Navigation Links
MRSA toxin acquitted: Study clears suspected key to severe bacterial illness

ness much more severe than traditional hospital-associated MRSA infections, where PVL is less common. These life-threatening infections can affect vital organs and lead to widespread infection (sepsis), toxic shock syndrome and flesh-eating pneumonia. It is not known why some healthy people develop CA-MRSA skin infections that are treatable whereas others infected with the same strain develop severe infections or die.

Scientists had recognized a connection between MRSA strains that contain PVL and the increased occurrence and severity of CA-MRSA disease, though no one had directly tested the role of PVL in CA-MRSA virulence. In striving to learn more about CA-MRSA, the RML scientists, with their colleagues at the International Center for Public Health (ICPH) in Newark, NJ, and the Université Claude Bernard in Lyon, France, decided to test the PVL virulence theory, thinking that if they could understand the role of this toxin in disease, they could more quickly diagnose serious cases and develop effective treatments.

In addition to observing the destruction of human white blood cells regardless of whether PVL was present, the researchers also used mouse models to learn that CA-MRSA strains are just as pathogenic with or without PVL present. These findings were seen in tests with mice that displayed skin and soft-tissue infection and bacterial sepsis.

"The strains were just as deadly with or without the PVL toxin," says lead investigator Frank DeLeo, Ph.D., of RML. "Unexpectedly, the average abscess volume in mice infected with strains absent the PVL was slightly greater than those containing the toxin. The strong association between PVL and CA-MRSA makes the toxin an excellent marker to track community strains, but the assumption that it is the major virulence determinant driving this epidemic is simply not true."

These findings are significant because some infectious disease physicians who treat MRSA patients had begun questio
'"/>

Source:NIH/National Institute of Allergy and Infectious Diseases


Page: 1 2 3

Related biology news :

1. Defensins neutralize anthrax toxin
2. Green catalyst destroys pesticides and munitions toxins, finds Carnegie Mellon University
3. Tetanus toxin found to have therapeutic properties
4. Structures of marine toxins provide insight into their effectiveness as cancer drugs
5. Prenatal exposure to marine toxin causes lasting damage
6. UCSD study finds anthrax toxins also harmful to fruit flies
7. Scientists design potent anthrax toxin inhibitor
8. Anthrax inhibitor counteracts toxin, may lead to new therapeutics
9. Scientists reveal how deadly toxin hijacks cells
10. Scientists develop a way to make the deadliest toxin known even more toxic
11. Yale researchers find environmental toxins disruptive to hearing in mammals
Post Your Comments:
(Date:8/28/2014)... MARC (Maximizing Access to Research Careers) Program has ... Society of America,s 27th Annual Mouse Molecular Genetics ... in Pacific Grove, California. These awards are ... doctorates and scientists from underrepresented groups into the ... encourage the participation of young scientists at the ...
(Date:8/28/2014)... delivering compounds that could positively impact the ... be possible, thanks to researchers in Penn ... vaginal suppository made from the seaweed-derived food ... drug Tenofovir provides a woman-initiated, drug-delivery vehicle ... sexually transmitted infections during unprotected heterosexual intercourse, ...
(Date:8/28/2014)... Dyslexia, the most commonly diagnosed learning disability in ... that occurs when the regions of the brain ... The use of non-invasive functional neuroimaging tools has ... dyslexia. However, most prior work has focused on ... a gap in our understanding of how multiple ...
Breaking Biology News(10 mins):Sensory-tested drug-delivery vehicle could limit spread of HIV, AIDS 2Sensory-tested drug-delivery vehicle could limit spread of HIV, AIDS 3Dyslexic readers have disrupted network connections in the brain 2
... , NEW YORK, Sept. 8 Reportlinker.com announces ... catalogue. , , Carbon Dioxide ... , , This report analyzes the ... by the following segments: End-tidal Carbon Dioxide (EtCO2) Monitors, and ...
... , , REDWOOD CITY, Calif., ... authentication solutions, today announced that NCR Corporation is now ... on NCR,s next-generation integrated point-of-sale (POS) workstation, the NCR RealPOS ... which is embedded in the top of the NCR RealPOS 70 ...
... MADISON, WI, SEPTEMBER 21, 2009 -- In looking ... carefully examining the role of nitrogen fixation in delivering ... long, nitrogen fixation of the soil has involved a ... thus tying the agricultural industry to the availability and ...
Cached Biology News:Reportlinker Adds Carbon Dioxide Monitors Report 2Reportlinker Adds Carbon Dioxide Monitors Report 3Reportlinker Adds Carbon Dioxide Monitors Report 4Reportlinker Adds Carbon Dioxide Monitors Report 5Reportlinker Adds Carbon Dioxide Monitors Report 6Reportlinker Adds Carbon Dioxide Monitors Report 7Reportlinker Adds Carbon Dioxide Monitors Report 8Reportlinker Adds Carbon Dioxide Monitors Report 9NCR Embeds DigitalPersona U.are.U(R) 4500HD Fingerprint Sensor in New NCR RealPOS(TM) 70XRT Point-of-Sale Workstations 2Is nitrogen the new carbon? 2
(Date:8/28/2014)... (PRWEB) August 28, 2014 Best Sanitizers, ... for the food processing industry, is asking industry professionals ... side comparison of the E2 soap they’re currently using ... Foam Soap . Hand hygiene is critical to ... food processing environment. Six key criteria are identified to ...
(Date:8/28/2014)... devices in spintronics, an electronic which is not ... also on their spin and the spin-related magnetism. ... magnetic signals and vice versa. Recently, the research ... of Physics at Johannes Gutenberg University Mainz in ... Japan, has for the first time realised a ...
(Date:8/28/2014)... ATLANTA , Aug. 28, 2014   SunTrust ... of three industry veterans to its equity research ... "Our ongoing expansion in equity research demonstrates ... with unique insights to enhance their investment decision ... Equities at STRH.  "We continue to make significant ...
(Date:8/28/2014)... Washington, USA (PRWEB) August 27, 2014 ... next month for SPIE Laser Damage 2014 ... optical materials for high-power lasers will run 14-17 September. ... society for optics and photonics . , The premier ... for understanding laser damage to optical materials will engage ...
Breaking Biology Technology:Best Sanitizers, Inc. Asks Food Industry Professionals: With Fall Harvest On the Way, Is Your E2 Hand Soap Up to the Task? 2A new, tunable device for spintronics 2A new, tunable device for spintronics 3SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 2SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 3Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 3
... Stock Exchange Symbol: MS, EDMONTON, June 12 /PRNewswire-FirstCall/ - BioMS ... sclerosis (MS), today,announced that Mr. Kevin Giese, President and CEO, will ... San Diego,California., WHEN: ... WHERE: ...
... Raptor Pharmaceuticals Corp.,(OTC Bulletin Board: RPTP), today announced ... development subsidiary, will,present at the 2008 BIO International Convention ... Convention Center in San Diego, CA., Mr. Daley,s ... 2008 at 1:15p.m. (PT) in room 4 of the ...
... Calif., June 11 Jazz,Pharmaceuticals, Inc. (Nasdaq: ... shelf registration statement with the U.S. Securities and,Exchange ... registration,statement has been declared effective by the SEC, ... to an aggregate of $100 million of its,common ...
Cached Biology Technology:BioMS Medical to present at 2008 BIO International Convention 2Raptor Pharmaceuticals Corp. To Present at BIO 2008 International Convention 2Raptor Pharmaceuticals Corp. To Present at BIO 2008 International Convention 3Raptor Pharmaceuticals Corp. To Present at BIO 2008 International Convention 4Jazz Pharmaceuticals Files Form S-3 Registration Statements 2Jazz Pharmaceuticals Files Form S-3 Registration Statements 3
... is a new technology for sensitive ... small amounts of DNA (5). This ... to modify the DNA, followed by ... to distinguish methylated from unmethylated DNA. ...
... used for the synthesis of 5' capped ... Substitution of cap analog for a large ... vitro transcription reaction results in the incorporation ... fraction of the transcripts. Capped mRNAs are ...
... Incubator/Shaker HT is designed for ... Incubator/Shaker HT is ideal for ... and primer extension assays. The ... as a one-cabinet model, allowing ...
The iEMS Incubator/Shaker is a high performance microplate incubator and orbital shaker. Its superior temperature control and efficient orbital shaking reduce incubation times. It can incubate up to ...
Biology Products: