Navigation Links
Loosen up, DNA: Leukemia gene changes genetic packaging

A signaling system involved in many forms of leukemia and lymphoma is more powerful than scientists have thought, exerting control over our genes by affecting whole swaths of chromosomes in global fashion, according to a paper in the September issue of Nature Genetics and appearing online August 6.

While the research involving a cellular signaling system known as JAK/STAT focused on complex questions involving the roots of cancer, the answers the researchers got came very simply and clearly ?in red and white. By looking at the eye color of a variety of mutant flies, the team at the University of Rochester Medical Center made a surprising finding about a known cancer gene that meshes nicely with current trends in cancer drug research.

Instead of developing drugs that target a single gene or protein, many companies are taking aim at the way whole sets of genes are packaged in an attempt to turn on or off several genes at a time. It's part of a field known as "epigenetics": Now that the sequence of chemical bases that make up our genes is largely known, scientists are turning more attention to broader mechanisms of how the body controls those genes, turning them on and off as needed.

It's a crucial issue for diseases like cancer, where many genes are turned on or off when or where they shouldn't be, causing cells to grow out of control. A system similar to JAK/STAT in humans, for instance, is vital for normal health, helping us fight disease and grow new blood cells, but when its signals run amok, those people are much more likely to get any one of several types of leukemia or lymphoma.

To learn more about how JAK/STAT works, a team led by Willis Li, Ph.D., assistant professor in the Department of Biomedical Genetics, devised a complex experiment involving fruit flies. Researchers created flies with normal amounts of the signaling system and compared them to mutant flies with increased or decreased JAK/STAT signaling. They moved the
'"/>

Source:University of Rochester Medical Center


Page: 1 2 3 4

Related biology news :

1. Loosen leash on cancer protein watchdog, researchers say
2. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
3. Protein That Promotes Survival Of Stem Cells Might Be Key To Poor Leukemia Prognosis
4. Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells
5. Leukemia drug turns mini-molecules up, cancer genes down
6. Researchers trace evolution to relatively simple genetic changes
7. Plants defy Mendels inheritance laws, may prompt textbook changes
8. Scientists find evidence of catastrophic sand avalanches, sea level changes in Gulf of Mexico
9. Customized gene chip provides rapid detection of genetic changes in childrens cancer
10. New amphibian species result from exploration, not from rule changes
11. Embryonic stem cells accrue genetic changes
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Loosen DNA Leukemia gene changes genetic packaging

(Date:9/17/2014)... scientists were instrumental in the creation of the Santa ... classify the fire threat potential of the powerful, hot, ... into an inferno. The index was introduced Sept. 17 ... and San Diego Gas and Electric. , The index ... that will be used to help fire agencies and ...
(Date:9/17/2014)... his doctoral student have designed a device based on ... fog and dew., The device could provide water in ... globe., Cheng Luo, professor in the Mechanical & Aerospace ... same College of Engineering department, published "Bioinspired Plate-Based Fog ... Chemical Society) Applied Materials & Interfaces ...
(Date:9/17/2014)... A rare genetic disorder known as Jacobsen syndrome has ... investigation by researchers at San Diego State University and ... suggesting better treatment options for people with Jacobsen syndrome, ... underpinnings of autism., Jacobsen syndrome affects approximately 1 in ... It occurs in a person when there is a ...
Breaking Biology News(10 mins):UCLA scientists play key role in developing new Santa Ana Wildfire Threat Index 2Shorebird's beak inspires UT Arlington research on water collection 2A link between Jacobsen syndrome and autism 2
... new field study confirms that an invasive weed called ... suggesting it will continue to spread across much of ... acres of grazing land almost worthless. The research, ... Research Service, was one of the most comprehensive studies ...
... What: , The 33rd CTRC-AACR San Antonio ... prevention, epidemiological, laboratory, translational and clinical breast cancer research. ... pipeline, new approaches with existing agents and emerging biology ... To help you plan your coverage of the symposium, ...
... growing potatoes, at least for growing seed potatoes. Newco ... together with Neiker-Tecnalia (the Basque Institute for Agricultural Research ... of a novel system known as aeroponics. What ... given that never before in this country the first ...
Cached Biology News:Invading weed threatens devastation to western rangelands 2Invading weed threatens devastation to western rangelands 3Newco produces seed potatoes in the open air 2Newco produces seed potatoes in the open air 3
(Date:9/18/2014)... -- MEI Pharma, Inc. (Nasdaq: MEIP ), an oncology ... cancer, announced today that Daniel P. Gold , Ph.D., ... NewsMakers in the Biotech Industry conference on Friday, September ... Broadway Hotel & Conference Center in New York ... accessed at www.meipharma.com . A replay will be available ...
(Date:9/18/2014)... 18 septembre 2014 Mapi, société créée ... 1974, a été depuis 40 ans l,un ... cliniques traditionnelles par des évaluations recentrées sur ... les impacts économiques des traitements. ... A cours d,une récente conférence téléphonique ...
(Date:9/18/2014)... SeqLL Inc., the owner of ... today the closing of a $1M Series-A funding ... Diagnostic Technologies, will increase the power of tSMS™ ... in March 2013 by Daniel Jones, a former ... BioSciences, SeqLL has continued to offer Helicos’ sequencing ...
(Date:9/18/2014)... sweeteners, promoted as aids to weight loss and diabetes ... and metabolic disease; and they do it in a ... the gut microbiota the substantial population of bacteria ... experiments in mice and humans, were published today in ... Elinav of the Weizmann Institute,s Immunology Department, who led ...
Breaking Biology Technology:MEI Pharma To Present At BioCentury's NewsMakers Conference 2MEI Pharma To Present At BioCentury's NewsMakers Conference 31974 - 2014 - Mapi fête ses 40 ans 2SeqLL Closes Series-A Funding Round for Expansion of Single Molecule Sequencing 2Gut bacteria, artificial sweeteners and glucose intolerance 2Gut bacteria, artificial sweeteners and glucose intolerance 3
... /PRNewswire-FirstCall/ - Angiotech Pharmaceuticals,Inc. (NASDAQ: ANPI , ... company, today announced that it has elected to ... trials for its Vascular Wrap,product candidate in patients ... to evaluate an imbalance of infections that have,been ...
... April 21 A group of German,investors is about to ... for a purchasing price of up to EUR 750,000. The ... will be subscribed,to by the investors. It will become effective ... Sangui account and after the capital increase will,have been entered ...
... an interview with a researcher, please contact the Communications and ... tip. For more information on ORNL and its research and ... If you have a general media-related question or comment, you ... HOMELAND SECURITY -- Protecting ports . . . ...
Cached Biology Technology:Angiotech elects to suspend Vascular Wrap(TM) pivotal clinical trials 2Angiotech elects to suspend Vascular Wrap(TM) pivotal clinical trials 3Angiotech elects to suspend Vascular Wrap(TM) pivotal clinical trials 4Investors Acquire Share in Sangui BioTech GmbH 2Story tips from the Department of Energy's Oak Ridge National Laboratory, March 2008 2Story tips from the Department of Energy's Oak Ridge National Laboratory, March 2008 3
... The MEGAscript RNAi Kit is ... large mass amounts of ready-to-use ... non-mammalian systems. The MEGAscript RNAi ... patented high-yield transcription technol-ogy and ...
UGT1A6 (D-20)...
... With its patented technology, the Lone Wolf ... any Normally Open proportional valve available on ... operation, provides repeatable high-speed performance, and ensures ... , Enhances system control and patient ...
Normal Hamster Serum...
Biology Products: