Navigation Links
MUHC researchers make cancer target breakthrough

Researchers at the McGill University Health Centre (MUHC), in Montreal, have identified a new gene to combat cancer. In a new study, published in the on-line edition of the journal Clinical Cancer Research this week, the researchers document a reduction in the growth of both colon and lung cancer tumors with inhibition of the gene.

The new target gene is called methylenetetrahydrofolate reductase, or MTHFR. Researchers were able to inhibit the function of the gene by creating antisense--an exact opposite of a tiny section of the MTHFR gene. "MTHFR is involved in the synthesis of methionine--a critical nutrient necessary for growth of cancer cells," explains Dr. Rima Rozen, principal investigator of the new study, and Deputy Scientific Director of the MUHC Research Institute. "By inhibiting the gene's function, we were able to slow the growth of tumors."

Researchers found that the antisense reduced lung and colon cancer tumors in both laboratory-based tissue cultures and in mice. "Discovering that the antisense works in animal models is a major step forward, and gives us hope that this might also work in humans," explains Dr. Rozen.

The research, funded by Strida Pharma--a McGill University spin-off company--also indicated that the antisense was particularly effective in reducing cancer tumors when administered in low doses and in combination with established cancer drugs. "All drugs and antisense have some level of toxicity," says Dr. Rozen. "An antisense that works in harmony with other drugs, and in such low doses, is a significant breakthrough in cancer research."


'"/>

Source:McGill University


Page: 1

Related biology news :

1. NYU researchers simulate molecular biological clock
2. Vital step in cellular migration described by UCSD medical researchers
3. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
4. UCSD researchers maintain stem cells without contaminated animal feeder layers
5. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
6. New protein discovered by Hebrew University researchers
7. First real-time view of developing neurons reveals surprises, say Stanford researchers
8. Agilent Technologies releases automated literature search tool for biology researchers
9. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
10. Yale researchers identify molecule for detecting parasitic infection in humans
11. US life expectancy about to decline, researchers say
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/18/2016)... --> --> Competitive Landscape Analysis ... Physical infrastructure and Perimeter Surveillance & Detection Systems ... and the continuing migration crisis in the Middle ... led visiongain to publish this unique report, which is crucial ... & security companies in the border security market and the ...
(Date:3/14/2016)... 2016 NXTD ) ("NXT-ID" or the ... announces the airing of a new series of commercials on ... March 21 st .  The commercials will air on Bloomberg ... on the Street show. --> NXTD ) ("NXT-ID" ... commerce market, announces the airing of a new series of ...
(Date:3/10/2016)... , March 10, 2016 ... new market research report "Identity and Access Management Market ... Audit, Compliance, and Governance), by Organization Size, by Deployment, ... 2020", published by MarketsandMarkets, The market is estimated to ... 12.78 Billion by 2020, at a Compound Annual Growth ...
Breaking Biology News(10 mins):
(Date:4/29/2016)... ... April 29, 2016 , ... Amendia, Inc., ... surgical procedures, today announced the completion of a significant transaction and partnership that ... future customers and partners. Kohlberg & Company, L.L.C. (“Kohlberg”), a leading private ...
(Date:4/29/2016)... CA (PRWEB) , ... April 29, 2016 , ... Summit ... (NSCF) to support the development of a patient-specific stem cell therapy for the treatment ... the lab of Dr. Jeanne Loring at The Scripps Research Institute in San Diego, ...
(Date:4/28/2016)... PUNE, India , April 28, 2016 ... PT, JT, Stirling, and Brayton Cryocoolers), Service (Technical Support, ... Application, and Geography - Global Forecast to 2022", published ... to USD 2.94 Billion by 2022, at a CAGR ... Browse 70 market data Tables and 94 Figures spread ...
(Date:4/28/2016)... , ... April 28, 2016 , ... ... will deliver a talk on its first-in-class technologies for tissue stem cell ... Meeting on RNAiMicroRNA Biology to Reprogramming & CRISPR-based Genome Engineering in Burlington, ...
Breaking Biology Technology: