Navigation Links
Many needles, many haystacks

Most of what happens in cells is the work of machines that contain dozens of molecules, chiefly proteins. With the completion of human and other genomes, researchers now have a nearly complete "parts list" of such machines; what's lacking now is the manual telling where all the pieces go. A new study by scientists at the European Molecular Biology Laboratory (EMBL) promises to answer this question for some of the smallest and trickiest components in the cellular toolbox. Their work appears in the current issue of the Public Library of Science's on-line journal, PLoS Biology.

A protein consists of a sticky string of amino acids which usually folds up because of attractions between some of its atoms. This creates a bundle called a globular domain whose shape and chemistry determine what other molecules can bind to it.

"If we could look at the chemical 'spelling' of a protein and guess what machines it fits into, we'd know a lot more about what happens in cells," says Rob Russell, head of the Heidelberg lab that carried out the current study. "We've made a lot of progress in predicting how globular domains interact with each other. But sometimes a surface on one globular domain will grab a tiny, string-like region of another protein called a linear motif. Finding such motifs and predicting where they fit in is like looking for needles in haystacks."

Or like looking at a line of automobiles and trying to decide which one a bulky motor fits into ?versus trying to find where a tiny screw goes. Linear motifs are so small that it is hard to tell what features allow them to bind to other molecules. Now Victor Neduva, a PhD student in Russell's group, has developed a method to scan molecules and tease out new linear motifs.

"If two or more different proteins share a binding partner, there is often a common motif," Neduva says. "The hard part is finding a 3-to-8 'letter' pattern in a protein sequence that may be thousands of amino acids long."The
'"/>

Source:European Molecular Biology Laboratory


Page: 1 2

Related biology news :

1. Finding Cures For Tropical Diseases: Is Open Source An Answer?
2. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
3. Findings have implications for tracking disease, drugs at the molecular level
4. Finding hidden invaders in a Hawaiian rain forest
5. New Finding May Aid Adult Stem Cell Collection
6. Finding the minds eye
7. Findings advance use of adult stem cells for replacement bone
8. Finding a virus is not all bad news
9. Finding a better way to make biodiesel
10. Finding paves way for better treatment of autoimmune disease
11. Finding the right mix: A biomaterial blend library
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Many needles many haystacks

(Date:8/21/2014)... finding that has implications for life in other extreme ... solar system, LSU Associate Professor of Biological Sciences Brent ... Foundation, or NSF, this week published a paper confirming ... lies 800 meters (2600 feet) beneath the surface of ... Given that more than 400 subglacial lakes and numerous ...
(Date:8/21/2014)... Saturday to Wednesday, Oct. 18-22, 2014 , ... Harbor Drive, San Diego, CA 92101 , ... other presentations of the latest research in human ... session featuring high-scoring abstracts on rare genetic variants ... cancers, and treatment for sun sensitivity (Saturday, Oct. ...
(Date:8/21/2014)... of researchers at Louisiana Tech University has ... consumer-grade 3D printers and materials to fabricate ... and chemotherapeutic compounds for targeted drug delivery. ... and research faculty from Louisiana Tech,s biomedical ... create filament extruders that can make medical-quality ...
Breaking Biology News(10 mins):800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 2800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 3800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 4American Society of Human Genetics 2014 Annual Meeting 2Louisiana Tech University researchers use 3D printers to create custom medical implants 2Louisiana Tech University researchers use 3D printers to create custom medical implants 3
... The notion of transplanting adult stem cells to treat or ... toward becoming a reality. In a study published today ... have demonstrated, for the first time, the ability to create ... the eye cells that die and cause loss of sight. ...
... Conservation Society and the State Institute of Animal Health (IAGRO) ... the first health assessments of white-lipped peccaries (medium-sized pig-like animals) ... the impact of Leptospirosis a zoonotic bacteria that affects ... and livestock. The studyconducted between 2003 and 2005 ...
... Exposure to alcohol in the womb doesn,t affect all fetuses ... give birth to a child with physical, behavioral or learning ... another woman who also drinks has a child without these ... by the mother to her son, according to new Northwestern ...
Cached Biology News:Stem cell therapy for age-related macular degeneration -- a step closer to reality 2Monitoring peccaries in Brazil benefits wildlife, local communities and food security 2Monitoring peccaries in Brazil benefits wildlife, local communities and food security 3Why some children are harmed by mother's alcohol, but others aren't 2
(Date:8/21/2014)... 2014 Ontotext S4 , The ... Ontotext . Now the same enterprise hardened text ... and unstructured data is available to start-ups and mid-size ... technology. Organizations that do not have resources to evaluate ... use S4 since there is no need for on ...
(Date:8/21/2014)... SoundConnect , a unified communication ... of the nation’s Fastest Growing Private Companies by ... consecutive year. Inc. magazine today ranked SoundConnect NO. ... exclusive ranking of the nation's fastest-growing private companies. ... the most important segment of the economy—America’s independent ...
(Date:8/20/2014)... , Aug. 20, 2014 Clintrax Global, ... located in Raleigh, NC , ... as Vice President of Administration. ... oversee all corporate processes, including their alignment with ... Global, Brad worked as an HR executive, specializing ...
(Date:8/20/2014)... it that American Indians largely were wiped out by ... tuberculosis brought to the New World by European explorers., ... people lived in the Americas shortly before Europeans arrived, ... European diseases., But new research led by anthropological geneticists ... of the University of Tubingen in Germany indicates the ...
Breaking Biology Technology:Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 3Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 4SoundConnect Returns on Inc. 5000 List of Fastest Growing Companies 2SoundConnect Returns on Inc. 5000 List of Fastest Growing Companies 3Clintrax Global, Inc. Announces Addition to Executive Team 2Unusual discovery leads to fascinating tuberculosis theory 2Unusual discovery leads to fascinating tuberculosis theory 3
... developer to describe a Web site, youre likely to learn about ... youre likely to learn a lot about pinball. , ,A pinball ... works not the mechanical side of working that involves ASP, ... attracts and retains customers. By thinking of the Internet as a ...
... putting their state into further debt to fund ... California voters approved Proposition 71, which will provide ... decade. , ,The proposition, which was endorsed by ... California Institute for Regenerative Medicine. The institute will ...
... labs at the research park. An investment of $8.5 ... niche-market biotech company to Wisconsin, where it will inhabit brand-new ... ,The company is targeting a type of debilitating genetic disease ... new technique. , , Symbiontics, Inc. , which drew about ...
Cached Biology Technology:My 50 cents: Web sites and pinball machines 2My 50 cents: Web sites and pinball machines 3My 50 cents: Web sites and pinball machines 4Californians: Stem cells important enough to go into debt for 2Wisconsin VCs draw Missouri biotech firm to state 2Wisconsin VCs draw Missouri biotech firm to state 3Wisconsin VCs draw Missouri biotech firm to state 4
1000X solution used for inducing CopyControl™ based vectors to high copy numbers...
Donor feline serum and plasma...
Request Info...
8 different frozen tissues are mounted on positively charged glass slides...
Biology Products: