Navigation Links
Manchester scientists create new bio-gel for 3D cell culture

Scientists at The University of Manchester have created a new type of 'bio-gel' which provides a pH neutral environment for culturing cells in 3D, as published in the journal Advanced Materials (March 2006).

The gel is the first pH neutral material made from combinations of dipeptides (pairs of amino acids) to provide an environment in which cells can be cultured under physiological conditions.

Uniquely, the gel mimics the properties of cell scaffolds which naturally occur in the body and has potential applications for wound healing and tissue engineering.

Cell scaffolds, known as the extra cellular matrix (ECM), are naturally produced by the body to grow new cells in order to repair damaged tissue. Like the ECM, the gel acts like a scaffold in which cells can grow.

In their paper, 'Nanostructured Hydrogels for Three-Dimensional Cell Culture Through Self-Assembly of Fluorenylmethoxycarbonyl-Dipeptides', Dr Rein Ulijn and collaborators describe how the gel is created through a process of self-assembly.

Dr Ulijn said: "We have used combinations of modified dipeptides which act like building blocks and spontaneously assemble into nanometer sized fibres when exposed to physiological conditions, to create a fibrous gel-like structure in which cells can be cultured. Because thismaterial is made up of 99% water and is pH neutral, it is compatible with biological systems.

"By using dipeptide building blocks instead of much larger oligo-peptides used by other researchers, we have greater control over the fibrous architecture and the physical properties of the gels. These materials offer us great potential for future applications in wound healing and regenerative medicine."

Dr Ulijn and his collaborators have successfully cultured cartilage cells using the gel. They found that both the properties of the gels formed and the cell response to the gels could be controlled by using different combinations of di-peptides. The team recently received a £630k award from EPSRC to develop the gels further.


'"/>

Source:University of Manchester


Related biology news :

1. University of Manchester makes made-to-measure skin and bones a reality using inkjet printers
2. Next Generation Body Scanner Launched By The University Of Manchester
3. Wisconsin scientists grow critical nerve cells
4. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
5. UAB scientists discover the origin of a mysterious physical force
6. Fox Chase Cancer Center scientists identify immune-system mutation
7. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
8. U-M scientists find genes that control growth of common skin cancer
9. UCLA scientists transform HIV into cancer-seeking missile
10. RNA project to create language for scientists worldwide
11. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/24/2017)... YORK , Jan. 24, 2017 ... study of the laboratory use of nuclear magnetic ... 363 experienced end-users and profiled current practices, developments, ... years, as well as growth and opportunities. These ... Instrument suppliers, NMR instruments, needs and innovation requirements, ...
(Date:1/21/2017)... Research and Markets has announced the addition ... to their offering. ... The global voice recognition biometrics market to grow at a ... report covers the present scenario and the growth prospects of the ... size, the report considers the revenue generated from the sales of ...
(Date:1/18/2017)...  In vitro diagnostic (IVD) companies were very active ... and Kalorama Information expects that trend to continue – ... Generally, uncertainty in reimbursement and healthcare reform in ... the acquisitions landscape. Instead of looking to buy technology, ... outside of their home country and also to increase ...
Breaking Biology News(10 mins):
(Date:2/22/2017)... Yorba Linda, Ca (PRWEB) , ... February 22, ... ... interactive virtual events for tech innovators, engineers, and scientists from around the world, ... event will place on February 22 and 23, 2017. This premier, online-only conference ...
(Date:2/22/2017)... Dublin - Research and Markets has announced ... Type, By Application, By End User, By Region, By Country: Opportunities ... ... is forecasted to grow at a CAGR of 11.33% during 2016-2021. ... protection market is driven by the surging demand for less toxic ...
(Date:2/22/2017)... , Feb. 22, 2017 Aethlon Medical, ... results of a study that validated the ability of ... are associated with increased mortality in immune-suppressed sepsis patients ... The objective of the study was ... Cytomegalovirus (CMV), Epstein-Barr virus (EBV) and Herpes Simplex virus ...
(Date:2/22/2017)... ... February 22, 2017 , ... ... of Tom Perkins as European director. Operating from Pennside’s Zurich headquarters, Pennside Partners, ... , Perkins joins Pennside after more than a decade with leading market research ...
Breaking Biology Technology: