Navigation Links
MBL leads effort to update E. coli genome

E.coli is one of the most important model organisms for molecular science today and is arguably the single organism about which the most is known. The genes of higher-level plants and animals, even humans, are often understood by their similarity to E. coli genes. As such, the accuracy and completeness of E.coli genome information is of great importance to the scientific community.

In an attempt to consolidate the efforts of scientists working independently on the genome of the E.coli K-12 strain, an international team of biologists, led by MBL (Marine Biological Laboratory) scientists Monica Riley and Margrethe "Gretta" Serres, has published a comprehensive, updated description of all 4,500 E. coli K-12 genes. The data is presented in the January 5, 2006 online issue of the journal Nucleic Acids Research.

"The E. coli scientific community is scattered," said Riley, a senior scientist in the MBL's Josephine Bay Paul Center for Comparative Molecular Biology and Evolution. "We determined that we needed to get together and pool everything we know into one package. E. coli is one of the most important model organisms for molecular science today. Our work will help move this forward."

A group of 19 scientists from four countries updated the annotation of E. coli K-12 at two MBL workshops organized by Riley and Serres. Annotation involves identification of genes, and their starting and ending sites, as well as the description of gene products. The process helps scientists to determine gene function.

During the MBL workshops, Riley and her colleagues assigned known or predicted gene functions to each E. coli K-12 product based on previously known experimental evidence or sequence analysis. "We cooperated to an amazing extent, reviewing every single one of 4,500 genes of E. coli K-12," said Riley. The scientists developed the best consensus on the status and properties of each of the E.coli K-12 genes at the present moment. Their goal was not to create a new database, but to present a comprehensive, updated annotation of E.coli K-12, which would be readily available to the public. "Our work puts a searchlight on the fraction of E. coli genes that are unknown and will accelerate laboratory work on the unknown functions with the goal of knowing what every gene does in the living organism," said Riley.

According to Riley, currently there is no funding by an agency for any kind of coordinated E. coli annotation effort, however interested members of the E. coli community are applying to NIH for support to establish a K-12 information resource. "Interaction among the scientists accelerates discovery and the hope is that this kind of work will soon be centralized," she said. "This would provide more efficient coordination of scientific groups that are working independently."


'"/>

Source:Marine Biological Laboratory


Related biology news :

1. Study of genomic DNA leads to new advances in cancer diagnostics
2. Combination therapy leads to partial recovery from spinal cord injury in rats
3. Chemical guidance of T cells leads to immunologic memory and long-term immunity
4. Basic research leads to a novel cancer therapy
5. Less antibiotic use in food animals leads to less drug resistance in people, study shows
6. With cochlear implants, earlier use leads to better speech
7. Pest control research leads to pain control discovery
8. UT Southwestern researchers find gene mutation that leads to broken hearts
9. Nicotine exposure during development leads to hearing problems
10. Combination therapy with a monocloncal antibody and a vaccine leads to tumor rejection
11. Dopamine drug leads to new neurons and recovery of function in rat model of Parkinsons
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/19/2016)... , UAE, April 20, 2016 ... be implemented as a compact web-based "all-in-one" system solution ... the biometric fingerprint reader or the door interface with ... of modern access control systems. The minimal dimensions of ... ID readers into the building installations offer considerable freedom ...
(Date:4/15/2016)... 2016 Research and Markets has ... Market 2016-2020,"  report to their offering.  , ... ,The global gait biometrics market is expected to ... period 2016-2020. Gait analysis generates multiple ... used to compute factors that are not or ...
(Date:4/13/2016)... -- IMPOWER physicians supporting Medicaid patients in Central ... in telehealth thanks to a new partnership with higi. ... patients can routinely track key health measurements, such as ... when they opt in, share them with IMPOWER clinicians ... retail location at no cost. By leveraging this data, ...
Breaking Biology News(10 mins):
(Date:4/28/2016)... Hill, Conn. (PRWEB) , ... April 28, 2016 ... ... of financing and ongoing support for Connecticut's innovative, growing companies, today announced the ... digital health and financial technology (fintech) companies. , “VentureClash looks to ...
(Date:4/27/2016)... ... , ... Shimadzu Scientific Instruments (SSI) will be showcasing a ... and Expo. Shimadzu’s high-performance instruments enable laboratories to test cannabis products for potency, ... by booth 1021 to learn how Shimadzu’s instruments can help improve QA/QC testing, ...
(Date:4/27/2016)... ... April 27, 2016 , ... The Board of Directors of ... John Tilton as Chief Commercial Officer.  Mr. Tilton joined Biohaven from Alexion Pharmaceuticals, ... leaders responsible for the commercialization of multiple orphan drug indications. Mr. Tilton ...
(Date:4/27/2016)... ... ... Global Stem Cells Group and the University of Santiago Biotechnology ... development initiatives for potential stem cell protocol management for 2016 – 2020. , ... meeting to establish a working agenda and foster initiatives to promote stem cell research ...
Breaking Biology Technology: