Navigation Links
MSKCC researchers uncover structure of key protein complex in cells

Scientists at Memorial Sloan-Kettering Cancer Center (MSKCC) have uncovered the structure of a network of proteins that help regulate the life cycle of cells. Understanding the network's physical layout is an important step toward learning its precise function, and in finding ways to correct flaws in the system that could lead to cancer.

Using x-ray crystallography, the researchers identified how one protein, a molecule called the Small Ubiquitin-related Modifier (SUMO-1), is connected or "conjugated" to another molecule within the complex. The findings, reported in the June 2, 2005, issue of Nature, offer the first complete look at the structure of these molecules as they are thought to exist in the cell.

"Understanding this process could be important in many physiological steps that are disrupted in cancer -- including error-prone DNA replication, chromosome segregation, the cell's response to stress, and normal signaling reactions," said Christopher Lima, PhD, a structural biologist at the Sloan-Kettering Institute and lead author of the study.

While there's no direct evidence that SUMO is important in cancer, research suggests that it is necessary for the normal assortment of chromosomes immediately before a cell splits. Yeast cells that lack SUMO cannot successfully divide, Dr. Lima noted.

Since cancer is characterized by cells dividing unchecked, proving SUMO's function could potentially yield novel anticancer therapies. "If sumoylation (when SUMO attaches to a protein) is promoting cell division, then inhibitors of SUMO may be a pretty good agent to block the cell cycle," said Dr. Lima.

Postdoctoral researcher David Reverter, PhD, collaborated with Dr. Lima on the work and is the first author on the Nature paper.

SUMO has been called a "mysterious cousin" of ubiquitin, a protein of increasing interest to cancer experts. The two molecules have remarkably similar structures, though they perform different tasks in c
'"/>

Source:Memorial Sloan-Kettering Cancer Center


Page: 1 2 3

Related biology news :

1. NYU and MSKCC research provides model for understanding chemically induced cancer initiation
2. NYU researchers simulate molecular biological clock
3. Vital step in cellular migration described by UCSD medical researchers
4. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
5. UCSD researchers maintain stem cells without contaminated animal feeder layers
6. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
7. New protein discovered by Hebrew University researchers
8. First real-time view of developing neurons reveals surprises, say Stanford researchers
9. Agilent Technologies releases automated literature search tool for biology researchers
10. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
11. Yale researchers identify molecule for detecting parasitic infection in humans
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: MSKCC researchers uncover structure key protein complex cells

(Date:8/5/2015)... August 5, 2015 According to ... Management Market by Software, Services, Vertical (BFSI, Airport, IT & ... - Global Forecast to 2020", published by MarketsandMarkets, defines ... globally into various segments. The global PIAM Market is ... $546.2 Million by 2019, at a CAGR of 14.9 ...
(Date:8/4/2015)... 4, 2015  AMRI (NASDAQ: AMRI ) today reported financial ... Highlights: , Second quarter contract revenue of ... , Adjusted contract margins of 26 ... including a $0.05 decrease in EPS from royalties in the current ... "We are very pleased to present another strong ...
(Date:7/31/2015)... China , 31 de julho de 2015 /PRNewswire/ ... (ICG-10, www.icg-10.org ) será realizada pela BGI de 22-25 ... . A conferência está celebrando seu ... em 2006, a ICG se tornou uma das reuniões ... um dos encontros científicos mais dinâmicos, entusiastas e prazerosos. ...
Breaking Biology News(10 mins):Physical Identity and Access Management Market Worth $546.2 Million by 2019 2Physical Identity and Access Management Market Worth $546.2 Million by 2019 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 4AMRI Announces Second Quarter 2015 Results 2AMRI Announces Second Quarter 2015 Results 3AMRI Announces Second Quarter 2015 Results 4AMRI Announces Second Quarter 2015 Results 5AMRI Announces Second Quarter 2015 Results 6AMRI Announces Second Quarter 2015 Results 7AMRI Announces Second Quarter 2015 Results 8AMRI Announces Second Quarter 2015 Results 9AMRI Announces Second Quarter 2015 Results 10AMRI Announces Second Quarter 2015 Results 11AMRI Announces Second Quarter 2015 Results 12AMRI Announces Second Quarter 2015 Results 13AMRI Announces Second Quarter 2015 Results 14AMRI Announces Second Quarter 2015 Results 15AMRI Announces Second Quarter 2015 Results 16AMRI Announces Second Quarter 2015 Results 17AMRI Announces Second Quarter 2015 Results 18AMRI Announces Second Quarter 2015 Results 19AMRI Announces Second Quarter 2015 Results 20AMRI Announces Second Quarter 2015 Results 21AMRI Announces Second Quarter 2015 Results 22AMRI Announces Second Quarter 2015 Results 23AMRI Announces Second Quarter 2015 Results 24A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3
... Based on Animal Protein May Increase Death Risk ... loss and improves some cardiovascular risk factors. However, health ... type of protein and fat consumed. Researchers followed 85,168 ... 26 and 20 years respectively. The patients ate either ...
... under pressurebut they consume parts of themselves. A multi-function protein ... in the September 6 issue of the Journal of Cell ... or stress by digesting some of their contents. The process, ... trash such as worn-out organelles and misshapen proteins. A team ...
... cells that act in their own interests and ... actually reduce the severity of infection. ... be exploited to treat antibiotic-resistant infections, according to ... Microbiology,s autumn meeting today. Bacteria work together ...
Cached Biology News:Embargoed news from Annals of Internal Medicine 2Backstabbing bacteria: A new treatment for infection? 2
(Date:9/3/2015)... , Sept. 3, 2015  Guardant Health®, ... five abstracts highlighting the performance and clinical utility ... accepted for oral and poster presentations at the ... 16th World Conference on Lung Cancer. These abstracts ... University of California, Davis; the University of Chicago; ...
(Date:9/3/2015)... SAN DIEGO , Sept. 3, 2015 /PRNewswire/ ... factors, and a recent spinout of Stemedica Cell ... Thomas H. Silberg as CEO of StemProtein. ... technology for producing and preserving Stem Cell Factors ... is a seasoned professional in the pharmaceutical and biopharmaceutical ...
(Date:9/3/2015)... ... September 03, 2015 , ... Michigan-based technology startup ... early 2016. , The device, called the Halo H1, is a wearable ... sensing technology. These sensors track trending interstitial fluid levels in the body, in ...
(Date:9/2/2015)... Sept. 2, 2015 Research and ... addition of Jain PharmaBiotech,s new report ... their offering. An increasing ... biotechnology industries is anticipated. Nanotechnology will be ... - from formulations for optimal delivery to ...
Breaking Biology Technology:Leading Cancer Centers to Present Clinical Utility Data For Guardant360 At IASLC's 16th World Conference on Lung Cancer in Denver Sept. 6-9 2Leading Cancer Centers to Present Clinical Utility Data For Guardant360 At IASLC's 16th World Conference on Lung Cancer in Denver Sept. 6-9 3Leading Cancer Centers to Present Clinical Utility Data For Guardant360 At IASLC's 16th World Conference on Lung Cancer in Denver Sept. 6-9 4StemProtein Names Thomas H. Silberg As CEO, To Focus On Stem Cell Secreted Proteins Addresing A Variety Of Health And Beauty Related Needs 2StemProtein Names Thomas H. Silberg As CEO, To Focus On Stem Cell Secreted Proteins Addresing A Variety Of Health And Beauty Related Needs 3Technology Startup Halo Wearables to Unveil Non-Invasive Hydration Monitoring Device Early 2016 2Global Nanobiotechnology Applications, Markets and Companies Report 2015-2024 2Global Nanobiotechnology Applications, Markets and Companies Report 2015-2024 3
... Inc.,(OTC Bulletin Board: NGNM) announced today that President ... the Rodman & Renshaw,10th Annual Healthcare Conference being ... Palace Hotel in New York City. The conference ... sciences and biotech companies.,Gasparini and other senior executives ...
... (Nasdaq: HGSI ) announced today that its presentation ... and may be accessed at, http://www.hgsi.com ., (Logo: ... Genome Sciences, senior management team will present,a corporate overview ... Time., Investors interested in listening to the live ...
... Nov. 7 Dendreon Corporation (Nasdaq:,DNDN) today reported results ... third quarter of 2008 was $26,000 compared to $112,000 ... nine months ended,September 30, 2008 was $83,000 compared to ... Dendreon,s total operating expenses for the third quarter of ...
Cached Biology Technology:NeoGenomics to Present at the Rodman & Renshaw Healthcare Conference on November 10 2Dendreon Reports Third Quarter 2008 Financial Results 2Dendreon Reports Third Quarter 2008 Financial Results 3Dendreon Reports Third Quarter 2008 Financial Results 4Dendreon Reports Third Quarter 2008 Financial Results 5
Anti-ADAM-12 (Meltrin Alpha); amino terminal region; rabbit host...
Mouse monoclonal [3G8] to MDMA ( Abpromise for all tested applications)....
Fluorescein isothiocyanate (FITC) mouse anti-human IFN-alpha2 25 tests...
Rabbit Anti-melatonin (different linkage) Polyclonal Antibody...
Biology Products: