Navigation Links
MUHC scientists describe genetic resistance to rampant virus

MUHC researchers have defined genetic resistance to the widespread virus, cytomegalovirus (CMV)--a member of the viral group that causes some of the world's most prevalent diseases, such as herpes, chicken pox and mononucleosis. The groundbreaking research published in Nature Genetics last week, provides a roadmap for the development of human therapies for CMV, which could prolong the life of HIV patients and improve the success of transplant surgery by reducing the risk of rejection. There is currently no treatment or cure for CMV.

Resistance to diseases like CMV depends, at least partially, on the ability of our body's defense mechanism to recognize and destroy them. "Detecting these pathogens is not always easy," says Dr. Silvia Vidal, a Canada Research Chair in Host Response to Virus Infection based at the MUHC and lead author of the new research. "CMV has developed cunning disguises to avoid detection by our Natural Killer cells--one of several cell types that hunt-down and terminate unwelcome invaders within our body." Our Natural Killer cells and the pathogens they fight have been locked in an evolutionary arms race for millions of years in an attempt to overwhelm each other.

Dr. Vidal and her team have spent the past 10 years studying CMV-resistant mouse strains in an attempt to describe the nature of their genetic resistance. "This research marks our second discovery of genetic resistance to CMV," she says. Most significantly, this new research documents an entirely new mechanism of resistance to CMV, involving the interaction between two genes. One gene flags virus-infected cells for destruction, the other gene allows our Natural Killers cells to recognize and terminate them. "This is a new concept in natural disease resistance," notes Dr. Vidal. "Our research suggests there are many different mechanisms for fighting viruses; in the future we expect to discover additional resistant genotypes."

CMV infects most of the world's organism
'"/>

Source:McGill University


Page: 1 2

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
3. UAB scientists discover the origin of a mysterious physical force
4. Fox Chase Cancer Center scientists identify immune-system mutation
5. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
6. U-M scientists find genes that control growth of common skin cancer
7. UCLA scientists transform HIV into cancer-seeking missile
8. RNA project to create language for scientists worldwide
9. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
10. To control germs, scientists deploy tiny agents provocateurs
11. Leprosy microbes lead scientists to immune discovery
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: MUHC scientists describe genetic resistance rampant virus

(Date:12/3/2014)... As part of our commitment to offering ... to announce the release of a new reader that ... workforce data that they need. The Atlas ... existing readers. Many such devices have serious shortcomings when ... Older models force users to navigate numerous complicated steps ...
(Date:11/21/2014)... Nov. 20, 2014 C-Labs LLC, a leading ... of Things (IoT), today announced the appointment of ... officer. Previously a strategic advisor to the firm, Mr. ... Mr. Traynor is based out of the C-Labs office ... to Chris Muench , Chief Executive Officer. ...
(Date:11/18/2014)... Nov. 17, 2014 The Parenteral Drug Association (PDA) ... agencies will speak and at least seven more will participate ... the Omni Shoreham Hotel in Washington D.C. ... to have significant support from the regulatory agencies in ... in our effort to help advance the use ...
Breaking Biology News(10 mins):Inception Technologies to Release New Biometric Reader 2C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2
... issue of the Journal of Integrated Pest Management ... western bean cutworm (WBC), Striacosta albicosta (Smith), ... genetically engineered corn." The Greenpeace Germany report, which was ... "surprisingly simplistic conclusion" regarding the spread of western bean ...
... of the Bulletin of the Atomic Scientists , published ... look out for in 2012 in the areas of nuclear ... made the headlines during the previous 12 months, including the ... Fukushima incident, and the state of US policy on climate ...
... New research highlights the possibility of reversing ageing in the central ... published today, 06 January, in the journal Cell Stem Cell ... decreases. This is not only true for our skin (which ... also true for other tissues in the body, including the regenerative ...
Cached Biology News:Scientists refute Greenpeace claim that genetically modified corn caused new insect pest 2The nuclear, biological and climate threat - 2011 reviewed 2The nuclear, biological and climate threat - 2011 reviewed 3Hopes for reversing age-associated effects in MS patients 2
(Date:12/17/2014)... (PRWEB) December 17, 2014 Gene ... that it has entered into a technology access ... (ADM) to apply DNA2.0’s proprietary protein engineering technology, ... process. , “We are extremely excited that the ... platform. This proprietary bioengineering technology has now ...
(Date:12/17/2014)... SOUTH SAN FRANCISCO, Calif. , Dec. 17, ... positive results of a Phase 2 study evaluating ... for the treatment of patients with severe, chronic ... the current standard of care, including topical steroids ... endpoint was percent change in Visual Analog Scale ...
(Date:12/15/2014)...  GlassesOff Inc. (OTCBB: GLSO) announced today the appointment ... director of the Company,s Board of Directors. ... its CEO until its acquisition by Stanley Black ... Recognized as the inventor of the first Wi-Fi-based Active ... -based RFID solutions focused on improving operational efficiency, safety ...
(Date:12/13/2014)... (PRWEB) December 12, 2014 Clarassance, a ... announced its new name: Therabron Therapeutics , Inc. ... and bronchioles (a type of structure in the lungs ... company’s mission to develop novel protein therapeutics for the ... directors decided to change the name to mark the ...
Breaking Biology Technology:ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4AeroScout Founder Joins GlassesOff's Board of Directors 2AeroScout Founder Joins GlassesOff's Board of Directors 3Maryland-based Biotech Company's Path Forward in Treating Respiratory Diseases Sparks Name Change 2
... , WILMINGTON, Del. and ... AZN ) and the University of Virginia (UVa) in ... strategic research collaboration to enhance development of new treatments ... focus on peripheral vascular disease (PAD). , (Logo: ...
... , , , ... for Medical Publication Professionals (ISMPP) today announced that the professional ... Meeting, which is being held in Arlington, VA, April 19-21, ... encouraging non-members to join the organization to submit an abstract ...
... and LONDON, Dec. 15 Thomson ... the first drug pipeline database to fully integrate detailed clinical ... is being provided to all Thomson Pharma customers this month. ... related clinical trial intelligence from registries, publications, press releases, conferences, ...
Cached Biology Technology:AstraZeneca and the University of Virginia Sign Strategic Research Collaboration to Develop Novel Treatments for Cardiovascular Disease 2AstraZeneca and the University of Virginia Sign Strategic Research Collaboration to Develop Novel Treatments for Cardiovascular Disease 3The International Society for Medical Publication Professionals Announces Call for Abstracts for Its 6th Annual Meeting 2The International Society for Medical Publication Professionals Announces Call for Abstracts for Its 6th Annual Meeting 3Thomson Reuters is First to Offer Fully Integrated Pipeline and Clinical Trials 2
... T2-04 is an ultra-compact pump available in single ... and ideal for use in portable air and ... this pump works well in environments where DC ... compact size are critical., Offers ultra-compact size, ...
Curcumin is an extract of turmeric root with antioxidant, anti-tumor promoter, and anti-inflammatory properties. Curcumin inhibits the induction of NOS in macrophages....
Total Proteins from over 50 different human Alzheimer, Diabetic, Liver Cirrhosis, and Lupus diseased tissues are available....
... Lone Wolf valve has the highest performance ... available on the market. This VSO valve ... and ensures maximum accuracy., Achieves rapid, ... and patient comfort. , Maintains ideal flow ...
Biology Products: