Navigation Links
Loosen leash on cancer protein 'watchdog,' researchers say

Scientists may have found a way to keep a protein "watchdog" on high alert to stop hereditary cancers from overrunning our bodies - if they can keep it on a leash of just the right length.

In a collaborative effort, a team of scientists including Purdue University's Susan M. Mendrysa has found that one of the proteins found naturally in cells has the ability to halt the progression of intestinal tumors that arise from genetic predisposition. When the activity of this protein, known only by the technical name of p53, was artificially increased in the cells of laboratory mice, those known to have a hereditary predisposition for developing cancer showed a marked decrease in tumor development when compared with mice that had normal p53 activity.

The study also indicated that the treated mice did not suffer from the side effect the research team most feared: premature aging, which has been linked to overproduction of p53 in other studies. The discovery could assist in future human cancer treatments.

"It's a question of balance," said Mendrysa (pronounced men-DRISS-ah), who is an assistant professor of basic medical sciences in Purdue's College of Veterinary Medicine and co-lead author of the work. "The p53 protein has been long known as an effective weapon against cancers, but we know from previous research that we can't just let it run rampant through the body without some very unpleasant side effects. But if we can give it just enough slack in its leash, it could help some patients from cancer-prone families from ever developing the disease."

The team's research appears in the Jan. 1 issue of the scientific journal Genes and Development. Members of the group include the University of Wisconsin - Madison's Kathleen A. O'Leary (co-lead author), Matthew K. McElwee and Jennifer Michalowski; the Fred Hutchinson Cancer Research Center's Robert N. Eisenman; and the National Cancer Institute's Mary Ellen Perry and Douglas A. Powell. When the grou
'"/>

Source:Purdue University


Page: 1 2 3 4

Related biology news :

1. Loosen up, DNA: Leukemia gene changes genetic packaging
2. How an AIDS-Related Cancer Unleashes Inflammation
3. Viral DNA sequence a possible trigger for breast cancer
4. Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
5. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
6. Columbia research lifts major hurdle to gene therapy for cancer
7. Combination therapy boosts effectiveness of telomere-directed cancer cell death
8. Mitochondrial DNA mutations play significant role in prostate cancer
9. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
10. BRCA1 causes ovarian cancer through indirect, biochemical route
11. Researchers identify target for cancer drugs
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Loosen leash cancer protein watchdog researchers say

(Date:7/24/2014)... RIVERSIDE, Calif. -- To reduce fire hazard in the ... of mechanically cutting woody shrubs and suppressed trees (ladder ... then burned during periods of low fire danger in ... burning and minimize hazardous air pollutants, managers often cover ... polyethylene plastic, commonly referred to as agricultural plastic, in ...
(Date:7/24/2014)... study funded by the New Jersey Recovery Fund and ... of Planning and Public Policy at Rutgers University has ... skeptical about the likelihood of community-based rebuilding solutions. Of ... indicated they were "pessimistic" or "very pessimistic" that the ... be rebuilt better than they were before the storm; ...
(Date:7/24/2014)... which life arose have been maintained in our cells today ... Research published today in the Journal of Biological Chemistry ... also in animals still perform ancient reactions thought to have ... billion years ago. , The primordial soup theory suggests that ... of the combination of metals, gases from the atmosphere and ...
Breaking Biology News(10 mins):Study gives new perspective on agricultural plastic, debris burning, and air quality 2Rutgers study explores attitudes, preferences toward post-Sandy rebuilding 2
... It just got easier to pinpoint biological hot spots in ... a pinpoint. Microscopic algae are called phytoplankton and range from ... being 1/100th the size of a human hair. But as ... of Vancouver Island, British Columbia, are big players when it ...
... MD FASEB MARC (Minority Access to Research Careers) ... American Society for Bone & Mineral Research (ASBMR) 2010 ... 2010. These awards are meant to promote the ... the mainstream of the basic science community and to ...
... October 6, 2010 - A first-of-its-kind study that tracked the ... tagged in the Hudson River discovered that these fish move ... south as Georgia and as far north as Nova Scotia, ... will need to address long-range oceanic threats to the species ...
Cached Biology News:UW-built device reveals invisible world teeming with microscopic algae 2Study provides data that can inform Atlantic sturgeon recovery efforts 2Study provides data that can inform Atlantic sturgeon recovery efforts 3
(Date:7/24/2014)... , July 24, 2014  Asterias Biotherapeutics, Inc. ... emerging field of regenerative medicine, announced today that ... presentation to investors on Tuesday, July 29, 2014, ... presentation will include an overview of Asterias, business ... webcast, visit http://www.ustream.tv/channel/asterias-biotherapeutics at least 15 ...
(Date:7/24/2014)... Yan, Distinguished Professor of Engineering at the University ... to solve problems in energy engineering, environmental sustainability ... on zeolites, porous rock with a well-defined, crystalline ... is so precisely decided that zeolites can separate ... of an angstrom (one-tenth of a nanometer), making ...
(Date:7/24/2014)... July 24, 2014 SRI International has been ... National Institute of Allergy and Infectious Diseases (NIAID), part ... development of potential therapies for HIV infection and AIDS. ... HIV and AIDS and the complications and opportunistic infections ... preventing sexual transmission of HIV. According ...
(Date:7/24/2014)... July 24, 2014 WIRB-Copernicus Group ® ... and ethical review services for clinical research, announced ... a division of Richmond, VA ... biosafety and biosecurity consulting firm in ... WCG,s biosafety division – WCG Biosafety™ – will ...
Breaking Biology Technology:Asterias Biotherapeutics Announces Live Investor Webcast 2Asterias Biotherapeutics Announces Live Investor Webcast 3Asterias Biotherapeutics Announces Live Investor Webcast 4University of Delaware researcher describes new approach for creating organic zeolites 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 3WIRB-Copernicus Group Announces Acquisition of Alliance Biosciences; Executives Join WCG Biosafety Division 2WIRB-Copernicus Group Announces Acquisition of Alliance Biosciences; Executives Join WCG Biosafety Division 3
... Sept. 14 Helix BioPharma Corp. (TSX, FSE: "HBP" / ... list its shares of common stock on the NYSE Amex ... stock will begin trading on the NYSE Amex on September ... delist from the OTCQX once trading begins on the NYSE ...
... 14 The launch of IntriMed Technologies and ... in Oxnard, Calif. were announced today by IntriPlex ... manufacture of ultra-precise components for the data storage ... heritage of engineering innovation, IntriMed ( www.intrimed.com ) ...
... HARBIN, China, Sept. 14 /PRNewswire-Asia-FirstCall/ -- ... ... ... keyed by longUrl, so we need to grab the first one. for (var r in data.results) { ...
Cached Biology Technology:Helix BioPharma Approved for NYSE Amex Listing 2Helix BioPharma Approved for NYSE Amex Listing 3IntriMed Technologies Launched to Address Challenges Faced by Medical Device Manufacturers 2IntriMed Technologies Launched to Address Challenges Faced by Medical Device Manufacturers 3Weikang Bio-Technology Issues 2010 and 2011 Fiscal Year Guidance 2Weikang Bio-Technology Issues 2010 and 2011 Fiscal Year Guidance 3Weikang Bio-Technology Issues 2010 and 2011 Fiscal Year Guidance 4Weikang Bio-Technology Issues 2010 and 2011 Fiscal Year Guidance 5Weikang Bio-Technology Issues 2010 and 2011 Fiscal Year Guidance 6Weikang Bio-Technology Issues 2010 and 2011 Fiscal Year Guidance 7Weikang Bio-Technology Issues 2010 and 2011 Fiscal Year Guidance 8
...
... receptors constitute the principal excitatory ... classes of glutamate receptors exist: ... Ionotropic glutamate receptors are oligomeric ... NMDA1-3, KAI-2) which comprise ligand-gated ...
Identify and characterize Phosphoinositide (PI(4,5)P2) binding...
Recommended fro Western blotting application...
Biology Products: