Navigation Links
Major obesity gene is 'lost in the shuffle'

Scientists from The University of Tokyo announce today that gibbons, arboreal primates that inhabit the jungles of Southeast Asia, do not carry a major obesity gene that is present in the genomes of all other primates, including humans. This omission is due to a genetic mis-shuffling event that occurred approximately 25 million years ago. Their results are reported in the April issue of the scientific journal Genome Research.

Agouti signaling protein (ASIP) was the first "obesity gene" to be cloned and characterized by geneticists, but it also plays an important role in other physiological processes ?ranging from hair color determination to energy homeostasis. Mice that over-produce ASIP are extremely obese, exhibit symptoms of diabetes, and have yellow fur, while mice that lack the ASIP gene are black in color. The gene is widely expressed in tissues throughout the body, so it presumably plays a yet-to-be-defined role in additional biological processes.

The ASIP gene has been characterized in fish, chickens, and various mammals, but no detailed investigation of ASIP has yet been performed in primates. With this in mind, Takafumi Ishida, Associate Professor of Biological Sciences at The University of Tokyo, and his colleague Kazuhiro Nakayama set out to compare the DNA sequences of the ASIP gene from various primates, including Old and New World monkeys, gibbons, gorillas, and chimpanzees. They discovered that the ASIP gene was highly conserved among most of these primates, but, surprisingly, a 100-kilobase segment of DNA harboring the ASIP gene was missing in gibbons.

"We found that this deletion occurred between two pieces of DNA that are quite abundant in primate genomes, called Alu elements," explains Nakayama. "We located one copy of a specific Alu element on either side of the ASIP gene. Our study shows that during the evolution of gibbons, these Alu elements lin ed up and recombined with each other, erasing approximately 100 kilobases of DNA that spanned the ASIP gene."

Ranging in size from 15 to 22 pounds, gibbons possess lithe, slender bodies that enable them to swing agilely across branches and vines in the jungles. Ishida and Nakayama speculate that the loss of the ASIP gene in gibbons may have played a role in the evolution of the gibbons' uniquely slender body shape and size, although there is no biochemical or physiological evidence to suggest this.

"In essence, we are observing the result of an ancient gene 'knockout' experiment," Ishida explains. "The deletion ?or 'knockout' ?of the ASIP gene may have helped gibbons adapt to arboreal niches. We know that the ASIP protein regulates lipid metabolism in humans, so there is certainly reason to presume that this deletion contributed to the gibbons' remarkably small body mass, enabling them to thrive in the jungle canopy."

Ishida points out that future studies of gibbons and other primates will enable scientists to examine the physiological effects of the ASIP deletion. "This will allow us to identify the specific metabolic roles of ASIP in vivo by comparing a species that has the gene versus a species that lacks the gene," he says.


'"/>

Source:Cold Spring Harbor Laboratory


Related biology news :

1. Major new UNC-based drinking water study suggests pregnancy fears may be overstated
2. Major breakthrough in the treatment of cancers and infectious diseases
3. Major advance made on DNA structure
4. Major WHO study concludes calcium supplements can reduce complications during pregnancy
5. Major initiative proposed to address amphibian crisis
6. Major cancer study aims to identify protein markers for early-stage disease
7. Major link in brain-obesity puzzle found
8. Major gene study uncovers secrets of leukemia
9. Canadian youth 4th highest in international obesity study
10. Weight control protein may yield antiobesity drugs
11. Contagious obesity? Identifying the human adenoviruses that may make us fat
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/3/2016)... , June 3, 2016 ... von Nepal hat ... Lieferung hochsicherer geprägter Kennzeichen, einschließlich Personalisierung, Registrierung ... in der Produktion und Implementierung von Identitätsmanagementlösungen. ... Ausschreibung im Januar teilgenommen, aber Decatur wurde ...
(Date:6/1/2016)... NEW YORK , June 1, 2016 ... Biometric Technology in Election Administration and Criminal Identification to ... According to a recently released TechSci Research report, " ... Sector, By Region, Competition Forecast and Opportunities, 2011 - ... $ 24.8 billion by 2021, on account of growing ...
(Date:5/12/2016)... May 12, 2016 WearablesResearch.com , a ... the overview results from the Q1 wave of its ... wave was consumers, receptivity to a program where they ... a health insurance company. "We were surprised ... says Michael LaColla , CEO of Troubadour Research, ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016   EpiBiome , ... secured $1 million in debt financing from Silicon Valley ... up automation and to advance its drug development efforts, ... new facility. "SVB has been an incredible ... the services a traditional bank would provide," said Dr. ...
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the sample tracking software company, ... Crime Laboratory, has joined STACS DNA as a Field Application Specialist. , “I ... President and COO of STACS DNA. “In further expanding our capacity as a scientific ...
(Date:6/23/2016)... 2016 Apellis Pharmaceuticals, Inc. today announced ... of its complement C3 inhibitor, APL-2. The trials ... dose studies designed to assess the safety, tolerability, ... in healthy adult volunteers. Forty subjects ... single dose (ranging from 45 to 1,440mg) or ...
(Date:6/23/2016)... 23, 2016 Andrew ... http://doi.org/10.17925/OHR.2016.12.01.22 Published recently in ... journal from touchONCOLOGY, Andrew D Zelenetz , ... cancer care is placing an increasing burden on ... biologic therapies. With the patents on many biologics ...
Breaking Biology Technology: