dodd and his team from UQ's School of Molecular and Microbial Sciences has secured a five-year, $1.23 million grant from the United States' biomedical funding arm, the National Institute of Health (NIH) to find out.

Chronic alcohol abuse kills brain cells in the front of the brain, which affect planning, and social interactions and inhibitions.

The UQ team with collaborators from The University of Texas, want to find out what makes these cells so vulnerable.

Professor Dodd said his team was analysing brain tissue from dead alcoholics, mostly Anglo-Celtic men who've averaged more than 10 drinks a day.

The group analyses samples using a microarray analysis, a process they pioneered with human brain samples in 2000.

From a DNA sample applied to a microscope slide, the microarray computer produces about 50,000 coloured spots showing which genes are expressed or switched on in the sample.

"What we're trying to find out is, what's different in the superior frontal cortex [front of brain] when you compare alcoholics with controls, that's not different in a spared area of the brain," Dr Dodd said.

"In that way we can start to find those messages that show altered expression in the area of the brain that shows the pathology."

He said the microarray analysis could be useful for many neurological diseases.

"It's got general applicability to neurological diseases, because most neurological diseases also exhibit regional selectivity of pathology."

Professor Dodd said researching proteins was the next step as that would tell them why some cells have impaired function.

He has also teamed up with United Kingdom colleagues to find out why people get addicted to alcohol -- with the long-term goal of producing a drug that could red uce alcohol dependence.


'"/>

Source:Research Australia


Related biology news :

1. Computational Method Speeds Mapping of Cell Signaling Networks
2. Mapping neuron connections in the brain
3. Mapping the protein world
4. Mapping the mouse genome
5. Controversial drug shown to act on brain protein to cut alcohol use
6. Owl genomics presents a HEPATOCHIP for diagnosis of non-alcoholic steatohepatitis
7. Investigating brain shrinkage in alcoholics
8. Russian surrogate alcohols are a killer
9. Looking for the genes that affect a persons level of response to alcohol
10. Genetic and environmental influences on alcohol consumption among rhesus monkeys
11. Both alcoholism and chronic smoking can damage the brains prefrontal cortex
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/31/2016)... , March 31, 2016   ... ("LegacyXChange" or the "Company") LegacyXChange is excited ... of its soon to be launched online site for ... https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also provide potential shareholders a ... DNA technology to an industry that is notorious for ...
(Date:3/23/2016)... WAKEFIELD, Massachusetts , March 23, 2016 ... kombiniert im Interesse erhöhter Sicherheit Gesichts- und ... Xura, Inc. (NASDAQ: MESG ... heute bekannt, dass das Unternehmen mit SpeechPro ... insbesondere aus der Finanzdienstleistungsbranche, wird die Möglichkeit ...
(Date:3/21/2016)... WAKEFIELD, Massachusetts , March 22, 2016 ... and facial recognition with passcodes for superior security ... MESG ), a leading provider of secure digital communications ... pilot their biometric technology and offer enterprise customers, particularly ... provide secure facial recognition and voice authentication within a ...
Breaking Biology News(10 mins):
(Date:5/4/2016)... City, Missouri (PRWEB) , ... May 04, 2016 , ... ... of Professional and Agricultural Sales. , Doug began his career at PBI-Gordon in ... since served in a wide variety of roles, ranging from customer service to national ...
(Date:5/3/2016)... ... May 03, 2016 , ... Morf Media ... compliance training platform on mobile devices, today released a new interactive Food ... Medical Devices. The course is essential for owners or operators of places of ...
(Date:5/3/2016)... ... May 03, 2016 , ... ... addition of Dr. Nancy Gillett to its Board of Directors. Dr. Gillett recently ... as Corporate Executive Vice President and Chief Scientific Officer. A board-certified veterinary pathologist, ...
(Date:5/3/2016)... , May 3, 2016 - ... Developers and Producers of Those Competitor Biologics  ... Companies, Activities and Prospects ,  Who are ... companies? And what are their sales potentials? Discover, in ... see results, trends, opportunities and revenue forecasting. ...
Breaking Biology Technology: