Navigation Links
Loosen leash on cancer protein 'watchdog,' researchers say

od news than we initially expected."

Mice with such a predisposition generally developed about 50 intestinal lesions within six months of birth, but mice modified for the study had only developed three or fewer within that time frame. Moreover, there was no sign that the mice had aged any faster than normal.

"We checked for the sort of characteristics that the elderly of many mammal species typically show - thinner skin, lower bone density, spinal hunching and the like," Mendrysa said. "We couldn't find any differences between them and normal mice. And their cancer rates were dramatically lower than expected, which turned out to be the more significant finding of the study."

Mendrysa said the results were an enlightening fundamental discovery about suppressing hereditary intestinal cancers. But she also said the work raised a number of questions that would need to be answered before the research could translate into human therapy.

"These mice were genetically modified at conception to produce higher p53 levels, which is quite a different treatment than just giving normal mice a pill," Mendrysa said. "Also, mice in our study are not subject to the same stresses as, for example, a person working on Wall Street. It remains to be seen whether higher p53, in conjunction with other factors such as stress, could still lead to negative consequences such as aging. We'll have to do a lot more work before this becomes a routine part of medicine's anticancer toolkit.

"Essentially, this study validates Mdm2 as a potentially powerful chemopreventative for some kinds of hereditary cancer, and, if used properly, it might perform well without elevating the risks of aging that other groups have found. The benefits seem to outweigh the risks.

"We'd like to expand the research and look into how Mdm2 and p53 affect other cancer predispositions. If we can find the right length for the leash, someday we may be able to find a way to specify i
'"/>

Source:Purdue University


Page: 1 2 3 4

Related biology news :

1. Loosen up, DNA: Leukemia gene changes genetic packaging
2. How an AIDS-Related Cancer Unleashes Inflammation
3. Viral DNA sequence a possible trigger for breast cancer
4. Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
5. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
6. Columbia research lifts major hurdle to gene therapy for cancer
7. Combination therapy boosts effectiveness of telomere-directed cancer cell death
8. Mitochondrial DNA mutations play significant role in prostate cancer
9. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
10. BRCA1 causes ovarian cancer through indirect, biochemical route
11. Researchers identify target for cancer drugs

Post Your Comments:
(Date:11/4/2009)...e University of Oklahoma at Norman has received mo...unding agencies as part of the federal stimulus pr...g received by OU researchers to $23 million. Thir...earch ranging from archaeology to weather. , "Th...tic approach to matching areasof scholarly excelle...
(Date:11/4/2009)..., MADISON, N.J., Oct. 20 ... world,s leading provider of diagnostic testing, i...ird quarter ended September 30, 2009, income from ...02 per diluted share, from $160 million, or $0.81 ...In 2008, third quarter results were reduced by a $...
(Date:11/4/2009)..., BEDFORD, Mass., Oct. 20 /PRNewswire-FirstCall/ -... of broadband technology and biometrics software, ...arter ended September 30, 2009. ,, Michael Tz...r, said, "Earlier today, we announced an agreement... to Lantiq, a new fabless semiconductor company be...
Breaking Biology News(10 mins):OU achieves $10 million in stimulus grants for 33 projects on the Norman campus 2OU achieves $10 million in stimulus grants for 33 projects on the Norman campus 3Quest Diagnostics Reports Strong Performance in Third Quarter 2009 2Quest Diagnostics Reports Strong Performance in Third Quarter 2009 3Quest Diagnostics Reports Strong Performance in Third Quarter 2009 4Quest Diagnostics Reports Strong Performance in Third Quarter 2009 5Quest Diagnostics Reports Strong Performance in Third Quarter 2009 6Quest Diagnostics Reports Strong Performance in Third Quarter 2009 7Quest Diagnostics Reports Strong Performance in Third Quarter 2009 8Quest Diagnostics Reports Strong Performance in Third Quarter 2009 9Quest Diagnostics Reports Strong Performance in Third Quarter 2009 10Quest Diagnostics Reports Strong Performance in Third Quarter 2009 11Quest Diagnostics Reports Strong Performance in Third Quarter 2009 12Quest Diagnostics Reports Strong Performance in Third Quarter 2009 13Quest Diagnostics Reports Strong Performance in Third Quarter 2009 14Quest Diagnostics Reports Strong Performance in Third Quarter 2009 15Quest Diagnostics Reports Strong Performance in Third Quarter 2009 16Quest Diagnostics Reports Strong Performance in Third Quarter 2009 17Aware, Inc. Reports Third Quarter 2009 Financial Results 2Aware, Inc. Reports Third Quarter 2009 Financial Results 3Aware, Inc. Reports Third Quarter 2009 Financial Results 4Aware, Inc. Reports Third Quarter 2009 Financial Results 5Aware, Inc. Reports Third Quarter 2009 Financial Results 6Aware, Inc. Reports Third Quarter 2009 Financial Results 7Matrixx Initiatives Voluntarily Withdraws Zicam Cold Remedy Swabs Zicam Cold Remedy Nasal Gel 49143 1Matrixx Initiatives Voluntarily Withdraws Zicam Cold Remedy Swabs Zicam Cold Remedy Nasal Gel 49143 2Matrixx Initiatives Voluntarily Withdraws Zicam Cold Remedy Swabs Zicam Cold Remedy Nasal Gel 49143 3AMA Inaugurates J James Rohack as President 49139 1AMA Inaugurates J James Rohack as President 49139 2Governors Unallotment Will Force More Minnesotans into Ranks of the Uninsured 49136 1Governors Unallotment Will Force More Minnesotans into Ranks of the Uninsured 49136 2
...eath bed in Alberta has helped map out the animal,... about how one species lived, says new research co...One of the surprises to me was that the overall pa...l model rather than the catastrophic model we were.... Phillip Currie and professor in the U of A,s Dep...
... of the 18th and 19th centuries led waves of darin...scoveries about its geography, flora and fauna and...us collectors of artifacts and statistics, says th...s were the producers and mediators of a new "globa...an Harry Liebersohn, the author of "The Travelers,...
...gton University in St. Louis have made an importan...lls take to silence unwanted or extra genes using ...ssible to see where, and how, the events in the pa...ing, as the old saying goes. , Craig Pikaar...gy in Arts & Sciences and his collaborators ha...
Other Biology News:Tyrannosaur survivorship -- tough times for teens 2Polynesia explorers created worldwide web of scientific knowledge 2Polynesia explorers created worldwide web of scientific knowledge 3Polynesia explorers created worldwide web of scientific knowledge 4Pathway toward gene silencing described in plants 2Pathway toward gene silencing described in plants 3Pathway toward gene silencing described in plants 4
(Date:11/5/2009)...ov. 5 /PRNewswire-Asia-FirstCall/ -- BMP Sunstone,...e "Company") today announced,that the Company plan...on,Monday, November 9, 2009, after the market clos...call at 5:00 pm ET on November 9, 2009,to discuss ...the call by,dialing 1-888-713-4211 or 1-617-213-48...
(Date:11/5/2009)...rgery and vision correction experts listed in the ...olved at the recently concluded American Academy o...rancisco, California. Dr. Stephen Brint, MD, Dr. F...D, Dr. Peter Rapoza, MD, Dr. Michael Raizman, MD, ...r. Edward Manche, MD, and Dr. Parag Majmudar, MD, ...
(Date:11/4/2009)...inar, which will be presented on November 19 and i... chemistry processing, will deal with the applicat...meso and micro scale flow chemistry equipment. Pr...en recognized with several prestigious prizes and ...on Prize. , Columbia, MD ...
(Date:11/4/2009)...Newswire/ -- DIATHERIX Laboratories, Inc. (DIATHER...e Michigan Security Network Homeland Security Mark... Grimaud, Chairman and Chief Executive Officer of ...dvanced molecular diagnostic testing on bio-prepar...nosis and military efforts. ,, "This conferenc...
Breaking Biology Technology:BMP Sunstone to Report Third Quarter 2009 Financial Results 2Leading Vision Correction Experts in Trusted LASIK Surgeons Directory Educate Fellow Doctors at AAO Annual Meeting 2Leading Vision Correction Experts in Trusted LASIK Surgeons Directory Educate Fellow Doctors at AAO Annual Meeting 3Leading Vision Correction Experts in Trusted LASIK Surgeons Directory Educate Fellow Doctors at AAO Annual Meeting 4Leading Vision Correction Experts in Trusted LASIK Surgeons Directory Educate Fellow Doctors at AAO Annual Meeting 5Leading Vision Correction Experts in Trusted LASIK Surgeons Directory Educate Fellow Doctors at AAO Annual Meeting 6Leading Vision Correction Experts in Trusted LASIK Surgeons Directory Educate Fellow Doctors at AAO Annual Meeting 7Leading Vision Correction Experts in Trusted LASIK Surgeons Directory Educate Fellow Doctors at AAO Annual Meeting 8Leading Vision Correction Experts in Trusted LASIK Surgeons Directory Educate Fellow Doctors at AAO Annual Meeting 9Professor Steven Ley of University of Cambridge will Present Free Webinar, 'Application of the ReactIR Flow Cell to Continuous Processing Technology' 2Professor Steven Ley of University of Cambridge will Present Free Webinar, 'Application of the ReactIR Flow Cell to Continuous Processing Technology' 3DIATHERIX Laboratories Presents at Homeland Security Conference 2
...Medical, Inc., a rapidly,growing medical device co...ms and surgical adhesives, announced today that it... $7.6 Million. The proceeds of this,transaction wi... clinical,trials for its lead product, TissuGlu(R)...as pre-clinical development of Cohera,s product pi...
...on Instruments, Inc., (http://www.nikoninstruments...rect,sales and technical support for Nikon,s BioSc...aging products, along with Industrial products,inc...n Systems, in the,Southern California and Rocky Mo...served by A.G. Heinze, Inc., "Nikon Instruments i...
...m cell company,Neuralstem, Inc. (Amex: CUR ) is f...among other things, that StemCells intentionally w... patentability of StemCells, "new" patent,(US Pat ...ent to deceive,the United States Patent Office in ...of these actions, Neuralstem is asking for a decla...
Other Biology Technology:Cohera Medical, Inc. Announces Closing of Insider Round of Financing for Over $7.6 Million 2Nikon Instruments Begins Direct Sales and Technical Support in Southern California and Rocky Mountain Territories 2Neuralstem Sues StemCells, Inc. Over New Patent 2Neuralstem Sues StemCells, Inc. Over New Patent 3
...bination with the corresponding optimized protocol...tor Kits are only functional in combination with t... be transfected with this kit. The corresponding e...in percent (Efficiency [%] / viability [%]). , C...
...nd antimicrobial stainless steel to create a dual-...ckly inactivate DNA between experiments with UV ...ated stainless steel Decontaminate apparatus and...imer UVP's Sterilizing UV PCR Workstation create...
...g multimode reader with built-in dispenser and inc...s superior flexibility and reliability for drug di...mited wavelength selection for fluorescence intens...says and a dispenser for optimization of kinetic a...
Strip Removal Tool from Thermo Scientific
Biology Products: