Navigation Links
MSKCC researchers uncover structure of key protein complex in cells

Scientists at Memorial Sloan-Kettering Cancer Center (MSKCC) have uncovered the structure of a network of proteins that help regulate the life cycle of cells. Understanding the network's physical layout is an important step toward learning its precise function, and in finding ways to correct flaws in the system that could lead to cancer.

Using x-ray crystallography, the researchers identified how one protein, a molecule called the Small Ubiquitin-related Modifier (SUMO-1), is connected or "conjugated" to another molecule within the complex. The findings, reported in the June 2, 2005, issue of Nature, offer the first complete look at the structure of these molecules as they are thought to exist in the cell.

"Understanding this process could be important in many physiological steps that are disrupted in cancer -- including error-prone DNA replication, chromosome segregation, the cell's response to stress, and normal signaling reactions," said Christopher Lima, PhD, a structural biologist at the Sloan-Kettering Institute and lead author of the study.

While there's no direct evidence that SUMO is important in cancer, research suggests that it is necessary for the normal assortment of chromosomes immediately before a cell splits. Yeast cells that lack SUMO cannot successfully divide, Dr. Lima noted.

Since cancer is characterized by cells dividing unchecked, proving SUMO's function could potentially yield novel anticancer therapies. "If sumoylation (when SUMO attaches to a protein) is promoting cell division, then inhibitors of SUMO may be a pretty good agent to block the cell cycle," said Dr. Lima.

Postdoctoral researcher David Reverter, PhD, collaborated with Dr. Lima on the work and is the first author on the Nature paper.

SUMO has been called a "mysterious cousin" of ubiquitin, a protein of increasing interest to cancer experts. The two molecules have remarkably similar structures, though they perform different tasks in c
'"/>

Source:Memorial Sloan-Kettering Cancer Center


Page: 1 2 3

Related biology news :

1. NYU and MSKCC research provides model for understanding chemically induced cancer initiation
2. NYU researchers simulate molecular biological clock
3. Vital step in cellular migration described by UCSD medical researchers
4. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
5. UCSD researchers maintain stem cells without contaminated animal feeder layers
6. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
7. New protein discovered by Hebrew University researchers
8. First real-time view of developing neurons reveals surprises, say Stanford researchers
9. Agilent Technologies releases automated literature search tool for biology researchers
10. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
11. Yale researchers identify molecule for detecting parasitic infection in humans
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: MSKCC researchers uncover structure key protein complex cells

(Date:6/30/2015)... NEW YORK , June 30, 2015 To ... biometric security provider HYPR Corp. announced today the addition of ... will serve as board advisor and David Raviv ... to the team underscore HYPR Corp.,s commitment to providing the ... , Dimitri Sirota co-founded Layer 7 Technologies, a ...
(Date:6/29/2015)... Research and Markets( http://www.researchandmarkets.com/research/zj7h4f/latin_america ) has ... Sensors Market - Growth, Trends & Forecasts (2014-2020)" ... Biomedical Sensors market is estimated at $0.65 billion by ... 2014-2020 The near future will bring Biomedical ... each individual. These sensors can be set to trigger ...
(Date:6/25/2015)... 2015 According to a ... & Area), Technology, Material (Optical Prism, Piezoelectric, Capacitive ... & Others) & Geography - Global Forecast to ... market is expected to reach $14,500.07 Million by ... Browse 76 market Tables and 109 Figures ...
Breaking Biology News(10 mins):HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 2HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 3Latin America Biomedical Sensors Market Report 2015-2020 2Fingerprint Sensors Market Worth $14,500.07 Million by 2020 2Fingerprint Sensors Market Worth $14,500.07 Million by 2020 3Fingerprint Sensors Market Worth $14,500.07 Million by 2020 4
... Mich. Bacteria in hyenas, scent glands may be ... in the current issue of Scientific Reports , ... clans and the distinct microbial communities that reside in ... author and Michigan State University postdoctoral researcher. "A ...
... - August 30, 2012 Captivated by a strange ... plant, researchers at Harvard University have characterized a new ... and stiff when pulled strongly. Instead of unwinding ... coil normally would, the cucumber,s tendrils actually coil further. ...
... German . The analyses of an international ... Planck Institute for Evolutionary Anthropology in Leipzig, Germany, show that ... although they were present in large parts of Asia, their ... addition, a comprehensive list documents the genetic changes that set ...
Cached Biology News:Microbes help hyenas communicate via scent 2Uncoiling the cucumber's enigma 2Uncoiling the cucumber's enigma 3Uncoiling the cucumber's enigma 4Uncoiling the cucumber's enigma 5Ancient genome reveals its secrets 2
(Date:7/29/2015)... 29, 2015 Research ... addition of the "Global Biosimilars Market, 2015 ... The Global Biosimilars Market, 2015 - 2025, ... growing biosimilars market. With the blockbuster biologics losing ... costs, biosimilars are being viewed as viable substitutes ...
(Date:7/29/2015)...  AmnioChor Inc., an early stage biotech startup based ... announce that the Musculoskeletal Transplant Foundation of ... their seed round of development of the proprietary AmnioCept™ ... AmnioChor,s technology allows cryopreservation of the amniotic ... living within those tissues. Amnion is a well-established source ...
(Date:7/29/2015)... DIEGO , July 29, 2015  Pfenex Inc. ... 2015 financial results will be released on Thursday, August ... am Eastern Time, Pfenex management will host a conference ... business update.  A press release outlining the financial results ... the call. Please call 1-866-376-8058 (US) or ...
(Date:7/29/2015)... ... July 29, 2015 , ... The third Medical Innovation Impact Index (MI3) Alert ... particular, drug/device combinations. The current system received a score of 0 (range -10 to ... Innovation (iPCI) of Fairleigh Dickinson University’s ( FDU ) Rothman Institute of Innovation ...
Breaking Biology Technology:Global Biosimilars Market to 2025: Monoclonal Antibodies (mAbs), Insulin, Interferons, G-CSF/ GM-CSF, Erythropoietins and Others 2Global Biosimilars Market to 2025: Monoclonal Antibodies (mAbs), Insulin, Interferons, G-CSF/ GM-CSF, Erythropoietins and Others 3The Musculoskeletal Transplant Foundation Agrees to Invest in AmnioChor 2Pfenex To Report Second Quarter 2015 Results and Provide Business Update on Thursday, August 13, 2015 2Third Medical Innovation Impact Index Issued by Fairleigh Dickinson University’s Initiative for Patient-Centered Innovation (iPCI) 2Third Medical Innovation Impact Index Issued by Fairleigh Dickinson University’s Initiative for Patient-Centered Innovation (iPCI) 3
... Third Sequential Profitable Quarter -- -- Conference ... --, BEIJING, March 31 /Xinhua-PRNewswire/ -- Sinovac Biotech Ltd. ... unaudited,financial results for the three months and twelve months ended ... year 2007 sales of $33.5 million, up 118% year-over-year ...
... and WOODCLIFF LAKE, N.J., March 28 Eisai ... "Eisai") today,announced that the United States District Court ... Eisai,s favor with respect to Eisai,s motion for ... Teva,Pharmaceuticals and its division Gate Pharmaceuticals (collectively,"Teva"), concerning ...
... Corp. (Nasdaq: MEMY ) today reported that ... explanatory,paragraph in their opinion on the Company,s financial ... Form 10-K for the year ended,December 31, 2007, ... a going,concern. The Company discusses this matter, including ...
Cached Biology Technology:Sinovac Reports Fourth Quarter and Full Year 2007 Financial Results 2Sinovac Reports Fourth Quarter and Full Year 2007 Financial Results 3Sinovac Reports Fourth Quarter and Full Year 2007 Financial Results 4Sinovac Reports Fourth Quarter and Full Year 2007 Financial Results 5Sinovac Reports Fourth Quarter and Full Year 2007 Financial Results 6Sinovac Reports Fourth Quarter and Full Year 2007 Financial Results 7Sinovac Reports Fourth Quarter and Full Year 2007 Financial Results 8Eisai is Granted Favorable Preliminary Injunction Ruling in Aricept(R) Patent Infringement Lawsuit Against Teva Pharmaceuticals 2Eisai is Granted Favorable Preliminary Injunction Ruling in Aricept(R) Patent Infringement Lawsuit Against Teva Pharmaceuticals 3Memory Pharmaceuticals Receives Audit Opinion Containing Going Concern Qualification 2
... This book is unique in that ... techniques currently used in the diagnosis ... virus-specific antibodies and clinical virus isolates. ... blotting and hybridization procedures, PCR for ...
...
... PureLink PCR Purification Kits provide rapid ... enzymes, short-failed PCR products, and salts from ... bind/wash/elute procedure:, provides two Binding Buffer ... bp* , can be performed in either ...
... Zero Blunt TOPO PCR Cloning Kit ... for high-efficiency (>=95%) cloning of blunt-end ... polymerases. The kit includes the linearized ... for 5-minute bench-top ligations without ligase ...
Biology Products: