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Macrophage signaling may affect hormone resistance in prostate tumors

androgen antagonists," said Rose.

The research shows at a mechanistic level that the physical interaction of macrophages with prostate tumor cells activates processes in both cell types that cause the activity of androgen antagonists to change, allowing the expression of androgen target genes in the tumor cells. The research team describes the signaling pathway involved in this process, involving several proteins that may be potential drug targets in the future.

Steroid receptors (the proteins that bind and mediate the effects of androgens, estrogens, and progesterone) contain within their structure a novel binding site not previously recognized by researchers, according to the study. This site makes these receptors uniquely responsive to inflammatory signals, because the protein that binds there, called TAB2, is the ultimate target of the signaling pathway. When pro-inflammatory signals cause the chemical modification of TAB2, the activity of the receptors is changed. Drugs that are normally antagonists now activate target genes, many of which are associated with tumor growth.


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Source:University of California - San Diego


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