Navigation Links
Major obesity gene is 'lost in the shuffle'

Scientists from The University of Tokyo announce today that gibbons, arboreal primates that inhabit the jungles of Southeast Asia, do not carry a major obesity gene that is present in the genomes of all other primates, including humans. This omission is due to a genetic mis-shuffling event that occurred approximately 25 million years ago. Their results are reported in the April issue of the scientific journal Genome Research.

Agouti signaling protein (ASIP) was the first "obesity gene" to be cloned and characterized by geneticists, but it also plays an important role in other physiological processes ?ranging from hair color determination to energy homeostasis. Mice that over-produce ASIP are extremely obese, exhibit symptoms of diabetes, and have yellow fur, while mice that lack the ASIP gene are black in color. The gene is widely expressed in tissues throughout the body, so it presumably plays a yet-to-be-defined role in additional biological processes.

The ASIP gene has been characterized in fish, chickens, and various mammals, but no detailed investigation of ASIP has yet been performed in primates. With this in mind, Takafumi Ishida, Associate Professor of Biological Sciences at The University of Tokyo, and his colleague Kazuhiro Nakayama set out to compare the DNA sequences of the ASIP gene from various primates, including Old and New World monkeys, gibbons, gorillas, and chimpanzees. They discovered that the ASIP gene was highly conserved among most of these primates, but, surprisingly, a 100-kilobase segment of DNA harboring the ASIP gene was missing in gibbons.

"We found that this deletion occurred between two pieces of DNA that are quite abundant in primate genomes, called Alu elements," explains Nakayama. "We located one copy of a specific Alu element on either side of the ASIP gene. Our study shows that during the evolution of gibbons, these Alu elements lin
'"/>

Source:Cold Spring Harbor Laboratory


Page: 1 2

Related biology news :

1. Major new UNC-based drinking water study suggests pregnancy fears may be overstated
2. Major breakthrough in the treatment of cancers and infectious diseases
3. Major advance made on DNA structure
4. Major WHO study concludes calcium supplements can reduce complications during pregnancy
5. Major initiative proposed to address amphibian crisis
6. Major cancer study aims to identify protein markers for early-stage disease
7. Major link in brain-obesity puzzle found
8. Major gene study uncovers secrets of leukemia
9. Canadian youth 4th highest in international obesity study
10. Weight control protein may yield antiobesity drugs
11. Contagious obesity? Identifying the human adenoviruses that may make us fat
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Major obesity gene lost the shuffle

(Date:4/22/2014)... Gables, Fla. (April 21, 2014) -- There are all ... their feathers and spread their colorful tails; satin bowbirds ... with blue and shiny objects; and European bitterling males ... species has evolved a unique method to communicate with ... "Signaling can have profound fitness implications ...
(Date:4/22/2014)... 2014 Scientists from the Florida campus of The ... that plays a critical but previously unknown role in ... showed a novel role for a protein known as ... eLife , a publisher supported by the Howard ... Wellcome Trust. , "This is a critical building block ...
(Date:4/22/2014)... International Science Consortium Ltd.,s nanotechnology expert will present a ... hazard assessment" at the 7th International Nanotoxicology Congress ... Turkey. , Dr. Monita Sharma will outline a ... National Academy of Sciences, " Toxicity Testing in the ... recommends use of non-animal methods involving human cells and ...
Breaking Biology News(10 mins):Best practices in communication for the animal world 2Best practices in communication for the animal world 3Scientists identify critical new protein complex involved in learning and memory 2
... air quality apparently affects the running times of women in ... environmental engineer Linsey Marr. Marr,s findings come from a ... air pollutant concentrations in seven marathons over a period of ... finishing times were compared with the course record and contrasted ...
... for Microbiology (ASM) Roche Diagnostics Alice C. Evans Award ... Science Director, Walter Reed Army Institute of Research, ... scientists. This award recognizes contributions toward the full participation ... in honor of Alice C. Evans, the first woman ...
... monkeys, mothers who weigh more and have had previous ... babies than mothers who weigh less and are less ... of California, Davis are using this natural variation in ... mother,s milk sends a reliable signal to infants about ...
Cached Biology News:Women more affected than men by air pollution when running marathons 2Baby monkeys receive signals through their mother's breast milk 2
(Date:1/15/2014)... 2014  Bill Jacobs Automotive, a group of car dealerships headquartered ... the Heartland Blood Center and offering free oil change coupons ... place Saturday, Jan. 18 at the Bill Jacobs Cadillac and ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  The Bill Jacobs ...
(Date:1/15/2014)... Westlake Village, Calif. (PRWEB) January 15, 2014 ... cancer treatment and management through the genomic analysis of ... will offer Therapy Finder™, a web-based cancer decision support ... a reporting option with Cynvenio’s ClearID™ genomic test, Therapy ...
(Date:1/15/2014)... A study has been launched to test whether technology ... help to tackle the problem of obesity.  This unique healthcare ... based in Stowmarket) and academics at University Campus Suffolk is ... which is inspired by equipment used to collect data about ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 DTS Language ... its Online Web Portal for Life Science organizations who need ... specify the subject matter of their documents in advance with ... help reduce time-to-delivery of translations, often a critical factor in ...
Breaking Biology Technology:Join the Bill Jacobs Auto blood drive and receive a free oil change 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4DTS Improves Efficiency for Life Science Document Translations 2
... Reliable, PCR-based mycoplasma detection , Douglas ... , Stratagene introduces the Mycoplasma PCR Primer Set ... method which specifically amplifies an 874-bp,PCR product from ... contains an internal,control template that serves as a ...
... kit for site-directed mutagenesis of,large plasmids ... Holly Hogrefe ,Jeff Braman ,Stratagene , The ... exceeding 80%. We have created a new ... QuikChange XL,site-directed mutagenesis kit ...
... transduction research and drug screening , , ... Inc. , , Stratagene has successfully expressed and ... constitutively active mutant (MEK1 CA ),using the ESP ... MEKs, produced in yeast, are full length and ...
Cached Biology Technology:A New PCR-based Mycoplasma Detection Method 2A New PCR-based Mycoplasma Detection Method 3A New PCR-based Mycoplasma Detection Method 4A New PCR-based Mycoplasma Detection Method 5A New PCR-based Mycoplasma Detection Method 6High-Efficiency Site-Directed Mutagenesis of Large Plasmid Vectors 2High-Efficiency Site-Directed Mutagenesis of Large Plasmid Vectors 3High-Efficiency Site-Directed Mutagenesis of Large Plasmid Vectors 4Production of Full-Length, Biologically Active MEK1WT and MEK1CA 2Production of Full-Length, Biologically Active MEK1WT and MEK1CA 3Production of Full-Length, Biologically Active MEK1WT and MEK1CA 4Production of Full-Length, Biologically Active MEK1WT and MEK1CA 5
... Blocker Array II can be used ... against various proteins and sera that are ... carriers. The array contains spots for 19 ... Application: Determination of antibody crossreactivity and species ...
... Tecans new HydroFlex platform provides excellent ... range of 96-well format applications, including ... protein arrays, and vacuum filtration-to-waste, such ... outstanding on-line control features set new ...
... and Accurate Results Laser Capture Microdissection ... sensitivity and accuracy of molecular assays by ... and multi-cellular structures isolated from whole tissue ... microdissection-developed in 1996 at the National Institutes ...
...
Biology Products: