Navigation Links
Major obesity gene is 'lost in the shuffle'

Scientists from The University of Tokyo announce today that gibbons, arboreal primates that inhabit the jungles of Southeast Asia, do not carry a major obesity gene that is present in the genomes of all other primates, including humans. This omission is due to a genetic mis-shuffling event that occurred approximately 25 million years ago. Their results are reported in the April issue of the scientific journal Genome Research.

Agouti signaling protein (ASIP) was the first "obesity gene" to be cloned and characterized by geneticists, but it also plays an important role in other physiological processes ?ranging from hair color determination to energy homeostasis. Mice that over-produce ASIP are extremely obese, exhibit symptoms of diabetes, and have yellow fur, while mice that lack the ASIP gene are black in color. The gene is widely expressed in tissues throughout the body, so it presumably plays a yet-to-be-defined role in additional biological processes.

The ASIP gene has been characterized in fish, chickens, and various mammals, but no detailed investigation of ASIP has yet been performed in primates. With this in mind, Takafumi Ishida, Associate Professor of Biological Sciences at The University of Tokyo, and his colleague Kazuhiro Nakayama set out to compare the DNA sequences of the ASIP gene from various primates, including Old and New World monkeys, gibbons, gorillas, and chimpanzees. They discovered that the ASIP gene was highly conserved among most of these primates, but, surprisingly, a 100-kilobase segment of DNA harboring the ASIP gene was missing in gibbons.

"We found that this deletion occurred between two pieces of DNA that are quite abundant in primate genomes, called Alu elements," explains Nakayama. "We located one copy of a specific Alu element on either side of the ASIP gene. Our study shows that during the evolution of gibbons, these Alu elements lin
'"/>

Source:Cold Spring Harbor Laboratory


Page: 1 2

Related biology news :

1. Major new UNC-based drinking water study suggests pregnancy fears may be overstated
2. Major breakthrough in the treatment of cancers and infectious diseases
3. Major advance made on DNA structure
4. Major WHO study concludes calcium supplements can reduce complications during pregnancy
5. Major initiative proposed to address amphibian crisis
6. Major cancer study aims to identify protein markers for early-stage disease
7. Major link in brain-obesity puzzle found
8. Major gene study uncovers secrets of leukemia
9. Canadian youth 4th highest in international obesity study
10. Weight control protein may yield antiobesity drugs
11. Contagious obesity? Identifying the human adenoviruses that may make us fat
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Major obesity gene lost the shuffle

(Date:10/22/2014)... 20, 2014 The Nano-Bio Manufacturing Consortium (NBMC), ... Research Laboratory (AFRL), has chosen a project proposed by ... University of Arizona College of Medicine – ... project,s goal is to assess different sweat collection methods ... of sweat under a variety of human-body conditions, the ...
(Date:10/18/2014)... and stress-related psychiatric disorders are associated with ... molecular mechanisms underlying this relation are unknown. ... development of targeted preventive strategies and new ... This work is presented at the European ... an international group of researchers from Germany ...
(Date:10/17/2014)... . Why do ... to reproduce? And why are there two sexes anyway? These ... of the research journal Molecular Human Reproduction published ... Bielefeld University Bielefeld has compiled this special issue on sperm ... to copulate with several males in quick succession – chimpanzees ...
Breaking Biology News(10 mins):Nano-Bio Manufacturing Consortium Selects Project Proposed by Arizona Center for Integrative Medicine to Optimize Human Performance Monitoring Techniques 2Nano-Bio Manufacturing Consortium Selects Project Proposed by Arizona Center for Integrative Medicine to Optimize Human Performance Monitoring Techniques 3Researchers find why depression and aging linked to increased disease risk 2Sperm wars 2
... "the trots," "Montezuma,s Revenge," "the runs" and worse. But no ... medicine that could go straight to the offending bacteria to ... true if work by Texas A&M University scientists stays on ... A "medicine that grows" is how the phage concept ...
... Unusual features of the human placenta may be ... of maternal deaths during childbirth, according to evolutionary research ... as the loss of more than a pint of ... accounts for nearly 35 percent, or 125,000, of the ...
... on the latest news in science and technology, consider a ... for Nov. 9, 2011. The event, sponsored by the ... and brightest graduate students to display their research on clearly ... Institute of Technology, Rutgers University -- Newark and the University ...
Cached Biology News:Texas A&M center confronts antibiotic crisis with potential new bacterial treatment 2Texas A&M center confronts antibiotic crisis with potential new bacterial treatment 3Texas A&M center confronts antibiotic crisis with potential new bacterial treatment 4Evolution offers clues to leading cause of death during childbirth 2NJIT grad students display work at 7th annual Research Day on Nov. 9 2
(Date:10/20/2014)... October 20, 2014 The report ... Dispensing Systems, Packaging and Labeling Systems, Table-top Counters) ... - Global Forecasts & Trends to 2019” analyzes ... opportunities in North America, Europe, Asia-Pacific, and the ... market tables and 30 figures spread through 300 ...
(Date:10/20/2014)... Calif. , Oct. 20, 2014 ... that the Company has signed a Notice of ... Regenerative Medicine (CIRM), effective October 1, 2014.  The ... Development payments and the release of additional grant ... CIRM grant award for clinical development of Asterias, ...
(Date:10/20/2014)...  GenVec, Inc. (NASDAQ: GNVC ) today announced ... its board of directors effective on October 24, 2014.   Dr. ... as its chairman from June 2006 to November 2013.  During ... Governance and Audit Committees of the board.  ... dedicated service to GenVec, and its stockholders," said Wayne ...
(Date:10/20/2014)... Earle Martin , Chief Executive ... Ellen Teplitzky, an experienced attorney specializing in business ... has joined the firm as Director of Legal ... NDA Partners provides legal services, including research, ... top law firms and their clients in cases ...
Breaking Biology Technology:Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 2Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 3Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 4Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 2Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 3Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 4Zola P. Horovitz To Retire From GenVec Board 2NDA Partners Appoints Ellen Teplitzky, JD as Director of its Legal Services Practice 2
... , , , ... , , , RNA ... tool for target identification and target validation,in therapeutic research. , ... A growing number of different cell lines are used for,gene ...
... , , ... , , , Since the ... of foreign genes,appeared a few years ago, RNAi has become a ... short double-stranded RNAs that are,homologous to the suppressed gene. These small ...
... , , ... , , , , ... detection of beer-spoilage bacteria on the,LightCycler Instrument) in combination with the ... on the MagNA Pure LC Instrument) offers,breweries an innovative and automated ...
Cached Biology Technology:Housekeeping Genes: Universal Positive,Controls in siRNA Knockdown Experiments 2Housekeeping Genes: Universal Positive,Controls in siRNA Knockdown Experiments 3Quantification of siRNA Silencing Efficiency,Using the LightCycler System 2Quantification of siRNA Silencing Efficiency,Using the LightCycler System 3Quantification of siRNA Silencing Efficiency,Using the LightCycler System 4Quantification of siRNA Silencing Efficiency,Using the LightCycler System 5Screening of Beer-Spoilage Bacteria Using,the LightCycler PCR Workflow System 2Screening of Beer-Spoilage Bacteria Using,the LightCycler PCR Workflow System 3Screening of Beer-Spoilage Bacteria Using,the LightCycler PCR Workflow System 4Screening of Beer-Spoilage Bacteria Using,the LightCycler PCR Workflow System 5
Request Info...
Myt 1 (N-17)...
... Stem cells are functionally defined by their ... to differentiate into multiple specialized progenitor cells, ... specific lineages. Neural stem cells (NSCs) are ... including astrocytes, neurons and oligodendrocytes. During the ...
BAI-1 (T-20)...
Biology Products: