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Malaria parasites develop in lymph nodes

on the body's immune response, he explained. They might alert the body that an invader is present and activate a protective immune response. On the other hand, their presence in the lymph nodes might desensitize the body to the parasites, blunting the immune system's response to liver and blood-cell infection.

"We have to integrate all these new data into something that makes sense from the immune standpoint," the researcher observed. Understanding the intricacies of the mammalian immune response to Plasmodium infection might help scientists create better vaccines, including vaccines that target parasites before they develop in the liver, Ménard said. Parasite development in lymph nodes could even be one reason there is so much tolerance to these parasites, he suggested.


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Source:Howard Hughes Medical Institute


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