Navigation Links
MIT's molecular sieve advances protein research

eve that is embedded into a silicon chip. A biological sample containing proteins is put through the sieve for separation.

The sieving process is based on a theoretical model known as the Ogston sieving mechanism. In the model, proteins move through deep and shallow regions that act together to form energy barriers. These barriers separate proteins by size. The smaller proteins go through more quickly, followed by increasingly larger proteins, with the largest passing through last.

Once the proteins are separated, scientists can isolate and capture the proteins of interest. These include the "biomarker" proteins that are present when the body has a disease. By studying changes in these biomarkers, researchers can identify disease early on, even before symptoms show up, and potentially develop new treatments.To date, the Ogston sieving model has been used to explain gel electrophoresis, even though no one has been able to unequivocally confirm this model in gel-based experiments. The MIT researchers were, however, able to confirm Ogston sieving in the nanopore sieves.

"This is the first time anyone was able to experimentally confirm this theoretical idea behind molecular sieving, which has been used for more than 50 years," Han said. "We can precisely control the pore size, so we can do better engineering. We can change the pore shape and engineer a better separation system." The sieve structure is based on work Han did earlier at Cornell University with large strands of DNA.

The performance of the researchers' current one-dimensional sieves matches the state-of-the-art speed of one-dimensional gels, but Han said the sieve's performance can be improved greatly.

"This device can replace gels and give us an ideal physical platform to investigate Ogston sieving," Fu said. The new sieves also potentially could be used to replace 2D gels in the process of discovering disease biomarkers, as well as to learn more about disease.


'"/>

Source:Massachusetts Institute of Technology


Page: 1 2 3

Related biology news :

1. MITs ocean model precisely mimics microbes life cycles
2. MITs ocean model captures diversity of underwater forests
3. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
4. Source of molecular triggers in cutaneous T cell lymphoma identified
5. Plants, animals share molecular growth mechanisms
6. NYU researchers simulate molecular biological clock
7. Scientists reveal molecular secrets of the malaria parasite
8. Scientists identify molecular events that drive cell senescence
9. Researchers discover molecular mechanism that desensitizes us to cold
10. Findings have implications for tracking disease, drugs at the molecular level
11. Successful Test Of Single Molecule Switch Opens The Door To Biomolecular Electronics
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: MIT molecular sieve advances protein research

(Date:8/29/2014)... been known about what genetic changes transform wild animals ... of whom is a University of Montana assistant professor, ... the development of the brain and the nervous system ... published Aug. 28 in Science and gives ... http://www.sciencemag.org/ ., The domestication of animals and plants, ...
(Date:8/29/2014)... release is available in German . ... players in the natural nitrogen cycle on Earth and ... bacteria were thought to depend on nitrite as their ... by Holger Daims, a microbiologist at the University of ... hydrogen as an alternative source of energy. The oxidation ...
(Date:8/29/2014)... them, stretch them, twist them, fold them: modern materials ... technological potential, whether as artificial skin or electronic paper. ... remains a challenge but a new way of working ... be a game-changer. , Previous success in the ... the use of precious gold and silver nanowires. ...
Breaking Biology News(10 mins):New research reveals how wild rabbits were genetically transformed into tame rabbits 2New research reveals how wild rabbits were genetically transformed into tame rabbits 3Hydrogen powers important nitrogen-transforming bacteria 2Hydrogen powers important nitrogen-transforming bacteria 3Copper shines as flexible conductor 2
... LANSING, Mich. A Michigan State University researcher ... Prize for the design of a low-cost, energy-efficient ... commercial spaces. Norbert Mϋller, assistant professor in ... John Barrie, of the Appropriate Technology Collaborative in ...
... (EPSCoR) has received $20 million in new funding from ... Regents for Higher Education. The combined $4 million ... years and enables Oklahoma EPSCoR to support research under ... Cellulosic Bioenergy." , Specifically, the funding supports a ...
... in order to survive? The answer changes depending on climate, ... new leaf sprouts. Stanford researchers have found that the ... word stoma, meaning mouth) is controlled by a specific signaling ... stomata development. The findings are described in a paper published ...
Cached Biology News:'Cool' idea for efficient climate control wins recognition 2Oklahoma EPSCoR receives $20 million for biofuels research 2Key link in how plants adapt to climate discovered by Stanford researchers 2
(Date:8/28/2014)... NEW YORK , Aug. ... announces that a new market ... its catalogue: Whole ... (Systems, Kits (Library Preparation, Target ... Technology (Sequencing by Synthesis), by ...
(Date:8/28/2014)... Aug. 28, 2014   SunTrust Robinson Humphrey ... veterans to its equity research team in biotechnology ... expansion in equity research demonstrates our commitment to ... to enhance their investment decision making," said ... "We continue to make significant investments in differentiated ...
(Date:8/28/2014)... by a Florida State University research team has led ... temperature, emit white light, and convert photon energy directly ... a butterfly. , Biwu Ma, associate professor in the ... College of Engineering, created the molecule in a lab ... that his creation has many other unique capabilities. , ...
(Date:8/28/2014)... August 28, 2014 Earlier this month, ... in partnership with the U.S. Air Force on ... The results indicated that this type of fuel made ... and will be important to America’s Eco friendly future. ... has a mandate to become independent of foreign oil ...
Breaking Biology Technology:Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 2Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 3Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 4Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 5Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 6Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 7Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 8Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 9Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 10Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 11Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 12Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 13SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 2SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 3Novel 'butterfly' molecule could build new sensors, photoenergy conversion devices 2Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 2Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 3Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 4Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 5
... than $1 million from 2003 , , MADISON, ... honored June 1 at the 2004 Technology Awards Banquet ... development grants. The awards, held in conjunction with the ... business technology transfer (STTR), small business innovation research (SBIR) ...
... information on the latest technology is available almost in real-time ... to look at what is new in tech. That could ... ITEC conference in Milwaukee that were demonstrating products. Only ... were networking. , ,I dont need to see the coolest ...
... Foundry s Mediasite have a home on ... capture presentations digitally and publish them on the Web. This ... the companies announced in statements released in tandem Friday. ... the power of rich media communications without the up-front expense ...
Cached Biology Technology:Wisconsin technology companies awarded over $24 million in government funding 2Wisconsin technology companies awarded over $24 million in government funding 3Wisconsin technology companies awarded over $24 million in government funding 4Conference roundup: ITEC Milwaukee smaller, friendlier 2BxVideo designs Web hosting service for Sonic Foundry media presentations 2
Request Info...
... ,ICC and IHC Protocol Development ,Antibody ... Screenings in Animal or Human Cells ... Cells and Tissues ,Peroxidase, Alkaline Phosphatase, ... or Electron Microscopy ,Protein Localization in ...
Request Info...
Request Info...
Biology Products: