Navigation Links
MIT creates 3-D scaffold for growing stem cells

y the cells, other structures and proteins around them. A cell's normal environment is a complex network of tiny fibers, gaps and pores through which oxygen, hormones and nutrients are delivered and waste products filtered away. Cells move within their natural environments in response to chemical signals or other stimuli.

Researchers are aware that cells on flat surfaces have skewed metabolisms, gene expression and growing patterns. But the only choices have been glass labware and a product called Matrigel, a gelatinous protein mixture secreted by mouse tumor cells. While Matrigel does resemble a complex extracellular environment, it also contains growth factors and unknown proteins that limit its desirability for experiments requiring precise conditions.

"Synthetic biopolymer microfiber scaffolds have been studied for more than 30 years to mimic a living 3D microenvironment, but concerns exist about their degradation products and chemicals," the authors wrote in the paper.

Other synthetic polymer biomaterials are simply too big. Getting cells to grow on them is like forcing spiders to build webs on skyscraper girders. Zhang's nanofiber scaffold, around 1,000 times smaller than the existing systems, is much closer in size to the extracellular matrices that living cells manufacture themselves.

Adding motifs

With the addition of defined amino acid fragments called active motifs, the scaffold can be fashioned to coax stem cells to behave in certain desirable ways-such as differentiating into needed body tissues or migrating toward bone marrow and other natural destinations.

"What makes these designer scaffolds particularly interesting is that cells survive longer and differentiate better without additional soluble growth factors," Zhang said. "This suggests that extracellular microenvironments may play a more important role for cell survival and for carrying out cell functions than previously thought."


'"/>

Source:Public Library of Science


Page: 1 2 3

Related biology news :

1. Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems
2. NIH creates nationwide network of molecular libraries screening centers
3. Purdue creates new low-cost system to detect bacteria
4. Brazil creates buffer zone around coral reefs off Atlantic coast
5. Hopkins scientists show hallucinogen in mushrooms creates universal mystical experience
6. Climate change creates dramatic decline in red-winged black bird population
7. How badger culling creates conditions for spread of bovine TB
8. Tiny scaffolding allows stem cells to become working fat cells
9. Bioactive cement scaffold may improve bone grafts
10. Microscopic scaffolding offers a simple solution to treating skin injuries
11. Bedsores and bald hides: Novel roles revealed for a scaffolding protein
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: MIT creates scaffold for growing stem cells

(Date:7/10/2014)... 2014 It is a great honor for ... of the world-renowned Thoracic and Cardiovascular surgeon, Mark E ... Dr. Ginsburg, with over 34 years of experience, is ... Good Samaritan Regional Medical Center. Dr. Ginsburg has been ... and is considered an expert in the implantation of ...
(Date:7/10/2014)... DALLAS , July 3, 2014 ... Sensors Market by Type (Swipe And Area), Material (Optical ... Defense, Healthcare, Commercial Security and Banking & Finance), and ... 2020", published by MarketsandMarkets, the global Fingerprint Sensors Market ... at a high CAGR of 16.8% from 2014 to ...
(Date:7/10/2014)... Sweden , July 7, 2014 ... its first major design win (DW). A Chinese Top 5 ... the planned start of mass production in October 2014.   ... a Chinese Top 5 smartphone OEM, which has a planned ... and a target sales volume for this phone of 3 ...
Breaking Biology News(10 mins):Avery Biomedical Devices, Inc. announces the appointment of Mark E Ginsburg, M.D. to its Board of Directors 2Fingerprint Sensors Market worth $14.35 Billion by 2020 2Fingerprint Sensors Market worth $14.35 Billion by 2020 3FPC Wins DW for 1021 Touch Sensor for Flagship Smartphone from Chinese Top 5 Smartphone OEM 2
... In our not-so-distant evolutionary past, stress often meant ... so part of our body,s stress response is ... Medicine Partnership Unit (MMPU), a collaboration between the ... and the University of Heidelberg Medical Centre, have ...
... in the long-standing arms race between the flowering plant ... Duke University researchers have found that the little mustard ... prepare for the greatest onslaught of infectious spores released by ... time of day it is and change their activities accordingly, ...
... PORTLAND, Ore. -- The pediatric cardiac team at Oregon ... first in the region and one of a handful ... without open-heart surgery. To date, four patients have ... Adult Congenital Cardiac Catheterization Lab. All reported immediate improvement ...
Cached Biology News:Blood-clotting protein linked to cancer and septicemia 2Blood-clotting protein linked to cancer and septicemia 3Plant's immune defense revs up for the morning attack 2Plant's immune defense revs up for the morning attack 3OHSU fixes complex heart problems without open-heart surgery 2
(Date:7/11/2014)... July 11, 2014 Cayenne Medical, ... specializing in the soft tissue reconstruction segment, announced ... System for surgeries involving the shoulder and extremities. ... a novel, inserter-controlled deployment method. The unique delivery ... deployment, anchor pull-out, or anchor displacement (also commonly ...
(Date:7/10/2014)... Ohio (PRWEB) July 10, 2014 Understanding ... ion channel-expressing cell lines, and the gap that currently ... cells that expand its industry-leading portfolio of validated ion ... on ion channel-expressing cell lines, as ion channels control ... to control this activity creates the potential to treat ...
(Date:7/10/2014)... Angeles, CA (PRWEB) July 10, 2014 ... and Bioanalytical techniques during 18-20 August, 2014 at Double ... critically review the recent developments in Analytical & Bioanalytical ... the globe. , Speaking on this occasion, Dr. Srinubabu ... Analytica Acta conference is a remarkable one in ...
(Date:7/10/2014)... PETERSBURG, Russia , July 10, 2014 ... Russian Federation Dmitry Medvedev , presented ... biopharmaceutical company BIOCAD . The Company is developing ... scope of MabNext project BIOCAD develops a number of ... cancer and autoimmune diseases. The ceremony took place at ...
Breaking Biology Technology:Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 2Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 3Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 3A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2
... on December 10, 2007, SPACE COAST, Fla., ... its Third Annual Colloquium on the Law of,Transbeman ... will,be held December 10, 2007 along Florida,s Space ... flesh and computerized,substrate., The colloquia are open ...
... quarters of our universe is made up of some weird, ... dark energy. This month in Physics World, Eric ... at Berkeley, reveal how little we know about dark energy ... we can expect in the coming decade from a series ...
... Inc. (Nasdaq: SGMO ) announced today that Edward ... the progress of,Sangamo,s ZFP Therapeutic development programs and an ... on Tuesday, December 4, 2007 at,the BMO Capital Markets ... The presentation will be webcast live and may be ...
Cached Biology Technology:International Human Rights Day Recognized by Terasem Movement, Inc.'s Third Annual Colloquium on the Law of Transbeman Persons 2Dark energy -- 10 years on 2Sangamo BioSciences to Present at the BMO Capital Markets Health Care Conference 2
...
...
...
DryStrip aligners, 4. Category: Electrophoresis Systems & Standards & Reagents, IEF & SDS-PAGE & 2-D Electrophoresis, Multiphor II Kits & Components and Accessories....
Biology Products: