Navigation Links
MIT researcher presents new view of how the cortex forms

A leading neuroscientist at MIT and one from the University of California at San Francisco (UCSF) report in the Nov. 4 special issue of Science dedicated to the brain that the controversy is over: The "protomap" and "protocortex" theories of brain development are dead.

The cerebral cortex is a sheet of around 10 billion neurons divided into distinctly separate areas that process particular aspects of sensation, movement and cognition. To what extent are these areas predetermined by genes or shaped by the environment? The protomap and protocortex theories developed before 1990 claimed, respectively, that the task-specific regions of the cortex are spawned by a zone of "originator" cells; or that long nerve fibers from the thalamus, a large ovoid mass that relays information to the cortex from other brain regions, are activated by external stimuli to impose identity on the homogeneous blob.

New evidence indicates that the development of cortical areas involves "a rich array of signals," an interwoven cascade of developmental events, some internal and some external, according to co-authors Mriganka Sur, Sherman Fairchild Professor of Neuroscience at the Picower Institute for Learning and Memory and the MIT Department of Brain and Cognitive Sciences, and John L. R. Rubenstein of UCSF.

"Recent evidence has altered researchers' understanding of how cortical areas form, connect with other brain regions, develop unique processing networks and adapt to changes in inputs," Sur said. "Understanding basic mechanisms of cortical development is central to understanding disorders of development."

Sur, chair of the Department of Brain and Cognitive Sciences at MIT, is leading an ambitious, multifaceted approach to understanding the genetic, molecular and behavioral aspects of autism.

In the Science review article, "Patterning and Plasticity of the Cerebral Cortex," Sur and Rubenstein point out that transcription factors are key. A transcripti
'"/>

Source:Massachusetts Institute of Technology


Page: 1 2

Related biology news :

1. U of M researcher examines newly emerging deadly disease
2. NYU researchers simulate molecular biological clock
3. Vital step in cellular migration described by UCSD medical researchers
4. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
5. UCSD researchers maintain stem cells without contaminated animal feeder layers
6. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
7. New protein discovered by Hebrew University researchers
8. First real-time view of developing neurons reveals surprises, say Stanford researchers
9. Agilent Technologies releases automated literature search tool for biology researchers
10. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
11. Yale researchers identify molecule for detecting parasitic infection in humans
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: MIT researcher presents new view how the cortex forms

(Date:4/14/2015)... Conn. , April 14, 2015 NXT-ID, ... a biometric authentication company focused on the growing mobile ... been nominated for the 2015 New York Design Awards ... The Design100, New York City Design Awards are part ... based on over 2,500 ratings from the marketplace, industry ...
(Date:4/13/2015)... April 13, 2015  higi, a leading cloud-based consumer ... more fully engage with their communities around health and ... protected and secure API.  ... most accessible, affordable, and convenient vehicle to receive validated ... The API will allow higi,s trusted ...
(Date:4/9/2015)... SAN JOSE, Calif. , April 9, 2015 /PRNewswire/ ... of human interface solutions, announced today that it will ... 2015 on Thursday, April 23, 2015, after the close ... call for analysts and investors at 2:00 p.m. PT ... information.    To participate on the live ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3Synaptics to Report Third Quarter Results on April 23 2
... 2013 -- Resveratrol, a naturally occurring polyphenol compound produced ... found in red wine, has been touted as a ... This has been supported by some experimental studies, whereas ... using two multiple sclerosis (MS) models published in ...
... metabolic pathway for breaking down glucose that could lead to ... The new pathway is intended to replace the ... reactions that nearly all organisms use to convert sugars into ... the six carbon atoms found in glucose into two-carbon molecules ...
... a diverse team of University of Pittsburgh scientists to report ... that they had solved the mystery of a basic ... mechanism by which mitochondria tiny structures inside cells often ... and need to be eliminated, the Pitt team has opened ...
Cached Biology News:Resveratrol, found in red wine, worsens MS-like symptoms and neuropathology in mice 2Resveratrol, found in red wine, worsens MS-like symptoms and neuropathology in mice 3UCLA engineers develop new metabolic pathway to more efficiently convert sugars into biofuels 2When cells 'eat' their own power plants; Pitt scientists solve mystery of cellular process 2When cells 'eat' their own power plants; Pitt scientists solve mystery of cellular process 3
(Date:4/17/2015)... Madison, WI (PRWEB) April 17, 2015 ... provide sales and marketing support for the powerful ... at the Chemical Genomics Center at the Lankenau ... LCGC’s mission is to measurably improve successful ... to HTS, by offering rare, drug-like libraries available ...
(Date:4/16/2015)... CAMBRIDGE, Mass. (PRWEB) April 16, 2015 ... of smart data solutions driven by Semantic Web ... provider of specialist information and services for the ... today announced that its joint solution ‘Smart Data ... named a finalist for the 2015 Bio-IT ‘Best ...
(Date:4/16/2015)... Irvine, CA (PRWEB) April 16, 2015 ... in the Buzz of BIO Contest for ... Industry Organization (BIO), the 2015 BIO International Convention will ... in Philadelphia, Pennsylvania. During the Buzz of BIO contest, ... like to see present at the conference. The community ...
(Date:4/16/2015)... According to the 2014 Liberty Mutual ... was ranked first among the leading causes of ... pushing, pulling, holding, carrying, or throwing and cost ... Round Company takes statistics like this very seriously. ... develop and design equipment that prevents these injuries ...
Breaking Biology Technology:BellBrook Labs and Lankenau Institute Partner to Accelerate Drug Discovery using Orthogonal Pooled Screening 2Cambridge Semantics and Informa Named Bio-IT Award Finalist for Smart Data Lake Solution for Clinical Trial and Competitive Intelligence 2Cambridge Semantics and Informa Named Bio-IT Award Finalist for Smart Data Lake Solution for Clinical Trial and Competitive Intelligence 3Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 2Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 3The David Round Company Helps Companies Meet OSHA Standards by Combining Safety, Ergonomics, and Productivity 2
... 7 /PRNewswire-FirstCall/ - ARIUS Research Inc., (TSX:,ARI), a ... of,antibody therapeutics, today announced that it will deliver ... for,two of its anti-cancer antibody drug candidates. ... Francisco on September 7-8,Arius will report recent results ...
... Announces ofatumumab Appeared More Effective Than rituximab ... ... Genmab A/S,(OMX: GEN) announced today that ofatumumab (HuMax-CD20(R)) appeared more,effective ... than rituximab in a pre-clinical study. The CD20,antibodies were incubated ...
... Feynman presented a talk entitled There,s Plenty of Room at ... reason why humans couldn,t manipulate atoms. However, if atomic ... positions remains. How do you know what you have ... of Science, IBM and Imago have taken a seminal step ...
Cached Biology Technology:Arius Features Preclinical Data on Antibody Candidates at Two Conferences 2Arius Features Preclinical Data on Antibody Candidates at Two Conferences 3Genmab Announces Encouraging Preclinical Data for ofatumumab 2IBM and Imago find a crucial difficulty in semiconductor device scaling 2
Mouse Endoglin/CD105 Fluorescein MAb (Clone 209701)...
... is an inhibitor of ... concentration of inhibitor required ... must be determined empirically ... micromolar inhibitor is sufficient ...
...
SNARE associated protein snapin, clone MGC:2717...
Biology Products: