Navigation Links
Malfunctioning bone marrow cells sabotage nerve cells in diabetes

we were developing gene therapy to cure diabetes in mice. By chance, we observed insulin-producing bone marrow cells outside the pancreas, and wondered why these cells were migrating to other organs and whether they were detrimental or beneficial," said Chan.

In pursuit of this curious phenomenon, Drs. Tomoya Terashima and Hideto Kojima from BCM and Dr. Mineko Fujimiya of Shiga University of Medical Science in Shiga, Japan, in collaboration with Chan, performed numerous experiments in diabetic rats and mice. Their work defined the role of the aberrant cells in causing neuropathy.

They found that, in diabetes, only nerve cells that have fused with bone marrow cells display the abnormal function and premature death found in neuropathy. Nerve cells that have not merged with the insulin-producing bone marrow cells remain intact and function normally.

"Based on these findings, we speculate that a similar process contributes to some, if not all, of the other chronic complications of diabetes, and we look forward to pursuing this possibility. Discovering an underlying cause of diabetic neuropathy may enable us to design treatment strategies to prevent this complication in the future," concluded Chan.


'"/>

Source:Baylor College of Medicine


Page: 1 2

Related biology news :

1. Stem cells in bone marrow replenish mouse ovaries
2. Bone marrow stem cells may heal hearts even years after heart attacks
3. New research demonstrates bone-marrow derived stem cells can reverse genetic kidney disease
4. Bone marrow cells can become functional gut lining cells
5. Bone marrow may restore cells lost in vision diseases
6. Healing the heart with bone marrow cells
7. Leukemic cells find safe haven in bone marrow
8. Early-stage sperm cells created from human bone marrow
9. Wisconsin scientists grow critical nerve cells
10. Spleen may be source of versatile stem cells
11. Researchers discover way to make cells in the eye sensitive to light

Post Your Comments:
(Date:11/24/2009)...Springer and the American College of Medical Toxic...te on the publication of the Journal of Medical T..., beginning in March 2010. It was previously publ... The Journal of Medical Toxicology , an internat...ncing the science and practice of medical toxicolo...
(Date:11/24/2009)... BATON ROUGE Antarctica has long held secrets of... until recently, there has been very little inform...neath miles of ice for millions of years. Now, a t...ng LSU have been funded to the tune of $10 millio...SF, to get to the bottom of things literally. The...
(Date:11/24/2009)...Cambridge, Md. (November 24, 2009) New research o...c river ecosystems reveals predictable temporal pa... communities as markers for monitoring climate cha...s week in the Proceedings of the National Academy...communities in the six rivers shifted synchronousl...
Breaking Biology News(10 mins):Springer and the American College of Medical Toxicology to work together 2LSU gets to the bottom of things -- in Antarctica 2Researchers establish common seasonal pattern among bacterial communities in Arctic rivers 2Sosei Assigns AD 923 Assets to Pharmasol 5243 1Sosei Assigns AD 923 Assets to Pharmasol 5243 2Dentist Office Music Gets A New Sound With Smile Radio 58906 1Dentist Office Music Gets A New Sound With Smile Radio 58906 2New Complimentary Wallet Card to Tackle Concussions Head On 58903 1New Complimentary Wallet Card to Tackle Concussions Head On 58903 2
...ss. (Dec. 15, 2008) Infants and adults with the b... have a poor prognosis, and most infants die befor...g causes of MLL, most cases are caused by a fusion...en the MLL gene is fused to the AF4 gene, a potent...archers have known that the MLL-AF4 protein produc...
...on who reminds you to floss might be your cardiolo...n for some time that a protein associated with inf...re at risk for heart disease. But where,s the infl...ian and U.K. scientists published online in The F...place. Indeed, proper dental hygiene should reduce...
.... 15, 2008) Using stem cell lines not typically c...l Center have designed a new way to "grow" bone an...enesis a physiological process involving the grow... has been a major roadblock in tissue regeneration...iogenic growth factors and the fabrication of arti...
Other Biology News:Tracking the molecular pathway to mixed-lineage leukemia 2Columbia University scientist devises new way to more rapidly generate bone tissue 2
(Date:11/24/2009)...TLE,Nov.24/PRNewswire/--BlueMarbleEnergyCorp.annou...ntAuthority(OPDA)wererecentlyawarded$2millionbyWas...(CERB)inaprivate/publicpartnershiptoconstructthest...County,WA. ,, "Thisinvestmentwillsignificantlys...eenjobstoLincolnCounty,"saidBlueMarbleEnergyCEOKel...
(Date:11/24/2009)...ENTURE:HTL , TORONTO,Nov.24/PRNewswire-FirstC...CapitalInc.,aleadingproviderofadvancedlasersystems...inicmarkets,todayreportedoperationalandfinancialre...Q32009Highlights,-Revenuewas$1.46millioncomparedw...ercentcomparedwith66.1percentinQ3,2008,-Netlossred...
(Date:11/24/2009)...OODCITY,Calif.,Nov.24/PRNewswire-FirstCall/--Genom...yScott,GenomicHealth,sExecutiveChairman,willpresen...NewYorkCityonTuesday,December1,2009at10:00a.m.ET. ...tofthepresentation,visittheInvestorRelationssectio...chealth.com .Pleaseconnecttothewebsiteatleast15min...
(Date:11/24/2009)... Chemical Abstracts Service (CAS), th...hat China,s patent office is now the world,s leadi...emistry. China trailed Japan,s patent office, the ...nd the United States Patent and Trademark Office (...O in 2005, WIPO in 2006, and exceeded Japan for th...
Breaking Biology Technology:Blue Marble Energy, OPDA Awarded $2M by WA's Community Economic Revitalization Board 2Hamilton Thorne announces third quarter results 2Hamilton Thorne announces third quarter results 3Hamilton Thorne announces third quarter results 4Hamilton Thorne announces third quarter results 5Hamilton Thorne announces third quarter results 6Hamilton Thorne announces third quarter results 7Genomic Health to Present at Piper Jaffray Health Care Conference 2China Leads All Nations in Publication of Chemical Patents According to CAS, the World's Most Authoritative Publisher of Chemical Information 2China Leads All Nations in Publication of Chemical Patents According to CAS, the World's Most Authoritative Publisher of Chemical Information 3
...al economic uncertainty, a top question of Jatroph...t economic crisis have on the Jatropha sector and ...uot; To address this critical concern and more, a ...recursor to Jatropha World Asia 2009, this not-to-...d-hitting inquiries by Jatropha investors. , ...
...n LLC (L3I) has,successfully completed the Quality... exceeding all of the requirements for ISO 9001 an...ospace standard. L3I passed their,ISO/AS audit wit..., Starting in May of 2008, Vice President of O...tion and refinement of the comprehensive QMS,docum...
...ecember,Trinitas Comprehensive Cancer Center becam... state of New Jersey to offer cancer patients trea...rom Varian Medical Systems (NYSE: VAR ).,RapidAr...ivered two to eight,times faster than is possible ... By delivering radiation doses more quickly and wi...
Other Biology Technology:Jatropha Sector Reality Check: Still Viable In Volatile Times? Upcoming Webcast Shares Latest Insights 2Jatropha Sector Reality Check: Still Viable In Volatile Times? Upcoming Webcast Shares Latest Insights 3Jatropha Sector Reality Check: Still Viable In Volatile Times? Upcoming Webcast Shares Latest Insights 4Level 3 Inspection Achieves 100% Compliance in ISO 9001 & AS 9100 Certification 2Trinitas Comprehensive Cancer Center Now Offering Cancer Patients Faster, Ultra-Precise Radiation Using New RapidArc Technology 2Trinitas Comprehensive Cancer Center Now Offering Cancer Patients Faster, Ultra-Precise Radiation Using New RapidArc Technology 3
IMAGEQUANT 400 WKSTN from GE Healthcare, formerly Amersham Biosciences
Rabbit Anti-Human JTV1 Polyclonal Antibody, Unconjugated from Proteintech Group, Inc.
ImageQuant 400 from GE Healthcare, formerly Amersham Biosciences
IMAGEQUANT 100 WKSTN from GE Healthcare, formerly Amersham Biosciences
Biology Products: