Navigation Links
Malaria parasites develop in lymph nodes

In the first quantitative, real-time imaging study of the travels of the malaria parasite Plasmodium through mammalian tissue, researchers at the Pasteur Institute in Paris found the parasites developing in an unexpected place: the lymph nodes.

The parasites' presence in the lymph nodes almost certainly has implications for the mammalian immune response, said Robert Ménard, a Howard Hughes Medical Institute (HHMI) international research scholar who led the study.

Ménard and colleagues report their findings in the February issue of the journal Nature Medicine, published online on January 22, 2006.

When a mosquito infected with Plasmodium bites a mammal, the immature parasites travel to the animal's liver, which, until now, scientists thought was the only place they could develop, Ménard said. Once they have fully developed, the parasites burst out of the liver cells and infect red blood cells, beginning the onset of malaria.

Although researchers understand this life cycle, no one has measured directly how many parasites a mosquito bite transmits or where else in a mammal's body they travel, said Ménard. To find out, he and his colleagues infected mosquitoes with fluorescently tagged Plasmodium parasites, and then allowed the mosquitoes to bite a mouse. From each mosquito bite, they found an average of 20 fluorescent parasites embedded in the animal's skin. Ménard found that the parasites moved through the skin in a random, circuitous path at a speed that is amongst the fastest recorded for any migrating cell. After leaving the skin, the parasites frequently invaded blood vessels. That was no surprise to Ménard, since they need to travel through blood vessels to get to the liver. However, many of the parasites also invaded lymphatic vessels. About 25 percent of the parasites injected by the mosquito bites were drained by lymphatic vessels and ended up in lymph nodes close to the site of the bite. Their journey seemed to stop there,
'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3

Related biology news :

1. Malaria mechanism revealed
2. Malaria killing a million a year
3. Malaria, potato famine pathogen share surprising trait
4. Malaria vaccine prompts victims immune system to eliminate parasite from mosquitoes
5. Twenty Years of Malaria Research: Outcomes and Perspectives
6. Malaria treatment efficacy compromised in certain HIV-positive patients
7. Malaria may fuel spread of HIV in sub-Saharan Africa
8. Protein offers way to stop microscopic parasites in their tracks
9. Measuring hidden parasites in falciparum malaria
10. Researchers at UGA provide first look at protein expression in Chagas disease-causing parasites
11. How healthy is that marsh? Biologists count parasites
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Malaria parasites develop lymph nodes

(Date:8/21/2014)... 21, 2014 /PRNewswire-iReach/ -- LiveScan Service Provider  ... to a partnership with Gabriel Health Institute, one ... growing Certified Nursing Assistant preparatory schools. The ... exclusive member of Binary,s LiveScan service provider,s owner/operator ... improve its service capabilities by widening the ...
(Date:8/21/2014)... researchers from Beth Israel Deaconess Medical Center (BIDMC ) ... Most Influential Scientific Minds 2014," a comprehensive list ... web resource for science metrics and research performance analysis. ... most influential "are performing and publishing work that their ... science," according to a Thomson Reuters statement. Researchers were ...
(Date:8/21/2014)... the Fram Strait is a key region in the global ... Greenland and Svalbard warm Atlantic water flows to the north ... Arctic water masses and sea ice push their way out ... of the Atlantic water cools here on its way to ... the water caused in this manner drives the global band ...
Breaking Biology News(10 mins):LiveScan Provider Binary Biometrics Announces Partnership with Preeminent CNA School, Gabriel Health Institute to Expand Services in Orlando Region 2LiveScan Provider Binary Biometrics Announces Partnership with Preeminent CNA School, Gabriel Health Institute to Expand Services in Orlando Region 3BIDMC researchers named among 'the most influential scientific minds' 2BIDMC researchers named among 'the most influential scientific minds' 3Arctic sea ice influenced force of the Gulf Stream 2Arctic sea ice influenced force of the Gulf Stream 3
... elbow may not have to look any further than ... treatment, according to a study published in the November ... Specially-prepared platelets taken from the patient which are then ... more relief than more commonly-used therapies which have failed ...
... Can nuclear energy save us from global warming? Perhaps, ... tons of nuclear waste generated each year and a ... of nuclear material into terrorists' hands. , So ... analyzed just how much nuclear power would need to ...
... the world may have a less-than-colorful future. Macaws, the ... decline in recent decades, and that trend is continuing today. ... A&M University's Schubot Exotic Bird Center, part of the College ... make sure macaws will not just be photos in a ...
Cached Biology News:New biologic treatment for tennis elbow may replace surgery for chronic sufferers 2New biologic treatment for tennis elbow may replace surgery for chronic sufferers 3Plutonium or greenhouse gases? Weighing the energy options 2Disappearing nest egg: Researcher studying declining numbers of macaws 2
(Date:8/20/2014)... 2014 Not long ago, it was ... be performed late in the development cycle – even ... regulatory trends suggest that, like many things GxP, expectations ... recent years, multiple drug sponsors have been required by ... questions during phase I/II. It’s not only clinical trial ...
(Date:8/20/2014)... improve the health of your heart, researchers have discovered. ... a standard TENS machine like those designed to relieve ... the small raised flap at the front of the ... The stimulation changed the influence of the nervous system ... can drive failing hearts too hard. , Professor Jim ...
(Date:8/20/2014)... 2014 GraphDB™ 6.0 ... improvements to the enterprise replication cluster, faster loading ... SOLR and Elasticsearch. This release happens to coincide ... triplestore – GraphDB™ was formerly known as OWLIM. ... only mature enterprise resilient RDF triplestore will also ...
(Date:8/19/2014)... (PRWEB) August 19, 2014 Shimadzu ... chromatography systems, Prominence-i and Nexera-i, adding to the ... Combining excellent functionality, an intuitive operating environment, and ... a more efficient workflow for conventional to ultra-high-speed ... innovative, intuitive and intelligent design so users can ...
Breaking Biology Technology:Are Extractable and Leachables going Phase-Appropriate? New Webinar Hosted by Xtalks 2'Tickling' your ear could be good for your heart 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 3Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 4Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 3
... 26, 2011 , Veeva Systems ... top 20 pharmaceutical companies, is replacing its legacy,on-premise ... the UK. Daiichi Sankyo will deploy Veeva CRM ... including integrated healthcare,specialty care, medical liaison scientists, and ...
... At an event at the University City Science ... U.S. Representatives Chaka Fattah (D-PA), Allyson Schwartz (D-PA) and ... that provides tax incentives for small and mid-sized businesses ... a targeted basis. The Life Sciences Jobs and ...
... Robert Ettinger, the founder of the cryonics movement and ... home in Clinton Township, Michigan, and has been frozen at ... temperatures after death in the hope that future technology will ... Mr. Ettinger wrote The Prospect of Immortality ...
Cached Biology Technology:Daiichi Sankyo Selects Veeva CRM to Support Customer Engagement Initiatives in the United Kingdom 2Daiichi Sankyo Selects Veeva CRM to Support Customer Engagement Initiatives in the United Kingdom 3Daiichi Sankyo Selects Veeva CRM to Support Customer Engagement Initiatives in the United Kingdom 4Coalition Applauds Introduction of Life Sciences Jobs and Investment Act 2Coalition Applauds Introduction of Life Sciences Jobs and Investment Act 3Coalition Applauds Introduction of Life Sciences Jobs and Investment Act 4Coalition Applauds Introduction of Life Sciences Jobs and Investment Act 5Founder of Cryonics Movement Dies, is Frozen at Cryonics Institute 2