Navigation Links
MIT finds most complex protein knot ever seen

An MIT team has discovered the most complicated knot ever seen in a protein, and they believe it may be linked to the protein's function as a rescue agent for proteins marked for destruction.

"In proteins, the three-dimensional structure is very important to the function, and this is just one example," said Peter Virnau, a postdoctoral fellow in physics and an author of a paper on the work that appears in the Sept. 15 issue of the Public Library of Science, Computational Biology.

Knots are rare in proteins - less than 1 percent of all proteins have any knots, and most are fairly simple. The researchers analyzed 32,853 proteins, using a computational technique never before applied to proteins at this scale.

Of those that had knots, all were enzymes. Most had a simple three-crossing, or trefoil knot, a few had four crossings, and the most complicated, a five-crossing knot, was initially found in only one protein - ubiquitin hydrolase.

That complex knot may hold some protective value for ubiquitin hydrolase, whose function is to rescue other proteins from being destroyed - a dangerous job.

When a protein in a cell needs to be destroyed, it gets labeled with another protein called ubiquitin. "It's a death mark for the protein," said Leonid Mirny, an author of the paper and an associate professor in the MIT-Harvard Division of Health Sciences and Technology.

Once the "death mark" is applied, proteins are shuttled to a cell structure called a proteasome, which pulls the protein in and chops it into pieces. However, if ubiquitin hydrolase intervenes and removes the ubiquitin, the protein is saved.

The complicated knot found in ubiquitin hydrolase may prevent it from getting sucked into the proteasome as it works, Mirny said. The researchers hypothesize that proteins with complex knots can't be pulled into the proteasome as easily, and the knots may make it harder for the protein to unfold, which is necessary fo
'"/>

Source:Massachusetts Institute of Technology


Page: 1 2

Related biology news :

1. Current human embryonic stem cell lines contaminated UCSD/Salk team finds
2. Study finds more than one-third of human genome regulated by RNA
3. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
4. Same mutation aided evolution in many fish species, Stanford study finds
5. NC State scientist finds soft tissue in T. rex bones
6. Genrate: a generative model that finds and scores new genes and exons in genomic microarray data
7. Genetically modified rice in China benefits farmers health, study finds
8. Survey finds silver contamination in North Pacific waters
9. Anti cancer virotherapy well tolerated in first human administration, research finds
10. NASA study finds snow melt causes large ocean plant blooms
11. Oceans more vulnerable to agricultural runoff than previously thought, study finds
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: MIT finds most complex protein knot ever seen

(Date:7/11/2014)... 11, 2014--Researchers at the Department of Energy,s Oak ... awards, presented by R&D Magazine in recognition of ... awards recognize the tremendous value of our National ... and development at the National Labs continues to ... pursue the scientific and technological innovations necessary to ...
(Date:7/11/2014)... BostonThe American Society for Bone and Mineral Research awarded ... of Medicine (BUSM), with the 2014 Louis V. Avioli ... at BUSM, is internationally known for revolutionizing the understanding ... , The award honors a member of the ... fundamental contributions to bone and mineral basic research. It ...
(Date:7/11/2014)... Stem Cell scientists have set a "mouse TRAP" to ... by a recent study published in the Journal ... uses a technique called TRAP to extract cellular and ... Invented by scientists at the Rockefeller Institute for Medical ... to the protein-making machinery, or ribosomes, of the cell ...
Breaking Biology News(10 mins):ORNL wins eight R&D 100s 2ORNL wins eight R&D 100s 3ORNL wins eight R&D 100s 4BUSM's Michael F. Holick receives American Society for Bone and Mineral Research award 2
... RIVERSIDE, Calif. Humans are conducting massive experiments on ... introducing exotic species, boosting nutrient concentrations, and altering climates. ... will give the Jane Block Distinguished Lecture in ... which he will discuss how our ability to assess ...
... May 7, 2013 /PRNewswire-iReach/ -- Glutathione is the ... oxidants and a large variety of other toxins and insults. ... enhancing glutathione levels in cells and tissues has simmered for ... oral supplementation is effective in increasing the body,s stores of ...
... For plants and animals forced to tough out harsh ... country is a refuge, a stable beneath-the-snow habitat that gives ... in a warming world, winter and spring snow cover in ... plants and animals that depend on the space beneath the ...
Cached Biology News:Public lecture at UC Riverside to discuss challenges in assessing human impact on ecosystems 2Clinical Tests Demonstrate Long-Term Effectiveness of Oral Glutathione Supplements - Kyowa Study 2Clinical Tests Demonstrate Long-Term Effectiveness of Oral Glutathione Supplements - Kyowa Study 3Decline in snow cover spells trouble for many plants, animals 2Decline in snow cover spells trouble for many plants, animals 3
(Date:7/11/2014)... (PRWEB) July 11, 2014 BCC Research ... DIGITAL POLYMERASE CHAIN REACTION (PCR) TECHNOLOGY: GLOBAL MARKETS ... (PCR) technology reached nearly $140 billion in 2013. This ... registering a five-year compound annual growth rate (CAGR) of ... number of interesting and exciting possibilities within the broader ...
(Date:7/10/2014)... Women in the West African ... additional family planning option. Sayana® Press has the ... levels of the health system and in communities ... used contraceptive—Pfizer’s Depo-Provera® (depot medroxyprogesterone acetate)—with the BD ... first of four African countries expected to begin ...
(Date:7/10/2014)... Francisco, CA (PRWEB) July 10, 2014 ... family closer together. The Archer Family purchased a ... contained within DNA, but ended up with a lifetime ... discoveries contained within the family members’ DNA genuinely brought ... had decided to search deeper into genetic history and ...
(Date:7/10/2014)... CROWN POINT, Ind. , July 10, ... recently expanded its use of capnography for ... a growing group of healthcare leaders in ... Capnography measures how effectively patients are breathing ... respiratory depression occurs. By measuring the amount ...
Breaking Biology Technology:Global Market for Digital Polymerase Chain Reaction Technology to Reach $490 Billion by 2018; Equipment Sector Accounts for the Fastest Growing Segment With 33% CAGR 2Global Market for Digital Polymerase Chain Reaction Technology to Reach $490 Billion by 2018; Equipment Sector Accounts for the Fastest Growing Segment With 33% CAGR 3Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 2Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 3Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 4Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 5Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 6Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2
... important to the economic growth of a municipality as ... viewed as transportation - rail, waterways, and air as ... definition of infrastructure must also include network infrastructure and ... , ,Just as you would not locate your company ...
... - Assembly Speaker Mike Huebsch , R-West Salem, ... named eight legislators to serve on the Speaker's Task Force ... charged with exploring a number of failed information technology projects ... public and private sectors. , ,In addition to Montgomery, who ...
... year's Biotechnology Industry Organization convention in Chicago, it wasn't ... While Chicago is a business leader in almost every ... its biotech. Pharmaceutical companies, yes; biotech firms, not really. ... so hopped up on biotech research, investors, and boom-time ...
Cached Biology Technology:States need to be more "connectivity conscious" 2States need to be more "connectivity conscious" 3States need to be more "connectivity conscious" 4Eight lawmakers named to Speaker's IT task force 2Getting noticed in Genetown: Wisconsin biotech on display 2Getting noticed in Genetown: Wisconsin biotech on display 3Getting noticed in Genetown: Wisconsin biotech on display 4
Anti-gamma Glutamyl Transferase (gammaGT) Host: mouse monoclonal Species Reactivity: human Applications: WB, IP, FC Storage: 4C...
Rabbit Anti-melatonin (different linkage) Polyclonal Antibody...
... Product Goat polyclonal to ... (Microorganism). Reactivity / Specificity Cross-reacts ... species. Background Information Cholesterol oxidases ... II oxidases and are implicated in bacterial ...
Anti-ACTH Immunogen: Porcine ACTH conjugated to BSA. Available Date: 38566...
Biology Products: