Navigation Links
MRSA use amoeba to spread, new research shows

The MRSA 'superbug' evades many of the measures introduced to combat its spread by infecting a common single-celled organism found almost everywhere in hospital wards, according to new research published in the journal Environmental Microbiology.

Scientists from the University of Bath have shown that MRSA infects and replicates in a species of amoeba, called Acanthamoeba polyphaga, which is ubiquitous in the environment and can be found on inanimate objects such as vases, sinks and walls.

As amoeba produce cysts to help them spread, this could mean that MRSA maybe able to be 'blown in the wind' between different locations.

Further evidence from research on other pathogens suggests that by infecting amoeba first, MRSA may emerge more virulent and more resistant to antibiotics when it infects humans.

"Infection control policies for hospitals should recognise the role played by amoeba in the survival of MRSA, and evaluate control procedures accordingly," said Professor Mike Brown from the Department of Pharmacy and Pharmacology at the University of Bath.

"Until now this source of MRSA has been totally unrecognised. This is a non-patient source of replication and given that amoeba and other protozoa are ubiquitous, including in hospitals, they are likely to contribute to the persistence of MRSA in the hospital environment".

"Adding to the concern is that amoebal cysts have been shown to trap pathogens and could potentially be dispersed widely by air currents, especially when they are dry.

"Replication of MRSA in amoeba and other protozoa raises several important concerns for hospital hygiene."

In laboratory tests, the researchers found that within 24 hours of its introduction, MRSA had infected around 50 per cent of the amoeba in the sample, with 2 per cent heavily infected throughout their cellular content.

Evidence with other pathogens suggests that pathogens that emerge from amoeba are more resist ant to antibiotics and more virulent.

"This makes matters even more worrying," said Professor Brown.

"It is almost as though the amoeba act like a gymnasium; helping MRSA get fitter and become more pathogenic".

"In many ways this may reflect how this kind of pathogenic behaviour first evolved. A good example is the bacterium that causes legionnaires disease. Probably it was pathogenic long before humans and other animals arrived on the evolutionary scene. Even today, it has no known animal host".

"The most likely reason is that Legionella and many pathogens learned their pathogenicity after sparring with single-celled organisms like amoeba for millions of years. Because our human cells are very similar to these primitive, single-celled organisms, they have acquired the skills to attack us".

For these reasons, such primitive cells are being used to replace animals for many kinds of biological tests.

"Effective control of MRSA within healthcare environments requires better understanding of their ecology," said Professor Brown.

"We now need to focus on improving our understanding of exactly how MRSA is transmitted, both in hospitals and in the wider environment, to develop control procedures that are effective in all scenarios."

Recently released figures show that infections caused by MRSA rose 5 per cent between 2003 and 2004, and mortality rates increased 15-fold between 1993 and 2002.


'"/>

Source:University of Bath


Related biology news :

1. Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
2. Biologists determine genetic blueprint of social amoeba
3. Single cell amoeba increases MRSA numbers 1000- fold
4. Silence of the amoebae
5. Columbia research lifts major hurdle to gene therapy for cancer
6. U of M researcher examines newly emerging deadly disease
7. NYU researchers simulate molecular biological clock
8. First atlas of key brain genes could speed research on cancer, neurological diseases
9. New research questions basic tenet of neuron function
10. Vital step in cellular migration described by UCSD medical researchers
11. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/9/2016)... YORK , March 9, 2016 This ... and future states of the RNA Sequencing (RNA Seq) ... segments such as instruments, tools and reagents, data analysis, ... Analyze various segments of the RNA-Sequencing market such as ... services Identify the main factors affecting each segment and ...
(Date:3/8/2016)... 2016   Valencell , the leading innovator ... has secured $11M in Series D financing. The ... venture fund being launched by UAE-based financial services ... investors TDF Ventures and WSJ Joshua Fund. Valencell ... triple-digit growth and accelerate its pioneering innovation in ...
(Date:3/3/2016)... NOTTINGHAM, England and DE SOTO, ... , U.S.-based Stroke Detection Plus® to offer Oncimmune,s ... the risk assessment and early detection of lung cancer ... include large employers, unions and individuals. --> ... employers, unions and individuals. --> Oncimmune, a ...
Breaking Biology News(10 mins):
(Date:4/28/2016)... ... April 28, 2016 , ... ... an open house for regional manufacturers at its Maple Grove, Minnesota technical center, ... Hardinge Group, Chiron and Trumpf. Almost 20 leading suppliers of tooling, accessories, ...
(Date:4/27/2016)... 27, 2016 NanoStruck Technologies ... NSKQB) ( Frankfurt : 8NSK) gibt ... vom 13. August 2015 die Genehmigung von der ... zusätzliche 200.000.000 Einheiten auf 400.000.000 Einheiten zu erhöhen, ... Davon wurden 157.900.000 Einheiten mit dem ersten Teil ...
(Date:4/27/2016)... ... April 27, 2016 , ... ... PET (Positron Emission Tomography) and MRI (Magnetic Resonance Imaging) in existing third-party MRI ... testing novel treatments in small animal subjects. Simultaneous PET/MRI imaging offers a solution ...
(Date:4/26/2016)... ... April 27, 2016 , ... Cameron Cushman has ... associate in the firm’s Intellectual Property practice group. , Clients turn to Cushman ... He has an electrical engineering and computer engineering background, and experience in the ...
Breaking Biology Technology: