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Making mice with enhanced color vision

he "green" their friend sees can attest to this -- the researchers only tested whether the mice could discriminate among the lights.

"Each photoreceptor absorbs a range of wavelengths, but the efficiency changes with wavelength," Nathans explains. "For example, one photoreceptor might absorb green light only half as efficiently as red light. If an animal had only this type of photoreceptor, then a green light that was twice as bright as a red light would look identical to the red one. But if the animal adds a second photoreceptor with different absorption properties, then by comparing both receptors, the red and green lights could always be distinguished."

Normal mice failed to discriminate yellow versus red lights when the light intensities were set to give equal activation of their middle wavelength receptor. However, mice with both the human long wavelength and the mouse middle wavelength receptors learned to tell the difference, although it took over 10,000 trials to learn to make the distinction.

Nathans suggests that these knock-in mice mimic how our earliest primate ancestors acquired trichromatic vision, color vision based on three receptors. At some point in the past, random mutations created a variant of one receptor gene, located on the X chromosome, producing two different receptor types. Present-day New World (South American) monkeys still use this system, which means that in these monkeys only certain females can acquire trichromatic color vision.

In contrast, among Old World (African) primates such as humans, the two different X chromosome genes duplicated so that each X chromosome now carries the genes for both receptor types, giving both males and females trichromatic color vision.

"You could say that the original primate color vision system, and the one that New World monkeys still use today, is the poor man's -- or to be accurate, poor woman's -- version of color vision," Nathans says.
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Source:Johns Hopkins Medical Institutions


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