Navigation Links
Major WHO study concludes calcium supplements can reduce complications during pregnancy

n."

Molecular dynamics simulations have already proved their value in steering drug design, McCammon said. "They helped in the discovery of the current HIV protease inhibitors, which bind to the active site of the enzyme. They were also key to the development of potential inhibitors of the third enzyme associated with HIV, the integrase enzyme.

"Other simulations by our group discovered an unknown binding site on the integrase enzyme, " McCammon explained. "Merck's new anti-integrase inhibitors include molecules that are designed to hit that site, in addition to a site that was known earlier from x-ray crystallography studies." These new inhibitors are moving into phase III human trials, he said.

For his first round of simulations, Perryman chose a rare double-mutant protease enzyme with two mutations in the 99 amino acids that make up each half of the enzyme. One of those mutations, V82F, is common, and it can emerge early during failure of therapy with most protease inhibitors. The other mutation, I84V, is frequently found after prolonged ineffective therapy with protease inhibitors and likely confers high-level resistance to most drugs in that class. The researchers wanted to compare the differences in the shapes of the non-mutated or wild-type enzyme, against which the drugs still worked well, and the drug-resistant double-mutant strain.

Perryman used a computer simulation program called AMBER that performs several different types of calculations. The x-ray crystal structure of the molecule is used as the input, and the various motions and shapes sampled are governed by Newtonian physics, the electric forces among atoms, the complementarity or clash of the different shapes that the enzyme takes, and penalties or bonuses for creating or relieving geometric strain.

The scientists depict the protease enzyme in a brightly colored cartoon, with features that resemble a fat cat face. From the front or the back, the identical ha
'"/>

Source:American Journal of Obstetrics and Gynecology


Page: 1 2 3 4 5

Related biology news :

1. Major new UNC-based drinking water study suggests pregnancy fears may be overstated
2. Major breakthrough in the treatment of cancers and infectious diseases
3. Major advance made on DNA structure
4. Major obesity gene is lost in the shuffle
5. Major initiative proposed to address amphibian crisis
6. Major cancer study aims to identify protein markers for early-stage disease
7. Major link in brain-obesity puzzle found
8. Major gene study uncovers secrets of leukemia
9. Bioartificial kidney under study at MCG
10. W.M. Keck Foundation funds study of friendly microbes
11. Yellowstone microbes fueled by hydrogen, according to U. of Colorado study
Post Your Comments:
(Date:3/10/2015)... -- Continuing its 167-year history of offering the Best, the ... Eye Scanning Password Authenticator , a device that confirms ... or sensitive data. Employing the same biometric ... device has a small camera that scans and saves ... them into an encrypted ID that cannot be forged ...
(Date:3/4/2015)... DUBLIN , Mar. 04, 2015 Research ... announced the addition of the "Global Biometrics ... their offering. The market for biometric ... CAGR of around 14% till 2020 ... will be increasing security needs, government projects and ...
(Date:2/25/2015)... 2015  ABC Financial Services (ABC), the leading ... and Fitness Industry, today announced enhancements to their ... latest upgrade includes advances to the agreement section ... via Identity One fingerprint biometrics. The features will ... displays at the International Health, Racquet & Sportsclub ...
Breaking Biology News(10 mins):Hammacher Schlemmer Introduces The Eye Scanning Password Authenticator 2Global Biometrics Market Forecast and Opportunities, 2020 2Global Biometrics Market Forecast and Opportunities, 2020 3ABC Financial Unveils New Software Enhancements 2ABC Financial Unveils New Software Enhancements 3
... a component of salt, are elevated in many urban streams ... government study. Chloride levels above the recommended federal criteria ... 40 percent of urban streams tested. The study was ... chloride can inhibit plant growth, impair reproduction, and reduce the ...
... 16th 2009 / b3c newswire / - NiKem Research ... the Italian Ministry of Health, GLP certification of its bioanalysis ... NiKem Research has provided for many years high quality cost-effective ... ADME(T) and in vivo PK services associated to ...
... including the University of Colorado at Boulder have sequenced ... species, providing information that can be used to better ... Identifying such DNA barcodes can help wildlife officials ... species are in sharp decline from illegal trade estimated ...
Cached Biology News:Chloride found at levels that can harm aquatic life in urban streams of the Northern US 2NiKem Research receives certification for GLP Bioanalysis 2CU-Boulder team identifies DNA "barcodes to help track illegal trading of wildlife products 2CU-Boulder team identifies DNA "barcodes to help track illegal trading of wildlife products 3
(Date:3/27/2015)... 27, 2015 Working in collaboration with ... London , Richmond Pharmacology is the first ... 3 study for an investigational RNAi therapeutic being developed for ... the nerves and heart. Read press release ... Based at St Georges University of London ...
(Date:3/26/2015)... 26, 2015  Roka Bioscience, Inc. (NASDAQ: ... providing advanced testing solutions for the detection of ... the three months and full year ended December ... Results:Revenue for the quarter ended December 31, 2014 ... fourth quarter of 2013 and $1.5 million for ...
(Date:3/26/2015)... 2015  BioNano Genomics, Inc., the leader in genome ... as chief commercial officer. Salyer has more than 20 ... in life sciences. At BioNano, Salyer will oversee the ... platform to assemble a comprehensive view of complex genomes ... 32 institutions located in the United States ...
(Date:3/26/2015)... 2015 ReliantHeart, Inc., an innovative supplier ... supplier of precision transit-time flow measurement solutions, are collaborating ... the efficiency of the HeartAssist5® Left Ventricular ... experience greater mobility and peace of mind. , ... board, will draw 1/6th of the power required by ...
Breaking Biology Technology:Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 2Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 3Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 4Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 5Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 6Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 7BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 2BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 3LVAD patients to have greater mobility and peace of mind through Transonic and ReliantHeart’s True Flow collaboration for the HeartAssist5® 2LVAD patients to have greater mobility and peace of mind through Transonic and ReliantHeart’s True Flow collaboration for the HeartAssist5® 3
... has purchased a LEAP 3000 metrology system made by ... Wis. The Tohoku University system is the third system Imago has ... system in conjunction with its representatives based in Japan, the Noah ... enabling metrology at the atomic scale. , , ...
... - In Victorian England, the game of croquet was ... matter, and people could share the latest news without inhibition. ... goal of a research team working from the University ... to capture that sense of interactivity and bring it to ...
... you noticed recently the earnest discussions about a seemingly inalienable ... maybe that overstates the argument a little bit, but the ... their blogging activities on what Apple considered competitive secrets is ... in various media. , ,Then in the not-quite-yet-news bin one ...
Cached Biology Technology:The Croquet Project: An open source solution to the OS monopoly 2The Croquet Project: An open source solution to the OS monopoly 3The Croquet Project: An open source solution to the OS monopoly 4The Croquet Project: An open source solution to the OS monopoly 5Social engineering - Coming to an IT ship near you? 2Social engineering - Coming to an IT ship near you? 3
... MBP Coated Microplate, 96 Well Anti-phospho-MBP, ... Magnesium/ATP Cocktail, #20-11 Blocking Buffer, 10X, ... LumiGLO™ Chemiluminescen Applications: ... Routinely evalauted by non-radioactive ...
... ActivePro In Vitro Translation ... E.coli lysate, synthesizes higher ... well as proteins with ... competing kits. This results ...
One-step, microplate or cuvet, colorimetric, detection range 0.3 g/dL to 5 g/dL. Procedure: 5 min....
The Varian 4000 GC/MS system offers three easily switchable ionization configurations: internal ionization (II), external ionization (EI) or hybrid chemical ionization (CI)...
Biology Products: