Navigation Links
MIT device draws cells close -- but not too close -- together

lve this cellular space and time problem involved another children's game: plastic puzzles with squares that slide around on a grid. They wondered if they could put different cells on each square and then move them around.

This idea quickly evolved into an elegant tool designed expressly for biologists.

The device involves two separate comb-shaped pieces coated with living cells. These two pieces can click into place at two settings: One allows cells on the edges of the combs to touch, the other maintains a gap of 80 micrometers, or about four cell widths. The assembly is geared so that switching between these two settings involves a movement of two millimeters, an amount controllable by the human hand. Hui selected 80 micrometers as the gap setting because at shorter distances, cells sometimes migrate across the gap and end up touching. And at wider distances, some soluble signals drop off.

Bhatia and Hui have used the new device to study liver cells. The two found that to get liver cells to express specific liver functions, they needed to touch supporting stromal cells for 18 hours. For the liver cells to survive and continue to act as liver cells, they don't have to keep touching these stromal cells, but they do need to stay close.

The finding will allow Bhatia and Hui to examine more deeply which surface molecules trigger liver cell differentiation and which soluble molecules maintain it.

Such information will help the team devise different approaches to engineering liver therapeutics by helping them understand exactly which signals are needed to support specific liver cell functions. Instead of building an entire liver from scratch, Bhatia wants to isolate the key cell type, "the business end of the organ," and get it to work without replicating the entire cellular environment that supports it. "If you can get away with it, you want to get rid of the supporting cells," she says.

This simple device
'"/>

Source:Massachusetts Institute of Technology


Page: 1 2 3

Related biology news :

1. Columbia study shows widely used artery clearing device does not help patients during heart attack
2. New defibrillator signals doctor of patients irregular heartbeat or device malfunction
3. Breakthrough in micro-device fabrication combines biology and synthetic chemistry
4. Carnegie Mellon scientists create PNA molecule with potential to build nanodevices
5. Researchers make long DNA wires for future medical and electronic devices
6. 3D ultrasound device poised to advance minimally invasive surgery
7. FDA approves first medical device using rutgers biomaterial
8. Underwater listening devices yield discoveries about endangered large whales
9. New device could cut chemotherapy deaths
10. Professors to develop hand-held pathogen testing device
11. Worlds smallest cancer detection device
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: MIT device draws cells close but not too close together

(Date:8/22/2014)... . NAIROBI (22 August ... looming as a major threat to food security across the ... last five years, 1.7 million African farmers in 13 countries ... and helped them double or even triple crop yields. , ... Africa (AGRA) focuses on intensive efforts initiated five years ago ...
(Date:8/22/2014)... and clinical research and technological advances, the fight ... spanning multiple fronts. , Work happening in a ... new and more selective therapies for cancer. Researchers ... enzyme overexpressed in certain cancersand they have tested ... Chemistry professor Christopher Cairo and his team synthesized ...
(Date:8/22/2014)... is a multifunctional enzyme that localizes ... neuroprotective and cholesterol-synthesizing activities. DHCR24 overexpression ... amyloid β deposition. Dr. Xiuli Lu ... China constructed two recombinant adenoviruses (Ad-rSYN1-DHCR24-myc ... specifically in neuronal cells. They also ...
Breaking Biology News(10 mins):Effort to confront Africa's soil health crisis helps millions of farmers triple yields 2Effort to confront Africa's soil health crisis helps millions of farmers triple yields 3Effort to confront Africa's soil health crisis helps millions of farmers triple yields 4New enzyme targets for selective cancer therapies 2New enzyme targets for selective cancer therapies 3
... , July 19, 2013 Research ... of the "Iris Biometrics - Global Strategic Business ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , This report analyzes the ... Thousands. The report provides separate comprehensive analytics for the ...
... 2013 Scientists have identified higher levels of a receptor ... that may serve as a new drug target for the ... in EMBO Molecular Medicine , show that elevated levels ... transfection", are associated with a lower likelihood of survival for ...
... take calcium supplements to lower their phosphorous levels may be ... those who take other non-calcium based treatments, according to a ... The study, published today in the Lancet , calls ... phosphate levels in patients with chronic kidney disease. The researchers ...
Cached Biology News:Iris Biometrics - Global Strategic Business Report 2Calcium linked to increased risk of heart disease and death in patients with kidney disease 2
(Date:8/22/2014)... 2014 Ophthalmic drug delivery technologies ... challenging endeavors as the anatomy, physiology and biochemistry ... the foreign substances. Ocular drug delivery technologies provide ... and minimal use of needles; also it enables ... provides specific targeting within the ocular globe. On ...
(Date:8/22/2014)... August 22, 2014 Nerium International, ... is in the spotlight again. Nerium will showcase ... its NeriumFirmTM Body Contouring Cream to Hollywood’s elite ... Creations during the 66th Primetime Emmy® Awards. , ... extract, third-party clinical trials show that NeriumAD night ...
(Date:8/21/2014)... group at the Institute for Molecular Medicine Finland ... has developed a novel "man and machine" decision ... diagnostic aid was described in PLOS One ... is based on computer vision algorithms similar to ... visualization of only the diagnostically most relevant areas. ...
(Date:8/21/2014)... , Aug. 21, 2014 Telomere Biosciences, ... their Nutraceutical "TELO-20 for Dogs" with Telomerase ... supplement in the world for dogs. Telomeres are ... chromosome in the body. A wealth of ground-breaking ... in Telomere Science and Aging, including Nobel laureates, ...
Breaking Biology Technology:Ocular Drug Delivery Technologies Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Ocular Drug Delivery Technologies Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3Ocular Drug Delivery Technologies Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 4Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 2Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 3A novel 'man and machine' decision support system makes malaria diagnostics more effective 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 3
... p.m., and do you know where your 16-year-old daughter is? ... homework. You wish. Chances are shes probably taking advantage of ... chat rooms, websites and to instant message her friends, including ... has never met in person. , ,Unfortunately, as most parents ...
... with two research grants coming over the transom almost ... a non-profit subsidiary of the Wisconsin Alumni Research Foundation ... study of human embryonic stem cells. , ,The grant ... Human Embryonic Stem Cell Research come from the National ...
... CHICAGO - Here is a joke my dad told me (actually, he ... guys were walking on a beach and they found a bottle with ... out. "Thanks guys! I was in that bottle for 150 years," the ... for letting me out." , ,So the first guy says: "I ...
Cached Biology Technology:Parental Control - Options Vary for Internet Restrictions 2Parental Control - Options Vary for Internet Restrictions 3Double header for research dollars from Washington 2Women in Midwest IT Have to Fight, Work Harder 2Women in Midwest IT Have to Fight, Work Harder 3
...
...
... kits are designed to rapidly and ... using our patented APA Technology. APAgene ... an extraordinarily competitive price. All necessary ... The Locator Kit can be used ...
Rabbit polyclonal to Yaf9 ( Abpromise for all tested applications)....
Biology Products: