Navigation Links
Loosen up, DNA: Leukemia gene changes genetic packaging

A signaling system involved in many forms of leukemia and lymphoma is more powerful than scientists have thought, exerting control over our genes by affecting whole swaths of chromosomes in global fashion, according to a paper in the September issue of Nature Genetics and appearing online August 6.

While the research involving a cellular signaling system known as JAK/STAT focused on complex questions involving the roots of cancer, the answers the researchers got came very simply and clearly ?in red and white. By looking at the eye color of a variety of mutant flies, the team at the University of Rochester Medical Center made a surprising finding about a known cancer gene that meshes nicely with current trends in cancer drug research.

Instead of developing drugs that target a single gene or protein, many companies are taking aim at the way whole sets of genes are packaged in an attempt to turn on or off several genes at a time. It's part of a field known as "epigenetics": Now that the sequence of chemical bases that make up our genes is largely known, scientists are turning more attention to broader mechanisms of how the body controls those genes, turning them on and off as needed.

It's a crucial issue for diseases like cancer, where many genes are turned on or off when or where they shouldn't be, causing cells to grow out of control. A system similar to JAK/STAT in humans, for instance, is vital for normal health, helping us fight disease and grow new blood cells, but when its signals run amok, those people are much more likely to get any one of several types of leukemia or lymphoma.

To learn more about how JAK/STAT works, a team led by Willis Li, Ph.D., assistant professor in the Department of Biomedical Genetics, devised a complex experiment involving fruit flies. Researchers created flies with normal amounts of the signaling system and compared them to mutant flies with increased or decreased JAK/STAT signaling. They moved the
'"/>

Source:University of Rochester Medical Center


Page: 1 2 3 4

Related biology news :

1. Loosen leash on cancer protein watchdog, researchers say
2. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
3. Protein That Promotes Survival Of Stem Cells Might Be Key To Poor Leukemia Prognosis
4. Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells
5. Leukemia drug turns mini-molecules up, cancer genes down
6. Researchers trace evolution to relatively simple genetic changes
7. Plants defy Mendels inheritance laws, may prompt textbook changes
8. Scientists find evidence of catastrophic sand avalanches, sea level changes in Gulf of Mexico
9. Customized gene chip provides rapid detection of genetic changes in childrens cancer
10. New amphibian species result from exploration, not from rule changes
11. Embryonic stem cells accrue genetic changes
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Loosen DNA Leukemia gene changes genetic packaging

(Date:12/17/2014)... , Dec. 15, 2014 Research and Markets ... the "Samsung Galaxy S5 - Home Button Synaptics ... http://photos.prnewswire.com/prnh/20130307/600769 ... iPhone 5S, Samsung introduces for the first time a ...
(Date:12/17/2014)... NEW YORK , Dec. 15, 2014  HITLAB SM ... Practices (GCP) audit to confirm its adherence to current ... enables HITLAB to conduct regulated smart device and smart ... safety and research quality. "HITLAB is determined ...
(Date:12/17/2014)... Markets ( http://www.researchandmarkets.com/research/9zq33j/global_chemical ) has announced the ... report to their offering. ... in this market is the increasing demand for medical ... of patient data for quick and correct diagnosis during ...
Breaking Biology News(10 mins):Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2
... to be essential in helping chemotherapy kill cancer cells, may ... patients, scientists at the Georgia Institute of Technology and the ... tumors had mutations in the gene p53 were still alive ... 30 percent survival rate. The findings raise the possibility of ...
... and tasty, but don’t count on them to ... of Cancer Epidemiology, Biomarkers & Prevention, researchers based ... Cancer Research Center report that lycopene, an antioxidant ... prostate cancer. In fact, the researchers noted ...
... in the prestigious international journal, the British Journal of ... be explained by increases in clinical reasons for caesareans ... more likely due to societal factors. , The research ... 1984 and 2003 (more than 430,000 births) and ...
Cached Biology News:Gene thought to assist chemo may help cancer thrive 2Gene thought to assist chemo may help cancer thrive 3No magic tomato? Study breaks link between lycopene and prostate cancer prevention 2Study shows dramatic increase in Caesarean sections 2
(Date:1/22/2015)... 22, 2015 Eckert & Ziegler Vitalea ... (AMS) services to the pharmaceutical and biotech industry, has ... company in the position of Director of Science & ... and valuable experience in drug metabolism and bioanalysis to ...
(Date:1/22/2015)... GEA Niro Soavi the leader in high ... PandaPLUS 2000, which is ideal for new applications for ... disruption . This compact laboratory homogenizer is the perfect ... food additives and ingredients as well as for the ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 The laboratory ... that has witnessed a number of technological advancements due ... regulatory requirements, growing need to integrate healthcare systems, and ... ease challenges in system integration. Key players in the ...
(Date:1/22/2015)... Pipette.com has added the Eppendorf Centrifuge ... of Eppendorf products. , The Eppendorf Centrifuge 5424/5424 R ... R and receive the following:, ,     Free ... Eppendorf Reference 2 ,     3 Free boxes ...
Breaking Biology Technology:Eckert & Ziegler Vitalea Science appoints Mark Seymour, PhD as Director of Science & Technology 2Eckert & Ziegler Vitalea Science appoints Mark Seymour, PhD as Director of Science & Technology 3GEA Niro Soavi Announces the PandaPLUS 2000 Homogenizer for Processing New Applications for Nanoemulsions and Cell Disruption 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 3Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 4Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2
... 7 /PRNewswire-FirstCall/ - Dragon Pharmaceutical Inc. ("Dragon" or the ... receipt of preliminary proxies, the Company believes that it has ... ("Merger") by and among Dragon, Chief Respect Limited, Datong Investment ... Yanlin Han . The Merger must be approved by holders ...
... , , ... a 25 percent replacement for petroleum oil more than doubles rubber,s stretchability and reduces its environmental ... Ford,s ... automotive parts such as deflector shields and baffles, radiator deflector shields, cupholder inserts and floor mats ...
... DATATRAK International, Inc. (OTCQX: DATA), a technology and services ... industry, today announced that it privately placed 357,857 common shares ... with certain members of its Board of Directors and management ... are restricted securities and are subject to the restrictions on ...
Cached Biology Technology:Dragon Pharma announces receipt of preliminary proxies to approve merger 2Dragon Pharma announces receipt of preliminary proxies to approve merger 3Ford Pioneers Patent-Pending Use of Eco-Friendly Soy Oil in Rubber Automotive Parts 2Ford Pioneers Patent-Pending Use of Eco-Friendly Soy Oil in Rubber Automotive Parts 3Ford Pioneers Patent-Pending Use of Eco-Friendly Soy Oil in Rubber Automotive Parts 4DATATRAK Completes Sale of 357,857 Common Shares to Directors and Management 2DATATRAK Completes Sale of 357,857 Common Shares to Directors and Management 3
... reagent (F-2902) was developed in collaboration with ... measurement of the kinetics of Fc receptor ... directly in the phagovacuole.2 The Fc OxyBURST ... albumin (BSA) that has been covalently linked ...
Because it is manufactured at our ISO 9001–certified facilities in Eugene, Oregon, we can guarantee that FluoroPure grade propidium iodide is greater than or equal to 98% pure by HPLC....
MOUSE ANTI RABBIT T LYMPHOCTYES Immunogen: Rabbit Thymocytes...
TACS Apoptotic DNA Laddering Kits are used to assay cells and tissues for apoptosis by...
Biology Products: