Navigation Links
Major breakthrough in the treatment of cancers and infectious diseases

Montreal researchers identify new anti-cancer, anti-infection response control mechanism

Dr. André Veillette, a researcher at the Institut de recherches cliniques de Montréal (IRCM), and his team will publish in the upcoming issue of the prestigious journal Nature Immunology of Nature Publishing Group, a discovery that could significantly advance the treatment of cancers and infectious diseases. Current treatments frequently achieve only limited results with these types of diseases, which affect hundreds of thousands of Canadians.

Dr. Veillette's team identified one of the basic mechanisms controlling NK ("natural killer") cell activity. Produced by the immune system, NK cells are responsible for recognizing and killing cancer cells and cells infected by viruses such as the viruses causing hepatitis and herpes. NK cell deficiency is associated with a higher frequency of cancers and serious infections. Dr. Veillette's breakthrough demonstrates that a molecule known as EAT-2, present in NK cells, suppresses its killer function. Inhibiting EAT-2 with medications could boost NK cell activity, helping to combat cancers and infections.

This publication constitutes a significant milestone for Dr. Veillette, an internationally renowned expert in the identification of the molecular mechanisms controlling the immune system. The article, which is slated for publication online on August 28 in Nature Immunology, gives genetic evidence for the inhibiting role of EAT-2 in NK cells. It is the product of over five years of intensive research by Dr. Veillette's team.

More specifically, by studying mice in which the EAT-2 protein is eliminated through genetic manipulations, Dr. Veillette's team has established that suppressing EAT-2 results in the production of NK cells that are much more effective at killing cancer cells. Inhibiting the function of EAT-2 with medications could therefore stimulate the killer function of NK cells, and increase their ca
'"/>

Source:Institut de recherches cliniques de Montreal


Page: 1 2

Related biology news :

1. Major new UNC-based drinking water study suggests pregnancy fears may be overstated
2. Major advance made on DNA structure
3. Major WHO study concludes calcium supplements can reduce complications during pregnancy
4. Major obesity gene is lost in the shuffle
5. Major initiative proposed to address amphibian crisis
6. Major cancer study aims to identify protein markers for early-stage disease
7. Major link in brain-obesity puzzle found
8. Major gene study uncovers secrets of leukemia
9. Recent breakthroughs in common adult leukemia highlighted in New England Journal of Medicine
10. MUHC researchers make cancer target breakthrough
11. Researchers report breakthrough against world’s deadliest viruses
Post Your Comments:
(Date:10/27/2014)... CA – October 28, 2014 – A new randomized ... proprietary blend of collagen and calcium, KoACT®, was far ... the leaching of calcium from bones and rebuilding new ... PubMed at: http://www.ncbi.nlm.nih.gov/pubmed/25314004 , ahead of print in ... The research was conducted by Bahram H. Arjmandi, PhD, ...
(Date:10/27/2014)... -- NXT-ID, Inc. (NASDAQ: NXTD and ... focused on the growing mobile commerce market issues a ... Chief Technology Officer. Mr Tunnell examines the case for ... the variety of new payment solutions being released, consumers ... has its own attributes that promise to make payments ...
(Date:10/27/2014)... results from a safety and immunogenicity study, which ... that a live attenuated enterotoxigenic Escherichia coli ... a novel adjuvant, provided significant protection against disease. ... vaccine/adjuvant combination, which was 58.5 percent efficacious in ... highly rigorous ETEC human challenge model. The vaccine/adjuvant ...
Breaking Biology News(10 mins):New RCT: KoACT® beats calcium and vitamin D for optimal bone strength 2Media Alert; NXT-ID Chief Technology Officer Comments on Why You Need a Smart Wallet 2Media Alert; NXT-ID Chief Technology Officer Comments on Why You Need a Smart Wallet 3Media Alert; NXT-ID Chief Technology Officer Comments on Why You Need a Smart Wallet 4Clinical results indicate vaccine candidate highly efficacious against bacterial diarrhea 2
... human health in the past, and are bound to ... for example, led to many illnesses and deaths from ... people vying for scarce food, shelter, and work. ... health ramifications. Following a request from Gov. Christine Gregoire, ...
... -- A slightly greater number of males than females are ... still more baby boys born than girls, there has been ... newborns in several industrialized countries, including Canada, Denmark, England, Germany, ... ask: Are there any factors that can influence the probability ...
... who have lower-pitched voices have more children than do ... their study suggests that for reproductive-minded women, mate selection ... in Biology Letters, offers insight into the evolution of ... our mates. In previous studies, David Feinberg, assistant ...
Cached Biology News:University and state agencies to forecast local health effects of climate change 2University and state agencies to forecast local health effects of climate change 3University and state agencies to forecast local health effects of climate change 4Weight gain between first and second pregnancies associated with increased odds of male second child 2
(Date:10/30/2014)... San Diego, CA (PRWEB) October 30, 2014 ... company announced today that they have manually curated public ... Pharma and non profit customers. the data is ... BioSciences manually curates and unifies public and internal data ... more value and knowledge out of the data that ...
(Date:10/30/2014)... 30, 2014 Grace Century portfolio project, ... Manganello, Chairman of the Board, to the National Stem ... appointment was made by the Ministry of Health on behalf ... , More than a year after Bahamian Parliament ... Prime Minister Perry Christie said the government has completed the ...
(Date:10/30/2014)... severe flooding that devastated a wide swath of Colorado ... bridges, roads and other infrastructure had been upgraded or ... of Colorado Denver. , "People need to understand the ... associate professor of structural engineering at the CU Denver ... the study. "There is an assumption that a bridge ...
(Date:10/27/2014)... -- Kalorama Information says that PCR is demonstrating its ... the United States and is the dominant ... the FDA,s Emergency Use Authorization (EUA) to authorize the emergency ... of the Ebola virus was an indication that the ... IVD industry and its biennial survey on diagnostics markets ...
Breaking Biology Technology:Rancho BioSciences Manually Curated TCGA Data Sets Available 2Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 2Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 3CU Denver study says upgrading infrastructure could reduce flood damage 2Kalorama: PCR The Go-to Test in Ebola Fight 2Kalorama: PCR The Go-to Test in Ebola Fight 3
... 2012 The Houston Technology Center (HTC), ... annual gala, "A Celebration of Entrepreneurs . " ... significant impact on the region,s economy; and developed lifesaving ... named Beth Williams, CEO of TechTrans International, Inc., as ...
... 21, 2012  Neuralstem, Inc. (NYSE MKT: CUR) announced ... at the World Stem Cells & Regenerative Medicine ... May 22nd at 12:30 PM. Mr. Garr,s presentation, ... Neuralstem,s cellular therapy trial in ALS, its neurogenic ...
...  Intellect Neurosciences, Inc. (OTCPK: ILNS) announces that Dr. ... will be presenting at the Seventh Annual Neurotech ... http://photos.prnewswire.com/prnh/20111214/NY22484LOGO ) The title of ... Attractive Targets for Active and Passive Immunotherapy." His ...
Cached Biology Technology:Leading Technology Incubator Honors Extraordinary Entrepreneurs 2Leading Technology Incubator Honors Extraordinary Entrepreneurs 3Neuralstem CEO to Present at the World Stem Cells and Regenerative Medicine Congress in London 2Intellect Neurosciences, Inc. to Present at Neurotech Investing and Partnering Conference 2Intellect Neurosciences, Inc. to Present at Neurotech Investing and Partnering Conference 3
... The Vibratome Company has joined forces with ... the Vibratome 411301 Tissue Chopper. This tissue ... sections of tissue for metabolic experiments and ... irregular specimens available at biopsy or from ...
... The Vibratome Company has joined forces ... introduce the Vibratome 800 Tissue Chopper. This ... prepare sections of tissue for metabolic experiments ... and irregular specimens available at biopsy or ...
... design, The Bioactive peptides are molecules of ... biological behaviour or activity which can be ... diagnostic, chemical and agro-food applications. In this ... peptides with superior properties for therapeutic applications. ...
... within neurons in vesicles called synaptosomes. ... synaptic bouton. Synaptosomes may be ... other cellular debris. Abnormalites in neurotransmitter ... pathological condtions. Conditions of release ...
Biology Products: