Navigation Links
Magnetic probe successfully tracks implanted cells in cancer patients

By using MRI to detect magnetic probes of tiny iron oxide particles, an international research team for the first time has successfully tracked immune-stimulating cells implanted into cancer patients for treatment purposes.

"In four of the eight patients, MRI revealed that the implanted cells weren't where they needed to be to be effective for treatment," says Jeff Bulte, Ph.D., an associate professor of radiology at Hopkins' Institute for Cell Engineering who developed methods to optimally label cells with the clinically approved iron oxide particles.

This new application of the probes -- already clinically approved for MRI scanning of the liver -- could dramatically improve efforts to test and use cellular therapies such as vaccines to treat cancer or prevent its recurrence or stem cells to repair damaged organs, say the researchers.

Bulte and a team of Dutch researchers used MRI and a magnetic probe approved by both European and U.S. agencies to locate therapeutic cells injected into eight melanoma patients.

"Our results show that the MRI-based technique was more accurate than tracking the cells using radioactivity and that ultrasound failed to accurately guide injection of the cells into lymph nodes in half of the patients," says Bulte, an author on the report, which appears in the November issue of Nature Biotechnology.

The cells used in the current study, so-called dendritic cells, are the immune system's own "most wanted posters" because they take up and display foreign proteins that tell the immune system's fighters what cells to look for and destroy.

Since the mid-1990s, clinical trials have been testing dendritic cells to see whether they can stimulate the immune system to kill cancer cells. In these trials, dendritic cells from patients are exposed to proteins from the patients' cancer cells and then returned to the patients.

However, some of the clinical trials of such "cancer vaccines" have bee
'"/>

Source:Johns Hopkins Medical Institutions


Page: 1 2 3

Related biology news :

1. Magnetic system could be key to surgery without scars
2. Magnetic computer sensors may help study biomolecules
3. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
4. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
5. Products containing specific probes for detecting alternative splice forms protected
6. Duke engineers develop new 3-D cardiac imaging probe
7. Agilent Technologies releases probe sequence, annotation information for all its commercial gene expression microarrays
8. A probe, not an echo
9. NASA probe could reveal comet life, scientists claim
10. Montreal researchers probe the genetic basis of memory
11. MBL researchers probe how an ancient microbe thrives and evolves without sex
Post Your Comments:
(Date:3/12/2015)... Va. , March 12, 2015 IriTech, ... and a member of the Texas Instruments Design Network, ... Naidu has demonstrated its IriShield USB MK2120U device ... scanning facility for pension distribution. The ... assembled to be marketed in India ...
(Date:3/12/2015)... -- Beta Systems today announced Fast ... (IAM) solution for a fixed price and with ... IAM package, customers benefit from the 30 years, ... implementations across different industries. The new fixed-price IAM ... necessary services and consulting. It spans the implementation ...
(Date:3/11/2015)... DUBLIN , Mar. 11, 2015 Research and ... addition of the "Access Control Market by Product, ... to 2020" report to their offering. , ... is expected to reach $10.4 billion by 2020, with ... control market report covers the products types such as ...
Breaking Biology News(10 mins):Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 2Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 3Beta Systems Fast Forward IAM Available Now: a Standardized IAM Package at a Fixed Price 2Global Access Control (Cards & Readers, Biometrics, Controllers, Management Software) Market 2015-2020 - Analysis of the $10 Billion Market 2
... December 1, 2008 Although naturally occurring smallpox was ... obtain smallpox from a laboratory and release it into ... vaccine may be insufficient for universal administration. In a ... The American Journal of Medicine , researchers found that ...
... induce major differentiations in the metabolic make-up of ... November 28 in the open-access journal PLoS ... led by Karsten Suhre, has conducted a genome-wide ... genes involved in the breakdown of fats. The ...
... through DNA but also through the millions of proteins and ... known as "epigenetic marks," act both as a switch and ... turned on or off, and how much message an "on" ... information is known to be passed from parent to offspring ...
Cached Biology News:New study indicates smallpox vaccination effective for decades 2Study identifies genetic variants giving rise to differences in metabolism 2CSHL scientists discover a new way in which epigenetic information is inherited 2CSHL scientists discover a new way in which epigenetic information is inherited 3
(Date:3/25/2015)... BLOOMINGTON, MN (PRWEB) March 25, 2015 ... a breakthrough in nanoparticle technology that will enable ... and many other diseases with a simple breath ... ahead on the U.S. Food and Drug Administration ... 2016 launch of the innovative Nanoparticle Biomarker Tagging ...
(Date:3/25/2015)... /CNW/ - The Gairdner Foundation is pleased to ... recognizing some of the most significant medical discoveries ... the world,s most esteemed medical research prizes, the ... a $100,000 (CDN) prize to each scientist for their work. ... and innovation across the country, inspiring the next ...
(Date:3/25/2015)... 2015 Proove Biosciences , a ... to announce the success of their commercially supported symposium, ... to Optimize the Management of Pain, at the 31st ... Harbor, Maryland on Thursday, March 19th, 2015. ... President Lynn Webster , M.D., former Florida Society ...
(Date:3/25/2015)... 25, 2015 Oxis International, Inc. (OXIS) (OXI.PA) ... commercialization, announced today Oxis CEO Tony Cataldo ... 2015 at 4:15pm EST to update shareholders and other ...     Oxis Chairman and CEO Tony ... been very exciting for Oxis and our shareholders. There ...
Breaking Biology Technology:Ancon Medical Researchers Make Nanotechnology Breakthrough for Disease Screening Technology 2Ancon Medical Researchers Make Nanotechnology Breakthrough for Disease Screening Technology 32015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 22015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 32015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 42015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 52015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 62015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 72015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 8Proove Biosciences Hosts Symposium on Incorporating Genetic Testing to Optimize the Management of Pain 2Oxis Biotech Inc. Announces Corporate Update Conference Call for March 31 2
... 7 Endocare, Inc. (Nasdaq: ENDO ) ... have entered into a settlement agreement stipulating to termination ... Galil Medical pursuant to which Endocare would have acquired ... in Delaware Chancery Court. , , ...
... Covance Inc. today ... company as vice president and chief scientific officer of ... industry experience, including bioanalytical research, translational research, and talent ... development strategy for Covance,s bioanalytical services. , ...
... advanced energy research , , MONTREAL, July 7 ... technology company, today announced that it will jointly form ... Edmonton and the Alberta Energy Research Institute (AERI). , ... demonstration of novel catalytic conversion processes to produce advanced ...
Cached Biology Technology:Endocare and Galil Medical Announce Settlement of Litigation 2Covance Appoints Dr. Steven M. Michael as Vice President and Chief Scientific Officer of Global Bioanalytical Services 2Enerkem Announces World-Class Advanced Energy Research Center in Edmonton, Alberta, Canada 2Enerkem Announces World-Class Advanced Energy Research Center in Edmonton, Alberta, Canada 3
... to siRNA library screening, optimal ... identified and verified for each ... CellReady siRNA Transfection Optimization Kit, ... optimizing transfection conditions in 96 ...
... positioning slides offers multiple drive technologies ... and manual. With this series, users ... systems. These slides also offer anti-cage ... to 10 nanometers, integrated home/ limit ...
Ethylene glycol-bis(2-aminoethyl ether)-N,N,N',N'-tetraacetic acid, Molecular Biology Grade...
Kit Components: Anti-PARP LumiGLO Chemiluminescent Substrate Immunoblot Blocking Reagent Pyronin Y Reagent Goat Anti-Rabbit IgG, HRP conjugate Double-It Reagent Film Exposure Folders Autor...
Biology Products: