( in egg whites. All of the conjugates p...)Malaria vaccine prompts victims' immune system to eliminate parasite from mosquitoes

in egg whites. All of the conjugates produced high levels of antibodies in mice. Adsorbing the conjugate molecules to the surface of molecules of aluminum hydroxide produced even higher levels of antibodies. (Adsorption is a chemical process in which one molecule accumulates on the surface of another, forming a molecular or atomic film.)

The researchers also discovered that the ability of the mice to produce antibodies to the vaccine increased with time. In fact, the animals produced higher levels of antibodies when they were tested three and seven months after their initial set of immunizations than they did one week after their immunizations were completed.

Next, the researchers fed serum containing the antibodies to mosquitoes carrying Plasmodium falciparum. (Serum is the fluid from which blood cells and clotting factors have been removed.) Microscopic examination of the mosquito digestive tracts revealed that the antibodies were capable of completely eliminating the ookinettes.

The study authors noted that Psv25H, a molecule similar to Pfs25, is found on the surface of ookinettes of another species of Plasmodium that causes malaria, Plasmodium vivax. They wrote that the conjugate technology could be easily adapted to make a vaccine against Psv25H.

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Source:NIH/National Institute of Child Health and Human Development


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