Navigation Links
MIT researcher presents new view of how the cortex forms

A leading neuroscientist at MIT and one from the University of California at San Francisco (UCSF) report in the Nov. 4 special issue of Science dedicated to the brain that the controversy is over: The "protomap" and "protocortex" theories of brain development are dead.

The cerebral cortex is a sheet of around 10 billion neurons divided into distinctly separate areas that process particular aspects of sensation, movement and cognition. To what extent are these areas predetermined by genes or shaped by the environment? The protomap and protocortex theories developed before 1990 claimed, respectively, that the task-specific regions of the cortex are spawned by a zone of "originator" cells; or that long nerve fibers from the thalamus, a large ovoid mass that relays information to the cortex from other brain regions, are activated by external stimuli to impose identity on the homogeneous blob.

New evidence indicates that the development of cortical areas involves "a rich array of signals," an interwoven cascade of developmental events, some internal and some external, according to co-authors Mriganka Sur, Sherman Fairchild Professor of Neuroscience at the Picower Institute for Learning and Memory and the MIT Department of Brain and Cognitive Sciences, and John L. R. Rubenstein of UCSF.

"Recent evidence has altered researchers' understanding of how cortical areas form, connect with other brain regions, develop unique processing networks and adapt to changes in inputs," Sur said. "Understanding basic mechanisms of cortical development is central to understanding disorders of development."

Sur, chair of the Department of Brain and Cognitive Sciences at MIT, is leading an ambitious, multifaceted approach to understanding the genetic, molecular and behavioral aspects of autism.

In the Science review article, "Patterning and Plasticity of the Cerebral Cortex," Sur and Rubenstein point out that transcription factors are key. A transcripti
'"/>

Source:Massachusetts Institute of Technology


Page: 1 2

Related biology news :

1. U of M researcher examines newly emerging deadly disease
2. NYU researchers simulate molecular biological clock
3. Vital step in cellular migration described by UCSD medical researchers
4. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
5. UCSD researchers maintain stem cells without contaminated animal feeder layers
6. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
7. New protein discovered by Hebrew University researchers
8. First real-time view of developing neurons reveals surprises, say Stanford researchers
9. Agilent Technologies releases automated literature search tool for biology researchers
10. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
11. Yale researchers identify molecule for detecting parasitic infection in humans
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: MIT researcher presents new view how the cortex forms

(Date:12/10/2014)... -- CIE San Diego has launched an innovative trust ... that enhances care coordination among social service and care ... earned a second $1 million grant from the Alliance ... in community and; will be recognized as a "Live ... 4-6p. CIE San Diego today announced the ...
(Date:12/5/2014)... Utah , Dec. 4, 2014  Tute Genomics, ... raised $2.3 million in Series A1 funding led by ... investors also participated in the investment round. ... the healthcare community adopts next-generation sequencing and seeks new ... said Reid Robison , MD MBA, and CEO ...
(Date:11/21/2014)... According to a new market research report ... Control, Intrusion Detection, Parking Management, Under Vehicle Inspection), End ... - Global Forecasts to 2020", published by MarketsandMarkets, The ... $25 Billion in 2014 and is expected to reach ... 8.69%. Browse 116 market data Tables and ...
Breaking Biology News(10 mins):Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3
... June 09, 2009 / b3c newswire / - ... Netherlands Organisation for Applied Scientific Research TNO today announced ... further develop Amarna’s viral gene delivery platform SVac ... for the manufacture, formulation and testing of viral gene ...
... axial complex of sea urchins ( Echinoidea ), an ... that group of marine invertebrates there exists a structural ... in BioMed Central,s open access journal Frontiers in ... structural data available on a given organ in combination ...
... Merck Irving S. Sigal Memorial Award is being presented ... Infectious Disease Initiative at the Broad Institute of MIT ... Medicine at Harvard Medical School. Sponsored by Merck Research ... presented in memory of Irving S. Sigal, who was ...
Cached Biology News:Amarna Therapeutics B.V. and TNO announce SVac research and development partnership 2Amarna Therapeutics B.V. and TNO announce SVac research and development partnership 3
(Date:12/17/2014)... , Dec. 17, 2014 Tigercat ... Phase 2 study evaluating the investigational oral NK-1 ... patients with severe, chronic itch who are unresponsive ... care, including topical steroids and antihistamines. ... in Visual Analog Scale (VAS) itch score from ...
(Date:12/15/2014)... & PETACH TIKVAH, Israel ... (NASDAQ: BCLI ), a leading developer of ... that wholly-owned subsidiary Brainstorm Cell Therapeutics Ltd. was awarded ... Israel,s Office of the Chief Scientist (OCS).  ... in receipt of grant support from the Office of ...
(Date:12/15/2014)... Dec. 15, 2014  Origin Agritech Limited (NASDAQ GS: SEED) ... supplier of crop seeds in China , ... fiscal year 2014 ended September 30, 2014, before the market ... will host a teleconference on January 8, 2015, at 8:00 ... time to discuss the results. To participate in the call, ...
(Date:12/13/2014)... - MaRS and Virgin Unite Canada, the non-profit foundation of ... to support Canadian entrepreneurs tackling social and environmental challenges. Today, ... the MaRS Centre to announce the new partnership, which includes ... fund has $1 million in seed capital provided by Virgin ... Social Innovation Foundation, founded by Alison Lawton . ...
Breaking Biology Technology:Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4BrainStorm Receives $1,100,000 for its 8th Annual Non-Dilutive Grant from Israel's Chief Scientist Office 2BrainStorm Receives $1,100,000 for its 8th Annual Non-Dilutive Grant from Israel's Chief Scientist Office 3Origin Agritech Limited to Announce Fiscal 2014 Annual Financial Results on January 8th, 2015 2Origin Agritech Limited to Announce Fiscal 2014 Annual Financial Results on January 8th, 2015 3MaRS and Virgin Unite partner to invest in business as a force for good 2MaRS and Virgin Unite partner to invest in business as a force for good 3
... million, -- Quarterly Net Income Increases 76.5% to ... YORK and HAIKOU, Hainan, China, May 2 /Xinhua-PRNewswire-FirstCall/,-- ... Board: CPHI),which develops, manufactures, and markets generic and ... results,for the first quarter of 2008., ...
... May 2 eResearchTechnology, Inc.,(eRT), (Nasdaq: ... (ECG) collection and interpretation services,announced today that ... and,Chief Executive Officer, and Richard Baron, the ... at the Deutsche Bank 33rd Annual,Healthcare Conference ...
... 2 /PRNewswire-FirstCall/ - GeneNews Limited (TSX: GEN), ... for the early,detection of diseases and personalized ... for the first quarter ended March 31,2008., ... of the key milestones,necessary to support the ...
Cached Biology Technology:China Pharma Holdings, Inc. Announces First Quarter 2008 Financial Results 2China Pharma Holdings, Inc. Announces First Quarter 2008 Financial Results 3China Pharma Holdings, Inc. Announces First Quarter 2008 Financial Results 4China Pharma Holdings, Inc. Announces First Quarter 2008 Financial Results 5China Pharma Holdings, Inc. Announces First Quarter 2008 Financial Results 6China Pharma Holdings, Inc. Announces First Quarter 2008 Financial Results 7China Pharma Holdings, Inc. Announces First Quarter 2008 Financial Results 8China Pharma Holdings, Inc. Announces First Quarter 2008 Financial Results 9eResearchTechnology to Present at the Deutsche Bank 33rd Annual Healthcare Conference on May 7th 2008 2GeneNews Announces First Quarter Results 2GeneNews Announces First Quarter Results 3GeneNews Announces First Quarter Results 4GeneNews Announces First Quarter Results 5GeneNews Announces First Quarter Results 6GeneNews Announces First Quarter Results 7GeneNews Announces First Quarter Results 8
Proteinase K Buffer 3.9 ml...
Rabbit polyclonal to VEGF Receptor 2 (phospho Y1214) ( Abpromise for all tested applications). entrezGeneID: 3791 SwissProtID: P35968...
Glutathione Agarose Beads 10 ml...
Anti-Ephrin B1 Host: rabbit polyclonal Species Reactivity: human Applications: WB Storage: 4C...
Biology Products: