Navigation Links
MIT's molecular sieve advances protein research

eve that is embedded into a silicon chip. A biological sample containing proteins is put through the sieve for separation.

The sieving process is based on a theoretical model known as the Ogston sieving mechanism. In the model, proteins move through deep and shallow regions that act together to form energy barriers. These barriers separate proteins by size. The smaller proteins go through more quickly, followed by increasingly larger proteins, with the largest passing through last.

Once the proteins are separated, scientists can isolate and capture the proteins of interest. These include the "biomarker" proteins that are present when the body has a disease. By studying changes in these biomarkers, researchers can identify disease early on, even before symptoms show up, and potentially develop new treatments.To date, the Ogston sieving model has been used to explain gel electrophoresis, even though no one has been able to unequivocally confirm this model in gel-based experiments. The MIT researchers were, however, able to confirm Ogston sieving in the nanopore sieves.

"This is the first time anyone was able to experimentally confirm this theoretical idea behind molecular sieving, which has been used for more than 50 years," Han said. "We can precisely control the pore size, so we can do better engineering. We can change the pore shape and engineer a better separation system." The sieve structure is based on work Han did earlier at Cornell University with large strands of DNA.

The performance of the researchers' current one-dimensional sieves matches the state-of-the-art speed of one-dimensional gels, but Han said the sieve's performance can be improved greatly.

"This device can replace gels and give us an ideal physical platform to investigate Ogston sieving," Fu said. The new sieves also potentially could be used to replace 2D gels in the process of discovering disease biomarkers, as well as to learn more about disease.


'"/>

Source:Massachusetts Institute of Technology


Page: 1 2 3

Related biology news :

1. MITs ocean model precisely mimics microbes life cycles
2. MITs ocean model captures diversity of underwater forests
3. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
4. Source of molecular triggers in cutaneous T cell lymphoma identified
5. Plants, animals share molecular growth mechanisms
6. NYU researchers simulate molecular biological clock
7. Scientists reveal molecular secrets of the malaria parasite
8. Scientists identify molecular events that drive cell senescence
9. Researchers discover molecular mechanism that desensitizes us to cold
10. Findings have implications for tracking disease, drugs at the molecular level
11. Successful Test Of Single Molecule Switch Opens The Door To Biomolecular Electronics
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: MIT molecular sieve advances protein research

(Date:1/22/2015)... CHICAGO , Jan. 9, 2015 Valid S.A. ("Company") ... the market in general the State of Washington,s ... contract for a new enrollment and central issuance system for ... The project planning and development will start ...
(Date:1/22/2015)... Hall E -   EyeLock Inc. , a market leader ... its EyeLock ID technology integrated in a 3D printed automobile ... Ridge National Laboratory (ORNL) at the 2015 North ... is being used to validate the driver and authorize the ...
(Date:1/22/2015)... NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) a biometric ... recent success of the Wocket™ smart wallet at CES 2015 in ... named as one of the "11 Hot Products at CES" in a ... CES So Far" by Newseveryday.com and "The top 10 gadgets from CES ...
Breaking Biology News(10 mins):Valid USA Signs Contract For Washington Driver's License Issuance 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 3CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3
... A Rhode Island Hospital researcher has found that emergency ... as alcohol use, unsafe sex and violence. ER patients ... or Internet) over traditional intervention methods such as in-person ... Ranney, M.D., is available now online in advance of ...
... waste time and money while reducing print quality. University of ... the human eye. "The nozzle cover we invented ... associate professor in the College of Engineering. "The eye and ... not be allowed to dry while, simultaneously, they must open. ...
... in German . Global warming also ... from the University of Zurich demonstrate that there is insufficient ... Burgundy blood algae are increasingly thriving. The warmer temperatures are ... Many large lakes in Central Europe became ...
Cached Biology News:RIH study: Emergency patients prefer technology-based interventions for behavioral issues 2Human eye inspires clog-free ink jet printer invented by MU researcher 2Global warming harms lakes 2Global warming harms lakes 3
(Date:1/22/2015)... CO / Rootstown, OH (PRWEB) January 22, 2015 ... detection platform, announced today that it has received AOAC-PTM Certifications ... O45, O1O3, O111, O121, and O145; collectively referred to as ... coli) O157, at 1 colony forming unit (cfu) per 325 ...
(Date:1/22/2015)... Controlled Substance Compliance Services (CSCS), a project managed ... legal requirements around using controlled substances in pharmaceutical research, ... their international operations expand and become increasingly complex, large ... a result of the first phase of the CSCS ...
(Date:1/22/2015)... 22, 2015   Cypher Genomics, Inc., the ... SQNM ), the leading molecular diagnostics ... generation noninvasive prenatal tests (NIPT). Through this agreement, ... Mantis™, to advance analysis of clinically-relevant fetal sub-chromosomal ...
(Date:12/25/2014)... The report “Service Quality Management and ... Provider Type - Global Advancements, Worldwide Forecasts & Analysis ... analysis and forecasting of revenues. , Browse 152 ... and in-depth TOC on “Service Quality Management (SQM) and ...
Breaking Biology Technology:Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2Global Compliance Service for Controlled Substances to Expand to China 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4
... , A ... coded affinity tags is to correctly identify and obtain accurate ... by mass spectrometry. Because MALDI-TOF mass spectrometry can easily generate ... used to quickly screen the ICAT reagent pairs representing the ...
... G. Vjial, M. Lamor, V. Pop and ... Introduction , ... and misused in sport. They are very potent drugs in the ... on the nervous system and can improve an athletes ability to ...
... , D. Garteiz, R. Morrow, and ... Schmidt, Varian, Inc., Walnut Creek, CA , ... Flavonoids are compounds that make up the pigments ... multiple beneficial therapeutic effects for a large number of serious illnesses, such ...
Cached Biology Technology:Achieving Reliable Protein Quantitation Results Using ICAT Reagents, MALDITOF Mass Spectrometry, and Advanced Data Interpretation Tool 2Achieving Reliable Protein Quantitation Results Using ICAT Reagents, MALDITOF Mass Spectrometry, and Advanced Data Interpretation Tool 3Screening of Corticosteroids in Urine by Negative Atmospheric Pressure Chemical Ionization LC/MS/MS 2Screening of Corticosteroids in Urine by Negative Atmospheric Pressure Chemical Ionization LC/MS/MS 3Screening of Corticosteroids in Urine by Negative Atmospheric Pressure Chemical Ionization LC/MS/MS 4Quantitation of a Dinitro Flavonoid (DNF) in Rat Plasma Using the Varian 1200L LC/MS/MS System 2Quantitation of a Dinitro Flavonoid (DNF) in Rat Plasma Using the Varian 1200L LC/MS/MS System 3
GOAT ANTI CARICA PAPAYA PAPAIN...
PAb to Hu-IFN-Alpha/Beta R2 [(IFNAR2) CD118], Rabbit Serum, neutralizing Binds to but does not neutralize human interferon alpha/beta receptor...
ImageQuant 400, 1 EA. Category: ImageQuant CCD Imagers....
ImageQuant 100 UV, 1 EA. Category: ImageQuant CCD Imagers....
Biology Products: