Navigation Links
MUHC scientists describe genetic resistance to rampant virus

MUHC researchers have defined genetic resistance to the widespread virus, cytomegalovirus (CMV)--a member of the viral group that causes some of the world's most prevalent diseases, such as herpes, chicken pox and mononucleosis. The groundbreaking research published in Nature Genetics last week, provides a roadmap for the development of human therapies for CMV, which could prolong the life of HIV patients and improve the success of transplant surgery by reducing the risk of rejection. There is currently no treatment or cure for CMV.

Resistance to diseases like CMV depends, at least partially, on the ability of our body's defense mechanism to recognize and destroy them. "Detecting these pathogens is not always easy," says Dr. Silvia Vidal, a Canada Research Chair in Host Response to Virus Infection based at the MUHC and lead author of the new research. "CMV has developed cunning disguises to avoid detection by our Natural Killer cells--one of several cell types that hunt-down and terminate unwelcome invaders within our body." Our Natural Killer cells and the pathogens they fight have been locked in an evolutionary arms race for millions of years in an attempt to overwhelm each other.

Dr. Vidal and her team have spent the past 10 years studying CMV-resistant mouse strains in an attempt to describe the nature of their genetic resistance. "This research marks our second discovery of genetic resistance to CMV," she says. Most significantly, this new research documents an entirely new mechanism of resistance to CMV, involving the interaction between two genes. One gene flags virus-infected cells for destruction, the other gene allows our Natural Killers cells to recognize and terminate them. "This is a new concept in natural disease resistance," notes Dr. Vidal. "Our research suggests there are many different mechanisms for fighting viruses; in the future we expect to discover additional resistant genotypes."

CMV infects most of the world's organism
'"/>

Source:McGill University


Page: 1 2

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
3. UAB scientists discover the origin of a mysterious physical force
4. Fox Chase Cancer Center scientists identify immune-system mutation
5. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
6. U-M scientists find genes that control growth of common skin cancer
7. UCLA scientists transform HIV into cancer-seeking missile
8. RNA project to create language for scientists worldwide
9. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
10. To control germs, scientists deploy tiny agents provocateurs
11. Leprosy microbes lead scientists to immune discovery
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: MUHC scientists describe genetic resistance rampant virus

(Date:4/2/2015)... -- According to preliminary estimates Fingerprint Cards, ... than 125 MSEK. This exceeds the guidance provided by ... for Q1 2015 would be in line with the ... The operating result for the first quarter is estimated ... will as previously communicated be published on May 21. ...
(Date:3/31/2015)...   Guidepoint , a leading global research services ... Management TRACKER, part of the Guidepoint TRACKER ... medical device and therapeutics markets. The Post-Surgical Pain Management ... market share, and adoption rates across three major modalities ... The Post-Surgical Pain Management TRACKER will provide ...
(Date:3/24/2015)... WASHINGTON , March 24, 2015   NexID ... applications with critical security-authentication needs, today announced the beginning ... fake-finger-detection (FFD) solution. The company, based in ... announcement at the three-day Connect:ID Expo, which began here ... NexID said version 2.0 of its SDK boosts ...
Breaking Biology News(10 mins):Fingerprint Cards Revises Revenues for Q1 2015 2Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2
... representatives of the tropical fish known as swordtail characins have ... on a fishing rod would. What,s more, a study reported ... Cell Press publication, shows just what any good fly-fisherman would ... fish most often eat. For some characins in the study, ...
... release is available in German . , It ... defects. This is because the development of the heart in the ... also error-prone. Scientists from the Max Planck Institute for Heart and ... that plays a central role in regulating the function of stem ...
... commonly used to convert chemical energy to electricity is made ... University argues. Rather than continue the futile effort to tweak ... Chemistry Professor Alfred Anderson urges his colleagues to start anew. ... system," he said. Anderson freely acknowledges he doesn,t know what ...
Cached Biology News:Male sex ornaments are fishing lures, literally 2Finished heart switches stem cells off 2Finished heart switches stem cells off 3Platinum is wrong stuff for fuel cells 2
(Date:5/5/2015)... SAN DIEGO , May 5, 2015 /PRNewswire/ ... today announced that David R. Parkinson , ... (NEA), has been appointed to the board of ... twenty years of experience in oncology clinical development, ... that resulted in global approvals of the cancer ...
(Date:5/5/2015)... 2015 GEA Pharma Systems, G-CON ... recipients of the INTERPHEX Exhibitor Awards for 2015 ... Portable, Continuous, Miniature and Modular (PCMM) platform. PCMM ... continuous processing equipment, smart control systems and PODs ... and inactive ingredients into bulk tablets. , ...
(Date:5/5/2015)... CA (PRWEB) May 05, 2015 Synedgen ... Nguyen, PhD as Regulatory Affairs Manager. , Dr. Nguyen ... an important juncture for the company as it moves ... drug products over the next two years. Dr. Nguyen ... of all the regulatory key documents that must be ...
(Date:5/4/2015)... , May 4, 2015 Many of ... But for certain infants with rare, inherited mutations ... stark consequences of their impaired immune responses. ... have identified an important role for calcium signaling ... Mycobacterium tuberculosis, the bacterium causing tuberculosis (TB). ...
Breaking Biology Technology:Tocagen Appoints David R. Parkinson, M.D., to the Board of Directors 2Tocagen Appoints David R. Parkinson, M.D., to the Board of Directors 3Tocagen Appoints David R. Parkinson, M.D., to the Board of Directors 4GEA Pharma Systems, G-CON Manufacturing and Pfizer Consortium Receives Best Technology Innovation Award at INTERPHEX 2015 2GEA Pharma Systems, G-CON Manufacturing and Pfizer Consortium Receives Best Technology Innovation Award at INTERPHEX 2015 3Synedgen Announces the Appointment of Regulatory Affairs Manager 2Researchers Discover A Novel And Unexpected Role For Calcium In Controlling Inflammation During Chronic Lung Infection 2Researchers Discover A Novel And Unexpected Role For Calcium In Controlling Inflammation During Chronic Lung Infection 3
... and Taq DNA Polymerases ,,,, pfuturbo DNA ... amplification , , Holly Hogrefe ... this update, we compare the PCR performances of ... polymerase. ,PCR product yields were higher (>3-kb ...
... Over 145,000 human cDNA clones arrayed for nucleic acid screening , ... de Leon Bruce Jerpseth , ... Stratagene has organized over 145,000 high-quality clones from a universal ... in 29 different human tissues. , This ...
... for Eagle Eye II still video system ... Coomassie ,Brilliant Blue Dye , Michelle Cayouette ... provides an optical bandpass filter with all Eagle,Eye ... visualizing,ethidium bromide fluorescence. However, a single filter specifically designed,for ...
Cached Biology Technology:PCR Performance Comparisons Between pfuturbo and Taq DNA,Polymerases 2PCR Performance Comparisons Between pfuturbo and Taq DNA,Polymerases 3PCR Performance Comparisons Between pfuturbo and Taq DNA,Polymerases 4Human Universal cDNA Library Array I 2Human Universal cDNA Library Array I 3Human Universal cDNA Library Array I 4Human Universal cDNA Library Array I 5Human Universal cDNA Library Array I 6Human Universal cDNA Library Array I 7Optimized Imaging of Protein Gels Stained with Coomassie,Brilliant Blue Dye 2Optimized Imaging of Protein Gels Stained with Coomassie,Brilliant Blue Dye 3Optimized Imaging of Protein Gels Stained with Coomassie,Brilliant Blue Dye 4
... tumor cells of embryonal carcinoma of testis and ... tumors like seminoma. Glandular epithelium of yolk sac ... endocrine cells of stomach and acini cells of ... Epitope: Carbohydrate portion on human embryonal ...
TP-1 (NDOG1)...
Ras-related C3 botulinum toxin substrate 1...
Mouse monoclonal [6G11] to Cytohesin 1 + 2 ( Abpromise for all tested applications)....
Biology Products: