Navigation Links
Macrophage signaling may affect hormone resistance in prostate tumors

Interaction between prostate cancer cells and immune cells called macrophages may be a source of inflammatory signals capable of impacting the effectiveness of androgen antagonists, the most common and effective treatment for prostate cancer, according to a new study by researchers at the University of California, San Diego (UCSD) School of Medicine.

Male hormones called androgens are essential for the physiological function and growth of the prostate gland, and anti-androgen treatment, which blocks the expression of androgen target genes, is widely used for the treatment of prostate cancer. Unfortunately, most patients eventually progress to an antagonist-resistant or hormone independent form of cancer, according to David W. Rose, Ph.D., associate professor in UCSD's Department of Medicine, Division of Endocrinology and Metabolism, and Moores Cancer Center. Rose is principle investigator of the study, to be published in the Feb. 10 issue of the journal Cell.

"These findings are exciting because we have shown on the cellular level that, when the immune cells interact with the tumor cells, the result essentially negates the effect of the very drug being used to repress the tumor. If we can show the same process occurs in animals and in people, we may be able to block the "de-repression" of these genes, and develop more effective drugs to target prostate cancer tumors," Rose said.

The UCSD research team explored the possibility that external signaling from macrophages in the prostate tumor microenvironment might affect hormone resistance.Using cell biology methods, they discovered a mechanistic explanation for at least one form of resistance to androgen antagonists.

"It was of particular interest for us to determine whether a macrophage/prostate cancer cell interaction occurs, if it is a common event in prostate cancer, and whether this serves as a source of inflammatory signals capable of impacting the therapeutic effectiveness of
'"/>

Source:University of California - San Diego


Page: 1 2

Related biology news :

1. Bound for destruction: Ubiquitination protects against improper Notch signaling
2. Viral protein influences key cell-signaling pathway
3. Researchers find promising cancer-fighting power of synthetic cell-signaling molecule
4. Leptin-signaling Protein Maintains Normal Body Weight And Energy Balance In Mice
5. Prostate cancer uses Wnt signaling proteins to promote growth of bone tumors
6. Yale scientists decipher wiring pattern of cell signaling networks
7. Chemical signaling helps regulate sensory map formation in the brain
8. Flick of whiskers helps tease out brains shadow signaling system
9. New study reveals signaling pathways required for expansion of pancreas stem cells
10. Salk scientists untangle steroid hormone signaling in plants
11. Key molecular signaling switch involved in allergic disease identified
Post Your Comments:
(Date:4/17/2014)... need to produce hydrogen sulfide in order to properly ... study from the Center for Craniofacial Molecular Biology at ... Professor Songtao Shi, principal investigator on the project, said ... governs the flow of calcium ions. The essential ions ... osteogenesis, or the creation of new bone tissue, and ...
(Date:4/17/2014)... in German . ... money demanded of him, he can expect his premises to ... fear of the consequences is enough to make restaurant owners ... which lay their eggs in other birds, nests. If the ... take their revenge by destroying the entire nest. Consequently, it ...
(Date:4/17/2014)... in France have hit on a novel method ... the correct and most effective treatment possible., Kidney ... western and developing world. If left untreated, apart ... renal failure and other complications. In many patients ... Clearly a more effective pathological approach to diagnosis ...
Breaking Biology News(10 mins):Fear of the cuckoo mafia 2Fear of the cuckoo mafia 3
... robust, efficient method of using hydrogen as a fuel source. ... converted to electricity in a fuel cell and because it is ... a gas, it can only be stored in high pressure or ... of hydrogen, "if you got into a wreck, you,d have a ...
... serve remote areas of the world, doctors, nurses and ... relatively inexpensive. Now researchers at the University of ... light-weight, dual-mode microscope that uses holograms instead of lenses. ... published today in the Optical Society,s (OSA) open-access journal ...
... environmental advocates are excited about the prospect of gaining ... like miscanthus or switchgrass rather than corn. ... but one key factor of agriculture has been overlooked: ... energy through bioenergy crops, dependence on water gets ignored, ...
Cached Biology News:Microscope on the go: Cheap, portable, dual-mode microscope uses holograms, not lenses 2Microscope on the go: Cheap, portable, dual-mode microscope uses holograms, not lenses 3Testing the water for bioenergy crops 2
(Date:1/15/2014)... TaiGen Biotechnology Company, Limited ("TaiGen") today announced that they ... Russian pharmaceutical company, to develop and commercialize nemonoxacin (Taigexyn ... , Turkey and other members ... antibiotic for the treatment of bacterial infections including those ...
(Date:1/14/2014)... , Jan. 14, 2014 As pet owners drew up ... many of them wrote: "Take better care of my furry companion." ... designer clothes and top-brand carrying cases to take the little canine ... might also feel compelled to buy some pricey toys at the ...
(Date:1/14/2014)... 2014 In recent years, growing suspicion ... in product development and promotion has led to unprecedented ... fueled by concerns about the insidious impact of commercialization ... spectacular fines to the world’s biggest pharmas for illegal ...
(Date:1/14/2014)... Kerr Corporation, a leading manufacturer of innovative dental products, has ... arch impressions on its dental blog. , Titled ... serves up a list of tips to help dentists best ... David Little as he crafts a porcelain crown using Kerr’s ...
Breaking Biology Technology:TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3
... /PRNewswire-FirstCall/ - Oncothyreon Inc. (Nasdaq: ONTY ... data demonstrating the effectiveness of Oncothyreon,s PX-866 in ... were presented earlier today by William D. Hardie, ... Center, Cincinnati, Ohio, at the American Thoracic Society ...
... Cumberland Pharmaceuticals announced today the launch of ... Acetadote (acetylcysteine) Injection , the company,s ... http://www.newscom.com/cgi-bin/prnh/20090518/CL18638 )Available at ... hospital pharmacists and physicians, educators and other healthcare ...
... Biologic,Products, Inc. (OTC Bulletin Board: CBPO) ("China Biologic," or ... the People,s,Republic of China ("PRC"), reported strong financial results ... First Quarter 2009 Highlights, -- ... -- Gross profit increased 153.1% to ...
Cached Biology Technology:Oncothyreon's PX-866 is effective in preclinical model of pulmonary fibrosis 2Oncothyreon's PX-866 is effective in preclinical model of pulmonary fibrosis 3Cumberland Pharmaceuticals Provides Hospital In-Service Webcast for Acetadote(R) 2Cumberland Pharmaceuticals Provides Hospital In-Service Webcast for Acetadote(R) 3China Biologic Products Announces Strong First Quarter 2009 Results 2China Biologic Products Announces Strong First Quarter 2009 Results 3China Biologic Products Announces Strong First Quarter 2009 Results 4China Biologic Products Announces Strong First Quarter 2009 Results 5China Biologic Products Announces Strong First Quarter 2009 Results 6China Biologic Products Announces Strong First Quarter 2009 Results 7China Biologic Products Announces Strong First Quarter 2009 Results 8China Biologic Products Announces Strong First Quarter 2009 Results 9China Biologic Products Announces Strong First Quarter 2009 Results 10China Biologic Products Announces Strong First Quarter 2009 Results 11China Biologic Products Announces Strong First Quarter 2009 Results 12China Biologic Products Announces Strong First Quarter 2009 Results 13China Biologic Products Announces Strong First Quarter 2009 Results 14
... high quality whole genome sequencing service. Our ... allow even the smallest of laboratories to ... features which set our whole genome sequencing ... strategies, proprietary assembly software, rapid project turnaround ...
Great for biotinylating DNA/RNA probes...
... polyclonal antibody to human XAB2 (amino terminus) ... identified through its interaction with XPA. Immunoprecipitation ... of XAB2 interacts with the transcription-coupled repair-specific ... with RNA polymerase II. Microinjection experiments with ...
... The Bio-Plex maintenance, calibration, ... is a custom 96-well plate ... validation, and calibration procedures using ... This MCV plate is for ...
Biology Products: