Navigation Links
Machine preservation may promote more organ sharing

Preserving the kidneys of deceased older donors on a pump ?as opposed to the conventional method of storing and transporting organs in a cooler ?may lower hospital costs, improve initial organ function, and promote greater use and more sharing of organs, according to new research by Wake Forest University Baptist Medical Center.

"By placing kidneys on a portable pump, preservation times can be safely extended to permit more time for sharing organs across the country," said Robert Stratta, M.D., lead researcher of the study, which is reported in the May issue of the Journal of the American College of Surgeons.

In addition, Stratta said, the pump can be used to project the kidney’s initial function ?allowing for more appropriate matching of donor organs and recipients.

While machine preservation, or pulsatile perfusion, is not new, it is not widely used because it is more costly and labor-intensive. According to the United Network for Organ Sharing, only 21 percent of kidneys from deceased donors are preserved on a pump.

The purpose of this study was to compare outcomes in kidney transplant patients receiving kidneys from older deceased donors based on whether organs were preserved by pump or cold storage.

"The critical organ shortage poses a challenge to optimize the use and function of all organs from deceased donors," said Stratta, explaining why it is important to compare the two methods of preservation.

With machine preservation, donated organs are connected to a portable pump to maintain a constant flow of a specialized preservation solution through the organs until transplantation. With both methods of preservation, a cooling solution is pumped into the organs during organ recovery. However, with simple cold storage, the kidneys are simply immersed in preservation solution and packed on ice until transplant.

The study involved organs from "expanded criteria" donors (ECDs). This category was cre ated by UNOS in 2002 so that higher risk donor organs, once considered unsuitable, could be transplanted safely. The category includes kidneys from deceased donors over age 60 years or those over age 50 with health conditions such as high blood pressure, stroke or elevated levels of a protein called creatinine. Levels of creatinine, which is produced by muscle, are used to determine kidney function.

The current study included 120 ECD kidney transplants -- 95 kidneys were preserved with machine and 25 with simple cold storage preservation techniques.

Despite the fact that the machine-preserved kidneys were out of the body for a longer period of time (a mean of 24 hours versus 19 hours for the cold stored organs), both groups of recipients had similar survival and functional outcomes. In addition, the patients receiving machine-preserved kidneys had a 50 percent reduction in the rates of viral infections and delayed graft function, which is the inability of the kidneys to start working on their own without dialysis.

"The routine use of machine preservation for ECD kidneys may lower hospital costs by reducing complications," said Stratta. "In addition, it may promote more sharing of organs; it is a superior means of preserving organs out of body and provides a way to assess the viability of the organ."

Stratta said machine preservation has played an important role in the Medical Center’s success transplanting kidneys at the outer limits of the ECD acceptance criteria, such as organs donated after cardiac death, preserved for more than 30 hours, or from donors over age 70. In previous studies with up to four years of follow-up data, Stratta has shown that success rates with these organs are equivalent to those of conventional donors, in part because of appropriate donor and recipient matching through using the pump to assess viability and function.

Source:Wake Forest University Baptist Medical Center

Related biology news :

1. Machinery of the marijuana munchies
2. Slow-frozen people? Latest research supports possibility of cyropreservation
3. New technology addresses female fertility preservation
4. Whole genome promoter mapping - Human Genome Project v2.0?
5. New insight into autoimmune disease: Bacterial infections promote recognition of self-glycolipids
6. Prostate cancer uses Wnt signaling proteins to promote growth of bone tumors
7. Have a taste for fat? Yes! A sensor in the mouth promotes preference for fatty foods
8. Texas scientists discover how a hepatitis C protein promotes liver cancer
9. New antimicrobial compound adheres to skin to promote healing
10. A Jekyll and Hyde of cytokines: IL-25 both promotes and limits inflammatory diseases
11. Free-radical busting antioxidants might not promote healthy hearts

Post Your Comments:

(Date:4/28/2016)... First quarter 2016:   , Revenues amounted to ... of 2015 The gross margin was 49% (27) ... operating margin was 40% (-13) Earnings per share rose ... was SEK 249.9 M (21.2) , Outlook   ... The operating margin for 2016 is estimated to exceed ...
(Date:4/15/2016)... CHICAGO , April 15, 2016  A ... companies make more accurate underwriting decisions in a ... offering timely, competitively priced and high-value life insurance ... health screenings. With Force Diagnostics, rapid ... and lifestyle data readings (blood pressure, weight, pulse, ...
(Date:3/31/2016)... , March 31, 2016 ... ) ("LegacyXChange" or the "Company") LegacyXChange is ... users of its soon to be launched online site ... ) will also provide potential shareholders ... of DNA technology to an industry that is notorious ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Apellis ... Phase 1 clinical trials of its complement C3 ... single and multiple ascending dose studies designed to ... (PD) of subcutaneous injection in healthy adult volunteers. ... (SC) either as a single dose (ranging from ...
(Date:6/23/2016)... -- On Wednesday, June 22, 2016, the NASDAQ ... Dow Jones Industrial Average edged 0.27% lower to finish at ... has initiated coverage on the following equities: Infinity Pharmaceuticals ... NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ARLZ ... Learn more about these stocks by accessing their free trade ...
(Date:6/23/2016)... ... June 23, 2016 , ... Velocity Products, a division of ... and optimized exclusively for Okuma CNC machining centers at The International Manufacturing Technology ... among several companies with expertise in toolholding, cutting tools, machining dynamics and distribution, ...
(Date:6/22/2016)... SAN DIEGO , June 22, 2016 /PRNewswire/ ... partnership that will allow them to produce up ... (HiPSC) from one lot within one week. These ... their time laboriously preparing cells and spend more ... made possible through a proprietary, high-volume manufacturing process ...
Breaking Biology Technology: