Navigation Links
Looking for the genes that affect a person's level of response to alcohol

the truth is that high levels of alcohol consumption over time have an impact on the immune function, liver, gastrointestinal system, etc. and we know that people are just not immune to that."

For this study, researchers examined 238 18-to-29-year-old pairs of siblings (about 365 people) who had at least one alcohol-dependent parent. All of the pairs of siblings had had some experience with alcohol use themselves, but were not yet alcohol dependent. The goal was to both measure their LR to alcohol and evaluate how their LR related to specific regions of chromosomes.

LR was established through use of the Subjective High Assessment Scale as well as measurements of body sway. "We looked at almost everything a person could feel after they drink alcohol ?whether dizzy, nauseated, happy, intoxicated, whatever ?and we asked the subjects to rate each one of these feelings from 0, meaning not at all, to 36, meaning the most they could imagine," said Schuckit.

"What's interesting about this design is that researchers used what we would say are two separate phenotypes," said Hesselbrock. "One is the person's subjective opinion of feeling intoxicated, which is the scale used, and the other one is an objective behavioral measure, which is body sway. We know that as people get intoxicated, their ability to stand still is impaired, so that they actually do move back and forth."

In addition, all of the participants supplied blood samples that were used to look for linkages of their LR characteristic to selected chromosomal regions.

Results indicate that an area on chromosome 10 is potentially linked to LR, in particular, the KCNMA1 gene. These results are particularly interesting, said Schuckit, because prior research had indicated a potential link between this section of this chromosome and a person's alcohol response.

"Researchers in San Francisco had previously carried out some research on worms," explained Schuckit, "fin
'"/>

Source:hesselb@psychiatry.uchc.edu


Page: 1 2 3

Related biology news :

1. Looking to a new era in bee research
2. Newly-discovered class of genes determines ?and restricts ?stem cell fate
3. Inexpensive, mass-produced genes core of synthetic biology advances at UH
4. First atlas of key brain genes could speed research on cancer, neurological diseases
5. U-M scientists find genes that control growth of common skin cancer
6. Researchers find missing genes of ancient organism
7. Scientists document complex genomic events leading to the birth of new genes
8. Genrate: a generative model that finds and scores new genes and exons in genomic microarray data
9. Advances in the characterisation of the oyster mushroom genes
10. Researchers find new genes necessary to make embryo
11. Protein helps regulate the genes of embryonic stem cells
Post Your Comments:
(Date:10/10/2008)...or Jim Doyle today announced a historic collaborat...o advance personalized health care leading to heal...isconsin Genomics Initiative is a collaborative re... College of Wisconsin (MCW), University of Wiscons...nd UW-Milwaukee (UWM). , Wisconsin is a leader i...
(Date:10/10/2008)...s aculeatus , is one of the most thoroughly studie...ly useful model for understanding variation in phy...sed by different ecological situations in the wild...tic to developmental and morphological, and finall...far more complex than even imagined. , Studies o...
(Date:10/10/2008)...reated nanowire sensors coupled with simple microp...pecific enough to be used for point-of-care (POC) ...Letters . , The sensors use activation of immune...bacteria, viruses or cancer cells as the detector...nd generate a tiny current in the nanowire electro...
(Date:10/10/2008)... , DNA, the molecule that acts as the carrier o...hly resistant against alteration by ultraviolet li...stability presents some puzzling problems. A key a... bases that make up the DNA molecule. Researchers ...DNA strands differ in their light sensitivity depe...
Breaking Biology News(10 mins):Governor Doyle announces historic genomic research collaboration 2Fitness in a changing world 2Fitness in a changing world 3Sensitive nanowire disease detectors made by Yale scientists 2Can genetic information be controlled by light? 2Switch for Internal Body Clock Found 8161 1Brown researchers create first ever HIV rapid test video 8157 1Brown researchers create first ever HIV rapid test video 8157 2Brown researchers create first ever HIV rapid test video 8157 3Echo Healthcare Reschedules Stockholder Vote on Proposed Merger With XLNT Veterinary Care to December 21 2007 8153 1Echo Healthcare Reschedules Stockholder Vote on Proposed Merger With XLNT Veterinary Care to December 21 2007 8153 2Echo Healthcare Reschedules Stockholder Vote on Proposed Merger With XLNT Veterinary Care to December 21 2007 8153 3Echo Healthcare Reschedules Stockholder Vote on Proposed Merger With XLNT Veterinary Care to December 21 2007 8153 4Echo Healthcare Reschedules Stockholder Vote on Proposed Merger With XLNT Veterinary Care to December 21 2007 8153 5Susan G Komen for the Cure Names Tim Doke Chief Marketing Officer 8149 1Susan G Komen for the Cure Names Tim Doke Chief Marketing Officer 8149 2
...alled Enigmols suppress the growth of human cell l... colon, ovary, pancreas, brain and blood, and redu...ows. , In addition, Enigmols did not show side eff... conducted at the Georgia Institute of Technology,...studies were funded by the National Cancer Institu...
...m from Maine could help to settle a long-standing ...separable in nature; they form a haplotype-a set o...ort the notion that mapping haplotypes may be more...e map could allow researchers to look for a single...l the variations associated with it, since all are...
...articular section of chromosome 11, the result is ...astoma. A new study suggests that detecting this g...hildren with neuroblastoma may indicate to physici...egimen of chemotherapy to fight the cancer. , Edwa...t The Children,s Hospital of Philadelphia, reporte...
...transports gene silencing nanoparticles into tumor...n an animal model of the disease. , In this class...ferrin that normally delivers iron into cells is m...ort interfering RNA) encased in nano-sized sugar p...ic growth-promoting gene called EWS-FLI1 that,s ac...
Other Biology News:Researchers find promising cancer-fighting power of synthetic cell-signaling molecule 2Researchers find promising cancer-fighting power of synthetic cell-signaling molecule 3 Maine Researchers Find Exceptions to Old Rules of Genetic Inheritance 2Chromosome Deletion Predicts Aggressive Neuroblastoma 2Novel gene-silencing nanoparticles shown to inhibit Ewing's sarcoma 2Novel gene-silencing nanoparticles shown to inhibit Ewing's sarcoma 3
(Date:10/10/2008)...ire-FirstCall/ -- Wyeth (NYSE: WYE ),announced to...dividually,and as Administrator of the Estate of E...rt of Common Pleas found in favor of Wyeth., "We ...e evidence," says,Bob Nicholas, an attorney from R...der,s death was tragic, the medical evidence clear...
(Date:10/10/2008)...e Sixth Milestone in its Ofatumumab ...mark, October 10 /- Genmab ...sixth milestone for,ofatumumab (HuMax-CD20(R)) und...line (GSK). A milestone payment of approximately D...triggered by the first patient,receiving treatment...
(Date:10/10/2008)...RNewswire/ -- Finesse Solutions, LLC,Santa Clara,...utions for,life science process applications, anno...reactor control software. TruBio 3.4 software can ...ications, ranging from 1L bench,top R&D glass to 1...4,software is optimized for DeltaV version 9.3 fro...
(Date:10/10/2008)...0 /Xinhua-- Beike,Biotechnology Co. L...ader in,stem cell research and treatment through e...ned eight separate mutual cooperation agreements w... stem cell research organizations.,As part of the ...l Expert,Advisory Committee" and a separate "Data ...
Breaking Biology Technology:Genmab Reaches Milestone in Ofatumumab Collaboration 2Finesse Solutions Launches TruBio 3.4 Bioreactor Control Software 2Stem Cell Leader Beike Signs 8 New Cooperation Agreements, Establishes Safety Monitoring Boards 2Stem Cell Leader Beike Signs 8 New Cooperation Agreements, Establishes Safety Monitoring Boards 3
...upport can help. , ,The manufacturing industry c...rnment help is needed, both at the federal and sta...ill depends on building wealth, for our citizens a...consin currently employs more than 500,000 people ...es in the state. Huge challenges face Wisconsins m...
...ets Get Serious Column that first appeared on The...mulated a great deal of mail with healthy debate a...Here is another look at the same topic that should... can be reached at john@wistechnology.com . , , ...mpressions gleaned from my editorial, I am not an ...
...f the many letters and e-mails that we received af... on July 17, 2003. See below for other related ar... on the Wisconsin Technology Network webpage the w...rsary party here in Milwaukee. Your comment regar...been involved in Wisconsin manufacturing for the p...
...elies on off-the-shelf chips, open-source OS , ,C...n Graphics Corp. (SGI) in more ways than one. , ,A...scrambles to push product out the back door in the...ing earnestly that the market for its latest flags...superclusters, can carry it back to profitability....
Other Biology Technology:Wisconsin Manufacturing - demise or survival? 2Wisconsin Manufacturing - demise or survival? 3Wisconsin Manufacturing - demise or survival? 4Lets Get Serious: Another Look 2Lets Get Serious: Another Look 3JohnLets Get Serious - Manufacturing is a critical part of the Wisconsin economy 2SGI banking on Altix to pay the freight 2SGI banking on Altix to pay the freight 3
DeStreak Reagent, 1 ml. Improves reproducibility and quality of 2-D gels by preventing streaking.Eliminates extra spots caused by nonspecific oxidation of proteins.Stabilizes proteins throughout enti
... major advantages over other RNA precipitation met...or carbohydrates. It is the method of choice for r...s from RNA preparations. Note, LiCl precipitation ...A isolations. If the RNA is to be used for RT-PCR,...
LIVE/DEAD® Sperm Viability Kit *200-1000 assays*
Human Xg Affinity Purified Polyclonal Ab Keywords: Xg glycoprotein, hereditary hemorrhagic telangiectasia Protein Family:
Biology Products: