Navigation Links
Mammalian Transcriptome Mapped

The FANTOM Consortium for Genome Exploration Research Group, a large international collection of scientists that includes researchers at The Scripps Research Institute's Florida campus, is reporting the results of a massive multi-year project to map the mammalian "transcriptome" in this week's issue of the journal Science.

The transcriptome, or transcriptional landscape as it is sometimes called, is the totality of RNA transcripts produced from DNA, by the cell in any tissue at any given time. It is a measure of how human genes are expressed in living cells, and its complete mapping gives scientists major insights into how our genome works.

"This is arguably the next major step after the human genome project," says Professor Claes Wahlestedt, M.D., Ph.D., who is the director of Pharmacogenomics at Scripps Florida. Wahlestedt is also a professor at the Karolinska Institute in Sweden, and is adjunct chief scientist at RIKEN Institutes, Japan. "Our Japanese collaborators, headed by Professor Yoshihide Hayashizaki, should be credited for their long-standing focus on generating novel data on the transcriptome," Wahlestedt continues.

The mammalian transcriptome has already revealed a number of new and startling things about the nature of mammalian biology. One of the most significant of these findings, about "antisense transcription," appears in a separate article by Wahlestedt and his colleagues in the same issue of Science.

Antisense transcription (see section below) was once thought to be rare, but the transcriptome reveals that it takes place to an extent that few could have imagined. "Instead of it being a rare phenomenon, we are showing that it is a massively abundant phenomenon," says Wahlestedt. "It is the rule rather than the exception."

This discovery has significant implications for the future of biological research, medicine, and biotechnology because antisense genes are likely to participate in the control of many, perha
'"/>

Source:Scripps Research Institute


Page: 1 2 3 4 5

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mammalian Transcriptome Mapped

(Date:11/6/2014)... Except when that predator runs so fast that it essentially ... is the fastest creature on Earth. Some of these half-inch-long ... five miles per hour). The fastest human can do about ... tiger beetle, a person would have to hit 480 miles ... At peak speeds, everything becomes a blur. They can,t gather ...
(Date:11/5/2014)... in their ability to identify scents and odors. ... perceptual evaluation of odors, with women outperforming men on ... differences in olfactory detection may play a role in ... perception of smell, which is naturally linked to associated ... suggested to be cognitive or emotional, rather than perceptual. ...
(Date:11/4/2014)... Think about the way our bodies are assembled during ... that they are supposed to become a nerve or ... the correct place and alignment? Researchers at the University ... In a new study, UM researchers describe the signaling ... neighbors, at the head-trunk region. Their discovery may have ...
Breaking Biology News(10 mins):The tiger beetle: Too fast to see 2The female nose always knows: Do women have more olfactory neurons? 2The inside story: How the brain and skull stay together 2
... U.S. Department of Energy (DOE) Joint Genome Institute (JGI) ... winning at the 13th Annual Applied Ergonomics Conference held ... The Ergo Cup highlights ergonomic innovations from institutions and ... in Ergonomics," was for the Ergonomic Program Improvement Initiatives ...
... A preliminary study by New Zealand company Plant ... may help breathing in some types of asthma. ... may reduce lung inflammation with a multi-action assault in ... to enhance the natural defence mechanisms in lung tissue ...
... Ghoneum today will discuss his findings on cancer research and ... event, sponsored by the Egyptian Cultural and Educational Bureau, will ... reception. Ghoneum, an Egyptian-born researcher and professor at Charles ... been studying natural cures for cancer for more than two ...
Cached Biology News:Breathe easy: A natural fruit compound may help asthma 2
(Date:11/26/2014)... 26, 2014 SoundConnect , an ... proud to announce that Darren Suders has joined the ... Darren will drive the partner program through ... , Darren brings more than 10-years of ... roles in channel operations, from policy development, to partner ...
(Date:11/26/2014)... 2014 Theravalues Corporation est fier d,annoncer ... européen au salon Hi Europe 2014 (du 2 ... Curcumine la plus biodisponible actuellement sur ... à des ingrédients approuvés par les règlements européens. ... présent dans la racine de curcuma ( Curcuma ...
(Date:11/26/2014)... 2014  Roka Bioscience, Inc. (NASDAQ: ROKA ), ... for the detection of foodborne pathogens, today announced that ... 26 th Annual Healthcare Conference on December 2, 2014 ... New York Palace in New York, NY ... the Company, its operations, strategies and prospects may be discussed. ...
(Date:11/24/2014)... -- Last week, Representatives Gus Bilirakis (R-FL) ... bold bipartisan step on behalf of patients with ... co-sponsors of the legislation include Representatives McCaul (R-TX) ... makers and innovators to "repurpose" major market drugs ... opens the door to the development of hundreds ...
Breaking Biology Technology:SoundConnect Appoints Director of Channel Development & Sales 2La curcumine présentant la plus haute biodisponibilité bientôt en vente en Europe 2La curcumine présentant la plus haute biodisponibilité bientôt en vente en Europe 3Roka Bioscience to Present at the Piper Jaffray Healthcare Conference 2OPEN Act Introduced to Repurpose Drugs for Rare Diseases 2
... begins its 2005 season, researchers at the University of ... school spirit. The only fans who can appreciate it, however, ... team of UW-Madison chemists led by professor Robert Hamers ... of nanofiber hairs each only 75 nanometers long. With each ...
... since I have had a chance to dig into some more music. ... musician son. As I am hoping that he is the next Jonny ... this summer to a week of rock 'n roll camp. , ,Can ... of the night? This kind of reminded me of the movie "School ...
... of Eau Claire, also operating as ... a channel program that enables resellers and systems ... products and subscription services to customers without major ... able to offer hosted digital signage solutions to ...
Cached Biology Technology:Nanotechnology minimizes UW's beloved mascot 2Historic lists - The greatest rock bands, rock guitarists of all time 2Historic lists - The greatest rock bands, rock guitarists of all time 3Historic lists - The greatest rock bands, rock guitarists of all time 4
... DNA detection has been improved. With Gene Coloring ... can be detected > 20 ng. The excised ... organic solvent extraction or with other commercially available ... DNA excised from agarose gel can be used ...
...
Mouse monoclonal antibody raised against a full length recombinant CSNK2A2. NCBI Entrez Gene ID = CSNK2A2...
... form of cell suicide, which follows a ... of this process is a cascade of ... participate in a series of reactions that ... and result in the cleavage of protein ...
Biology Products: