Navigation Links
Many needles, many haystacks

method Neduva and his colleagues invented draws on large-scale studies of protein binding in the cells of yeast, flies, worms and humans. Those studies have produced parts lists of molecular machines. And the data holds a wealth of information about linear motifs ?if it can be mined.

The scientists distilled all of this information in a series of steps ?discarding parts of the proteins likely to dock via large surfaces, and zooming in on small regions of the remaining molecules that might hold motifs. Then it was up to the computer to scan the sequences for small patterns. The attempt was successful: in the fly data, for example, 26 sets of proteins seemed to be interacting through linear motifs.

"One challenge was to eliminate red herrings, which crop up everywhere when you look for very small patterns," Russell says. "The fact that nine of these motifs were already known was a sign we were on the right trail; we then did follow-up experiments in collaboration with Luis Serrano's group at EMBL to test some of the others."

One prediction, for example, suggested that a linear motif would bind to the fly protein translin. The scientists verified that this happened, then they made subtle changes in the sequence. When these changes stopped the molecules binding, they knew they had a new linear motif.

Now the lab will expand the method; Russell predicts that hundreds of linear motifs remain to be discovered. This has important implications for the study of genetic diseases. "A lot of work has gone into discovering mutations that affect protein binding," he says. "Because linear motifs are so small, every bit of information is crucial, and any change is likely to be disruptive. But so far, because of their size, these motifs have been below the radar of most methods to tie protein structures to disease."


'"/>

Source:European Molecular Biology Laboratory


Page: 1 2

Related biology news :

1. Finding Cures For Tropical Diseases: Is Open Source An Answer?
2. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
3. Findings have implications for tracking disease, drugs at the molecular level
4. Finding hidden invaders in a Hawaiian rain forest
5. New Finding May Aid Adult Stem Cell Collection
6. Finding the minds eye
7. Findings advance use of adult stem cells for replacement bone
8. Finding a virus is not all bad news
9. Finding a better way to make biodiesel
10. Finding paves way for better treatment of autoimmune disease
11. Finding the right mix: A biomaterial blend library
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Many needles many haystacks

(Date:4/2/2015)... , April 2, 2015 ... DERMALOG by far outperforms the strongest competitors, showing ... high accuracy, the system is capable of a ... speed proves up to be ten times faster ... its runner-up performance.      (Photo: ...
(Date:4/1/2015)... Apr. 1, 2015  NXT-ID, Inc. (NASDAQ: NXTD ... focused on the growing mobile commerce market, announces the ... wallets is underway to early access pre-order customers. ... usage at retail outlets including Walmart, Target, AT&T, Dunkin, ... Wocket was accepted at all outlets and very easy ...
(Date:3/30/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/lc9bnl/global_gesture ) has ... Market in Automotive Sector 2014-2018" report to their ... Recognition market in Automotive Sector to grow at a ... Gesture recognition is the ability of a device to ... Gesture recognition technology can be 2D-based or 3D-based. It ...
Breaking Biology News(10 mins):DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2
... to have a bad reputation. They sleep all day, party at ... study by University of Calgary researchers has confirmed that bats are ... that bats have high rates of rabies is not true," says ... the lead author of a paper published in the Journal ...
... Research by the University of Exeter has revealed that ants ... result of their activity as ,ecosystem engineers, and predators. ... , found that ants have two distinct effects on their ... building activity and by collecting food they affect the level ...
... Scripps Research Institute scientists have converted adult skin ... to first go through the laborious process of generating ... lead to new treatments for a range of diseases ... heart disease, Parkinson,s, and Alzheimer,s disease. The work ...
Cached Biology News:Researchers bust bat rabies stereotype 2Ants' ecosystem role is 'key' 2Scripps Research scientists convert skin cells to beating heart cells 2Scripps Research scientists convert skin cells to beating heart cells 3
(Date:5/1/2015)... OncoTAb, Inc., a University ... announced that Pinku Mukherjee, Ph.D. has received the ... Governors’ highest faculty honor. Mukherjee received the award, which ... her innovative research and development of cancer diagnostics and ... crowning moment in my scientific career,” said Mukherjee, OncoTAb ...
(Date:5/1/2015)... -- Investor-Edge has initiated coverage on ... GENE ), Agilent Technologies Inc. (NYSE: A ... ), Sequenom Inc. (NASDAQ: SQNM ), and ... report on Genetic Technologies can be accessed at ... the NASDAQ Composite ended at 4,941.42, down 1.64%, ...
(Date:4/30/2015)... April 30, 2015  Roka Bioscience, Inc. (NASDAQ: ... advanced testing solutions for the detection of foodborne pathogens, ... first quarter of 2015 on May 7, 2015 after ... Bioscience will also host a conference call at 4:30 ... its first quarter financial results. During the conference call, ...
(Date:4/30/2015)... April 30, 2015 Oxford Finance LLC ("Oxford"), ... life sciences and healthcare services companies, today announced the ... agreement with Celula, Inc., a diagnostic testing company focused ... better patient care and improved outcomes.  Proceeds of the ... expand the commercialization of its products in the U.S. ...
Breaking Biology Technology:OncoTAb CSO Awarded the University of North Carolina’s O. Max Gardner Award 2Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 2Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 3Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 4Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 5Roka Bioscience to Report First Quarter 2015 Financial Results On May 7, 2015 2Oxford Finance Provides $10 Million Debt Financing to Celula 2
... New Practice Leaders Appointed, RESEARCH TRIANGLE ... today announced the appointment of three new ... part of its expanding Quintiles,Consulting business, which ... strategic guidance to maximize potential and minimize,risk ...
... Across All Product Lines ... - Special ... 22 Edwards Lifesciences,Corporation (NYSE: EW ), a world leader ... income for the,quarter ended March 31, 2008 of $18.2 million, or ...
... April 22 Rochester,Medical Corporation (Nasdaq: ROCM ) ... April 29, 2008. The Company will then,hold a quarterly ... begin at 4:00 p.m. central daylight time (5:00 p.m. ... Thomson/CCBN and can be accessed at,Rochester Medical,s website at ...
Cached Biology Technology:Quintiles Consulting Business Expands 2Quintiles Consulting Business Expands 3Quintiles Consulting Business Expands 4Edwards Lifesciences Reports Strong First Quarter Results and Raises 2008 Guidance 2Edwards Lifesciences Reports Strong First Quarter Results and Raises 2008 Guidance 3Edwards Lifesciences Reports Strong First Quarter Results and Raises 2008 Guidance 4Edwards Lifesciences Reports Strong First Quarter Results and Raises 2008 Guidance 5Edwards Lifesciences Reports Strong First Quarter Results and Raises 2008 Guidance 6Edwards Lifesciences Reports Strong First Quarter Results and Raises 2008 Guidance 7Edwards Lifesciences Reports Strong First Quarter Results and Raises 2008 Guidance 8Edwards Lifesciences Reports Strong First Quarter Results and Raises 2008 Guidance 9Edwards Lifesciences Reports Strong First Quarter Results and Raises 2008 Guidance 10Edwards Lifesciences Reports Strong First Quarter Results and Raises 2008 Guidance 11Edwards Lifesciences Reports Strong First Quarter Results and Raises 2008 Guidance 12Edwards Lifesciences Reports Strong First Quarter Results and Raises 2008 Guidance 13Edwards Lifesciences Reports Strong First Quarter Results and Raises 2008 Guidance 14Rochester Medical Announces Second Quarter 2008 Earnings Conference Call April 29, 2008 2
... GX-1000 3-D Shaker , ,Product Information ... of the GyroTwister GX-1000 is extremely efficient, ... general mixing as well as staining gels, ... continuously adjustable across a broad range. A ...
...
... Radiolabeled Ligands\n\nReceptor-related research has long been enabled ... ligands selected to keep pace with new ... products and services for receptor research and ... If you do not find exactly what ...
...
Biology Products: