Navigation Links
Loosen up, DNA: Leukemia gene changes genetic packaging

A signaling system involved in many forms of leukemia and lymphoma is more powerful than scientists have thought, exerting control over our genes by affecting whole swaths of chromosomes in global fashion, according to a paper in the September issue of Nature Genetics and appearing online August 6.

While the research involving a cellular signaling system known as JAK/STAT focused on complex questions involving the roots of cancer, the answers the researchers got came very simply and clearly ?in red and white. By looking at the eye color of a variety of mutant flies, the team at the University of Rochester Medical Center made a surprising finding about a known cancer gene that meshes nicely with current trends in cancer drug research.

Instead of developing drugs that target a single gene or protein, many companies are taking aim at the way whole sets of genes are packaged in an attempt to turn on or off several genes at a time. It's part of a field known as "epigenetics": Now that the sequence of chemical bases that make up our genes is largely known, scientists are turning more attention to broader mechanisms of how the body controls those genes, turning them on and off as needed.

It's a crucial issue for diseases like cancer, where many genes are turned on or off when or where they shouldn't be, causing cells to grow out of control. A system similar to JAK/STAT in humans, for instance, is vital for normal health, helping us fight disease and grow new blood cells, but when its signals run amok, those people are much more likely to get any one of several types of leukemia or lymphoma.

To learn more about how JAK/STAT works, a team led by Willis Li, Ph.D., assistant professor in the Department of Biomedical Genetics, devised a complex experiment involving fruit flies. Researchers created flies with normal amounts of the signaling system and compared them to mutant flies with increased or decreased JAK/STAT signaling. They moved the
'"/>

Source:University of Rochester Medical Center


Page: 1 2 3 4

Related biology news :

1. Loosen leash on cancer protein watchdog, researchers say
2. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
3. Protein That Promotes Survival Of Stem Cells Might Be Key To Poor Leukemia Prognosis
4. Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells
5. Leukemia drug turns mini-molecules up, cancer genes down
6. Researchers trace evolution to relatively simple genetic changes
7. Plants defy Mendels inheritance laws, may prompt textbook changes
8. Scientists find evidence of catastrophic sand avalanches, sea level changes in Gulf of Mexico
9. Customized gene chip provides rapid detection of genetic changes in childrens cancer
10. New amphibian species result from exploration, not from rule changes
11. Embryonic stem cells accrue genetic changes
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Loosen DNA Leukemia gene changes genetic packaging

(Date:7/11/2014)... members to reduce aggression and gain access to scarce ... activities shows a certain pattern across the day. The ... Biology Letters . , Grooming between individuals in a ... To be groomed has hygienic benefits and is stress ... provide access to infants, mating opportunities and high quality ...
(Date:7/11/2014)... stem cells can stimulate neurogenesis in the brain of ... and improve tissue and function injury under the condition ... therapeutic effect of adipose-derived stem cells (ADSCs) transplantation in ... injury and neurogenesis in the brain of AD mice. ... Sciences, Tsinghua University, China transplanted ADSCs into the hippocampus ...
(Date:7/11/2014)... to study the proteins that let nerve cells send ... stumbled upon a biological tactic that may offer a ... a safe and environmentally responsible way. , Their ... one species and harmless for a closely related onesuggests ... without harming beneficial species like bees. A summary of ...
Breaking Biology News(10 mins):Baboons groom early in the day to get benefits later 2Potent spider toxin 'electrocutes' German, not American, cockroaches 2Potent spider toxin 'electrocutes' German, not American, cockroaches 3
... Researchers at the University of Southern California's Viterbi ... "High-resolution Ultrasonic Transmission Tomography" (HUTT) system that offers ... to those produced by existing commercial X-ray, ultrasound ... of biomedical engineering at the Viterbi School, presented ...
... Fry, Ph.D., a scientist from the University of Melbourne, ... origin and evolution of one of nature's most sophisticated ... March issue of the journal Genome Research. , Venomous ... evolved glands for the storage and dispersal of their ...
... from bat bites, far more people are treated for raccoon ... reported rabid mammal. Controlling the spread of rabies depends on ... outbreaks might occur and how the virus might spread. In ... Biology, Real and colleagues apply a mathematical model to predict ...
Cached Biology News:A probe, not an echo 2A probe, not an echo 3A probe, not an echo 4Venom doc tracks down snake bioweapons 2Rabies spread speeds up 2
(Date:7/11/2014)... , July 11, 2014 ... to announce the appointment of John P. Donoghue ... Biotech   in  Geneva . The ... Campus Biotech in Geneva , has ... recognised neuroscientists. John P. Donoghue , founder of ...
(Date:7/10/2014)... 10, 2014 Product and process ... low abundance and are often “lost in the ... , Join presenters Dr. Rowel Tobias, Senior Scientist, ... Anders, Head of Quality at Nanotherapeutics, Inc., to ... can speed detection and quantitation while achieving the ...
(Date:7/10/2014)... 2014 Robert Harman, DVM, Founder and CEO ... proud to announce the relaunch of his highly informative blog, ... series called “ What are Stem Cells ?” Dr. ... straightforward foundation in the basics of stem cell therapy so ... right type of treatment when considering regenerative medicine. , A ...
(Date:7/10/2014)... 10, 2014 On July 9 ... , presented Russia,s first national ... The Company is developing a unique project called ... develops a number of innovative drugs based on monoclonal ... ceremony took place at the International Exhibition "Innoprom 2014" ...
Breaking Biology Technology:John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 2John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 3Novel Ms Techniques Speed Detection of Biopharmaceutical Product and Process Impurities, New Webinar Hosted by Xtalks 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2
... Widespread use of nanoscale silver will challenge regulatory ... possibility of significant environmental risk, highlighting the need ... according to a new report released today by ... But existing information about the impact of silver ...
... Inc., (TSX:,ARI), a biotechnology company discovering and developing ... RiskMetrics ISS Canada,Canada,s leading independent proxy firm, has ... and are recommending that ARIUS shareholders,and warrant holders ... Roche,will acquire all of ARIUS, outstanding shares and ...
... NewsRx, a 25-year-old publisher and,international news organization headquartered ... and psychiatry/psychology., These new titles will cover ... news and developments in pediatric,and psychiatric medicine. The ... print or online at http://www.NewsRx.com . ...
Cached Biology Technology:Nanoscale silver: No silver lining? 2Nanoscale silver: No silver lining? 3Arius announces leading independent proxy firm, RiskMetrics ISS Canada, recommends shareholders vote for the arrangement involving its acquisition by Roche 2Arius announces leading independent proxy firm, RiskMetrics ISS Canada, recommends shareholders vote for the arrangement involving its acquisition by Roche 3NewsRx Adds Pediatrics and Psychiatry Titles 2
...
... 13(S)-HODE-d4 contains 4 deuterium atoms at the 9, ... for use as an internal standard for the ... 13(S)-HODE is produced by incubation of linoleic acid ... shown to inhibit the adhesion of tumor cells ...
... and TriEx Insect Cell Medium are recommended ... This cell/medium combination has been selected based ... protein expression levels observed specifically with baculoviruses ... that our Ready-Plaque Sf9 Cells and BacVector ...
...
Biology Products: