Navigation Links
Macrophage signaling may affect hormone resistance in prostate tumors

Interaction between prostate cancer cells and immune cells called macrophages may be a source of inflammatory signals capable of impacting the effectiveness of androgen antagonists, the most common and effective treatment for prostate cancer, according to a new study by researchers at the University of California, San Diego (UCSD) School of Medicine.

Male hormones called androgens are essential for the physiological function and growth of the prostate gland, and anti-androgen treatment, which blocks the expression of androgen target genes, is widely used for the treatment of prostate cancer. Unfortunately, most patients eventually progress to an antagonist-resistant or hormone independent form of cancer, according to David W. Rose, Ph.D., associate professor in UCSD's Department of Medicine, Division of Endocrinology and Metabolism, and Moores Cancer Center. Rose is principle investigator of the study, to be published in the Feb. 10 issue of the journal Cell.

"These findings are exciting because we have shown on the cellular level that, when the immune cells interact with the tumor cells, the result essentially negates the effect of the very drug being used to repress the tumor. If we can show the same process occurs in animals and in people, we may be able to block the "de-repression" of these genes, and develop more effective drugs to target prostate cancer tumors," Rose said.

The UCSD research team explored the possibility that external signaling from macrophages in the prostate tumor microenvironment might affect hormone resistance.Using cell biology methods, they discovered a mechanistic explanation for at least one form of resistance to androgen antagonists.

"It was of particular interest for us to determine whether a macrophage/prostate cancer cell interaction occurs, if it is a common event in prostate cancer, and whether this serves as a source of inflammatory signals capable of impacting the therapeutic effectiveness of
'"/>

Source:University of California - San Diego


Page: 1 2

Related biology news :

1. Bound for destruction: Ubiquitination protects against improper Notch signaling
2. Viral protein influences key cell-signaling pathway
3. Researchers find promising cancer-fighting power of synthetic cell-signaling molecule
4. Leptin-signaling Protein Maintains Normal Body Weight And Energy Balance In Mice
5. Prostate cancer uses Wnt signaling proteins to promote growth of bone tumors
6. Yale scientists decipher wiring pattern of cell signaling networks
7. Chemical signaling helps regulate sensory map formation in the brain
8. Flick of whiskers helps tease out brains shadow signaling system
9. New study reveals signaling pathways required for expansion of pancreas stem cells
10. Salk scientists untangle steroid hormone signaling in plants
11. Key molecular signaling switch involved in allergic disease identified
Post Your Comments:
(Date:8/20/2014)... past few years, Virginia Tech,s Wu Feng has built ... from the "Computing in the Cloud" program, and synergistically ... million award from the Air Force on "big computing" ... and the National Institutes of Health on "big data" ... the "parallel computing" aspects from each grant, he was ...
(Date:8/20/2014)... University researchers have developed methods for electronically manipulating the ... signals moths use to control those muscles. The work ... or "biobots," for use in emergency response. , "In ... can control the movement of moths for use in ... Alper Bozkurt, an assistant professor of electrical and computer ...
(Date:8/19/2014)... 19, 2014 To improve students, chances of ... the University of Houston (UH) implemented a comprehensive ... at risk for failure. , Through a ... (THECB), the Department of Biology and Biochemistry embarked ... taking "General Biology" for non-majors and "Introductory Biology" ...
Breaking Biology News(10 mins):The internet was delivered to the masses; parallel computing is not far behind 2The internet was delivered to the masses; parallel computing is not far behind 3The internet was delivered to the masses; parallel computing is not far behind 4Research paves way for development of cyborg moth 'biobots' 2University of Houson program earns kudos for improving grades, retaining students 2University of Houson program earns kudos for improving grades, retaining students 3
... reside in designated Special Areas of Conservation throughout the ... risk from pile driving. The frequency range of pile ... find food and avoid predators. This has the potential ... breed successfully. Lactating females and young calves might be ...
... Special Areas of Conservation throughout the UK, including Dorset, ... driving. The frequency range of pile driving noise could ... avoid predators. This has the potential to affect their ... females and young calves might be particularly vulnerable ...
... fruits and vegetables to their daily diets. Now, UC Davis ... the kinds of cellular activity that leads to the development ... "We've known for a long time that it's the flavonoids ... known exactly how. Now, at least in the case of ...
Cached Biology News:South Pacific plant may be missing link in evolution of flowering plants 2Dolphins at risk 2UC Davis researchers reveal apples' protective ways 2
(Date:8/19/2014)... -- Research and Markets  has announced the addition of ... Business Report" report to their offering. ... Cells (SOFCs) in US$ Thousands. The report provides separate comprehensive ... Europe , Asia-Pacific , and ... the period 2012 through 2020. Market data and analytics are ...
(Date:8/19/2014)... Research and Markets ... "Spectroscopy Equipment and Accessories - Global Strategic ... This report analyzes the ... in US$ Thousands by the following Product ... NMR-EPR Spectrometers, Near Infrared (NIR) Spectrometers, IR ...
(Date:8/19/2014)... Aug. 19, 2014   Synthetic Biologics, Inc. ... novel anti-infective biologic and drug programs targeting specific ... today that its novel C. difficile ... th Interscience Conference on Antimicrobial Agents and ... D.C. Synthetic Biologics, Senior ...
(Date:8/18/2014)... (PRWEB) August 19, 2014 2014 ... Industryā€¯ is a professional and in-depth research report ... basic Linalool information, including its definition, classification, ... industry overview. This research covers the international market ... global industry analysis covering macroeconomic environment & economic ...
Breaking Biology Technology:Global Solid Oxide Fuel Cells (SOFCs) - Strategic Business Report 2014 2Global Spectroscopy Equipment and Accessories - Strategic Business Report 2014 2Synthetic Biologics Announces Late-Breaking Poster Presentation for C. difficile Program at 54th ICAAC 2Synthetic Biologics Announces Late-Breaking Poster Presentation for C. difficile Program at 54th ICAAC 3Synthetic Biologics Announces Late-Breaking Poster Presentation for C. difficile Program at 54th ICAAC 4Linalool Industry & Diphenylamine Market (Global, China) 2014 Analysis Now Available at DeepResearchReports.com 2Linalool Industry & Diphenylamine Market (Global, China) 2014 Analysis Now Available at DeepResearchReports.com 3Linalool Industry & Diphenylamine Market (Global, China) 2014 Analysis Now Available at DeepResearchReports.com 4
... 2011 VIGILAIR Systems, an industry leader ... a newly published, and first of its kind hospital ... Acquired Infections (HAI) with the application of VIGILAIR® air ... The published article , Effect of enhanced ...
... Calif., April 8, 2011 Sangamo BioSciences, Inc. (Nasdaq: ... announced public offering of 6,700,000 shares of its common stock ...  The public offering is expected to close on or around ... Capital Inc. is the sole book-running manager in this offering ...
... 7, 2011 Cephalon, Inc. (NASDAQ: CEPH ... filed with the Securities and Exchange Commission (SEC) that ... Valeant Pharmaceuticals International, Inc.,s proposals to remove and replace ... consent solicitation cards to Valeant.  On April 5, 2011, ...
Cached Biology Technology:Newly Published Study Shows Dramatic Reduction in Hospital Acquired Infections 2Sangamo Announces Pricing of Public Offering of Common Stock 2Sangamo Announces Pricing of Public Offering of Common Stock 3Cephalon Recommends Shareholders Reject Valeant Nominees 2Cephalon Recommends Shareholders Reject Valeant Nominees 3Cephalon Recommends Shareholders Reject Valeant Nominees 4Cephalon Recommends Shareholders Reject Valeant Nominees 5
Phospho-FAK (Tyr576/577) Antibody...
... Anti-Natural Killer Cell Receptor-P1, ... Immunogen: Hybridoma produced ... from BALB/c mice immunized (BALB/c ... (LAK) cells and mouse myeloma ...
... to Yersinia pestis This antibody ... . Immunogen: Purified ... vaccine strain EV76. ... F1 capsular antigen. There is no ...
Rabbit polyclonal to ZFP200 ( Abpromise for all tested applications). Antigen: Synthetic peptide: CGKSFNHKTNLNKHER (Human) Entrez Gene ID: 7752 Swiss Protein ID: P98182...
Biology Products: