Navigation Links
Malaria vaccine prompts victims' immune system to eliminate parasite from mosquitoes

ren each year. The disease can result in severe headache, high fever, chills, and vomiting. Malaria is caused by a single celled parasite, Plasmodium. In all, four species of Plasmodium cause malaria in people, with Plasmodium falciparum causing the most severe form. The malarial parasite spends part of its life cycle in humans, and part in mosquitoes. The parasite is injected into an individual by the bite of an infected mosquito. Numerous experimental vaccines have been tried against the form of the parasite that resides in humans, but have been unsuccessful or produced limited immunity. The Plasmodium cells escape the human immune system by hiding in liver and blood cells, making them difficult to target with a vaccine. During the human phase of the infection, these cells, for the most part, exist in an asexual form.

Some of the Plasmodium cells, however, transform into gametocytes—the sexual forms of the parasite that are equivalent to sperm and eggs. Fertilization takes place in the mosquito gut, after which the parasite imbeds itself in the gut lining. There, it passes through discrete stages, before migrating to the insect's salivary glands, where it is passed on to the next host through a mosquito bite.

The protein Pfs25 (Plasmodium falciparum surface protein 25) is found only on the surface of the ookinette, a stage of the parasite living in the mosquito gut, and does not appear on any other stage of the parasite. When injected into human volunteers, Pfs25 fails to generate a sufficient level of antibodies to target the parasite.

In their article, the researchers described several strategies for using conjugate technology to make an effective vaccine based on Pfs25. These consisted of chemically linking numerous Pfs25 molecules to each other and to other proteins: Pseudomonas aeruginosa exotoxin A, a protein from a species of bacteria that infects people with weakened immune systems, and ovalbumin, a protein found
'"/>

Source:NIH/National Institute of Child Health and Human Development


Page: 1 2 3

Related biology news :

1. Malaria mechanism revealed
2. Malaria killing a million a year
3. Malaria parasites develop in lymph nodes
4. Malaria, potato famine pathogen share surprising trait
5. Twenty Years of Malaria Research: Outcomes and Perspectives
6. Malaria treatment efficacy compromised in certain HIV-positive patients
7. Malaria may fuel spread of HIV in sub-Saharan Africa
8. Research advances quest for HIV-1 vaccine
9. A much-needed shot in the arm for HIV vaccine development
10. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
11. Gene vaccine for Alzheimers disease shows promising results
Post Your Comments:
(Date:11/7/2014)... Leading Biometric companies aim to provide ... online transactions.  Companies in focus today are: NXT-ID, Inc. (NASDAQ: ... BABA ), Google Inc. (NASDAQ: GOOG ), Microsoft ... EBAY ) and MasterCard Inc. (NYSE: MA) ... biometric authentication company focused on the growing mobile commerce is ...
(Date:11/6/2014)... Baltimore, MD, November 6, 2014 - Insilico Medicine, ... in aging and age related diseases announced a ... medicine of cancer, Champions Oncology, Inc (OTC: CSBR). ... genomics for personalized medicine, but Champions Oncology,s TumorGraft ... can validate the chemotherapy regimen experimentally generating vast ...
(Date:11/4/2014)... 2014 – University of Utah engineers developed the first ... fuel produce electricity without needing to ignite the fuel. ... portable electronics, off-grid power and sensors. , A study ... American Chemical Society journal ACS Catalysis . , ... reaction between a fuel and an oxygen-rich source such ...
Breaking Biology News(10 mins):Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2Jet-fueled electricity at room temperature 2
... University of York's Department of Chemistry have developed a ... unpleasant and dangerous side-effects of radiotherapy. , PhD students ... fellow Mark Godber, have developed the gel which will ... Now, the group has secured £30,000 under the Bioscience ...
... oil, which have antioxidant, anti-inflammatory and anti-clotting properties, ... so-called Mediterranean Diet, according to a new study ... Journal of the American College of Cardiology. , ... the Mediterranean diet on cardiovascular disease and arteriosclerosis ...
... California condors raised in captivity be released near seal and ... feast on the carcasses of marine mammals as their ancestors ... four other institutions base their conclusion on the feeding behavior ... in the Nov. 7 online edition of the Proceedings of ...
Cached Biology News:Young scientists turn to gel to ease side-effects of cancer treatment 2Phenolic compounds may explain Mediterranean diet benefits 2Phenolic compounds may explain Mediterranean diet benefits 3Seal rookeries could provide a reliable food source for endangered California condors, study finds 2Seal rookeries could provide a reliable food source for endangered California condors, study finds 3Seal rookeries could provide a reliable food source for endangered California condors, study finds 4Seal rookeries could provide a reliable food source for endangered California condors, study finds 5
(Date:11/22/2014)... (PRWEB) November 22, 2014 Respiratory ... simulate the proper management of life-like respiratory ailments ... lung devices . Grand Rapids-based, Michigan Instruments Inc. ... donate two of the respiratory simulation units to ... each. Grand Valley and Muskegon Community College are ...
(Date:11/21/2014)... Washington, USA (PRWEB) November 19, 2014 ... in our lives was shared with more than 200 ... and postgraduate students from the University of Otago Physics ... Grant . The Otago students, members of the university’s ... New Zealand in early September, giving children from small, ...
(Date:11/21/2014)... 2014 The November 2014 issue of ... open access journal featuring the following articles:, ... preserve photoresponsiveness in the retina , DNA ... hybridization using chromogenic substrates in zebrafish , ... protein electrophoresis , Nuclear LC3-positive puncta in ...
(Date:11/21/2014)... 2014 Polaris Group announced today that ... Phase 1 trial of ADI-PEG 20 in combination ... malignant pleural mesothelioma (MPM) and non-squamous non-small cell ... on ADI-PEG 20, both as monotherapy and in ... several other indications, including breast cancer, melanomas, ovarian ...
Breaking Biology Technology:Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 2Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 3Optics and photonics outreach programs share science, spark fascination with light 2Optics and photonics outreach programs share science, spark fascination with light 3BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 2BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 3Polaris Group Announces Treatment of First Patient in Phase 1 Study of ADI-PEG 20 plus Pemetrexed and Cisplatin in Malignant Pleural Mesothelioma And Non-Squamous Non-Small Cell Lung Carcinoma 2
... May 12 Aton Pharma, Inc., a global,specialty ... a,distribution agreement with Meizler Biopharma S/A to commercialize,CUPRIMINE(R) ... in,Brazil, and Meizler is working to obtain regulatory ... medically essential products, and Aton is,committed to making ...
... Poised to Impact Lung Cancer Care, ST. ... medical,device start-up company, has secured $4.75M in venture ... IG4 delivery system for minimally,invasive biopsy and ablation ... and was joined by Advantage Capital Partners and ...
... (NYSE:,CVD) today announced that it will present at the ... 2008 at 10:30 am ET. Investors may,access a live ... order to,register and download any necessary software, please log ... New Jersey, is one of the,world,s largest and most ...
Cached Biology Technology:Aton Pharma Announces Distribution Partnership in Brazil 2Veran Medical Technologies Secures $4.75M in First Institutional Funding 2
... ProteinChip Antibody Capture Kit ... and optimization steps typically ... interactions. This kit enables ... of multiple antigens based ...
... Custom design, The Bioactive peptides are molecules ... a biological behaviour or activity which can ... pharmaceutical, diagnostic, chemical and agro-food applications. In ... modified peptides with superior properties for therapeutic ...
... This CLS number is ... to easily match Cornings product ... yet, please order under the ... contact customer service for assistance. ...
... Series Hybridization chambers with forced convection ... ambient up to 99.9 C / 212 F ... and reproducible results DS controller Timer ... with an accuracy of a tenth of a ...
Biology Products: