Navigation Links
MBL leads effort to update E. coli genome

E.coli is one of the most important model organisms for molecular science today and is arguably the single organism about which the most is known. The genes of higher-level plants and animals, even humans, are often understood by their similarity to E. coli genes. As such, the accuracy and completeness of E.coli genome information is of great importance to the scientific community.

In an attempt to consolidate the efforts of scientists working independently on the genome of the E.coli K-12 strain, an international team of biologists, led by MBL (Marine Biological Laboratory) scientists Monica Riley and Margrethe "Gretta" Serres, has published a comprehensive, updated description of all 4,500 E. coli K-12 genes. The data is presented in the January 5, 2006 online issue of the journal Nucleic Acids Research.

"The E. coli scientific community is scattered," said Riley, a senior scientist in the MBL's Josephine Bay Paul Center for Comparative Molecular Biology and Evolution. "We determined that we needed to get together and pool everything we know into one package. E. coli is one of the most important model organisms for molecular science today. Our work will help move this forward."

A group of 19 scientists from four countries updated the annotation of E. coli K-12 at two MBL workshops organized by Riley and Serres. Annotation involves identification of genes, and their starting and ending sites, as well as the description of gene products. The process helps scientists to determine gene function.

During the MBL workshops, Riley and her colleagues assigned known or predicted gene functions to each E. coli K-12 product based on previously known experimental evidence or sequence analysis. "We cooperated to an amazing extent, reviewing every single one of 4,500 genes of E. coli K-12," said Riley. The scientists developed the best consensus on the status and properties of each of the E.coli K-12 genes at the present moment. Their goal was not to create a new database, but to present a comprehensive, updated annotation of E.coli K-12, which would be readily available to the public. "Our work puts a searchlight on the fraction of E. coli genes that are unknown and will accelerate laboratory work on the unknown functions with the goal of knowing what every gene does in the living organism," said Riley.

According to Riley, currently there is no funding by an agency for any kind of coordinated E. coli annotation effort, however interested members of the E. coli community are applying to NIH for support to establish a K-12 information resource. "Interaction among the scientists accelerates discovery and the hope is that this kind of work will soon be centralized," she said. "This would provide more efficient coordination of scientific groups that are working independently."


'"/>

Source:Marine Biological Laboratory


Related biology news :

1. Study of genomic DNA leads to new advances in cancer diagnostics
2. Combination therapy leads to partial recovery from spinal cord injury in rats
3. Chemical guidance of T cells leads to immunologic memory and long-term immunity
4. Basic research leads to a novel cancer therapy
5. Less antibiotic use in food animals leads to less drug resistance in people, study shows
6. With cochlear implants, earlier use leads to better speech
7. Pest control research leads to pain control discovery
8. UT Southwestern researchers find gene mutation that leads to broken hearts
9. Nicotine exposure during development leads to hearing problems
10. Combination therapy with a monocloncal antibody and a vaccine leads to tumor rejection
11. Dopamine drug leads to new neurons and recovery of function in rat model of Parkinsons
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/15/2016)... , April 15, 2016  A new ... make more accurate underwriting decisions in a fraction ... timely, competitively priced and high-value life insurance policies ... screenings. With Force Diagnostics, rapid testing ... lifestyle data readings (blood pressure, weight, pulse, BMI, ...
(Date:4/13/2016)... CHICAGO , April 13, 2016  IMPOWER physicians ... are setting a new clinical standard in telehealth ... By leveraging the higi platform, IMPOWER patients can ... weight, pulse and body mass index, and, when they ... quick and convenient visit to a local retail location ...
(Date:3/29/2016)... 2016 LegacyXChange, Inc. (OTC: ... SelectaDNA/CSI Protect are pleased to announce our successful effort ... variety of writing instruments, ensuring athletes signatures against counterfeiting ... from athletes on LegacyXChange will be assured of ongoing ... Bill Bollander , CEO states, "By ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 23, 2016  The Biodesign Challenge (BDC), a university ... to harness living systems and biotechnology, announced its winning ... New York City . ... showcased projects at MoMA,s Celeste Bartos Theater during the ... MoMA,s senior curator of architecture and design, and ...
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, the Industry Network for ... Design Lab . Located in Pasadena, Calif., the Design Lab’s mission is to ... are designed, built and brought to market. , The Design Lab is Supplyframe’s ...
(Date:6/23/2016)... ... June 23, 2016 , ... In a new case report published today ... a patient who developed lymphedema after being treated for breast cancer benefitted from an ... paradigm for dealing with this debilitating, frequent side effect of cancer treatment. ...
(Date:6/23/2016)... June 23, 2016  Blueprint Bio, a company dedicated ... the medical community, has closed its Series A funding ... . "We have received a commitment from ... we need to meet our current goals," stated ... the runway to complete validation on the current projects ...
Breaking Biology Technology: